Gaboxadol - a different hypnotic profile with no tolerance to sleep EEG and sedative effects after repeated daily dosing

Pharmacology Biochemistry and Behavior

Volumn 90, Issue 1, 2008, Pages 113-122

  Ebert, Bjarke ^a   Anderson, Neil J ^a   Cremers, Thomas I ^c   Rasmussen, Stine ^d   Vogel, Vanessa ^a   Fahey, Jeanne M ^d   Sánchez, Connie ^b  

^a H LUNDBECK A S   (Denmark)

^b LUNDBECK RESEARCH USA   (United States)

^c CHARLES RIVER LABORATORIES   (United States)

^d TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Discontinuation; Extra synaptic receptor; GABA; Gaboxadol; In vitro; In vivo; Tolerance

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; BICUCULLINE; GABOXADOL; INDIPLON; SYNAPSE RECEPTOR; ZOLPIDEM;

ANIMAL EXPERIMENT; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE RESPONSE; DRUG BRAIN LEVEL; DRUG DETERMINATION; DRUG DOSE REGIMEN; DRUG EFFECT; DRUG EXPOSURE; DRUG POTENCY; DRUG RESPONSE; DRUG TOLERANCE; DRUG WITHDRAWAL; ELECTROENCEPHALOGRAM; EXPERIMENTAL RAT; HYPNOSIS; IN VITRO STUDY; MALE; MOTOR COORDINATION; NONHUMAN; OOCYTE; PRIORITY JOURNAL; RAT; REM SLEEP; ROTAROD TEST; SEDATION; SEIZURE SUSCEPTIBILITY; SEIZURE THRESHOLD; SLEEP; SLEEP WAKING CYCLE; TREATMENT WITHDRAWAL; WITHDRAWAL SYNDROME; XENOPUS;

ANESTHETICS; ANIMALS; BICUCULLINE; CENTRAL NERVOUS SYSTEM; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; DRUG TOLERANCE; ELECTRODES, IMPLANTED; ELECTROENCEPHALOGRAPHY; GABA ANTAGONISTS; HYPNOTICS AND SEDATIVES; ISOXAZOLES; MALE; MUSCULOSKELETAL EQUILIBRIUM; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GABA-A; SEIZURES; SLEEP;

ANIMALIA; RATTUS;

EID: 44649163885     PISSN: 00913057     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pbb.2008.01.021     Document Type: Article

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