-
1
-
-
0001172918
-
Chemical production of mutations
-
Auerbach, C., and J. M. Robson, 1946 Chemical production of mutations. Nature 157: 302.
-
(1946)
Nature
, vol.157
, pp. 302
-
-
Auerbach, C.1
Robson, J.M.2
-
2
-
-
0026584289
-
Oligonucleotide-directed sitespecific mutagenesis in Drosophila melanogaster
-
Banga, S. S., and J. B. Boyd, 1992 Oligonucleotide-directed sitespecific mutagenesis in Drosophila melanogaster. Proc. Natl. Acad. Sci. USA 89: 1735-1739.
-
(1992)
Proc. Natl. Acad. Sci. USA
, vol.89
, pp. 1735-1739
-
-
Banga, S.S.1
Boyd, J.B.2
-
3
-
-
84892437994
-
Highly efficient targeted mutagenesis of Drosophila with the CRISPR/ Cas9 system
-
Bassetta, R., C. Tibbit, C. P. Ponting, and J.-L. Liu, 2013 Highly efficient targeted mutagenesis of Drosophila with the CRISPR/ Cas9 system. Cell Reports: 1-10.
-
(2013)
Cell Reports
, pp. 1-10
-
-
Bassetta, R.1
Tibbit, C.2
Ponting, C.P.3
Liu, J.-L.4
-
4
-
-
0001194208
-
Genetic control of biochemical reactions in Neurospora
-
Beadle, G. W., and E. L. Tatum, 1941 Genetic control of biochemical reactions in Neurospora. Proc. Natl. Acad. Sci. USA 27: 499-506.
-
(1941)
Proc. Natl. Acad. Sci. USA
, vol.27
, pp. 499-506
-
-
Beadle, G.W.1
Tatum, E.L.2
-
5
-
-
0027619051
-
The discovery of mustard gas mutagenesis by Auerbach and Robson in 1941
-
Beale, G., 1993 The discovery of mustard gas mutagenesis by Auerbach and Robson in 1941. Genetics 134: 393-399.
-
(1993)
Genetics
, vol.134
, pp. 393-399
-
-
Beale, G.1
-
6
-
-
33646182222
-
Efficient gene targeting in Drosophila with zincfinger nucleases
-
Beumer, K., G. Bhattacharyya, M. Bibikova, J. K. Trautman, and D. Carroll, 2006 Efficient gene targeting in Drosophila with zincfinger nucleases. Genetics 172: 2391-2403.
-
(2006)
Genetics
, vol.172
, pp. 2391-2403
-
-
Beumer, K.1
Bhattacharyya, G.2
Bibikova, M.3
Trautman, J.K.4
Carroll, D.5
-
7
-
-
58149374562
-
Efficient gene targeting in Drosophila by direct embryo injection with zinc-finger nucleases
-
Beumer, K. J., J. K. Trautman, A. Bozas, J.-L. Liu, J. Rutter et al., 2008 Efficient gene targeting in Drosophila by direct embryo injection with zinc-finger nucleases. Proc. Natl. Acad. Sci. USA 105: 19821-19826.
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 19821-19826
-
-
Beumer, K.J.1
Trautman, J.K.2
Bozas, A.3
Liu, J.-L.4
Rutter, J.5
-
8
-
-
84885791114
-
Comparing ZFNs and TALENs for gene targeting in Drosophila. G3: Genes, Genomes
-
DOI: 10.1534/g3.113.007260
-
Beumer, K. J., J. K. Trautman, M. Christian, and T. J. Dahlem, C. M. Lake et al., 2013a Comparing ZFNs and TALENs for gene targeting in Drosophila. G3: Genes, Genomes, Genetics DOI: 10.1534/g3.113.007260.
-
(2013)
Genetics
-
-
Beumer, K.J.1
Trautman, J.K.2
Christian, M.3
Dahlem, T.J.4
Lake, C.M.5
-
9
-
-
84881060423
-
Donor DNA utilization during gene targeting with zinc-finger nucleases
-
Beumer, K. J., J. K Trautman, K Mukherjee, and D, Carroll 2013b Donor DNA utilization during gene targeting with zinc-finger nucleases. G3 3: 657-664.
-
(2013)
G3
, vol.3
, pp. 657-664
-
-
Beumer, K.J.1
Trautman, J.K.2
Mukherjee, K.3
Carroll, D.4
-
10
-
-
0036021389
-
Targeted chromosomal cleavage and mutagenesis in Drosophila using zinc-finger nucleases
-
Bibikova, M., M. Golic, K. G. Golic, and D. Carroll, 2002 Targeted chromosomal cleavage and mutagenesis in Drosophila using zinc-finger nucleases. Genetics 161: 1169-1175.
