Highway driving performance and cognitive functioning the morning after bedtime and middle-of-the-night use of gaboxadol, zopiclone and zolpidem

Journal of Sleep Research

Volumn 18, Issue 4, 2009, Pages 387-396

  Leufkens, Tim R M ^a   Lund, Jesper S ^b   Vermeeren, Annemiek ^a  

^a MAASTRICHT UNIVERSITY   (Netherlands)

^b H LUNDBECK A S   (Denmark)

Author keywords

Gaboxadol; Hypnotics; On the road driving; Residual effects; Zolpidem; Zopiclone

Indexed keywords

GABOXADOL; PLACEBO; ZOLPIDEM; ZOPICLONE;

ADULT; ARTICLE; ATTENTION; BEDTIME DOSAGE; BODY EQUILIBRIUM; BODY POSTURE; CHRONOTHERAPY; CLINICAL TRIAL; COGNITION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DIZZINESS; DOUBLE BLIND PROCEDURE; DRIVING ABILITY; DRUG EFFECT; DRUG INDUCED HEADACHE; DYSGEUSIA; EVENING DOSAGE; FATIGUE; FEMALE; HIGHWAY; HUMAN; MALE; MEMORY; MENTAL FUNCTION; MOTOR COORDINATION; NAUSEA; NAUSEA AND VOMITING; NORMAL HUMAN; PRIORITY JOURNAL; PSYCHOMOTOR PERFORMANCE; SIDE EFFECT; SINGLE DRUG DOSE; SOMNOLENCE; TASK PERFORMANCE; VOMITING;

ADULT; AFFECT; AROUSAL; ATTENTION; AUTOMOBILE DRIVING; AZABICYCLO COMPOUNDS; COGNITION; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; DRUG ADMINISTRATION SCHEDULE; FEMALE; GABA AGONISTS; HUMANS; ISOXAZOLES; MALE; MEMORY, SHORT-TERM; NEUROPSYCHOLOGICAL TESTS; ORIENTATION; PIPERAZINES; POSTURAL BALANCE; PSYCHOMOTOR PERFORMANCE; PYRIDINES; REACTION TIME; RETENTION (PSYCHOLOGY); SLEEP INITIATION AND MAINTENANCE DISORDERS; YOUNG ADULT;

EID: 69949159923     PISSN: 09621105     EISSN: 13652869     Source Type: Journal    
DOI: 10.1111/j.1365-2869.2009.00746.x     Document Type: Article

References (35)

