Suppression of colon carcinogenesis by targeting notch signaling

Carcinogenesis

Volumn 34, Issue 10, 2013, Pages 2415-2423

  Miyamoto, Shingo ^a   Nakanishi, Masako ^a   Rosenberg, Daniel W ^a  

^a UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; AZOXYMETHANE; GAMMA SECRETASE INHIBITOR; KI 67 ANTIGEN; KRUPPEL LIKE FACTOR 4; N (N 3,5 DIFLUOROPHENACETYL)ALANYLPHENYLGLYCINE METHYL ESTER; NOTCH RECEPTOR; NOTCH1 RECEPTOR; PROTEIN P21; UNCLASSIFIED DRUG;

ADENOMATOUS POLYP; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CANCER CELL; CANCER INHIBITION; CANCER RESISTANCE; CELL STRAIN HCT116; CELL VIABILITY; CLINICAL ARTICLE; COLON BIOPSY; COLON CARCINOGENESIS; COLON POLYP; COLONOSCOPY; CONTROLLED STUDY; DRUG MECHANISM; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPERPLASIA; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TUMOR BIOPSY; TUMOR VOLUME;

AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; CARCINOGENESIS; CELL LINE, TUMOR; CELL PROLIFERATION; COLONIC NEOPLASMS; COLONIC POLYPS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; KI-67 ANTIGEN; KRUPPEL-LIKE TRANSCRIPTION FACTORS; MALE; MICE; NEOPLASMS, EXPERIMENTAL; PHENYLALANINE; PROTO-ONCOGENE PROTEINS P21(RAS); RECEPTORS, NOTCH; SIGNAL TRANSDUCTION;

EID: 84885109066     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgt191     Document Type: Article

References (53)