-
(2002)
Genetics
, vol.161
, pp. 1169-1175
-
-
Bibikova, M.1
Golic, M.2
Golic, K.G.3
Carroll, D.4
-
11
-
-
72149110399
-
Breaking the code of DNA binding specificity of TAL-type III effectors
-
Boch, J., H. Scholze, S. Schornack, A. Landgraf, S. Hahn et al., 2009 Breaking the code of DNA binding specificity of TAL-type III effectors. Science 326: 1509-1512.
-
(2009)
Science
, vol.326
, pp. 1509-1512
-
-
Boch, J.1
Scholze, H.2
Schornack, S.3
Landgraf, A.4
Hahn, S.5
-
12
-
-
70349313064
-
Genetic analysis of zinc-finger nuclease-induced gene targeting in Drosophila
-
Bozas, A., K. J. Beumer, J. K. Trautman, and D. Carroll, 2009 Genetic analysis of zinc-finger nuclease-induced gene targeting in Drosophila. Genetics 182: 641-651.
-
(2009)
Genetics
, vol.182
, pp. 641-651
-
-
Bozas, A.1
Beumer, K.J.2
Trautman, J.K.3
Carroll, D.4
-
13
-
-
80051535219
-
Genome engineering with zinc-finger nucleases
-
Carroll, D., 2011 Genome engineering with zinc-finger nucleases. Genetics 188: 773-782.
-
(2011)
Genetics
, vol.188
, pp. 773-782
-
-
Carroll, D.1
-
14
-
-
84876409836
-
Genome editing with RNA-guided Cas9 nuclease in zebrafish embryos
-
Chang, N., C. Sun, L. Gao, D. Zhu, X. Xu et al., 2013 Genome editing with RNA-guided Cas9 nuclease in zebrafish embryos. Cell Res. 23: 465-472.
-
(2013)
Cell Res.
, vol.23
, pp. 465-472
-
-
Chang, N.1
Sun, C.2
Gao, L.3
Zhu, D.4
Xu, X.5
-
15
-
-
84884923061
-
Transgene-free genome editing in Caenorhabditis elegans using CRISPR-Cas
-
DOI: 10.1534/genetics.113.155879
-
Chiu, H., H. T. Schwartz, I. Antoshechkin, and P. W. Sternberg, 2013 Transgene-free genome editing in Caenorhabditis elegans using CRISPR-Cas. Genetics DOI: 10.1534/genetics.113.155879.
-
(2013)
Genetics
-
-
Chiu, H.1
Schwartz, H.T.2
Antoshechkin, I.3
Sternberg, P.W.4
-
16
-
-
84874624936
-
Targeted genome engineering in human cells with the Cas9 RNA-guided endonuclease
-
Cho, S. W., S. Kim, J. M. Kim, and J.-S. Kim, 2013 Targeted genome engineering in human cells with the Cas9 RNA-guided endonuclease. Nat. Biotechnol. 31: 230-232.
-
(2013)
Nat. Biotechnol.
, vol.31
, pp. 230-232
-
-
Cho, S.W.1
Kim, S.2
Kim, J.M.3
Kim, J.-S.4
-
17
-
-
84884911076
-
Heritable gene knockout in Caenorhabditis elegans by direct injection of Cas9-sgRNA ribonucleoproteins
-
DOI: 10.1534/genetics. 113.155853
-
Cho, S. W., J. Lee, D. Carroll, J.-S. Kim, and J. Lee, 2013 Heritable gene knockout in Caenorhabditis elegans by direct injection of Cas9-sgRNA ribonucleoproteins. Genetics DOI: 10.1534/genetics. 113.155853.
-
(2013)
Genetics
-
-
Cho, S.W.1
Lee, J.2
Carroll, D.3
Kim, J.-S.4
Lee, J.5
-
18
-
-
0028919608
-
Induction of homologous recombination in mammalian chromosomes by using the I-SceI system of Saccharomyces cerevisiae
-
Choulika, A., A. Perrin, B. Dujon, and J. F. Nicolas, 1995 Induction of homologous recombination in mammalian chromosomes by using the I-SceI system of Saccharomyces cerevisiae. Mol. Cell. Biol. 15: 1968-1973.
-
(1995)
Mol. Cell. Biol.
, vol.15
, pp. 1968-1973
-
-
Choulika, A.1
Perrin, A.2
Dujon, B.3
Nicolas, J.F.4
-
19
-
-
78951479577
-
Targeting DNA double-strand breaks with TAL effector nucleases
-
Christian, M., T. Cermak, E. L. Doyle, C. Schmidt, F. Zhang et al., 2010 Targeting DNA double-strand breaks with TAL effector nucleases. Genetics 186: 757-761.
-
(2010)
Genetics
, vol.186
, pp. 757-761
-
-
Christian, M.1
Cermak, T.2
Doyle, E.L.3
Schmidt, C.4
Zhang, F.5
-
20
-
-
84873729095
-
Multiplex genome engineering using CRISPR/Cas systems
-
Cong, L., F. A. Ran, D. Cox, S. Lin, R. Barretto et al., 2013 Multiplex genome engineering using CRISPR/Cas systems. Science 339: 819-823.
