Cancer-induced immunosuppression: IL-18-elicited immunoablative NK cells

Cancer Research

Volumn 72, Issue 11, 2012, Pages 2757-2767

  Terme, Magali ^a,b,e   Ullrich, Evelyn ^a,b,i   Aymeric, Laetitia ^a,b   Meinhardt, Kathrin ⁱ   Coudert, Jérôme D ^j,k   Desbois, Mélanie ^a,b   Ghiringhelli, François ^a,b,d   Viaud, Sophie ^a,b   Ryffel, Bernard ^l   Yagita, Hideo ^m   Chen, Lieping ⁿ   Mécheri, Salaheddine ^g   Kaplanski, Gilles ^o   Prévost Blondel, Armelle ^f   Kato, Masashi ^p   Schultze, Joachim L ^q   Tartour, Eric ^e   Kroemer, Guido ^a,c,h   Degli Esposti, Mariapia ^j   Chaput, Nathalie ^a,d   Zitvogel, Laurence ^a,b,d   more..

^a INSTITUT GUSTAVE ROUSSY   (France)

^b University Paris XI   (France)

^c Institut Gustave Roussy   (France)

^d Center of Clinical Investigations CBT507   (France)

^e PARIS CARDIOVASCULAR RESEARCH CENTER   (France)

^f INSTITUT COCHIN   (France)

^g INSTITUT PASTEUR   (France)

^h UNIVERSITÉ PARIS SACLAY   (France)

ⁱ UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^j UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^k LIONS EYE INSTITUTE   (Australia)

^l CNRS   (France)

^m JUNTENDO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

ⁿ JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^o HÔPITAL DE LA CONCEPTION   (France)

^p CHUBU UNIVERSITY   (Japan)

^q UNIVERSITY OF BONN   (Germany)

more..

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 18; INTERLEUKIN 18 BINDING PROTEIN; PROGRAMMED DEATH 1 LIGAND 1; STEM CELL FACTOR RECEPTOR;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; FEMALE; LUNG METASTASIS; LYMPHOID ORGAN; MOUSE; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; RNA INTERFERENCE; TUMOR GROWTH;

ANIMALS; ANTIGENS, CD11B; ANTIGENS, CD274; FEMALE; INTERLEUKIN-18; KILLER CELLS, NATURAL; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; NEOPLASMS; PROTO-ONCOGENE PROTEINS C-KIT;

EID: 84861888837     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-11-3379     Document Type: Article

References (31)

