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Volumn 29, Issue 8, 2008, Pages 383-390

Multi-layered action mechanisms of CD137 (4-1BB)-targeted immunotherapies

Author keywords

[No Author keywords available]

Indexed keywords

CD137 ANTIGEN; CD137 LIGAND; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY CD137; TUMOR ANTIGEN;

EID: 47849106040     PISSN: 01656147     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tips.2008.05.005     Document Type: Article
Times cited : (91)

References (59)
  • 1
    • 33748286793 scopus 로고    scopus 로고
    • Dual immunoregulatory pathways of 4-1BB signaling
    • Vinay D.S., et al. Dual immunoregulatory pathways of 4-1BB signaling. J. Mol. Med. 84 (2006) 726-736
    • (2006) J. Mol. Med. , vol.84 , pp. 726-736
    • Vinay, D.S.1
  • 3
    • 17644389199 scopus 로고    scopus 로고
    • TNF/TNFR family members in costimulation of T cell responses
    • Watts T.H. TNF/TNFR family members in costimulation of T cell responses. Annu. Rev. Immunol. 23 (2005) 23-68
    • (2005) Annu. Rev. Immunol. , vol.23 , pp. 23-68
    • Watts, T.H.1
  • 4
    • 33846784977 scopus 로고    scopus 로고
    • CD137 is expressed on blood vessel walls at sites of inflammation and enhances monocyte migratory activity
    • Drenkard D., et al. CD137 is expressed on blood vessel walls at sites of inflammation and enhances monocyte migratory activity. FASEB J. 21 (2007) 456-463
    • (2007) FASEB J. , vol.21 , pp. 456-463
    • Drenkard, D.1
  • 5
    • 0031007143 scopus 로고    scopus 로고
    • Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors
    • Melero I., et al. Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors. Nat. Med. 3 (1997) 682-685
    • (1997) Nat. Med. , vol.3 , pp. 682-685
    • Melero, I.1
  • 6
    • 0036913169 scopus 로고    scopus 로고
    • Costimulatory molecule-targeted antibody therapy of a spontaneous autoimmune disease
    • Sun Y., et al. Costimulatory molecule-targeted antibody therapy of a spontaneous autoimmune disease. Nat. Med. 8 (2002) 1405-1413
    • (2002) Nat. Med. , vol.8 , pp. 1405-1413
    • Sun, Y.1
  • 7
    • 7044261952 scopus 로고    scopus 로고
    • 4-1BB-mediated immunotherapy of rheumatoid arthritis
    • Seo S.K., et al. 4-1BB-mediated immunotherapy of rheumatoid arthritis. Nat. Med. 10 (2004) 1088-1094
    • (2004) Nat. Med. , vol.10 , pp. 1088-1094
    • Seo, S.K.1
  • 8
    • 22444432047 scopus 로고    scopus 로고
    • Interfacing T-cell effector and regulatory function through CD137 (4-1BB) co-stimulation
    • Myers L.M., and Vella A.T. Interfacing T-cell effector and regulatory function through CD137 (4-1BB) co-stimulation. Trends Immunol. 26 (2005) 440-446
    • (2005) Trends Immunol. , vol.26 , pp. 440-446
    • Myers, L.M.1    Vella, A.T.2
  • 9
    • 38149096315 scopus 로고    scopus 로고
    • + T cells and inhibit tumor growth in mice
    • + T cells and inhibit tumor growth in mice. J. Clin. Invest. 118 (2008) 376-386
    • (2008) J. Clin. Invest. , vol.118 , pp. 376-386
    • McNamara, J.O.1
  • 10
    • 33846465547 scopus 로고    scopus 로고
    • Immunostimulatory monoclonal antibodies for cancer therapy
    • Melero I., et al. Immunostimulatory monoclonal antibodies for cancer therapy. Nat. Rev. Cancer 7 (2007) 95-106
    • (2007) Nat. Rev. Cancer , vol.7 , pp. 95-106
    • Melero, I.1
  • 11
    • 41149173311 scopus 로고    scopus 로고