-
(2013)
Science
, vol.339
, pp. 819-823
-
-
Cong, L.1
Ran, F.A.2
Cox, D.3
Lin, S.4
Barretto, R.5
-
21
-
-
84884950106
-
CRISPR/ Cas9 systems targeting b-globin and CCR5 genes have substantial off-target activity
-
(in press)
-
Cradick, T. J., E. J. Fine, C. J. Antico, and G. Bao, 2013 CRISPR/ Cas9 systems targeting b-globin and CCR5 genes have substantial off-target activity. Nucleic Acids Res. (in press).
-
(2013)
Nucleic Acids Res.
-
-
Cradick, T.J.1
Fine, E.J.2
Antico, C.J.3
Bao, G.4
-
22
-
-
84876575031
-
Genome engineering in Saccharomyces cerevisiae using CRISPR-Cas systems
-
Dicarlo, J. E., J. E. Norville, P. Mali, X. Rios, J. Aach et al., 2013 Genome engineering in Saccharomyces cerevisiae using CRISPR-Cas systems. Nucleic Acids Res. 41: 4336-4343.
-
(2013)
Nucleic Acids Res.
, vol.41
, pp. 4336-4343
-
-
Dicarlo, J.E.1
Norville, J.E.2
Mali, P.3
Rios, X.4
Aach, J.5
-
23
-
-
84875963894
-
Enhanced efficiency of human pluripotent stem cell genome editing through replacing TALENs with CRISPRs
-
Ding, Q., S. N Regan, Y. Xia, L. A. Oostrom, C. A. Cowan et al., 2013 Enhanced efficiency of human pluripotent stem cell genome editing through replacing TALENs with CRISPRs. Stem Cells 12: 393-394.
-
(2013)
Stem Cells
, vol.12
, pp. 393-394
-
-
Ding, Q.1
Regan, S.N.2
Xia, Y.3
Oostrom, L.A.4
Cowan, C.A.5
-
24
-
-
0031863007
-
Analysis of gene targeting and intrachromosomal homologous recombination stimulated by genomic double-strand breaks in mouse embryonic stem cells
-
Donoho, G., M. Jasin, and P. Berg, 1998 Analysis of gene targeting and intrachromosomal homologous recombination stimulated by genomic double-strand breaks in mouse embryonic stem cells. Mol. Cell. Biol. 18: 4070-4078.
-
(1998)
Mol. Cell. Biol.
, vol.18
, pp. 4070-4078
-
-
Donoho, G.1
Jasin, M.2
Berg, P.3
-
25
-
-
84881475586
-
Heritable genome editing in C. Elegans via a CRISPR-Cas9 system
-
Friedland, A. E., Y. B. Tzur, K. M. Esvelt, M. P. C. A. Covo, G. M. Church et al., 2013 Heritable genome editing in C. elegans via a CRISPR-Cas9 system. Nat. Methods 10: 741-743.
-
(2013)
Nat. Methods
, vol.10
, pp. 741-743
-
-
Friedland, A.E.1
Tzur, Y.B.2
Esvelt, K.M.3
Covo, M.P.C.A.4
Church, G.M.5
-
26
-
-
84880570576
-
High-frequency off-target mutagenesis induced by CRISPRCas nucleases in human cells
-
(in press)
-
Fu, Y, J. A. Foden, and C. Khayter, M. L Maeder, D Reyon et al., 2013 High-frequency off-target mutagenesis induced by CRISPRCas nucleases in human cells. Nat. Biotechnol. (in press).
-
(2013)
Nat. Biotechnol.
-
-
Fu, Y.1
Foden, J.A.2
Khayter, C.3
Maeder, M.L.4
Reyon, D.5
-
27
-
-
84866859751
-
Cas9-crRNA ribonucleoprotein complex mediates specific DNA cleavage for adaptive immunity in bacteria
-
Gasiunas, G., R. Barrangou, P. Horvath, and V. Siksnys, 2012 Cas9-crRNA ribonucleoprotein complex mediates specific DNA cleavage for adaptive immunity in bacteria. Proc. Natl. Acad. Sci. USA 109: E2579-E2586.
-
(2012)
Proc. Natl. Acad. Sci. USA
, vol.109
-
-
Gasiunas, G.1
Barrangou, R.2
Horvath, P.3
Siksnys, V.4
-
28
-
-
84879264708
-
ZFN, TALEN, and CRISPR/Cas-based methods for genome engineering
-
Gaj, T., C. A. Gersbach, and C. F. Barbas, 2013 ZFN, TALEN, and CRISPR/Cas-based methods for genome engineering. Trends Biotechnol. 31: 397-405.
-
(2013)
Trends Biotechnol.
