-
1
-
-
33748286793
-
Dual immunoregulatory pathways of 4-1BB signaling
-
Vinay D.S., et al. Dual immunoregulatory pathways of 4-1BB signaling. J. Mol. Med. 84 (2006) 726-736
-
(2006)
J. Mol. Med.
, vol.84
, pp. 726-736
-
-
Vinay, D.S.1
-
3
-
-
17644389199
-
TNF/TNFR family members in costimulation of T cell responses
-
Watts T.H. TNF/TNFR family members in costimulation of T cell responses. Annu. Rev. Immunol. 23 (2005) 23-68
-
(2005)
Annu. Rev. Immunol.
, vol.23
, pp. 23-68
-
-
Watts, T.H.1
-
4
-
-
33846784977
-
CD137 is expressed on blood vessel walls at sites of inflammation and enhances monocyte migratory activity
-
Drenkard D., et al. CD137 is expressed on blood vessel walls at sites of inflammation and enhances monocyte migratory activity. FASEB J. 21 (2007) 456-463
-
(2007)
FASEB J.
, vol.21
, pp. 456-463
-
-
Drenkard, D.1
-
5
-
-
0031007143
-
Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors
-
Melero I., et al. Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors. Nat. Med. 3 (1997) 682-685
-
(1997)
Nat. Med.
, vol.3
, pp. 682-685
-
-
Melero, I.1
-
6
-
-
0036913169
-
Costimulatory molecule-targeted antibody therapy of a spontaneous autoimmune disease
-
Sun Y., et al. Costimulatory molecule-targeted antibody therapy of a spontaneous autoimmune disease. Nat. Med. 8 (2002) 1405-1413
-
(2002)
Nat. Med.
, vol.8
, pp. 1405-1413
-
-
Sun, Y.1
-
7
-
-
7044261952
-
4-1BB-mediated immunotherapy of rheumatoid arthritis
-
Seo S.K., et al. 4-1BB-mediated immunotherapy of rheumatoid arthritis. Nat. Med. 10 (2004) 1088-1094
-
(2004)
Nat. Med.
, vol.10
, pp. 1088-1094
-
-
Seo, S.K.1
-
8
-
-
22444432047
-
Interfacing T-cell effector and regulatory function through CD137 (4-1BB) co-stimulation
-
Myers L.M., and Vella A.T. Interfacing T-cell effector and regulatory function through CD137 (4-1BB) co-stimulation. Trends Immunol. 26 (2005) 440-446
-
(2005)
Trends Immunol.
, vol.26
, pp. 440-446
-
-
Myers, L.M.1
Vella, A.T.2
-
9
-
-
38149096315
-
+ T cells and inhibit tumor growth in mice
-
+ T cells and inhibit tumor growth in mice. J. Clin. Invest. 118 (2008) 376-386
-
(2008)
J. Clin. Invest.
, vol.118
, pp. 376-386
-
-
McNamara, J.O.1
-
10
-
-
33846465547
-
Immunostimulatory monoclonal antibodies for cancer therapy
-
Melero I., et al. Immunostimulatory monoclonal antibodies for cancer therapy. Nat. Rev. Cancer 7 (2007) 95-106
-
(2007)
Nat. Rev. Cancer
, vol.7
, pp. 95-106
-
-
Melero, I.1
-
11
-
-
41149173311
-
The promise of 4-1BB (CD137)-mediated immunomodulation and the immunotherapy of cancer
-
Lynch D.H. The promise of 4-1BB (CD137)-mediated immunomodulation and the immunotherapy of cancer. Immunol. Rev. 222 (2008) 277-286
-
(2008)
Immunol. Rev.
, vol.222
, pp. 277-286
-
-
Lynch, D.H.1
-
12
-
-
33744987907
-
Eradication of established tumors in mice by a combination antibody-based therapy
-
Uno T., et al. Eradication of established tumors in mice by a combination antibody-based therapy. Nat. Med. 12 (2006) 693-698
-
(2006)
Nat. Med.
