Antitumor activity of a pyrrole-imidazole polyamide

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 5, 2013, Pages 1863-1868

  Yang, Fei ^a   Nickols, Nicholas G ^a,b   Li, Benjamin C ^a   Marinov, Georgi K ^c   Said, Jonathan W ^d   Dervan, Peter B ^a  

^a California Institute of Technology   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c CALIFORNIA INSTITUTE OF TECHNOLOGY   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

ChIP Seq; Minor groove binder; Small molecule transcription inhibitor

Indexed keywords

ANTINEOPLASTIC AGENT; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; DOXORUBICIN; PROTEASOME; PROTEIN P53; PYRROLE IMIDAZOLE POLYAMIDE; RNA POLYMERASE II; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL CULTURE; CELL CYCLE REGULATION; CELL STRAIN LNCAP; CONTROLLED STUDY; CYTOTOXICITY; DNA DAMAGE; ENHANCER REGION; ENZYME ACTIVITY; ENZYME INHIBITION; GENE MAPPING; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN DEPLETION; PROTEIN DNA INTERACTION; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; STARVATION; TRANSCRIPTION INITIATION SITE; TUMOR VOLUME;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; IMIDAZOLES; IMMUNOBLOTTING; INTERLEUKIN RECEPTOR COMMON GAMMA SUBUNIT; MALE; MICE; MICE, INBRED C57BL; MICE, INBRED NOD; MICE, KNOCKOUT; MICE, SCID; NYLONS; PROSTATIC NEOPLASMS; PROTEASOME INHIBITORS; PROTEIN SUBUNITS; PYRROLES; RNA POLYMERASE II; SIGNAL TRANSDUCTION; TIME FACTORS; TRANSCRIPTION, GENETIC; TUMOR SUPPRESSOR PROTEIN P53; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84873150881     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1222035110     Document Type: Article

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