, vol.31
, pp. 397-405
-
-
Gaj, T.1
Gersbach, C.A.2
Barbas, C.F.3
-
29
-
-
0026418313
-
Targeted gene replacement in Drosophila via P element-induced gap repair
-
Gloor, G. B., N. A. Nassif, D. M. Johnson-Schlitz, C. R. Preston, and W. R. Engels, 1991 Targeted gene replacement in Drosophila via P element-induced gap repair. Science 253: 1110-1117.
-
(1991)
Science
, vol.253
, pp. 1110-1117
-
-
Gloor, G.B.1
Nassif, N.A.2
Johnson-Schlitz, D.M.3
Preston, C.R.4
Engels, W.R.5
-
30
-
-
0037418177
-
Ends-out, or replacement, gene targeting in Drosophila
-
Gong, W. J., and K. G. Golic, 2003 Ends-out, or replacement, gene targeting in Drosophila. Proc. Natl. Acad. Sci. USA 100: 2556-2561.
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 2556-2561
-
-
Gong, W.J.1
Golic, K.G.2
-
31
-
-
84880088705
-
Genome engineering of Drosophila with the CRISPR RNA-guided Cas9 nuclease
-
Gratz, S. J., A. M. Cummings, J. N. Nguyen, D. C. Hamm, L. K. Donohue et al., 2013 Genome engineering of Drosophila with the CRISPR RNA-guided Cas9 nuclease. Genetics 194: 1029-1035.
-
(2013)
Genetics
, vol.194
, pp. 1029-1035
-
-
Gratz, S.J.1
Cummings, A.M.2
Nguyen, J.N.3
Hamm, D.C.4
Donohue, L.K.5
-
32
-
-
0017069880
-
Interconversion of yeast mating types I. Direct observations of the action of the homothallism (HO) gene
-
Hicks, J. B., and I. Herskowitz, 1976 Interconversion of yeast mating types I. Direct observations of the action of the homothallism (HO) gene. Genetics 83: 245-258.
-
(1976)
Genetics
, vol.83
, pp. 245-258
-
-
Hicks, J.B.1
Herskowitz, I.2
-
34
-
-
84884165315
-
DNA targeting specificity of RNA-guided Cas9 nucleases
-
(in press)
-
Hsu, P. D., D. A. Scott, and J. A. Weinstein, F. A. Ran, S. Konermann et al., 2013 DNA targeting specificity of RNA-guided Cas9 nucleases. Nat. Biotechnol. (in press).
-
(2013)
Nat. Biotechnol.
-
-
Hsu, P.D.1
Scott, D.A.2
Weinstein, J.A.3
Ran, F.A.4
Konermann, S.5
-
35
-
-
84879949311
-
Heritable and precise Zebrafish genome editing using a CRISPR-Cas system
-
Hwang, W. Y., Y. Fu, D. R. Reyon, M. L. Maeder, P. Kaini et al., 2013a Heritable and precise Zebrafish genome editing using a CRISPR-Cas system. PLoS ONE 8: e68708.
-
(2013)
PLoS ONE
, vol.8
-
-
Hwang, W.Y.1
Fu, Y.2
Reyon, D.R.3
Maeder, M.L.4
Kaini, P.5
-
36
-
-
84874617789
-
Efficient genome editing in zebrafish using a CRISPRCas system
-
Hwang, W. Y., Y. Fu, D. Reyon, M. L. Maeder, S. Q. Tsai et al., 2013b Efficient genome editing in zebrafish using a CRISPRCas system. Nat. Biotechnol. 31: 227-229.
-
(2013)
Nat. Biotechnol.
, vol.31
, pp. 227-229
-
-
Hwang, W.Y.1
Fu, Y.2
Reyon, D.3
Maeder, M.L.4
Tsai, S.Q.5
-
37
-
-
0034730077
-
Studies of promoter recognition and start site selection by T7 RNA polymerase using a comprehensive collection of promoter variants
-
Imburgio, D., M. Rong, K. Ma, and W. T. McAllister, 2000 Studies of promoter recognition and start site selection by T7 RNA polymerase using a comprehensive collection of promoter variants. Biochemistry 39: 10419-10430.
-
(2000)
Biochemistry
, vol.39
, pp. 10419-10430
-
-
Imburgio, D.1
Rong, M.2
Ma, K.3
McAllister, W.T.4
-
38
-
-
84874608929
-
RNA-guided editing of bacterial genomes using crisPrcas systems
-
Jiang, W., D. Bikard, D. Cox, F. Zhang, and L. A. Marraffini, 2013 RNA-guided editing of bacterial genomes using crisPrcas systems. Nat. Biotechnol. 31: 233-239.
-
(2013)
Nat. Biotechnol.