, vol.12
, pp. 693-698
-
-
Uno, T.1
-
13
-
-
33750600017
-
Complete regression of large solid tumors using engineered drug-resistant hematopoietic cells and anti-CD137 immunotherapy
-
McMillin D.W., et al. Complete regression of large solid tumors using engineered drug-resistant hematopoietic cells and anti-CD137 immunotherapy. Hum. Gene Ther. 17 (2006) 798-806
-
(2006)
Hum. Gene Ther.
, vol.17
, pp. 798-806
-
-
McMillin, D.W.1
-
14
-
-
33750719582
-
Augmented antitumor effects of radiation therapy by 4-1BB antibody (BMS-469492) treatment
-
Shi W., and Siemann D.W. Augmented antitumor effects of radiation therapy by 4-1BB antibody (BMS-469492) treatment. Anticancer Res. 26 (2006) 3445-3453
-
(2006)
Anticancer Res.
, vol.26
, pp. 3445-3453
-
-
Shi, W.1
Siemann, D.W.2
-
15
-
-
0036195860
-
Provision of antigen and CD137 signaling breaks immunological ignorance, promoting regression of poorly immunogenic tumors
-
Wilcox R.A., et al. Provision of antigen and CD137 signaling breaks immunological ignorance, promoting regression of poorly immunogenic tumors. J. Clin. Invest. 109 (2002) 651-659
-
(2002)
J. Clin. Invest.
, vol.109
, pp. 651-659
-
-
Wilcox, R.A.1
-
16
-
-
8544249166
-
Anti-CD137 monoclonal antibody administration augments the antitumor efficacy of dendritic cell-based vaccines
-
Ito F., et al. Anti-CD137 monoclonal antibody administration augments the antitumor efficacy of dendritic cell-based vaccines. Cancer Res. 64 (2004) 8411-8419
-
(2004)
Cancer Res.
, vol.64
, pp. 8411-8419
-
-
Ito, F.1
-
17
-
-
34548512807
-
Established B16 tumors are rejected following treatment with GM-CSF-secreting tumor cell immunotherapy in combination with anti-4-1BB mAb
-
Li B., et al. Established B16 tumors are rejected following treatment with GM-CSF-secreting tumor cell immunotherapy in combination with anti-4-1BB mAb. Clin. Immunol. 125 (2007) 76-87
-
(2007)
Clin. Immunol.
, vol.125
, pp. 76-87
-
-
Li, B.1
-
18
-
-
45949112050
-
+ T cells confers resistance to suppression by virus-induced regulatory T cells
-
+ T cells confers resistance to suppression by virus-induced regulatory T cells. J. Immunol. 180 (2008) 5267-5274
-
(2008)
J. Immunol.
, vol.180
, pp. 5267-5274
-
-
Robertson, S.J.1
-
19
-
-
0036569392
-
Cutting edge: Expression of functional CD137 receptor by dendritic cells
-
Wilcox R.A., et al. Cutting edge: Expression of functional CD137 receptor by dendritic cells. J. Immunol. 168 (2002) 4262-4267
-
(2002)
J. Immunol.
, vol.168
, pp. 4262-4267
-
-
Wilcox, R.A.1
-
20
-
-
1642432078
-
+ regulatory T cells in induced tolerance to experimental autoimmune thyroiditis
-
+ regulatory T cells in induced tolerance to experimental autoimmune thyroiditis. Cell. Immunol. 226 (2003) 20-29
-
(2003)
Cell. Immunol.
