Regulation of lipopolysaccharide-induced inducible nitric-oxide synthase expression through the nuclear factor-κB pathway and interferon-β/ tyrosine kinase 2/janus tyrosine kinase 2-signal transducer and activator of transcription-1 signaling cascades by 2-naphthylethyl-6,7-dihydroxy-1,2,3,4- tetrahydroisoquinoline (THI 53), a new synthetic isoquinoline alkaloid

Journal of Pharmacology and Experimental Therapeutics

Volumn 320, Issue 2, 2007, Pages 782-789

  Hye, Jung Kim ^a   Tsoyi, Konstantin ^a   Ja, Myung Heo ^a   Young, Jin Kang ^a,c   Min, Kyu Park ^a   Young, Soo Lee ^a   Jae, Heun Lee ^a   Han, Geuk Seo ^a   Hye, Sook Yun Choi ^b   Ki, Churl Chang ^a  

^a Gyeongsang National University School of Medicine   (South Korea)

^b Seoul National University   (South Korea)

^c Yeungnam University College of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 NAPHTHYLETHYL 6,7 DIHYDROXY 1,2,3,4 TETRAHYDROISOQUINOLINE; 5 (2,2 DICYANOVINYL) 2 NITROPHENOL; ALPHA CYANO (3 HYDROXY 4 NITRO)CINNAMONITRILE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; BETA INTERFERON; FOCAL ADHESION KINASE 1; GENISTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; ISOQUINOLINE ALKALOID; JANUS KINASE 2; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE P38 INHIBITOR; N BENZYL 2 CYANO 3 (3,4 DIHYDROXYPHENYL)ACRYLAMIDE; PD 98029; PROTEIN TYROSINE KINASE INHIBITOR; STAT1 PROTEIN; STRESS ACTIVATED PROTEIN KINASE INHIBITOR; THI 53; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG INHIBITION; DRUG STRUCTURE; GENE CONTROL; INFLAMMATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ANIMALS; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INDUCTION; INTERFERON-BETA; ISOQUINOLINES; JANUS KINASE 2; LIPOPOLYSACCHARIDES; MICE; NAPHTHALENES; NF-KAPPA B; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; STAT1 TRANSCRIPTION FACTOR; TETRAHYDROISOQUINOLINES; TYK2 KINASE;

EID: 33846462057     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.106.112052     Document Type: Article

References (40)