1. Artavanis-Tsakonas, S. et al. (1999) Notch signaling: cell fate control and signal integration in development. Science, 284, 770-776.
2. Baron, M. (2003) An overview of the Notch signalling pathway. Semin. Cell Dev. Biol., 14, 113-119.
3. Iso, T. et al. (2003) HES and HERP families: multiple effectors of the Notch signaling pathway. J. Cell. Physiol., 194, 237-255.
4. Katoh, M. et al. (2007) Notch signaling in gastrointestinal tract (review). Int. J. Oncol., 30, 247-251.
5. Ghaleb, A.M. et al. (2008) Notch inhibits expression of the Krüppel-like factor 4 tumor suppressor in the intestinal epithelium. Mol. Cancer Res., 6, 1920-1927.
6. Shields, J.M. et al. (1996) Identification and characterization of a gene encoding a gut-enriched Krüppel-like factor expressed during growth arrest. J. Biol. Chem., 271, 20009-20017.
7. Abbas, T. et al. (2009) p21 in cancer: intricate networks and multiple activities. Nat. Rev. Cancer, 9, 400-414.
8. Ellisen, L.W. et al. (1991) TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms. Cell, 66, 649-661.
9. Lobry, C. et al. (2011) Oncogenic and tumor suppressor functions of Notch in cancer: it's NOTCH what you think. J. Exp. Med., 208, 1931-1935.
10. Reedijk, M. et al. (2008) Activation of Notch signaling in human colon adenocarcinoma. Int. J. Oncol., 33, 1223-1229.
11. Fre, S. et al. (2005) Notch signals control the fate of immature progenitor cells in the intestine. Nature, 435, 964-968.
12. Fre, S. et al. (2009) Notch and Wnt signals cooperatively control cell proliferation and tumorigenesis in the intestine. Proc. Natl Acad. Sci. USA, 106, 6309-6314.
13. Moser, A.R. et al. (1990) A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse. Science, 247, 322-324.
14. Kadaveru, K. et al. (2012) Dietary Methyl Donor Depletion Protects Against Intestinal Tumorigenesis in ApcMin/+ Mice. Cancer Prevent. Res., 5, 911-920.
15. Rodilla, V. et al. (2009) Jagged1 is the pathological link between Wnt and Notch pathways in colorectal cancer. Proc. Natl Acad. Sci. USA, 106, 6315-6320.
16. Wolfe, M.S. et al. (1998) A substrate-based difluoro ketone selectively inhibits Alzheimer's gamma-secretase activity. J. Med. Chem., 41, 6-9.
17. van Es, J.H. et al. (2005) Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells. Nature, 435, 959-963.
18. Papanikolaou, A. et al. (2000) Sequential and morphological analyses of aberrant crypt foci formation in mice of differing susceptibility to azoxymethane- induced colon carcinogenesis. Carcinogenesis, 21, 1567-1572.
19. Nambiar, P.R. et al. (2002) Role of the alternating reading frame (P19)-p53 pathway in an in vivo murine colon tumor model. Cancer Res., 62, 3667-3674.
20. Guda, K. et al. (2004) Carcinogen-induced colon tumors in mice are chromosomally stable and are characterized by low-level microsatellite instability. Oncogene, 23, 3813-3821.
21. Rosenberg, D.W. et al. (2009) Mouse models for the study of colon carcinogenesis. Carcinogenesis, 30, 183-196.
22. Nakanishi, M. et al. (2007) Utilizing endoscopic technology to reveal realtime proteomic alterations in response to chemoprevention. Proteomics. Clin. Appl., 1, 1660-1666.
23. Becker, C. et al. (2006) High resolution colonoscopy in live mice. Nat. Protoc., 1, 2900-2904.
24. Nakanishi, M. et al. (2011) Selective PGE(2) suppression inhibits colon carcinogenesis and modifies local mucosal immunity. Cancer Prev. Res., 4, 1198-1208.
25. Murata, K. et al. (2005) Hes1 directly controls cell proliferation through the transcriptional repression of p27Kip1. Mol. Cell. Biol., 25, 4262-4271.
26. van de Wetering, M. et al. (2002) The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells. Cell, 111, 241-250.
27. Carr, N.J. et al. (2009) Serrated and non-serrated polyps of the colorectum: their prevalence in an unselected case series and correlation of BRAF mutation analysis with the diagnosis of sessile serrated adenoma. J. Clin. Pathol., 62, 516-518.
28. Torlakovic, E. et al. (2003) Morphologic reappraisal of serrated colorectal polyps. Am. J. Surg. Pathol., 27, 65-81.
29. Higuchi, T. et al. (2005) Demographic and pathological characteristics of serrated polyps of colorectum. Histopathology, 47, 32-40.
30. Garrett-Sinha, L.A. et al. (1996) A gene for a novel zinc-finger protein expressed in differentiated epithelial cells and transiently in certain mesenchymal cells. J. Biol. Chem., 271, 31384-31390.
31. Ranganathan, P. et al. (2011) Notch signalling in solid tumours: a little bit of everything but not all the time. Nat. Rev. Cancer, 11, 338-351.
32. Shih, I.e. M. et al. (2007) Notch signaling, gamma-secretase inhibitors, and cancer therapy. Cancer Res., 67, 1879-1882.
33. Dees, C. et al. (2011) Inhibition of Notch signaling prevents experimental fibrosis and induces regression of established fibrosis. Arthritis Rheum., 63, 1396-1404.
34. higurupati, S. et al. (2007) Involvement of notch signaling in wound healing. PLoS One, 2, e1167.
35. Czvitkovich, S. et al. (2011) Comparison of pharmacological modulation of APP metabolism in primary chicken telencephalic neurons and in a human neuroglioma cell line. J. Mol. Neurosci., 43, 257-267.
36. Miyamoto, S. et al. (2011) Role of Notch signaling in colon homeostasis and carcinogenesis. Cancer Sci., 102, 1938-1942.
37. Dang, D.T. et al. (2000) The biology of the mammalian Krüppel-like family of transcription factors. Int. J. Biochem. Cell Biol., 32, 1103-1121.
38. Katz, J.P. et al. (2002) The zinc-finger transcription factor Klf4 is required for terminal differentiation of goblet cells in the colon. Development, 129, 2619-2628.
39. Zhang, Y. et al. (2010) Notch1 regulates the growth of human colon cancers. Cancer, 116, 5207-5218.
40. Xu, J. et al. (2008) Dynamic down-regulation of Krüppel-like factor 4 in colorectal adenoma-carcinoma sequence. J. Cancer Res. Clin. Oncol., 134, 891-898.
41. Real, P.J. et al. (2009) Gamma-secretase inhibitors reverse glucocorticoid resistance in T cell acute lymphoblastic leukemia. Nat. Med., 15, 50-58.
42. Plentz, R. et al. (2009) Inhibition of gamma-secretase activity inhibits tumor progression in a mouse model of pancreatic ductal adenocarcinoma. Gastroenterology, 136, 1741-9.e6.
43. Maraver, A. et al. (2012) Therapeutic effect of ?-secretase inhibition in KrasG12V-driven non-small cell lung carcinoma by derepression of DUSP1 and inhibition of ERK. Cancer Cell, 22, 222-234.
44. Rasul, S. et al. (2009) Inhibition of gamma-secretase induces G2/M arrest and triggers apoptosis in breast cancer cells. Br. J. Cancer, 100, 1879-1888.
45. Chen, X. et al. (2001) Krüppel-like factor 4 (gut-enriched Krüppel-like factor) inhibits cell proliferation by blocking G1/S progression of the cell cycle. J. Biol. Chem., 276, 30423-30428.
46. Yoon, H.S. et al. (2003) Kruppel-like factor 4 mediates p53-dependent G1/S cell cycle arrest in response to DNA damage. J. Biol. Chem., 278, 2101-2105.
47. Yoon, H.S. et al. (2004) Requirement of Krüppel-like factor 4 in preventing entry into mitosis following DNA damage. J. Biol. Chem., 279, 5035-5041.
48. Surh, Y.J. (2003) Cancer chemoprevention with dietary phytochemicals. Nat. Rev. Cancer, 3, 768-780.
49. Logan, C.Y. et al. (2004) The Wnt signaling pathway in development and disease. Annu. Rev. Cell Dev. Biol., 20, 781-810.
50. Reya, T. et al. (2005) Wnt signalling in stem cells and cancer. Nature, 434, 843-850.
51. Kwon, C. et al. (2009) A regulatory pathway involving Notch1/beta-catenin/Isl1 determines cardiac progenitor cell fate. Nat. Cell Biol., 11, 951-957.
52. Kwon, C. et al. (2011) Notch post-translationally regulates ß-catenin protein in stem and progenitor cells. Nat. Cell Biol., 13, 1244-1251.
53. Zhang, W. et al. (2006) Novel cross talk of Kruppel-like factor 4 and betacatenin regulates normal intestinal homeostasis and tumor repression. Mol. Cell. Biol., 26, 2055-2064.