HPLC-MS/MS Analysis of a Traditional Chinese Medical Formulation of Bu-Yang-Huan-Wu-Tang and Its Pharmacokinetics after Oral Administration to Rats

PLoS ONE

Volumn 7, Issue 8, 2012, Pages

  Shaw, Lee Hsin ^a   Lin, Lie Chwen ^a,b   Tsai, Tung Hu ^a,c,d  

^a NATIONAL YANG MING UNIVERSITY   (Taiwan)

^b NATIONAL RESEARCH INSTITUTE OF CHINESE MEDICINE   (Taiwan)

^c CHINA MEDICAL UNIVERSITY   (Taiwan)

^d TAIPEI CITY HOSPITAL   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

ASTRAGALOSIDE I; ASTRAGALOSIDE II; ASTRAGALOSIDE IV; BU YANG HUAN WU TANG; CALYCOSIN; CALYCOSIN 7 O BETA DEXTRO GLUCOSIDE; CHINESE DRUG; DIGOXIN; FORMONONETIN; LIGUSTILIDE; ONONIN; PAENONIFLORIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CHINESE MEDICINE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG FORMULATION; DRUG HALF LIFE; DRUG STABILITY; DRUG STRUCTURE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIMIT OF DETECTION; LIMIT OF QUANTITATION; MALE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; QUANTITATIVE ANALYSIS; RAT; SENSITIVITY ANALYSIS; SIGNAL NOISE RATIO; TANDEM MASS SPECTROMETRY; TIME TO MAXIMUM PLASMA CONCENTRATION;

ABSORPTION; ADMINISTRATION, ORAL; ANIMALS; CHEMISTRY, PHARMACEUTICAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG PRESCRIPTIONS; DRUG STABILITY; DRUGS, CHINESE HERBAL; LIMIT OF DETECTION; MALE; RATS; RATS, SPRAGUE-DAWLEY; TANDEM MASS SPECTROMETRY;

RATTUS;

EID: 84865579649     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0043848     Document Type: Article

References (36)

