Promoter hypermethylation leads to decreased APC mRNA expression in familial polyposis and sporadic colorectal tumours, but does not substitute for truncating mutations

Experimental and Molecular Pathology

Volumn 85, Issue 3, 2008, Pages 201-206

  Segditsas, Stefania ^a   Sieber, Oliver M ^a   Rowan, Andrew ^a   Setien, Fernando ^b   Neale, Kay ^c   Phillips, Robin K S ^c   Ward, Robyn ^d   Esteller, Manel ^b   Tomlinson, Ian P M ^a  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^b Centro Nacional de Investigaciones Oncológicas   (Spain)

^c ST MARK S HOSPITAL   (United Kingdom)

^d ST VINCENT S HOSPITAL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; WNT PROTEIN;

APC GENE; ARTICLE; CANCER CELL CULTURE; CODON; COLON BIOPSY; COLORECTAL CANCER; CONTROLLED STUDY; CPG ISLAND; DNA METHYLATION; FAMILIAL POLYPOSIS; GENE INACTIVATION; HETEROZYGOSITY LOSS; HUMAN; HUMAN CELL; HUMAN TISSUE; MAJOR CLINICAL STUDY; SOMATIC MUTATION; TUMOR SUPPRESSOR GENE;

ADENOMATOUS POLYPOSIS COLI; ADENOMATOUS POLYPOSIS COLI PROTEIN; CELL LINE, TUMOR; DNA METHYLATION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LOSS OF HETEROZYGOSITY; MOLECULAR MIMICRY; MUTATION; PROMOTER REGIONS, GENETIC; RNA, MESSENGER; RNA, SMALL INTERFERING; WNT PROTEINS;

EID: 56549109267     PISSN: 00144800     EISSN: 10960945     Source Type: Journal    
DOI: 10.1016/j.yexmp.2008.09.006     Document Type: Article

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