, vol.226
, pp. 20-29
-
-
Morris, G.P.1
-
21
-
-
44749092588
-
-
Calarota, S.A. et al. Augmentation of SIV DNA vaccine-induced cellular immunity by targeting the 4-1BB costimulatory molecule. Vaccine DOI:10.1016/j.vaccine.2008.02.017 (www.sciencedirect.com)
-
Calarota, S.A. et al. Augmentation of SIV DNA vaccine-induced cellular immunity by targeting the 4-1BB costimulatory molecule. Vaccine DOI:10.1016/j.vaccine.2008.02.017 (www.sciencedirect.com)
-
-
-
-
22
-
-
44449086793
-
Human glucocorticoid-induced TNF receptor ligand regulates its signaling activity through multiple oligomerization states
-
Zhou Z., et al. Human glucocorticoid-induced TNF receptor ligand regulates its signaling activity through multiple oligomerization states. Proc. Natl. Acad. Sci. U.S.A. 105 (2008) 5465-5470
-
(2008)
Proc. Natl. Acad. Sci. U.S.A.
, vol.105
, pp. 5465-5470
-
-
Zhou, Z.1
-
23
-
-
0029900295
-
The tumor necrosis factor ligand and receptor families
-
Bazzoni F., and Beutler B. The tumor necrosis factor ligand and receptor families. N. Engl. J. Med. 334 (1996) 1717-1725
-
(1996)
N. Engl. J. Med.
, vol.334
, pp. 1717-1725
-
-
Bazzoni, F.1
Beutler, B.2
-
24
-
-
0027285735
-
Inducible T cell antigen 4-1BB. Analysis of expression and function
-
Pollok K.E., et al. Inducible T cell antigen 4-1BB. Analysis of expression and function. J. Immunol. 150 (1993) 771-781
-
(1993)
J. Immunol.
, vol.150
, pp. 771-781
-
-
Pollok, K.E.1
-
25
-
-
24744440360
-
The expression and the regulatory role of OX40 and 4-1BB heterodimer in activated human T cells
-
Ma B.Y., et al. The expression and the regulatory role of OX40 and 4-1BB heterodimer in activated human T cells. Blood 106 (2005) 2002-2010
-
(2005)
Blood
, vol.106
, pp. 2002-2010
-
-
Ma, B.Y.1
-
26
-
-
0032567645
-
Human 4-1BB (CD137) signals are mediated by TRAF2 and activate nuclear factor-κB
-
Jang I.K., et al. Human 4-1BB (CD137) signals are mediated by TRAF2 and activate nuclear factor-κB. Biochem. Biophys. Res. Commun. 242 (1998) 613-620
-
(1998)
Biochem. Biophys. Res. Commun.
, vol.242
, pp. 613-620
-
-
Jang, I.K.1
-
27
-
-
13544252809
-
+ T lymphocytes
-
+ T lymphocytes. J. Immunol. 174 (2005) 1898-1905
-
(2005)
J. Immunol.
, vol.174
, pp. 1898-1905
-
-
Nam, K.O.1
-
28
-
-
84934437026
-
Ubiquitination and TRAF signaling
-
Pineda G., et al. Ubiquitination and TRAF signaling. Adv. Exp. Med. Biol. 597 (2007) 80-92
-
(2007)
Adv. Exp. Med. Biol.
, vol.597
, pp. 80-92
-
-
Pineda, G.1
-
29
-
-
33544470185
-
TRAF2: a double-edged sword?
-
Xia Z.P., and Chen Z.J. TRAF2: a double-edged sword?. Sci. STKE 2005 (2005) e7
-
(2005)
Sci. STKE
, vol.2005
-
-
Xia, Z.P.1
Chen, Z.J.2
-
30
-
-
0033567975
-
Role of the stress kinase pathway in signaling via the T cell costimulatory receptor 4-1BB
-
Cannons J.L., et al. Role of the stress kinase pathway in signaling via the T cell costimulatory receptor 4-1BB. J. Immunol. 163 (1999) 2990-2998
-
(1999)
J. Immunol.
, vol.163
, pp. 2990-2998
-
-
Cannons, J.L.1
-
31
-
-
35448936377
-
Adoptively transferred tumor-specific T cells stimulated ex vivo using herpes simplex virus amplicons encoding 4-1BBL persist in the host and show antitumor activity in vivo
-
Yi K.H., et al. Adoptively transferred tumor-specific T cells stimulated ex vivo using herpes simplex virus amplicons encoding 4-1BBL persist in the host and show antitumor activity in vivo. Cancer Res. 67 (2007) 10027-10037
-
(2007)
Cancer Res.