, vol.31
, pp. 233-239
-
-
Jiang, W.1
Bikard, D.2
Cox, D.3
Zhang, F.4
Marraffini, L.A.5
-
39
-
-
84865070369
-
A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity
-
Jinek, M., K. Chylinski, I. Fonfara, M. Hauer, J. A. Doudna et al., 2012 A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity. Science 337: 816-821.
-
(2012)
Science
, vol.337
, pp. 816-821
-
-
Jinek, M.1
Chylinski, K.2
Fonfara, I.3
Hauer, M.4
Doudna, J.A.5
-
40
-
-
84876567971
-
RNAprogrammed genome editing in human cells
-
Jinek, M., A. East, A. Cheng, S. Lin, E. Ma et al., 2013 RNAprogrammed genome editing in human cells. eLife 2: e00471.
-
(2013)
eLife
, vol.2
-
-
Jinek, M.1
East, A.2
Cheng, A.3
Lin, S.4
Ma, E.5
-
41
-
-
0027486933
-
P-elementinduced interallelic gene conversion of insertions and deletions in Drosophila melanogaster
-
Johnson-Schlitz, D. M., and W. R. Engels, 1993 P-elementinduced interallelic gene conversion of insertions and deletions in Drosophila melanogaster. Mol. Cell. Biol. 13: 7006-7018.
-
(1993)
Mol. Cell. Biol.
, vol.13
, pp. 7006-7018
-
-
Johnson-Schlitz, D.M.1
Engels, W.R.2
-
42
-
-
84884943528
-
Targeted heritable mutation and gene conversion by Cas9-CRISPR in Caenorhabditis elegans
-
DOI: 10.1534/genetics.113.155754
-
Katic, I., and H. Großhans, 2013 Targeted heritable mutation and gene conversion by Cas9-CRISPR in Caenorhabditis elegans. Genetics DOI: 10.1534/genetics.113.155754.
-
(2013)
Genetics
-
-
Katic, I.1
Großhans, H.2
-
43
-
-
84884944076
-
An efficient strategy for TALEN-mediated genome engineering in Drosophila
-
(in press)
-
Katsuyama, T., A. Akmammedov, M. Seimiya, and S. C. Hess, C. Sievers et al., 2013 An efficient strategy for TALEN-mediated genome engineering in Drosophila. Nucleic Acids Res. (in press).
-
(2013)
Nucleic Acids Res.
-
-
Katsuyama, T.1
Akmammedov, A.2
Seimiya, M.3
Hess, S.C.4
Sievers, C.5
-
44
-
-
0030025984
-
Gene targeting of a plasmid-borne sequence to a double-strand DNA break in Drosophila melanogaster
-
Keeler, K. J., T. Dray, J. E. Penney, and G. B. Gloor, 1996 Gene targeting of a plasmid-borne sequence to a double-strand DNA break in Drosophila melanogaster. Mol. Cell. Biol. 16: 522-528.
-
(1996)
Mol. Cell. Biol.
, vol.16
, pp. 522-528
-
-
Keeler, K.J.1
Dray, T.2
Penney, J.E.3
Gloor, G.B.4
-
45
-
-
84861990434
-
Precision genome engineering with programmable DNA-nicking enzymes
-
Kim, E., S. Kim, D. H. Kim, B. S. Choi, I. Y. Choi et al., 2012 Precision genome engineering with programmable DNA-nicking enzymes. Genome Res. 22: 1327-1333.
-
(2012)
Genome Res.
, vol.22
, pp. 1327-1333
-
-
Kim, E.1
Kim, S.2
Kim, D.H.3
Choi, B.S.4
Choi, I.Y.5
-
46
-
-
0030032063
-
Hybrid restriction enzymes: Zinc finger fusions to Fok I cleavage domain
-
Kim, Y. G., J. Cha, and S. Chandrasegaran, 1996 Hybrid restriction enzymes: zinc finger fusions to Fok I cleavage domain. Proc. Natl. Acad. Sci. USA 93: 1156-1160.
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 1156-1160
-
-
Kim, Y.G.1
Cha, J.2
Chandrasegaran, S.3
-
47
-
-
84884925278
-
Highly improved gene targeting by germline-specific Cas9 expression in Drosophila
-
DOI: 10.1534/genetics.113.156737
-
Kondo, S., and R. Ueda, 2013 Highly improved gene targeting by germline-specific Cas9 expression in Drosophila. Genetics DOI: 10.1534/genetics.113.156737.
-
(2013)
Genetics
-
-
Kondo, S.1
Ueda, R.2
-
48
-
-
0021053220
-
A site-specific endonuclease essential for mating-type switching in Saccharomyces cerevisiae
-
Kostriken, R., J. N. Strathern, A. J. Klar, J. B. Hicks, and F. Heffron, 1983 A site-specific endonuclease essential for mating-type switching in Saccharomyces cerevisiae. Cell 35: 167-174.
