Excitability changes related to GABAA receptor plasticity during pregnancy

Journal of Neuroscience

Volumn 29, Issue 30, 2009, Pages 9592-9601

  Maguire, Jamie ^a   Ferando, Isabella ^a   Simonsen, Charlotte ^b   Mody, Istvan ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

3ALPHA HYDROXY 5ALPHA PREGNAN 20 ONE; 4 AMINOBUTYRIC ACID A RECEPTOR; GAMMA AMINOBUTYRIC ACID A RECEPTOR DELTA; NEUROSTEROID; STEROID RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN LEVEL; BRAIN REGION; BRAIN SLICE; CONTROLLED STUDY; CORPUS STRIATUM; DENTATE GYRUS; DOWN REGULATION; EPILEPTIC DISCHARGE; FEMALE; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; MENTAL DISEASE; MOUSE; NERVE CELL EXCITABILITY; NERVE CELL NETWORK; NERVE CELL PLASTICITY; NERVE CELL STIMULATION; NEUROLOGIC DISEASE; NONHUMAN; PERFORANT NERVE TRACT; PREGNANCY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PUERPERIUM; STEADY STATE; SYNAPSE; THALAMUS;

ACTION POTENTIALS; ANIMALS; BRAIN; DOWN-REGULATION; FEMALE; HIPPOCAMPUS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NEURONAL PLASTICITY; NEURONS; POTASSIUM CHLORIDE; PREGNANCY; PREGNANOLONE; RECEPTORS, GABA-A; SYNAPTIC TRANSMISSION;

EID: 68049148067     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.2162-09.2009     Document Type: Article

References (32)