, vol.67
, pp. 10027-10037
-
-
Yi, K.H.1
-
32
-
-
22544437564
-
+ memory T cells and their capacity for secondary expansion
-
+ memory T cells and their capacity for secondary expansion. J. Immunol. 175 (2005) 1665-1676
-
(2005)
J. Immunol.
, vol.175
, pp. 1665-1676
-
-
Hendriks, J.1
-
33
-
-
0032535119
-
NK1.1 cells express 4-1BB (CDw137) costimulatory molecule and are required for tumor immunity elicited by anti-4-1BB monoclonal antibodies
-
Melero I., et al. NK1.1 cells express 4-1BB (CDw137) costimulatory molecule and are required for tumor immunity elicited by anti-4-1BB monoclonal antibodies. Cell. Immunol. 190 (1998) 167-172
-
(1998)
Cell. Immunol.
, vol.190
, pp. 167-172
-
-
Melero, I.1
-
34
-
-
0037108355
-
+ cytolytic T cells and responsiveness to IL-2 but not cytolytic activity
-
+ cytolytic T cells and responsiveness to IL-2 but not cytolytic activity. J. Immunol. 169 (2002) 4230-4236
-
(2002)
J. Immunol.
, vol.169
, pp. 4230-4236
-
-
Wilcox, R.A.1
-
35
-
-
0036104604
-
Gene therapy for cancer using single-chain Fv fragments specific for 4-1BB
-
Ye Z., et al. Gene therapy for cancer using single-chain Fv fragments specific for 4-1BB. Nat. Med. 8 (2002) 343-348
-
(2002)
Nat. Med.
, vol.8
, pp. 343-348
-
-
Ye, Z.1
-
36
-
-
40949132423
-
Interleukin-15 liver gene transfer increases the number and function of IKDCs and NK cells
-
Arina A., et al. Interleukin-15 liver gene transfer increases the number and function of IKDCs and NK cells. Gene Ther. 15 (2008) 473-483
-
(2008)
Gene Ther.
, vol.15
, pp. 473-483
-
-
Arina, A.1
-
37
-
-
35748943227
-
+ interferon-producing killer dendritic cells are activated natural killer cells
-
+ interferon-producing killer dendritic cells are activated natural killer cells. J. Exp. Med. 204 (2007) 2569-2578
-
(2007)
J. Exp. Med.
, vol.204
, pp. 2569-2578
-
-
Vosshenrich, C.A.1
-
38
-
-
35748942920
-
Putative IKDCs are functionally and developmentally similar to natural killer cells, but not to dendritic cells
-
Caminschi I., et al. Putative IKDCs are functionally and developmentally similar to natural killer cells, but not to dendritic cells. J. Exp. Med. 204 (2007) 2579-2590
-
(2007)
J. Exp. Med.
, vol.204
, pp. 2579-2590
-
-
Caminschi, I.1
-
39
-
-
35748972077
-
+ cells identify them as a subset of NK cells
-
+ cells identify them as a subset of NK cells. J. Exp. Med. 204 (2007) 2561-2568
-
(2007)
J. Exp. Med.
, vol.204
, pp. 2561-2568
-
-
Blasius, A.L.1
-
40
-
-
42149174964
-
4-1BB engagement costimulates NKT cell activation and exacerbates NKT cell ligand-induced airway hyperresponsiveness and inflammation
-
Kim D.H., et al. 4-1BB engagement costimulates NKT cell activation and exacerbates NKT cell ligand-induced airway hyperresponsiveness and inflammation. J. Immunol. 180 (2008) 2062-2068
-
(2008)