    • The promise of 4-1BB (CD137)-mediated immunomodulation and the immunotherapy of cancer
    • Lynch D.H. The promise of 4-1BB (CD137)-mediated immunomodulation and the immunotherapy of cancer. Immunol. Rev. 222 (2008) 277-286
    • (2008) Immunol. Rev. , vol.222 , pp. 277-286
    • Lynch, D.H.1
  • 12
    • 33744987907 scopus 로고    scopus 로고
    • Eradication of established tumors in mice by a combination antibody-based therapy
    • Uno T., et al. Eradication of established tumors in mice by a combination antibody-based therapy. Nat. Med. 12 (2006) 693-698
    • (2006) Nat. Med. , vol.12 , pp. 693-698
    • Uno, T.1
  • 13
    • 33750600017 scopus 로고    scopus 로고
    • Complete regression of large solid tumors using engineered drug-resistant hematopoietic cells and anti-CD137 immunotherapy
    • McMillin D.W., et al. Complete regression of large solid tumors using engineered drug-resistant hematopoietic cells and anti-CD137 immunotherapy. Hum. Gene Ther. 17 (2006) 798-806
    • (2006) Hum. Gene Ther. , vol.17 , pp. 798-806
    • McMillin, D.W.1
  • 14
    • 33750719582 scopus 로고    scopus 로고
    • Augmented antitumor effects of radiation therapy by 4-1BB antibody (BMS-469492) treatment
    • Shi W., and Siemann D.W. Augmented antitumor effects of radiation therapy by 4-1BB antibody (BMS-469492) treatment. Anticancer Res. 26 (2006) 3445-3453
    • (2006) Anticancer Res. , vol.26 , pp. 3445-3453
    • Shi, W.1    Siemann, D.W.2
  • 15
    • 0036195860 scopus 로고    scopus 로고
    • Provision of antigen and CD137 signaling breaks immunological ignorance, promoting regression of poorly immunogenic tumors
    • Wilcox R.A., et al. Provision of antigen and CD137 signaling breaks immunological ignorance, promoting regression of poorly immunogenic tumors. J. Clin. Invest. 109 (2002) 651-659
    • (2002) J. Clin. Invest. , vol.109 , pp. 651-659
    • Wilcox, R.A.1
  • 16
    • 8544249166 scopus 로고    scopus 로고
    • Anti-CD137 monoclonal antibody administration augments the antitumor efficacy of dendritic cell-based vaccines
    • Ito F., et al. Anti-CD137 monoclonal antibody administration augments the antitumor efficacy of dendritic cell-based vaccines. Cancer Res. 64 (2004) 8411-8419
    • (2004) Cancer Res. , vol.64 , pp. 8411-8419
    • Ito, F.1
  • 17
    • 34548512807 scopus 로고    scopus 로고
    • Established B16 tumors are rejected following treatment with GM-CSF-secreting tumor cell immunotherapy in combination with anti-4-1BB mAb
    • Li B., et al. Established B16 tumors are rejected following treatment with GM-CSF-secreting tumor cell immunotherapy in combination with anti-4-1BB mAb. Clin. Immunol. 125 (2007) 76-87
    • (2007) Clin. Immunol. , vol.125 , pp. 76-87
    • Li, B.1
  • 18
    • 45949112050 scopus 로고    scopus 로고
    • + T cells confers resistance to suppression by virus-induced regulatory T cells
    • + T cells confers resistance to suppression by virus-induced regulatory T cells. J. Immunol. 180 (2008) 5267-5274
    • (2008) J. Immunol. , vol.180 , pp. 5267-5274
    • Robertson, S.J.1
  • 19
    • 0036569392 scopus 로고    scopus 로고
    • Cutting edge: Expression of functional CD137 receptor by dendritic cells
    • Wilcox R.A., et al. Cutting edge: Expression of functional CD137 receptor by dendritic cells. J. Immunol. 168 (2002) 4262-4267
    • (2002) J. Immunol. , vol.168 , pp. 4262-4267