1. Barbone, F., McMahon, A. D., Davey, P. G. et al. Association of road-traffic accidents with benzodiazepine use. Lancet, 1998, 352 : 1331 1336.
2. Bond, A. Lader, M. The use of analogue scales in rating subjective feelings. Br. J. Med. Psychol., 1974, 47 : 211 218.
3. Curran, H. V., Collins, R., Fletcher, S., Kee, S. C. Y., Woods, B. Iliffe, S. Older adults and withdrawal from benzodiazepine hypnotics in general practice: effects on cognitive function, sleep, mood and quality of life. Psychol. Med., 2003, 33 : 1223 1237.
4. Deacon, S., Staner, L., Staner, C., Vorstrup, S. Lundahl, J. Acute administration of gaboxadol improves sleep initiation and maintenance in patients with primary insomnia. Sleep, 2005, 28 : A240.
5. Deacon, S., Staner, L., Staner, C., Legters, A., Loft, H. Lundahl, J. Effect of short-term treatment with gaboxadol on sleep maintenance and initiation in patients with primary insomnia. Sleep, 2007, 30 : 281 287. (Pubitemid 46494403)
6. Ebert, B., Wafford, K. A. Deacon, S. Treating insomnia: current and investigational pharmacological approaches. Pharmacol. Ther., 2006, 112 : 612 629.
7. Faulhaber, J., Steiger, A. Lancel, M. The GABAA agonist THIP produces slow wave sleep and reduces spindling activity in NREM sleep in humans. Psychopharmacology, 1997, 130 : 285 291.
8. Jex, H. R., Mcdonnell, J. D. Phatak, A. V. A 'critical' tracking task for man-machine research related to the operator's effective delay time. I. Theory and experiments with a first-order divergent controlled element. NASA CR-616. NASA Contract Rep. NASA CR, 1966, 1 105.
9. Kapteyn, T. S., Bles, W., Njiokiktjien, C. J., Kodde, L., Massen, C. H. Mol, J. M. Standardization in platform stabilometry being part of posturography. Agressologie, 1983, 24 : 321 326.
10. Lancel, M., Wetter, T. C., Steiger, A. Mathias, S. Effect of the GABAA agonist gaboxadol on nocturnal sleep and hormone secretion in healthy elderly subjects. Am. J. Physiol. Endocrinol. Metab., 2001, 281 : E130 E137.
11. Louwerens, J. W., Gloerich, A. B. M., De Vries, G., Brookhuis, K. A. O'Hanlon, J. F. The relationship between drivers' blood alcohol concentration (BAC) and actual driving performance during high speed travel. In : P. C. Noordzij R. Roszbach (Eds) International Congress on Alcohol, Drugs and Traffic Safety, T86. Exerpta Medica, Amsterdam, 1987 : 183 186.
12. Lund, J., Lundahl, J., Nielsen, G. M. Mengel, H. The pharmacokinetic properties of gaboxadol, a new hypnotic, in young and elderly men. Sleep, 2005, 28 : A48.
13. Lund, J., Helboe, T. Mengel, H. Absorption, metabolism, and excretion profile of gaboxadol in humans. Sleep, 2006, 29 : A41.
14. Lundahl, J., Staner, L., Staner, C. Deacon, S. The selective extrasynaptic GABAa agonist, gaboxadol, improves sleep maintenance and enhances slow wave sleep in adult patients with primary insomnia. J. Sleep Res., 2006, 15 : 194 195.
15. Mathias, S., Steiger, A. Lancel, M. The GABAa agonist gaboxadol improves the quality of post-nap sleep. Psychopharmacology, 2001, 157 : 299 304.
16. Mathias, S., Zihl, J., Steiger, A. Lancel, M. Effect of repeated gaboxadol administration on night sleep and next-day performance in healthy elderly subjects. Neuropsychopharmacology, 2005, 30 : 833 841.
17. Moskowitz, H. Laboratory studies of the effects of alcohol on some variables related to driving. J. Safety Res., 1973, 5 : 185 199.
18. Mulder-Hajonides Van Der Meulen, W. R. E. H. Measurement of Subjective Sleep Quality. Elsevier, Amsterdam, 1981.
19. Neutel, I. Benzodiazepine-related traffic accidents in young and elderly drivers. Hum. Psychopharmacol. Clin., 1998, 13 : S115 S123.
20. O'Hanlon, J. F. Driving performance under the influence of drugs: rationale for, and application of, a new test. Br. J. Clin. Pharmacol., 1984, 18 (Suppl. 1 121s 129s.
21. Ramaekers, J. G., Muntjewerff, N. D., Uiterwijk, M. M. C. et al. A study of the pharmacodynamic interaction between befloxatone and ethanol on performance and mood in healthy volunteers. J. Psychopharmacol., 1996, 10 : 288 294.
22. Rey, A. L'examen clinique en psychologie. Presses Universitaires de France, Paris, 1964.
23. Sanders, A. F. Towards a model of stress and human performance. Acta Psychol., 1983, 53 : 61 97.
24. Savic, M. M., Obradovic, D. I., Ugresic, N. D. Bokonjic, D. R. Memory effects of benzodiazepines: memory stages and types versus binding-site subtypes. Neural Plast., 2005, 12 : 289 298.
25. Schultz, B., Aaes Jorgensen, T., Bogeso, K. P. Jorgensen, A. Preliminary studies on the absorption, distribution, metabolism, and excretion of THIP in animal and man using 14C-labelled compound. Acta Pharmacol. Toxicol., 1981, 49 : 116 124.
26. Storustovu, S. I. Ebert, B. Pharmacological characterization of agonists at delta-containing GABAA receptors: functional selectivity for extrasynaptic receptors is dependent on the absence of gamma2. J. Pharmacol. Exp. Ther., 2006, 316 : 1351 1359.
27. Swainston Harrison, T. Keating, G. M. Zolpidem: a review of its use in the management of insomnia. CNS Drugs, 2005, 19 : 65 89.
28. Vermeeren, A. Residual effects of hypnotics: epidemiology and clinical implications. CNS Drugs, 2004, 18 : 297 328.
29. Vermeeren, A., O'Hanlon, J. F., Declerck, A. C. Kho, L. Acute effects of zolpidem and flunitrazepam on sleep, memory and driving performance, compared to those of partial sleep deprivation and placebo. Acta Ther., 1995, 21 : 47 64.
30. Vermeeren, A., Danjou, P. E. O'Hanlon, J. F. Residual effects of evening and middle-of-the-night administration of zaleplon 10 and 20 mg on memory and actual driving performance. Hum. Psychopharmacol., 1998, 13 : S98 S107.
31. Vermeeren, A., Riedel, W. J., Van Boxtel, M. P., Darwish, M., Paty, I. Patat, A. Differential residual effects of zaleplon and zopiclone on actual driving: a comparison with a low dose of alcohol. Sleep, 2002, 25 : 224 231.
32. Verster, J. C., Volkerts, E. R., Schreuder, A. H. et al. Residual effects of middle-of-the-night administration of zaleplon and zolpidem on driving ability, memory functions, and psychomotor performance. J. Clin. Psychopharmacol., 2002, 22 : 576 583.
33. Verster, J. C., Veldhuijzen, D. S. Volkerts, E. R. Residual effects of sleep medication on driving ability. Sleep Med. Rev., 2004, 8 : 309 325.
34. Verster, J. C., Volkerts, E. R., Olivier, B., Johnson, W. Liddicoat, L. Zolpidem and traffic safety - the importance of treatment compliance. Curr. Drug Saf., 2007, 2 : 220 226.
35. Walsh, J. K., Deacon, S., Dijk, D. J. Lundahl, J. The selective extrasynaptic GABAA agonist, gaboxadol, improves traditional hypnotic efficacy measures and enhances slow wave activity in a model of transient insomnia. Sleep, 2007, 30 : 593 602.