1. Zhang H, Wang WR, Lin R, Zhang JY, Ji QL, et al. (2010) Buyang Huanwu decoction ameliorates coronary heart disease with Qi deficiency and blood stasis syndrome by reducing CRP and CD40 in rats. J Ethnopharmacol 130: 98-102.
2. Wang WR, Lin R, Zhang H, Lin QQ, Yang LN, et al. (2011) The effects of Buyang Huanwu Decoction on hemorheological disorders and energy metabolism in rats with coronary heart disease. J Ethnopharmacol 137: 214-220.
3. Wang HW, Liou KT, Wang YH, Lu CK, Lin YL, et al. (2011) Deciphering the neuroprotective mechanisms of Bu-yang Huan-wu decoction by an integrative neurofunctional and genomic approach in ischemic stroke mice. J Ethnopharmacol 138: 22-33.
4. Zhao LD, Wang JH, Jin GR, Zhao Y, Zhang HJ, (2012) Neuroprotective effect of Buyang Huanwu decoction against focal cerebral ischemia/reperfusion injury in rats-time window and mechanism. J Ethnopharmacol 140: 339-344.
5. Qi LW, Yu QT, Yi L, Ren MT, Wen XD, et al. (2008) Simultaneous determination of 15 marker constituents in various radix Astragali preparations by solid-phase extraction and high-performance liquid chromatography. J Sep Sci 31: 97-106.
6. Yesilada E, Bedir E, Calis I, Takaishi Y, Ohmoto Y, (2005) Effects of triterpene saponins from Astragalus species on in vitro cytokine release. J Ethnopharmacol 96: 71-77.
7. Ma X, Tu P, Chen Y, Zhang T, Wei Y, et al. (2004) Preparative isolation and purification of isoflavan and pterocarpan glucosides from Astragalus membranaceus Bge. var. mongholicus (Bge.) Hsiao by high-speed counter-current chromatography. J Chromatogr A 1023: 311-315.
8. Xiao HB, Krucker M, Albert K, Liang XM, (2004) Determination and identification of isoflavonoids in Radix astragali by matrix solid-phase dispersion extraction and high-performance liquid chromatography with photodiode array and mass spectrometric detection. J Chromatogr A 1032: 117-124.
9. Zhang D, Wang D, Yu Y, (2011) [Effects and mechanisms of total flavonoids of astragali radix and calycosin on inhibiting human erythroleukemia cell line K562]. Zhongguo Zhong Yao Za Zhi 36: 3502-3505.
10. Yan R, Ko NL, Li SL, Tam YK, Lin G, (2008) Pharmacokinetics and metabolism of ligustilide, a major bioactive component in Rhizoma Chuanxiong, in the rat. Drug Metab Dispos 36: 400-408.
11. Lu Q, Qiu TQ, Yang H, (2006) Ligustilide inhibits vascular smooth muscle cells proliferation. Eur J Pharmacol 542: 136-140.
12. Ji B, Geng P, Liu JG, Shi DZ, Wang YY, (2006) [Effects of active components extracted from Qixue Bingzhi Recipe on proliferation of vascular smooth muscle cells and expressions of platelet-derived growth factor and its receptor genes]. Zhong Xi Yi Jie He Xue Bao 4: 30-34.
13. Liu EH, Qi LW, Cheng XL, Peng YB, Li P, (2010) Simultaneous determination of twelve bioactive constituents in Buyang Huanwu decoction by HPLC-DAD-ELSD and HPLC-TOF/MS. Biomed Chromatogr 24: 125-131.
14. Liu EH, Qi LW, Peng YB, Cheng XL, Wu Q, et al. (2009) Rapid separation and identification of 54 major constituents in Buyang Huanwu decoction by ultra-fast HPLC system coupled with DAD-TOF/MS. Biomed Chromatogr 23: 828-842.
15. Zhang J, Yang G, Lin R, Hu Z, (2011) Determination of paeoniflorin, calycosin-7-O-beta-D-glucoside, ononin, calycosin and formononetin in rat plasma after oral administration of Buyang Huanwu decoction for their pharmacokinetic study by liquid chromatography-mass spectrometry. Biomed Chromatogr 25: 450-457.
16. Wu YT, Wu MT, Lin CC, Chien CF, Tsai TH, et al. (2011) Pharmacokinetic studies of Chinese medicinal herbs using an automated blood sampling system and liquid chromatography-mass Spectrometry. J Tradition Complement Med 2: 30-40.
17. Reagan-Shaw S, Nihal M, Ahmad N, (2008) Dose translation from animal to human studies revisited. FASEB J 22: 659-661.
18. Wu YT, Huang CM, Lin CC, Ho WA, Lin LC, et al. (2010) Oral bioavailability, urinary excretion and organ distribution of melamine in Sprague-Dawley rats by high-performance liquid chromatography with tandem mass spectrometry. J Agric Food Chem 58: 108-111.
19. Hsieh YJ, Lin LC, Tsai TH, (2006) Measurement and pharmacokinetic study of plumbagin in a conscious freely moving rat using liquid chromatography/tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci 844: 1-5.
20. Guidance for Industry. Available: http://www.fda.gov/downloads/Drugs/GuidanceComplianceRegulatoryInformation/Guidances/ucm070107.pdf. Accessed 2001 May.
21. Zu Y, Yan M, Fu Y, Liu W, Zhang L, et al. (2009) Determination and quantification of astragalosides in Radix Astragali and its medicinal products using LC-MS. J Sep Sci 32: 517-525.
22. Wen XD, Qi LW, Li B, Li P, Yi L, et al. (2009) Microsomal metabolism of calycosin, formononetin and drug-drug interactions by dynamic microdialysis sampling and HPLC-DAD-MS analysis. J Pharm Biomed Anal 50: 100-105.
23. Tong L, Wan M, Zhou D, Gao J, Zhu Y, et al. (2010) LC-MS/MS determination and pharmacokinetic study of albiflorin and paeoniflorin in rat plasma after oral administration of Radix Paeoniae Alba extract and Tang-Min-Ling-Wan. Biomed Chromatogr 24: 1324-1331.
24. Wang D, Song Y, Li SL, Bian YY, Guan J, et al. (2006) Simultaneous analysis of seven astragalosides in Radix Astragali and related preparations by liquid chromatography coupled with electrospray ionization time-of-flight mass spectrometry. J Sep Sci 29: 2012-2022.
25. Lu T, Song J, Huang F, Deng Y, Xie L, et al. (2007) Comparative pharmacokinetics of baicalin after oral administration of pure baicalin, Radix scutellariae extract and Huang-Lian-Jie-Du-Tang to rats. J Ethnopharmacol 110: 412-418.
26. Li P, Zhang Y, Xiao L, Jin X, Yang K, (2007) Simultaneous determination of harpagoside and cinnamic acid in rat plasma by high-performance liquid chromatography: application to a pharmacokinetic study. Anal Bioanal Chem 389: 2259-2264.
27. Huang Y, Bai Y, Zhao L, Hu T, Hu B, et al. (2007) Pharmacokinetics and metabolism of neferine in rats after a single oral administration. Biopharm Drug Dispos 28: 361-372.
28. Zhu Z, Zhao L, Liu X, Chen J, Zhang H, et al. (2010) Comparative pharmacokinetics of baicalin and wogonoside by liquid chromatography-mass spectrometry after oral administration of Xiaochaihu Tang and Radix scutellariae extract to rats. J Chromatogr B Analyt Technol Biomed Life Sci 878: 2184-2190.
29. Yin OQ, Tomlinson B, Chow AH, Chow MS, (2003) A modified two-portion absorption model to describe double-peak absorption profiles of ranitidine. Clin Pharmacokinet 42: 179-192.
30. Mummaneni V, Amidon GL, Dressman JB, (1995) Gastric pH influences the appearance of double peaks in the plasma concentration-time profiles of cimetidine after oral administration in dogs. Pharm Res 12: 780-786.
31. Mostafavi SA, Foster RT, (2003) Influence of cimetidine co-administration on the pharmacokinetics of acebutolol enantiomers and its metabolite diacetolol in a rat model: the effect of gastric pH on double-peak phenomena. Int J Pharm 255: 81-86.
32. Tsai PL, Tsai TH, (2002) High-performance liquid chromatographic determination of berberine contained in medicinal herbs and a related traditional Chinese medicine. Anal Let 35: 2459-2470.
33. Tsai TH, Chang CH, Lin LC, (2005) Effects of Evodia rutaecarpa and rutaecarpine on the pharmacokinetics of caffeine in rats. Planta Med 71: 640-645.
34. Lin LC, Chen YF, Lee WC, Wu YT, Tsai TH, (2008) Pharmacokinetics of gastrodin and its metabolite p-hydroxybenzyl alcohol in rat blood, brain and bile by microdialysis coupled to LC-MS/MS. J Pharm Biomed Anal 48: 909-917.
35. Chen YJ, Huang SM, Liu CY, Yeh PH, Tsai TH, (2008) Hepatobiliary excretion and enterohepatic circulation of colchicine in rats. Int J Pharm 350: 230-239.
36. Zhou S, Koh HL, Gao Y, Gong ZY, Lee EJ, (2004) Herbal bioactivation: the good, the bad and the ugly. Life Sci 74: 935-968.