1. Akira S (2003) Mammalian Toll-like receptors. Curr Opin Immunol 15:5-11.
2. Car BD, Eng VM, Schnyder B, Ozmen L, Huang S, Gallay P, Heumann D, Aguet M, and Ryffel B (1994) Interferon γ receptor deficient mice are resistant to endotoxic shock. J Exp Med 179:1437-1444.
3. Chakravortty D, Kato Y, Sugiyama T, Koide N, Mu MM, Yoshida T, and Yokochi T (2001) The inhibitory action of sodium arsenite on lipopolysaccharide-induced nitric oxide production in RAW 267.4 macrophage cells: a role of Raf-1 in lipopolysaccharide signaling. J Immunol 166:2011-2017.
4. Chen F, Sun S, Kuhn DC, Lu Y, Gaydos LJ, Shi X, and Demers LM (1997) Tetrandrine inhibits signal-induced NF-κB activation in rat alveolar macrophages. Biochem Biophys Res Commun 231:99-102.
5. Cruz MT, Duarte CB, Goncalo M, Carvalho AP, and Lopes MC (2001) LPS induction of IκB-α degradation and iNOS expression in a skin dendritic cell line is prevented by the Janus kinase 2 inhibitor, Tyrphostin b42. Nitric Oxide 5:53-61.
6. Dell'Albani P, Santangelo R, Torrisi L, Nicoletti VG, de Vellis J, and Giuffrida Stella AM (2001) JAK/STAT signaling pathway mediates cytokine-induced iNOS expression in primary astroglial cell cultures. J Neurosci Res 65:417-424.
7. Dong Z, O'Brian CA, and Fidler IJ (1993) Activation of tumoricidal properties in macrophages by lipopolysaccharide requires protein-tyrosine kinase activity. J Leukoc Biol 53:53-60.
8. Gao JJ, Filla MB, Fultz MJ, Vogel SN, Russell SW, and Murphy WJ (1998) Autocrine/paracrine IFN-α/β mediates the lipopolysaccharide-induced activation of transcription factor Stat1α in mouse macrophages: pivotal role of Stat1α in induction of the inducible nitric oxide synthase gene. J Immunol 161:4803-4810.
9. Hambleton J, Weinstein SL, Lem L, and DeFranco AL (1996) Activation of c-Jun N-terminal kinase in bacterial lipopolysaccharide-stimulated macrophages. Proc Natl Acad Sci USA 93:2774-2778.
10. Ihle JN (1995) The Janus protein tyrosine kinase family and its role in cytokine signaling. Adv Immunol 60:1-35.
11. Ihle JN (2001) The Stat family in cytokine signaling. Curr Opin Cell Biol 13:211-217.
12. Jung DY, Lee H, Jung BY, Ock J, Lee MS, Lee WH, and Suk K (2005) TLR4, but not TLR2, signals autoregulatory apoptosis of cultured microglia: a critical role of IFN-β as a decision maker. J Immunol 174:6467-6476.
13. Kamezaki K, Shimoda K, Numata A, Matsuda T, Nakayama K, and Harad a M(2004) The role of Tyk2, Stat1 and Stat4 in LPS-induced endotoxin signals. Int Immunol 16:1173-1179.
14. Kang JH, Lewis DM, Castranova V, Rojanasakul Y, Banks DE, MA JY, and MA JK (1992) Inhibitory action of tetrandrine on macrophage production of interleukin-1 (IL-1)-like activity and thymocyte proliferation. Exp Lung Res 18:715-729.
15. Kang YJ, Koo EB, Lee YS, Yun-Choi HS, and Chang KC (1999a) Prevention of the expression of inducible nitric oxide synthase by a novel positive inotropic agent, YS 49, in rat vascular smooth muscle and RAW 264.7 macrophages. Br J Pharmacol 128:357-364.
16. Kang YJ, Lee BK, Lee YS, Seo HG, Park MK, Kim HJ, Pyo HS, Chong WS, Jung HJ, Yun-Choi HS, et al. (2003) Suppression of tumor necrosis factor-α and inducible nitric oxide synthase gene expression by THI52, a new synthetic naphthyl-benzylisoquinoline alkaloid. Biochem Pharmacol 65:457-464.
17. Kang YJ, Lee YS, Lee GW, Lee DH, Ryu JC, Yun-Choi HS, and Chang KC (1999b) Inhibition of activation of nuclear factor κB is responsible for inhibition of inducible nitric oxide synthase expression by higenamine, an active component of aconite root. J Pharmacol Exp Ther 291:314-320.
18. Karaghiosoff M, Neubauer H, Lassnig C, Kovarik P, Schindler H, Pircher H, McCoy B, Bogdan C, Decker T, Brem G, et al. (2000) Partial impairment of cytokine responses in Tyk2-deficient mice. Immunity 13:549-560.
19. Karaghiosoff M, Steinborn R, Kovarik P, Kriegshauser G, Baccarini M, Donabauer B, Reichart U, Kolbe T, Bogdan C, Leanderson T, et al. (2003) Central role for type I interferons and Tyk2 in lipopolysaccharide-induced endotoxin shock. Nat Immunol 4:471-477.
20. Kilbourn RG and Belloni P (1990) Endothelial cell production of nitrogen oxides in response to interferon in combination with tumor necrosis factor, interleukin-1, or endotoxin. J Natl Cancer Inst 82:772-776.
