Animal toxicity of hairpin pyrrole-imidazole polyamides varies with the turn unit

Journal of Medicinal Chemistry

Volumn 56, Issue 18, 2013, Pages 7449-7457

  Yang, Fei ^a   Nickols, Nicholas G ^a,b   Li, Benjamin C ^a   Szablowski, Jerzy O ^a   Hamilton, Shari R ^c   Meier, Jordan L ^a   Wang, Chieh Mei ^a   Dervan, Peter B ^a  

^a California Institute of Technology   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c IDEXX RADIL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; IMIDAZOLE DERIVATIVE; POLYAMIDE; PYRROLE DERIVATIVE; PYRROLE IMIDAZOLE POLYAMIDE; UNCLASSIFIED DRUG; IMIDAZOLE; NYLON;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BETA TURN; CONTROLLED STUDY; CYTOTOXICITY; DRUG DOSE ESCALATION; FEMALE; GAMMA TURN; HISTOPATHOLOGY; LIVER TOXICITY; MALE; MOUSE; NONHUMAN; PROSTATE CANCER; SINGLE DRUG DOSE; WEIGHT REDUCTION; ANIMAL; BODY WEIGHT; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; DRUG SCREENING; DRUG STABILITY; HUMAN; LIVER; LIVER MICROSOME; METABOLISM; STRUCTURE ACTIVITY RELATION; TOXICITY; TOXICITY TESTING; TRANSPORT AT THE CELLULAR LEVEL;

ANIMALS; ANTINEOPLASTIC AGENTS; BIOLOGICAL TRANSPORT; BODY WEIGHT; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG STABILITY; HUMANS; IMIDAZOLES; LIVER; MALE; MICE; MICROSOMES, LIVER; NYLONS; PYRROLES; STRUCTURE-ACTIVITY RELATIONSHIP; TOXICITY TESTS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84885012480     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm401100s     Document Type: Article

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