Acutely increasing δGABAA receptor activity impairs memory and inhibits synaptic plasticity in the hippocampus

Frontiers in Neural Circuits

Volumn 7, Issue SEP, 2013, Pages

  Whissell, Paul D ^a   Eng, Dave ^a   Lecker, Irene ^a   Martin, Loren J ^a   Wang, Dian Shi ^a   Orser, Beverley A ^a,b,c  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c SUNNYBROOK RESEARCH INSTITUTE   (Canada)

Author keywords

CA1; D subunit; Dentate gyrus; Extrasynaptic GABAA receptors; Long term potentiation; Memory; THIP; Tonic inhibition

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID A RECEPTOR DELTA; BICUCULLINE; GABOXADOL; UNCLASSIFIED DRUG; 4 AMINOBUTYRIC ACID RECEPTOR STIMULATING AGENT; ISOXAZOLE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ASSOCIATION; BRAIN ELECTROPHYSIOLOGY; BRAIN SLICE; CONTROLLED STUDY; DENTATE GYRUS; FEAR; HIPPOCAMPAL CA1 REGION; HIPPOCAMPUS; LONG TERM POTENTIATION; MALE; MAZE TEST; MEMORY DISORDER; MENTAL PERFORMANCE; MOUSE; NERVE CELL PLASTICITY; NONHUMAN; POSTSYNAPTIC POTENTIAL; RECOGNITION; SHORT TERM MEMORY; SPATIAL MEMORY; SYNAPTIC TRANSMISSION; WORKING MEMORY; ANIMAL; CONDITIONING; DRUG EFFECTS; GENETICS; KNOCKOUT MOUSE; MEMORY; METABOLISM; PHYSIOLOGY; Δ SUBUNIT; CA1; DRUG EFFECT; EXTRASYNAPTIC GABAA RECEPTORS; TONIC INHIBITION;

ANIMALS; CONDITIONING (PSYCHOLOGY); CUES; FEAR; GABA AGONISTS; HIPPOCAMPUS; ISOXAZOLES; LONG-TERM POTENTIATION; MAZE LEARNING; MEMORY; MICE; MICE, KNOCKOUT; RECEPTORS, GABA-A; RECOGNITION (PSYCHOLOGY);

Δ SUBUNIT; CA1; DENTATE GYRUS; EXTRASYNAPTIC GABAA RECEPTORS; LONG-TERM POTENTIATION; MEMORY; THIP; TONIC INHIBITION;

EID: 84885067343     PISSN: 16625110     EISSN: None     Source Type: Journal    
DOI: 10.3389/fncir.2013.00146     Document Type: Article

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