The GABA(A) agonist THIP produces slow wave sleep and reduces spindling activity in NREM sleep in humans

Psychopharmacology

Volumn 130, Issue 3, 1997, Pages 285-291

  Faulhaber, Johannes ^a   Steiger, Axel ^a   Lancel, Marike ^a  

^a MAX PLANCK INSTITUTE OF PSYCHIATRY   (Germany)

Author keywords

GABA; GABA(A) receptor; gaboxadol; human; sleep state; spectral analysis

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR STIMULATING AGENT; GABOXADOL; PLACEBO; 4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID RECEPTOR STIMULATING AGENT; 4,5,6,7-TETRAHYDROISOXAZOLO(5,4-C)PYRIDIN-3-OL; ISOXAZOLE DERIVATIVE;

ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; ELECTROENCEPHALOGRAM; HUMAN; HUMAN EXPERIMENT; MALE; NONREM SLEEP; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; POWER SPECTRUM; PRIORITY JOURNAL; REGULATORY MECHANISM; REM SLEEP; SLEEP PATTERN; SLEEP SPINDLE; SLOW WAVE SLEEP; DRUG EFFECT; PHYSIOLOGY; RANDOMIZED CONTROLLED TRIAL; SLEEP STAGE;

ADULT; DOUBLE-BLIND METHOD; GABA AGONISTS; HUMANS; ISOXAZOLES; MALE; RECEPTORS, GABA-A; SLEEP STAGES; SLEEP, REM;

EID: 0030610051     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002130050241     Document Type: Article

References (34)

1. Aeschbach D, Borbély AA (1993) All-night dynamics of the human sleep EEG. J Sleep Res 2:70-81
2. Aeschbach D, Dijk DJ, Trachsel L, Brunner DP, Borbély AA (1994) Dynamics of slow-wave activity and spindle frequency activity in the human sleep EEG: effect of midazolam and zopiclone. Neuropsychopharmacology 11:237-244
3. 1 adenosine receptors mimics the electroencephalographic effects of sleep deprivation. Brain Res 692:79-85
4. Blake H, Gerard RW (1937) Brain potentials during sleep. Am J Physiol 119:692-703
5. Borbély AA, Baumann F, Brandeis D, Strauch I, Lehmann D (1981) Sleep deprivation: effect on sleep stages and EEG power density in man. Electroencephalogr Clin Neurophysiol 51:483-493
6. Borbély AA, Mattmann P, Loepfe M, Strauch I, Lehmann D (1985) Effect of benzodiazepine hypnotics on all-night sleep EEG spectra. Hum Neurobiol 4:189-194
7. Borbély AA, Neuhaus HU (1979) Sleep-deprivation: effects on sleep and EEG in the rat. J Comp Physiol 133:71-87
8. Borbély AA, Trachsel L, Tobler I (1988) Effect of ritanserin on sleep stages and sleep EEG in the rat. Eur J Pharmacol 156: 275-278
9. Brunner DP, Dijk DJ, Münch M, Borbély AA (1991) Effect of zolpidem on sleep and sleep EEG spectra in healthy young men. Psychopharmacology 104:1-5
10. Dijk DJ, Czeisler CA (1993) Body temperature is elevated during the rebound of slow-wave sleep following 40 h of sleep deprivation on a constant routine. J Sleep Res 2:117-120
11. 2 antagonist, and temazepam on human sleep stages and EEG power spectra. Eur J Pharmacol 171:207-218
12. Dijk DJ, Brunner DP, Borbély AA (1990) Time course of EEG power density during long sleep in humans. Am J Physiol 258: R650-R661
13. Dijk, DJ, Hayes B, Czeisler CA (1993) Dynamics of electroencephalographic sleep spindles and slow wave activity in men: effect of sleep deprivation. Brain Res 626:190-199
14. Feinberg I, Fein G, Floyd TC (1980) EEG patterns during and following extended sleep in young adults. Electoencephalogr Clin Neurophysiol 50:467-476
15. Friess E, Wiedemann K, Steiger A, Holsboer F (1995) The hypothalamic-pituitary-adrenocortical system and sleep in man. Adv Neuroimmunol 5:111-125
16. Gaillard JM, Schulz P, Tissot R (1973) Effects of three benzodiazepines (nitrazepam, flunitrazepam and bromazepam) on sleep of normal subjects, studied with an automatic sleep scoring system. Pharmakopsychiatry 6:207-217
17. Grahnstedt S, Ursin R (1980) Awakening thresholds for electrical brain stimulation in five sleep-waking stages in the cat. Electroencephalogr Clin Neurophysiol 48:222-229
18. Hoehn-Saric R (1983) Effects of THIP on chronic anxiety. Psychopharmacology 80:338-341
19. Johnson LC, Hanson K, Bickford RG (1976) Effect of flurazepam on sleep spindles and K-complexes. Electroencephalogr Clin Neurophysiol 40:67-77
20. Kim Y, Zhuang H, Tsutsumi M, Okabe A, Kurachi M, Kamikawa Y (1993) Comparison of the effect of zopiclone and brotizolam on sleep EEG by quantitative evaluation in healthy young women. Sleep 16:655-661
21. Lancel M, Faulhaber J (1996) The GABAAagonist THIP (gaboxadol) increases non-REM sleep and enhances delta activity in the rat. Neuro Report 7:2241-2245
22. Lancel M, Kerkhof GA (1989) Effects of repeated sleep deprivation in the dark- or light-period on sleep in rats. Physiol Behav 45:289-297
23. Lancel M, van Riezen H, Glatt A (1992) Enhanced slow-wave activity within NREM sleep in the cortical and subcortical EEG of the cat after sleep deprivation. Sleep 15:102-118
24. A receptors in sleep regulation: differential effects of muscimol and midazolam on sleep in rats. Neuropsychopharmacology 15:63-74
25. Mendelson WB, Martin JV (1990) Effects of muscimol and flurazepam on the sleep EEG in the rat. Life Sei 47:99-101
26. Neckelmann D, Ursin R (1993) Sleep stages and EEG power spectrum in relation to acoustical stimulus arousal thresholds in the rat. Sleep 16:467-477
27. Areceptors activation on brain glucose metabolism in normal subjects and temporal lobe epilepsy (TLE) patients. A positron emission tomography (PET) study part I: brain glucose metabolism is increased after GABAA receptors activation. Epilepsy Res 19:45-54
28. Rechtschaffen A, Kales A (1968) A manual of standardized terminology, techniques and scoring system for sleep stages of human subjects. National Institute of Health Publication 204, US Government Printing Office, Washington, DC
29. 14C-labelled compound. Acta Pharmacol Toxicol 49:116-124
30. A receptor subtypes. Pharmacol Rev 47:181-234
31. Steriade M, McCormick DA, Sejnowski TJ (1993) Thalamocortical oscillations in the sleeping and aroused brain. Science 262: 679-685
32. Tobler I, Borbély AA (1990) The effect of 3-h and 6-h sleep deprivation on sleep and EEG spectra of the rat. Behav Brain Res 36:73-78
33. Trachsel L, Tobler I, Borbély AA (1989) Effect of sleep deprivation on EEG slow wave activity within non-REM sleep episodes in the rat. Electroencephalogr Clin Neurophysiol 73:167-171
34. Trachsel L, Dijk DJ, Brunner DP, Klene C, Borbély AA (1990) Effect of zopiclone and midazolam on sleep and EEG spectra in a phase-advanced sleep schedule. Neuropsychopharmacology 3:11-18