-
(1983)
Cell
, vol.35
, pp. 167-174
-
-
Kostriken, R.1
Strathern, J.N.2
Klar, A.J.3
Hicks, J.B.4
Heffron, F.5
-
49
-
-
84883785822
-
Multiplex and homologous recombination-mediated genome editing in Arabidopsis and Nicotiana benthamiana using guide RNA and Cas9
-
Li, J.-F., J. E. Norville, J. Aach, M. McCormack, D. Zhang et al., 2013 Multiplex and homologous recombination-mediated genome editing in Arabidopsis and Nicotiana benthamiana using guide RNA and Cas9. Nat Biotechnol 31: 688-691.
-
(2013)
Nat Biotechnol
, vol.31
, pp. 688-691
-
-
Li, J.-F.1
Norville, J.E.2
Aach, J.3
McCormack, M.4
Zhang, D.5
-
50
-
-
78651270582
-
TAL nucleases (TALNs): Hybrid proteins composed of TAL effectors and FokI DNA-cleavage domain
-
Li, T., S. Huang, W. Z. Jiang, D. Wright, M. H. Spalding et al., 2011 TAL nucleases (TALNs): hybrid proteins composed of TAL effectors and FokI DNA-cleavage domain. Nucleic Acids Res. 39: 359-372.
-
(2011)
Nucleic Acids Res.
, vol.39
, pp. 359-372
-
-
Li, T.1
Huang, S.2
Jiang, W.Z.3
Wright, D.4
Spalding, M.H.5
-
51
-
-
84884922656
-
Heritable genome editing using TALENs and CRISPR/ Cas9 to engineer precise insertions and deletions in evolutionarily diverse nematode species
-
Lo, T.-W., C. S. Pickle, S. Lin, and E. J. Ralston, M. Gurling et al., 2013 Heritable genome editing using TALENs and CRISPR/ Cas9 to engineer precise insertions and deletions in evolutionarily diverse nematode species. Genetics 195: 331-348.
-
(2013)
Genetics
, vol.195
, pp. 331-348
-
-
Lo, T.-W.1
Pickle, C.S.2
Lin, S.3
Ralston, E.J.4
Gurling, M.5
-
52
-
-
84884160273
-
Cas9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering
-
(in press)
-
Mali, P., J. Aach, P. B. Stranges, K. M. Esvelt, M. Moosburner et al., 2013a Cas9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering. Nat. Biotechnol. (in press).
-
(2013)
Nat. Biotechnol.
-
-
Mali, P.1
Aach, J.2
Stranges, P.B.3
Esvelt, K.M.4
Moosburner, M.5
-
53
-
-
84873734105
-
RNA-guided human genome engineering via Cas9
-
Mali, P., L. Yang, K. M. Esvelt, J. Aach, M. Guell et al., 2013b RNA-guided human genome engineering via Cas9. Science 339: 823-826.
-
(2013)
Science
, vol.339
, pp. 823-826
-
-
Mali, P.1
Yang, L.2
Esvelt, K.M.3
Aach, J.4
Guell, M.5
-
54
-
-
0024296027
-
Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: A general strategy for targeting mutations to non-selectable genes
-
Mansour, S. L., K. R. Thomas, and M. R. Capecchi, 1988 Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes. Nature 336: 348-352.
-
(1988)
Nature
, vol.336
, pp. 348-352
-
-
Mansour, S.L.1
Thomas, K.R.2
Capecchi, M.R.3
-
55
-
-
79551685675
-
A TALE nuclease architecture for efficient genome editing
-
Miller, J. C., S. Tan, G. Qiao, K. A. Barlow, J. Wang et al., 2011 A TALE nuclease architecture for efficient genome editing. Nat. Biotechnol. 29: 143-148.
-
(2011)
Nat. Biotechnol.
, vol.29
, pp. 143-148
-
-
Miller, J.C.1
Tan, S.2
Qiao, G.3
Barlow, K.A.4
Wang, J.5
-
56
-
-
72149090954
-
A simple cipher governs DNA recognition by TAL effectors
-
Moscou, M. J., and A. J. Bogdanove, 2009 A simple cipher governs DNA recognition by TAL effectors. Science 326: 1501.
-
(2009)
Science
, vol.326
, pp. 1501
-
-
Moscou, M.J.1
Bogdanove, A.J.2
-
57
-
-
33747830026
-
Artificial transmutation of the gene
-
Muller, H. J., 1927 Artificial transmutation of the gene. Science 66: 84-87.
-
(1927)
Science
, vol.66
, pp. 84-87
-
-
Muller, H.J.1
-
58
-
-
0028197257
-
Efficient copying of nonhomologous sequences from ectopic sites via P-element-induced gap repair
-
Nassif, N., J. Penney, S. Pal, W. R. Engels, and G. B. Gloor, 1994 Efficient copying of nonhomologous sequences from ectopic sites via P-element-induced gap repair. Mol. Cell. Biol. 14: 1613-1625.