1. Nishikawa H, Jager E, Ritter G, Old LJ, Gnjatic S. CD4+ CD25+ regulatory T cells control the induction of antigen-specific CD4+ helper T cell responses in cancer patients. Blood 2005;106:1008-11. (Pubitemid 41076447)
2. Chen ML, Pittet MJ, Gorelik L, Flavell RA, Weissleder R, von Boehmer H, et al. Regulatory T cells suppress tumor-specific CD8 T cell cytotoxicity through TGF-beta signals in vivo. Proc Natl Acad Sci U S A 2005;102:419-24. (Pubitemid 40116782)
3. Vivier E, Ugolini S. Regulatory natural killer cells: new players in the IL-10 anti-inflammatory response. Cell Host Microbe 2009;6:493-5.
4. Zhang C, Zhang J, Tian Z. The regulatory effect of natural killer cells: do "NK-reg cells" exist? Cell Mol Immunol 2006;3:241-54.
5. Shibatomi K, Ida H, Yamasaki S, Nakashima T, Origuchi T, Kawakami A, et al. A novel role for interleukin-18 in human natural killer cell death: high serum levels and low natural killer cell numbers in patients with systemic autoimmune diseases. Arthritis Rheum 2001;44:884-92. (Pubitemid 32319781)
6. Mazodier K, Marin V, Novick D, Farnarier C, Robitail S, Schleinitz N, et al. Severe imbalance of IL-18/IL-18BP in patients with secondary hemophagocytic syndrome. Blood 2005;106:3483-9. (Pubitemid 41609184)
7. Dinarello CA. Interleukin-18. Methods 1999;19:121-32. (Pubitemid 29497762)
8. Dinarello CA. The paradox of pro-inflammatory cytokines in cancer. Cancer Metastasis Rev 2006;25:307-13. (Pubitemid 44922351)
9. Taieb J, Chaput N, Menard C, Apetoh L, Ullrich E, Bonmort M, et al. A novel dendritic cell subset involved in tumor immunosurveillance. Nat Med 2006;12:214-9. (Pubitemid 43214748)
10. Zhou P, L'Italien L, Hodges D, Schebye XM. Pivotal roles of CD4+ effector T cells in mediating agonistic anti-GITR mAb-induced-immune activation and tumor immunity in CT26 tumors. J Immunol 2007;179:7365-75.
11. Terme M, Ullrich E, Aymeric L, Meinhardt K, Desbois M, Delahaye N, et al. IL-18 induces PD-1-dependent immunosuppression in cancer. Cancer Res 2011;71:5393-9.
12. Azuma T, Yao S, Zhu G, Flies AS, Flies SJ, Chen L. B7-H1 is a ubiquitous antiapoptotic receptor on cancer cells. Blood 2008;111:3635-43.
13. Dinarello CA. Targeting interleukin 18 with interleukin 18 binding protein. Ann Rheum Dis 2000;59 Suppl 1:i17-20.
14. Debey S, Schoenbeck U, Hellmich M, Gathof BS, Pillai R, Zander T, et al. Comparison of different isolation techniques prior gene expression profiling of blood derived cells: impact on physiological responses, on overall expression and the role of different cell types. Pharmacogenomics J 2004;4:193-207. (Pubitemid 38786558)
15. Schultze JL, Eggle D. Illumina GUI: graphical user interface for analyzing gene expression data generated on the Illumina platform. Bioinformatics 2007;23:1431-3. (Pubitemid 47050529)
16. Scalzo AA, Brown MG, Chu DT, Heusel JW, Yokoyama WM, Forbes CA. Development of intra-natural killer complex (NKC) recombinant and congenic mouse strains for mapping and functional analysis of NK cell regulatory loci. Immunogenetics 1999;49:238-41. (Pubitemid 29054584)
17. Smyth MJ, Swann J, Kelly JM, Cretney E, Yokoyama WM, Diefenbach A, et al. NKG2D recognition and perforin effector function mediate effective cytokine immunotherapy of cancer. J Exp Med 2004;200:1325-35. (Pubitemid 39552573)
18. Hayakawa Y, Smyth MJ. CD27 dissects mature NK cells into two subsets with distinct responsiveness and migratory capacity. J Immunol 2006;176:1517-24. (Pubitemid 43134295)
19. Mortier E, Advincula R, Kim L, Chmura S, Barrera J, Reizis B, et al. Macrophage- and dendritic-cell-derived interleukin-15 receptor alpha supports homeostasis of distinct CD8+ T cell subsets. Immunity 2009;31:811-22.
20. Lucas M, Schachterle W, Oberle K, Aichele P, Diefenbach A. Dendritic cells prime natural killer cells by trans-presenting interleukin 15. Immunity 2007;26:503-17. (Pubitemid 46602996)
21. Huang CT, Workman CJ, Flies D, Pan X, Marson AL, Zhou G, et al. Role of LAG-3 in regulatory T cells. Immunity 2004;21:503-13. (Pubitemid 39370506)
22. Bach FH. Heme oxygenase-1 and transplantation tolerance. Hum Immunol 2006;67:430-2. (Pubitemid 43765607)
23. Zang X, Allison JP. The b7 family and cancer therapy: costimulation and coinhibition. Clin Cancer Res 2007;13:5271-9. (Pubitemid 47510350)
24. Chen L. Co-inhibitory molecules of the B7-CD28 family in the control of T-cell immunity. Nat Rev Immunol 2004;4:336-47. (Pubitemid 38649276)
25. Dokun AO, Chu DT, Yang L, Bendelac AS, Yokoyama WM. Analysis of in situ NK cell responses during viral infection. J Immunol 2001;167:5286-93. (Pubitemid 33009767)
26. Andrews DM, Scalzo AA, Yokoyama WM, Smyth MJ, Degli-Esposti MA. Functional interactions between dendritic cells and NK cells during viral infection. Nat Immunol 2003;4:175-81. (Pubitemid 36193020)
27. Johansson S, Berg L, Hall H, Hoglund P. NK cells: elusive players in autoimmunity. Trends Immunol 2005;26:613-8. (Pubitemid 41726450)
28. Mehrotra PT, Donnelly RP, Wong S, Kanegane H, Geremew A, Mostowski HS, et al. Production of IL-10 by human natural killer cells stimulated with IL-2 and/or IL-12. J Immunol 1998;160:2637-44. (Pubitemid 28136713)
29. Taniguchi RT, Guzior D, Kumar V. 2B4 inhibits NK-cell fratricide. Blood 2007;110:2020-3. (Pubitemid 47443917)
30. Saudemont A, Jouy N, Hetuin D, Quesnel B. NK cells that are activated by CXCL10 can kill dormant tumor cells that resist CTL-mediated lysis and can express B7-H1 that stimulates T cells. Blood 2005;105:2428-35. (Pubitemid 40387042)
31. Mailliard RB, Alber SM, Shen H, Watkins SC, Kirkwood JM, Herberman RB, et al. IL-18-induced CD83+CCR7+ NK helper cells. J Exp Med 2005;202:941-53.