Upregulation of PTEN by CKD712, a synthetic tetrahydroisoquinoline alkaloid, selectively inhibits lipopolysaccharide-induced VCAM-1 but not ICAM-1 expression in human endothelial cells

Atherosclerosis

Volumn 207, Issue 2, 2009, Pages 412-419

  Tsoyi, Konstantin ^a   Kim, Woo Sang ^a   Kim, Young Min ^a   Kim, Hye Jung ^a   Seo, Han Geuk ^a   Lee, Jae Heun ^a   Yun Choi, Hye Sook ^b   Chang, Ki Churl ^a  

^a Gyeongsang National University School of Medicine   (South Korea)

^b Seoul National University   (South Korea)

Author keywords

Atherosclerosis; Endothelial cells; Lipopolysaccharide; PTEN; Tetrahydroisoquinoline; Vascular adhesion molecule 1

Indexed keywords

1 (ALPHA NAPHTHYLMETHYL) 6,7 DIHYDROXY 1,2,3,4 TETRAHYDROISOQUINOLINE; CKD 712; INTERCELLULAR ADHESION MOLECULE 1; LIPOPOLYSACCHARIDE; LUCIFERASE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; PROTEIN KINASE C; SMALL INTERFERING RNA; SYNAPTOPHYSIN; TETRAHYDROISOQUINOLINE DERIVATIVE; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL ADHESION; CELL STIMULATION; CELL VIABILITY; CONTROLLED STUDY; DRUG ACTIVITY; ENDOTHELIUM CELL; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IMMUNOHISTOCHEMISTRY; INHIBITION KINETICS; MALE; MONOCYTE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEPHOSPHORYLATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; THORACIC AORTA; UMBILICAL VEIN; UPREGULATION; WESTERN BLOTTING;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; ANTI-INFLAMMATORY AGENTS; AORTA, THORACIC; CELL ADHESION; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIAL CELLS; HUMANS; INTERCELLULAR ADHESION MOLECULE-1; LIPOPOLYSACCHARIDES; MALE; MONOCYTES; PHOSPHORYLATION; PROTEIN KINASE C; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE; RATS; RATS, SPRAGUE-DAWLEY; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TETRAHYDROISOQUINOLINES; TIME FACTORS; TRANSFECTION; U937 CELLS; UP-REGULATION; VASCULAR CELL ADHESION MOLECULE-1;

EID: 70450242882     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2009.05.012     Document Type: Article

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