J. Immunol.
, vol.180
, pp. 2062-2068
-
-
Kim, D.H.1
-
41
-
-
4644245852
-
CD137-deficient mice have reduced NK/NKT cell numbers and function, are resistant to lipopolysaccharide-induced shock syndromes, and have lower IL-4 responses
-
Vinay D.S., et al. CD137-deficient mice have reduced NK/NKT cell numbers and function, are resistant to lipopolysaccharide-induced shock syndromes, and have lower IL-4 responses. J. Immunol. 173 (2004) 4218-4229
-
(2004)
J. Immunol.
, vol.173
, pp. 4218-4229
-
-
Vinay, D.S.1
-
42
-
-
34547628869
-
Combined natural killer T-cell based immunotherapy eradicates established tumors in mice
-
Teng M.W., et al. Combined natural killer T-cell based immunotherapy eradicates established tumors in mice. Cancer Res. 67 (2007) 7495-7504
-
(2007)
Cancer Res.
, vol.67
, pp. 7495-7504
-
-
Teng, M.W.1
-
43
-
-
38849108168
-
+ T regulatory cells based on synergy between IL-2 and 4-1BB signaling
-
+ T regulatory cells based on synergy between IL-2 and 4-1BB signaling. J. Immunol. 179 (2007) 7295-7304
-
(2007)
J. Immunol.
, vol.179
, pp. 7295-7304
-
-
Elpek, K.G.1
-
45
-
-
36349037090
-
Rejection of metastatic 4T1 breast cancer by attenuation of Treg cells in combination with immune stimulation
-
Chen L., et al. Rejection of metastatic 4T1 breast cancer by attenuation of Treg cells in combination with immune stimulation. Mol. Ther. 15 (2007) 2194-2202
-
(2007)
Mol. Ther.
, vol.15
, pp. 2194-2202
-
-
Chen, L.1
-
46
-
-
34548759728
-
Mechanisms involved in synergistic anticancer immunity of anti-4-1BB and anti-CD4 therapy
-
Choi B.K., et al. Mechanisms involved in synergistic anticancer immunity of anti-4-1BB and anti-CD4 therapy. Cancer Res. 67 (2007) 8891-8899
-
(2007)
Cancer Res.
, vol.67
, pp. 8891-8899
-
-
Choi, B.K.1
-
47
-
-
42249097689
-
OX40 triggering blocks suppression by regulatory T cells and facilitates tumor rejection
-
Piconese S., et al. OX40 triggering blocks suppression by regulatory T cells and facilitates tumor rejection. J. Exp. Med. 205 (2008) 825-839
-
(2008)
J. Exp. Med.
, vol.205
, pp. 825-839
-
-
Piconese, S.1
-
48
-
-
38049046025
-
Absence of surface expression of CD137 (4-1BB) on myeloid-derived suppressor cells
-
Dubrot J., et al. Absence of surface expression of CD137 (4-1BB) on myeloid-derived suppressor cells. Inmunologia 26 (2007) 121-126
-
(2007)
Inmunologia
, vol.26
, pp. 121-126
-
-
Dubrot, J.1
-
49
-
-
34249822498
-
Genes that distinguish physiological and pathological angiogenesis
-
Seaman S., et al. Genes that distinguish physiological and pathological angiogenesis. Cancer Cell 11 (2007) 539-554
-
(2007)
Cancer Cell
, vol.11
, pp. 539-554
-
-
Seaman, S.1
-
50
-
-
0033571176
-
Anti-4-1BB monoclonal antibodies abrogate T cell-dependent humoral immune responses in vivo through the induction of helper T cell anergy
-
Mittler R.S., et al. Anti-4-1BB monoclonal antibodies abrogate T cell-dependent humoral immune responses in vivo through the induction of helper T cell anergy. J. Exp. Med. 190 (1999) 1535-1540
-
(1999)
J. Exp. Med.
, vol.190
, pp. 1535-1540
-
-
Mittler, R.S.1
-
51
-
-
34948859589
-
Immune suppression or enhancement by CD137 T cell costimulation during acute viral infection is time dependent
-
Zhang B., et al. Immune suppression or enhancement by CD137 T cell costimulation during acute viral infection is time dependent. J. Clin. Invest. 117 (2007) 3029-3041
-
(2007)
