Determination of pyrrole-imidazole polyamide in rat plasma by liquid chromatography-tandem mass spectrometry

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 877, Issue 11-12, 2009, Pages 1070-1076

  Nagashima, Takashi ^a   Aoyama, Takahiko ^a   Fukasawa, Akiko ^a   Watabe, Satoshi ^a   Fukuda, Noboru ^a   Ueno, Takahiro ^b   Sugiyama, Hiroshi ^c   Nagase, Hiroki ^a,b   Matsumoto, Yoshiaki ^a  

^a NIHON UNIVERSITY   (Japan)

^b NIHON UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c KYOTO UNIVERSITY   (Japan)

Author keywords

LC MS MS; Plasma; Pyrrole imidazole polyamide; Rat; Solid phase extraction

Indexed keywords

ACQUITY; DISTILLED WATERS; GENE THERAPIES; GRADIENT ELUTIONS; INTRAVENOUS ADMINISTRATIONS; LC-MS/MS; LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRIES; LOWER LIMIT OF QUANTIFICATIONS; METHYLIMIDAZOLE; N-METHYLPYRROLE; PYRROLE-IMIDAZOLE POLYAMIDE; RAT PLASMAS; SENSITIVE METHODS; SOLID-PHASE EXTRACTION;

ACETIC ACID; ACETONITRILE; AMIDES; AMINES; AMINO ACIDS; BODY FLUIDS; CHROMATOGRAPHIC ANALYSIS; CHROMATOGRAPHY; ELECTROSPRAY IONIZATION; GENETIC ENGINEERING; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIQUIDS; MASS SPECTROMETERS; MASS SPECTROMETRY; NITROGEN COMPOUNDS; NYLON POLYMERS; ORGANIC ACIDS; PH EFFECTS; PLASMA (HUMAN); PLASMAS; POLYMERS; SPECTRUM ANALYSIS;

EXTRACTION;

POLYAMIDE; PYRROLE IMIDAZOLE POLYAMIDE; UNCLASSIFIED DRUG;

ACCURACY; ANIMAL EXPERIMENT; ARTICLE; CONCENTRATION RESPONSE; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG ISOLATION; ELECTROSPRAY; LIQUID CHROMATOGRAPHY; MALE; NONHUMAN; PLASMA CONCENTRATION-TIME CURVE; PRIORITY JOURNAL; QUANTITATIVE ASSAY; RAT; SENSITIVITY AND SPECIFICITY; SEPARATION TECHNIQUE; SOLID PHASE EXTRACTION; TANDEM MASS SPECTROMETRY; VALIDITY;

ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HYDROGEN-ION CONCENTRATION; IMIDAZOLES; INDICATORS AND REAGENTS; MALE; NYLONS; PYRROLES; QUALITY CONTROL; RATS; RATS, WISTAR; REFERENCE STANDARDS; REPRODUCIBILITY OF RESULTS; SOLID PHASE EXTRACTION; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TANDEM MASS SPECTROMETRY;

RATTUS;

EID: 63249108262     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2009.02.041     Document Type: Article

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