Pharmacokinetic modeling and prediction of plasma pyrrole-imidazole polyamide concentration in rats using simultaneous urinary and biliary excretion data

Biological and Pharmaceutical Bulletin

Volumn 32, Issue 5, 2009, Pages 921-927

  Nagashima, Takashi ^a   Aoyama, Takahiko ^a   Yokoe, Tsubasa ^a   Fukasawa, Akiko ^a   Fukuda, Noboru ^a   Ueno, Takahiro ^b   Sugiyama, Hiroshi ^b   Nagase, Hiroki ^a,c   Matsumoto, Yoshiaki ^a  

^a NIHON UNIVERSITY   (Japan)

^b NIHON UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c KYOTO UNIVERSITY   (Japan)

Author keywords

Bile; Modeling; Pharmacokinetics; Prediction; Pyrrole imidazole polyamide; Urine

Indexed keywords

POLYAMIDE; PYRROLE IMIDAZOLE POLYAMIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BILIARY EXCRETION; BLOOD LEVEL; CONTROLLED STUDY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIVER METABOLISM; LIVER MICROSOME; MALE; MATHEMATICAL MODEL; MOLECULAR WEIGHT; NONHUMAN; RAT; URINARY EXCRETION;

ANIMALS; BILE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HUMANS; IMIDAZOLES; MALE; MICROSOMES, LIVER; MODELS, BIOLOGICAL; NYLONS; PREDICTIVE VALUE OF TESTS; PYRROLES; RATS; RATS, WISTAR; URINE;

EID: 66749124720     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.32.921     Document Type: Article

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