1. Belelli D, Lambert JJ (2005) Neurosteroids: endogenous regulators of the GABA(A) receptor. Nat Rev Neurosci 6:565-575. (Pubitemid 40942823)
2. Biggio G, Follesa P, Sanna E, Purdy RH, Concas A (2001) GABA(A)-receptor plasticity during long-term exposure to and withdrawal from progesterone. Int Rev Neurobiol 46:207-241. (Pubitemid 33798723)
3. Concas A, Mostallino MC, Porcu P, Follesa P, Barbaccia ML, Trabucchi M, Purdy RH, Grisenti P, Biggio G (1998) Role of brain allopregnanolone in the plasticity of gamma-aminobutyric acid type A receptor in rat brain during pregnancy and after delivery. Proc Natl Acad Sci U S A 95:13284-13289. (Pubitemid 28509563)
4. Concas A, Follesa P, Barbaccia ML, Purdy RH, Biggio G (1999) Physiological modulation of GABA(A) receptor plasticity by progesterone metabolites. Eur J Pharmacol 375:225-235. (Pubitemid 29317607)
5. Farrant M, Nusser Z (2005) Variations on an inhibitory theme: Phasic and tonic activation of GABA(A) receptors. Nat Rev Neurosci 6:215-229. (Pubitemid 40342416)
6. Follesa P, Floris S, Tuligi G, Mostallino MC, Concas A, Biggio G (1998) Molecular and functional adaptation of the GABA(A) receptor complex during pregnancy and after delivery in the rat brain. Eur J Neurosci 10:2905-2912. (Pubitemid 29073963)
7. Follesa P, Serra M, Cagetti E, Pisu MG, Porta S, Floris S, Massa F, Sanna E, Biggio G (2000) Allopregnanolone synthesis in cerebellar granule cells: roles in regulation of GABA(A) receptor expression and function during progesterone treatment and withdrawal. Mol Pharmacol 57:1262-1270. (Pubitemid 30354400)
8. Follesa P, Concas A, Porcu P, Sanna E, Serra M, Mostallino MC, Purdy RH, Biggio G (2001) Role of allopregnanolone in regulation of GABA(A) receptor plasticity during long-term exposure to and withdrawal from progesterone. Brain Res Rev 37:81-90. (Pubitemid 34020722)
9. Follesa P, Porcu P, Sogliano C, Cinus M, Biggio F, Mancuso L, Mostallino MC, Paoletti AM, Purdy RH, Biggio G, Concas A (2002) Changes in GABA(A) receptor gamma 2 subunit gene expression induced by long-term administration of oral contraceptives in rats. Neuropharmacology 42:325-336. (Pubitemid 34230485)
10. Follesa P, Biggio F, Caria S, Gorini G, Biggio G (2004) Modulation of GABA(A) receptor gene expression by allopregnanolone and ethanol. Eur J Pharmacol 500:413-425. (Pubitemid 39304024)
11. Glykys J, Mann EO, Mody I (2008) Which GABA(A) receptor subunits are necessary for tonic inhibition in the hippocampus? J Neurosci 28:1421-1426.
12. Gould E, Woolley CS, Frankfurt M, McEwen BS (1990) Gonadal steroids regulate dendritic spine density in hippocampal pyramidal cells in adulthood. J Neurosci 10:1286-1291.
13. Holmes GL, Weber DA (1985) Effect of pregnancy on development of seizures. Epilepsia 26:299-302.
14. Huber D, Veinante P, Stoop R (2005) Vasopressin and oxytocin excite distinct neuronal populations in the central amygdala. Science 308:245-248. (Pubitemid 40558858)
15. Maguire J, Mody I (2007) Neurosteroid synthesis-mediated regulation of GABA(A) receptors: relevance to the ovarian cycle and stress. J Neurosci 27:2155-2162. (Pubitemid 46340948)
16. Maguire J, Mody I (2008) GABA(A)R plasticity during pregnancy: relevance to postpartum depression. Neuron 59:207-213. (Pubitemid 352033688)
17. Majewska MD, Ford-Rice F, Falkay G (1989) Pregnancy-induced alterations of Gabaa receptor sensitivity in maternal brain: an antecedent of post-partum blues. Brain Res 482:397-401. (Pubitemid 19066557)
18. Paul SM, Purdy RH (1992) Neuroactive steroids. FASEB J 6:2311-2322.
19. Peng Z, Huang CS, Stell BM, Mody I, Houser CR (2004) Altered expression of the delta subunit of the GABA(A) receptor in a mouse model of temporal lobe epilepsy. J Neurosci 24:8629-8639. (Pubitemid 39313785)
20. Raggenbass M (2008) Overview of cellular electrophysiological actions of vasopressin. Eur J Pharmacol 583:243-254.
21. Rück J, Bauer J (2008) Pregnancy and epilepsy. Retrospective analysis of 118 patients (in German). Nervenarzt 79:691-695.
22. Sabers A, aRogvi-Hansen B, Dam M, Fischer-Rasmussen W, Gram L, Hansen M, Møller A, Winkel H (1998) Pregnancy and epilepsy: a retrospective study of 151 pregnancies. Acta Neurol Scand 97:164-170. (Pubitemid 28254912)
23. Sanna E, Mostallino MC, Murru L, Carta M, Talani G, Zucca S, Mura ML, Maciocco E, Biggio G (2009) Changes in expression and function of extrasynaptic GABAA receptors in the rat hippocampus during pregnancy and after delivery. J Neurosci 29:1755-1765.
24. Schmidt D (1982) The effect of pregnancy on the natural history of epilepsy: review of the literature, pp 3-14. New York: Raven.
25. Smith SS (2002) Withdrawal properties of a neuroactive steroid: implications for GABA(A) receptor gene regulation in the brain and anxiety behavior. Steroids 67:519-528.
26. Smith SS, Gong QH, Hsu FC, Markowitz RS, ffrench-Mullen JM, Li X (1998) GABA(A) receptor alpha 4 subunit suppression prevents withdrawal properties of an endogenous steroid. Nature 392:926-930.
27. Stell BM, Brickley SG, Tang CY, Farrant M, Mody I (2003) Neuroactive steroids reduce neuronal excitability by selectively enhancing tonic inhibition mediated by delta subunit-containing GABA(A) receptors. Proc Natl Acad Sci U S A 100:14439-14444. (Pubitemid 37499255)
28. Sundstrom-Poromaa I, Smith DH, Gong QH, Sabado TN, Li X, Light A, Wiedmann M, Williams K, Smith SS (2002) Hormonally regulated alpha(4)beta(2)delta GABA(A) receptors are a target for alcohol. Nat Neurosci 5:721-722.
29. Swartjes JM, van Geijn HP (1998) Pregnancy and epilepsy. Eur J Obstet Gynecol Reprod Biol 79:3-11.
30. Woolley CS, McEwen BS (1992) Estradiol mediates fluctuation in hippocampal synapse density during the estrous cycle in the adult rat. J Neurosci 12:2549-2554.
31. Woolley CS, McEwen BS (1993) Roles of estradiol and progesterone in regulation of hippocampal dendritic spine density during the estrous cycle in the rat. J Comp Neurol 336:293-306.
32. Woolley CS, Weiland NG, McEwen BS, Schwartzkroin PA (1997) Estradiol increases the sensitivity of hippocampal CA1 pyramidal cells to NMDA receptor-mediated synaptic input: correlation with dendritic spine density. J Neurosci 17:1848-1859.