-
(1994)
Mol. Cell. Biol.
, vol.14
, pp. 1613-1625
-
-
Nassif, N.1
Penney, J.2
Pal, S.3
Engels, W.R.4
Gloor, G.B.5
-
59
-
-
84883828590
-
Targeted mutagenesis in the model plant Nicotiana benthamiana using Cas9 RNA-guided endonuclease
-
Nekrasov, V., B. Staskawicz, D. Weigel, J. D. G. Jones, and S. Kamoun, 2013 Targeted mutagenesis in the model plant Nicotiana benthamiana using Cas9 RNA-guided endonuclease. Nat Biotechnol 31: 691-693.
-
(2013)
Nat Biotechnol
, vol.31
, pp. 691-693
-
-
Nekrasov, V.1
Staskawicz, B.2
Weigel, D.3
Jones, J.D.G.4
Kamoun, S.5
-
61
-
-
84884155038
-
High-throughput profiling of off-target DNA cleavage reveals RNA-programmed Cas9 nuclease specificity
-
(in press)
-
Pattanayak, V., S. Lin, J. P. Guilinger, E. Ma, J. A. Doudna et al., 2013 High-throughput profiling of off-target DNA cleavage reveals RNA-programmed Cas9 nuclease specificity. Nat Biotechnol (in press).
-
(2013)
Nat Biotechnol
-
-
Pattanayak, V.1
Lin, S.2
Guilinger, J.P.3
Ma, E.4
Doudna, J.A.5
-
62
-
-
0026573892
-
Site-specific recombination determined by I-SceI, a mitochondrial group I intron-encoded endonuclease expressed in the yeast nucleus
-
Plessis, A., A. Perrin, J. E. Haber, and B. Dujon, 1992 Site-specific recombination determined by I-SceI, a mitochondrial group I intron-encoded endonuclease expressed in the yeast nucleus. Genetics 130: 451-460.
-
(1992)
Genetics
, vol.130
, pp. 451-460
-
-
Plessis, A.1
Perrin, A.2
Haber, J.E.3
Dujon, B.4
-
63
-
-
0034674713
-
Gene targeting by homologous recombination in Drosophila
-
Rong, Y. S., and K. G. Golic, 2000 Gene targeting by homologous recombination in Drosophila. Science 288: 2013-2018.
-
(2000)
Science
, vol.288
, pp. 2013-2018
-
-
Rong, Y.S.1
Golic, K.G.2
-
64
-
-
0347992015
-
The homologous chromosome is an effective template for the repair of mitotic DNA doublestrand breaks in Drosophila
-
Rong, Y. S., and K. G. Golic, 2003 The homologous chromosome is an effective template for the repair of mitotic DNA doublestrand breaks in Drosophila. Genetics 165: 1831-1842.
-
(2003)
Genetics
, vol.165
, pp. 1831-1842
-
-
Rong, Y.S.1
Golic, K.G.2
-
65
-
-
0037097866
-
Targeted mutagenesis by homologous recombination in D. Melanogaster
-
Rong, Y. S., S. W. Titen, H. B. Xie, M. M. Golic, M. Bastiani et al., 2002 Targeted mutagenesis by homologous recombination in D. melanogaster. Genes Dev. 16: 1568-1581.
-
(2002)
Genes Dev.
, vol.16
, pp. 1568-1581
-
-
Rong, Y.S.1
Titen, S.W.2
Xie, H.B.3
Golic, M.M.4
Bastiani, M.5
-
66
-
-
0028237305
-
Expression of a site-specific endonuclease stimulates homologous recombination in mammalian cells
-
Rouet, P., F. Smih, and M. Jasin, 1994 Expression of a site-specific endonuclease stimulates homologous recombination in mammalian cells. Proc. Natl. Acad. Sci. USA 91: 6064-6068.
-
(1994)
Proc. Natl. Acad. Sci. USA
, vol.91
, pp. 6064-6068
-
-
Rouet, P.1
Smih, F.2
Jasin, M.3
-
67
-
-
0009453976
-
Replacement of chromosome segments with altered DNA sequences constructed in vitro
-
Scherer, S., and R. W. Davis, 1979 Replacement of chromosome segments with altered DNA sequences constructed in vitro. Proc. Natl. Acad. Sci. USA 76: 4951-4955.
-
(1979)
Proc. Natl. Acad. Sci. USA
, vol.76
, pp. 4951-4955
-
-
Scherer, S.1
Davis, R.W.2
-
68
-
-
84877103949
-
Generation of gene-modified mice via Cas9/RNA-mediated gene targeting
-
Shen, B., J. Zhang, H. Wu, J. Wang, K. Ma et al., 2013 Generation of gene-modified mice via Cas9/RNA-mediated gene targeting. Cell Res. 23: 720-723.
-
(2013)
Cell Res.