21. Kim HJ, Tsoy I, Park JM, Chung JI, Shin SC, and Chang KC (2006) Anthocyanins from soybean seed coat inhibit the expression of TNF-α-induced genes associated with ischemia/reperfusion in endothelial cell by NF-κB-dependent pathway and reduce rat myocardial damages incurred by ischemia and reperfusion in vivo. FEBS Lett 580:1391-1397.
22. Kondo Y, Takano F, and Hojo H (1993) Inhibitory effect of bisbenzylisoquinoline alkaloids on nitric oxide production in activated macrophages. Biochem Pharmacol 46:1887-1892.
23. Lee YW, Han SH, Lee M, Yang KH, Kim HM, and Jeon YJ (2000) 2-Amino-3-methylimidazo[4,5-f]quinoline inhibits nitric oxide production in lipopolysaccharide-stimulated RAW 264.7 cells by blocking p38 kinase activation. Cancer Lett 156:133-139.
24. Liu W, Kato M, Itoigawa M, Murakami H, Yajima M, Wu J, Ishikawa N, and Nakashima I (2001) Distinct involvement of NF-κB and p38 mitogen-activated protein kinase pathways in serum deprivation-mediated stimulation of inducible nitric oxide synthase and its inhibition by 4-hydroxynonenal. J Cell Biochem 83:271-280.
25. MacMicking JD, Nathan C, Hom G, Chartrain N, Fletcher DS, Trumbauer M, Stevens K, Xie QW, Sokol K, Hutchinson N, et al. (1995) Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase. Cell 81:641-650.
26. Marczin N, Papapetropoulos A, and Catravas JD (1993) Tyrosine kinase inhibitors suppress endotoxin- and IL-1β-induced NO synthesis in aortic smooth muscle cells. Am J Physiol 265:H1014-H1018.
27. Nathan CF (1987) Secretory products of macrophages. J Clin Investig 79:319-326.
28. Novogrodsky A, Vanichkin A, Patya M, Gazit A, Osherov N, and Levitzki A (1994) Prevention of lipopolysaccharide-induced lethal toxicity by tyrosine kinase inhibitors. Science (Wash DC) 264:1319-1322.
29. O'Shea JJ, Gadina M, and Schreiber RD (2002) Cytokine signaling in 2002: new surprises in the Jak/Stat pathway. Cell 109:S121-S131.
30. Okugawa S, Ota Y, Kitazawa T, Nakayama K, Yanagimoto S, Tsukada K, Kawada M, and Kimura S (2003) Janus kinase 2 is involved in lipopolysaccharide-induced activation of macrophages. Am J Physiol 285:C399-C408.
31. Paul A, Cuenda A, Bryant CE, Murray J, Chilvers ER, Cohen P, Gould GW, and Plevin R (1999) Involvement of mitogen-activated protein kinase homologues in the regulation of lipopolysaccharide-mediated induction of cyclo-oxygenase-2 but not nitric oxide synthase in RAW 264.7 macrophages. Cell Signal 11:491-497.
32. Paul A, Pendreigh RH, and Plevin R (1995) Protein kinase C and tyrosine kinase pathways regulate lipopolysaccharide-induced nitric oxide synthase activity in RAW 264.7 murine macrophages. Br J Pharmacol 114:482-488.
33. Rane SG and Reddy EP (2000) Janus kinases: components of multiple signaling pathways. Oncogene 19:5662-5679.
34. Schindler CW (2002) Series introduction. JAK-STAT signaling in human disease. J Clin Investig 109:1133-1137.
35. Shimoda K, Kato K, Aoki K, Matsuda T, Miyamoto A, Shibamori M, Yamashita M, Numata A, Takase K, Kobayashi S, et al. (2000) Tyk2 plays a restricted role in IFN α signaling, although it is required for IL-12-mediated T cell function. Immunity 13:561-571.
36. Tainlin L, Tingyi H, Changqi Z, Peipei Y, and Qiong Z (1982) Studies of the chronic toxicity of tetrandrine in dogs: an inhibitor of silicosis. Ecotoxicol Environ Saf 6:528-534.
37. Tan C, Mui A, and Dedhar S (2002) Integrin-linked kinase regulates inducible nitric oxide synthase and cyclooxygenase-2 expression in an NF-κB-dependent manner. J Biol Chem 277:3109-3116.
38. Thiemermann C and Vane J (1990) Inhibition of nitric oxide synthesis reduces the hypotension induced by bacterial lipopolysaccharides in the rat in vivo. Eur J Pharmacol 182:591-595.
39. Wei XQ, Charles IG, Smith A, Ure J, Feng GJ, Huang FP, Xu D, Muller W, Moncada S, and Liew FY (1995) Altered immune responses in mice lacking inducible nitric oxide synthase. Nature (Lond) 375:408-411.
40. Xie QW, Kashiwabara Y, and Nathan C (1994) Role of transcription factor NF-κB/Rel in induction of nitric oxide synthase. J Biol Chem 269:4705-4708.