J. Clin. Invest.
, vol.117
, pp. 3029-3041
-
-
Zhang, B.1
-
52
-
-
20944446056
-
Enhancement of CD4 and CD8 immunity by anti-CD137 (4-1BB) monoclonal antibodies during hepatitis C vaccination with recombinant adenovirus
-
Arribillaga L., et al. Enhancement of CD4 and CD8 immunity by anti-CD137 (4-1BB) monoclonal antibodies during hepatitis C vaccination with recombinant adenovirus. Vaccine 23 (2005) 3493-3499
-
(2005)
Vaccine
, vol.23
, pp. 3493-3499
-
-
Arribillaga, L.1
-
53
-
-
33947696816
-
Cytokine-mediated disruption of lymphocyte trafficking, hemopoiesis, and induction of lymphopenia, anemia, and thrombocytopenia in anti-CD137-treated mice
-
Niu L., et al. Cytokine-mediated disruption of lymphocyte trafficking, hemopoiesis, and induction of lymphopenia, anemia, and thrombocytopenia in anti-CD137-treated mice. J. Immunol. 178 (2007) 4194-4213
-
(2007)
J. Immunol.
, vol.178
, pp. 4194-4213
-
-
Niu, L.1
-
54
-
-
16244408626
-
Inhibition of indoleamine 2,3-dioxygenase, an immunoregulatory target of the cancer suppression gene Bin1, potentiates cancer chemotherapy
-
Muller A.J., et al. Inhibition of indoleamine 2,3-dioxygenase, an immunoregulatory target of the cancer suppression gene Bin1, potentiates cancer chemotherapy. Nat. Med. 11 (2005) 312-319
-
(2005)
Nat. Med.
, vol.11
, pp. 312-319
-
-
Muller, A.J.1
-
55
-
-
34347398235
-
+ T cells responding to antigen without requiring knowledge of epitope specificities
-
+ T cells responding to antigen without requiring knowledge of epitope specificities. Blood 110 (2007) 201-210
-
(2007)
Blood
, vol.110
, pp. 201-210
-
-
Wolfl, M.1
-
56
-
-
34249689632
-
CD137 stimulation delivers an antigen-independent growth signal for T lymphocytes with memory phenotype
-
Zhu Y., et al. CD137 stimulation delivers an antigen-independent growth signal for T lymphocytes with memory phenotype. Blood 109 (2007) 4882-4889
-
(2007)
Blood
, vol.109
, pp. 4882-4889
-
-
Zhu, Y.1
-
57
-
-
40549112657
-
CD137 is expressed in human atherosclerosis and promotes development of plaque inflammation in hypercholesterolemic mice
-
Olofsson P.S., et al. CD137 is expressed in human atherosclerosis and promotes development of plaque inflammation in hypercholesterolemic mice. Circulation 117 (2008) 1292-1301
-
(2008)
Circulation
, vol.117
, pp. 1292-1301
-
-
Olofsson, P.S.1
-
58
-
-
1642291001
-
Serum concentrations of soluble 4-1BB and 4-1BB ligand correlated with the disease severity in rheumatoid arthritis
-
Jung H.W., et al. Serum concentrations of soluble 4-1BB and 4-1BB ligand correlated with the disease severity in rheumatoid arthritis. Exp. Mol. Med. 36 (2004) 13-22
-
(2004)
Exp. Mol. Med.
, vol.36
, pp. 13-22
-
-
Jung, H.W.1
-
59
-
-
34249077931
-
Cell surface 4-1BBL mediates sequential signaling pathways 'downstream' of TLR and is required for sustained TNF production in macrophages
-
Kang Y.J., et al. Cell surface 4-1BBL mediates sequential signaling pathways 'downstream' of TLR and is required for sustained TNF production in macrophages. Nat. Immunol. 8 (2007) 601-609
-
(2007)
Nat. Immunol.
, vol.8
, pp. 601-609
-
-
Kang, Y.J.1
|