, vol.23
, pp. 720-723
-
-
Shen, B.1
Zhang, J.2
Wu, H.3
Wang, J.4
Ma, K.5
-
69
-
-
0020213475
-
Homothallic switching of yeast mating type cassettes is initiated by a double-stranded cut in the MAT locus
-
Strathern, J. N., A. J. Klar, J. B. Hicks, J. A. Abraham, J. M. Ivy et al., 1982 Homothallic switching of yeast mating type cassettes is initiated by a double-stranded cut in the MAT locus. Cell 31: 183-192.
-
(1982)
Cell
, vol.31
, pp. 183-192
-
-
Strathern, J.N.1
Klar, A.J.2
Hicks, J.B.3
Abraham, J.A.4
Ivy, J.M.5
-
70
-
-
84884968656
-
Heritable custom genomic modifications in Caenorhabditis elegans via a CRISPR-Cas9 system
-
DOI: 10.1534/genetics.113.156075
-
Tzur, Y. B., A. E. Friedland, S. Nadarajan, G. M. Church, J. A. Calarco et al., 2013 Heritable custom genomic modifications in Caenorhabditis elegans via a CRISPR-Cas9 system. Genetics DOI: 10.1534/genetics.113.156075.
-
(2013)
Genetics
-
-
Tzur, Y.B.1
Friedland, A.E.2
Nadarajan, S.3
Church, G.M.4
Calarco, J.A.5
-
71
-
-
84884930591
-
CRISPR/Cas9-targeted mutagenesis in Caenorhabditis elegans
-
DOI: 10.1534/genetics.113.156299
-
Waaijers, S., V. Portegijs, J. Kerver, B. B. C. G. Lemmens, M. Tijsterman et al., 2013 CRISPR/Cas9-targeted mutagenesis in Caenorhabditis elegans. Genetics DOI: 10.1534/genetics.113.156299.
-
(2013)
Genetics
-
-
Waaijers, S.1
Portegijs, V.2
Kerver, J.3
Lemmens, B.B.C.G.4
Tijsterman, M.5
-
72
-
-
84877707375
-
One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering
-
Wang, H., H. Yang, C. S. Shivalila, M. M. Dawlaty, A. W. Cheng et al., 2013 one-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering. Cell 153: 910-918.
-
(2013)
Cell
, vol.153
, pp. 910-918
-
-
Wang, H.1
Yang, H.2
Shivalila, C.S.3
Dawlaty, M.M.4
Cheng, A.W.5
-
73
-
-
84879410743
-
TALEN or Cas9: Rapid, efficient and specific choices for genome modifications
-
Wei, C., J. Liu, Z. Yu, B. Zhang, G. Gao et al., 2013 TALEN or Cas9: rapid, efficient and specific choices for genome modifications. J. Genet. Genomics 40: 281-289.
-
(2013)
J. Genet. Genomics
, vol.40
, pp. 281-289
-
-
Wei, C.1
Liu, J.2
Yu, Z.3
Zhang, B.4
Gao, G.5
-
74
-
-
84857097177
-
RNAguided genetic silencing systems in bacteria and archaea
-
Wiedenheft, B., S. H. Sternberg, and J. A. Doudna, 2012 RNAguided genetic silencing systems in bacteria and archaea. Nature 482: 331-338.
-
(2012)
Nature
, vol.482
, pp. 331-338
-
-
Wiedenheft, B.1
Sternberg, S.H.2
Doudna, J.A.3
-
75
-
-
84880117972
-
Chromosomal deletions and inversions mediated by TALENs and CRISPR/Cas in zebrafish
-
(in press)
-
Xiao, A., Z. Wang, Y. Hu, Y. Wu, Z. Luo et al., 2013 Chromosomal deletions and inversions mediated by TALENs and CRISPR/Cas in zebrafish. Nucleic Acids Res. (in press).
-
(2013)
Nucleic Acids Res.
-
-
Xiao, A.1
Wang, Z.2
Hu, Y.3
Wu, Y.4
Luo, Z.5
-
76
-
-
84884962826
-
RNA-guided genome editing in plants using a CRISPR-Cas system
-
(in press)
-
Xie, K., and Y. Yang, 2013 RNA-guided genome editing in plants using a CRISPR-Cas system. Mol Plant (in press).
-
(2013)
Mol Plant
-
-
Xie, K.1
Yang, Y.2
-
77
-
-
84883809403
-
Highly efficient Genome modifications mediated by CRISPR/Cas9 in Drosophila
-
Yu, Z., M. Ren, Z. Wang, B. Zhang, Y. S. Rong et al., 2013 Highly efficient Genome modifications mediated by CRISPR/Cas9 in Drosophila. Genetics 195: 289-291.
-
(2013)
Genetics
, vol.195
, pp. 289-291
-
-
Yu, Z.1
Ren, M.2
Wang, Z.3
Zhang, B.4
Rong, Y.S.5
|