Polyenylpyrrole Derivatives Inhibit NLRP3 Inflammasome Activation and Inflammatory Mediator Expression by Reducing Reactive Oxygen Species Production and Mitogen-Activated Protein Kinase Activation

PLoS ONE

Volumn 8, Issue 10, 2013, Pages

  Hua, Kuo Feng ^a   Chou, Ju Ching ^a   Lam, Yulin ^b   Tasi, Yu Ling ^c   Chen, Ann ^d   Ka, Shuk Man ^c   Fang, Zhanxiong ^b   Liu, May Lan ^e   Yang, Feng Ling ^f   Yang, Yu Liang ^g   Chiu, Yi Chich ^a   Wu, Shih Hsiung ^f  

^a NATIONAL ILAN UNIVERSITY   (Taiwan)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^c NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

^d TRI SERVICE GENERAL HOSPITAL   (Taiwan)

^e TOKO UNIVERSITY   (Taiwan)

^f INSTITUTE OF BIOLOGICAL CHEMISTRY   (Taiwan)

^g AGRICULTURAL BIOTECHNOLOGY RESEARCH CENTER   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; COMPOUND 1H; COMPOUND 1I; COMPOUND 1N; CRYOPYRIN; CYCLOOXYGENASE 2; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INFLAMMASOME; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE KINASE; POLYENE; POLYENYLPYRROLE DERIVATIVE; PYRROLE DERIVATIVE; REACTIVE OXYGEN METABOLITE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ASCOMYCETES; BONE MARROW CELL; CONTROLLED STUDY; CYTOKINE RELEASE; DENDRITIC CELL; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; ENZYME SYNTHESIS; INFLAMMATORY MEDIATOR EXPRESSION; MEDIATOR; MOUSE; NONHUMAN; PERITONEUM MACROPHAGE; PROTEIN EXPRESSION; PROTEIN SECRETION;

ANIMALS; BLOTTING, WESTERN; CARRIER PROTEINS; CELL LINE; CELL SURVIVAL; CYCLOOXYGENASE 2; CYTOKINES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; INFLAMMASOMES; INFLAMMATION MEDIATORS; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; MICE, INBRED C57BL; MITOGEN-ACTIVATED PROTEIN KINASES; MOLECULAR STRUCTURE; NF-KAPPA B; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; PHOSPHORYLATION; PROTEIN KINASE C-ALPHA; PYRONES; PYRROLES; REACTIVE OXYGEN SPECIES;

EID: 84885038256     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0076754     Document Type: Article

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