    • Wilcox, R.A.1
  • 20
    • 1642432078 scopus 로고    scopus 로고
    • + regulatory T cells in induced tolerance to experimental autoimmune thyroiditis
    • + regulatory T cells in induced tolerance to experimental autoimmune thyroiditis. Cell. Immunol. 226 (2003) 20-29
    • (2003) Cell. Immunol. , vol.226 , pp. 20-29
    • Morris, G.P.1
  • 21
    • 44749092588 scopus 로고    scopus 로고
    • Calarota, S.A. et al. Augmentation of SIV DNA vaccine-induced cellular immunity by targeting the 4-1BB costimulatory molecule. Vaccine DOI:10.1016/j.vaccine.2008.02.017 (www.sciencedirect.com)
    • Calarota, S.A. et al. Augmentation of SIV DNA vaccine-induced cellular immunity by targeting the 4-1BB costimulatory molecule. Vaccine DOI:10.1016/j.vaccine.2008.02.017 (www.sciencedirect.com)
  • 22
    • 44449086793 scopus 로고    scopus 로고
    • Human glucocorticoid-induced TNF receptor ligand regulates its signaling activity through multiple oligomerization states
    • Zhou Z., et al. Human glucocorticoid-induced TNF receptor ligand regulates its signaling activity through multiple oligomerization states. Proc. Natl. Acad. Sci. U.S.A. 105 (2008) 5465-5470
    • (2008) Proc. Natl. Acad. Sci. U.S.A. , vol.105 , pp. 5465-5470
    • Zhou, Z.1
  • 23
    • 0029900295 scopus 로고    scopus 로고
    • The tumor necrosis factor ligand and receptor families
    • Bazzoni F., and Beutler B. The tumor necrosis factor ligand and receptor families. N. Engl. J. Med. 334 (1996) 1717-1725
    • (1996) N. Engl. J. Med. , vol.334 , pp. 1717-1725
    • Bazzoni, F.1    Beutler, B.2
  • 24
    • 0027285735 scopus 로고
    • Inducible T cell antigen 4-1BB. Analysis of expression and function
    • Pollok K.E., et al. Inducible T cell antigen 4-1BB. Analysis of expression and function. J. Immunol. 150 (1993) 771-781
    • (1993) J. Immunol. , vol.150 , pp. 771-781
    • Pollok, K.E.1
  • 25
    • 24744440360 scopus 로고    scopus 로고
    • The expression and the regulatory role of OX40 and 4-1BB heterodimer in activated human T cells
    • Ma B.Y., et al. The expression and the regulatory role of OX40 and 4-1BB heterodimer in activated human T cells. Blood 106 (2005) 2002-2010
    • (2005) Blood , vol.106 , pp. 2002-2010
    • Ma, B.Y.1
  • 26
    • 0032567645 scopus 로고    scopus 로고
    • Human 4-1BB (CD137) signals are mediated by TRAF2 and activate nuclear factor-κB
    • Jang I.K., et al. Human 4-1BB (CD137) signals are mediated by TRAF2 and activate nuclear factor-κB. Biochem. Biophys. Res. Commun. 242 (1998) 613-620
    • (1998) Biochem. Biophys. Res. Commun. , vol.242 , pp. 613-620
    • Jang, I.K.1
  • 27
    • 13544252809 scopus 로고    scopus 로고
    • + T lymphocytes
    • + T lymphocytes. J. Immunol. 174 (2005) 1898-1905
    • (2005) J. Immunol. , vol.174 , pp. 1898-1905
    • Nam, K.O.1
  • 28
    • 84934437026 scopus 로고    scopus 로고
    • Ubiquitination and TRAF signaling
    • Pineda G., et al. Ubiquitination and TRAF signaling. Adv. Exp. Med. Biol. 597 (2007) 80-92
    • (2007) Adv. Exp. Med. Biol. , vol.597 , pp. 80-92
    • Pineda, G.1
  • 29
    • 33544470185 scopus 로고    scopus 로고
    • TRAF2: a double-edged sword?
    • Xia Z.P., and Chen Z.J. TRAF2: a double-edged sword?. Sci. STKE 2005 (2005) e7
    • (2005) Sci. STKE , vol.2005
    • Xia, Z.P.1    Chen, Z.J.2
  • 30
    • 0033567975 scopus 로고    scopus 로고
    • Role of the stress kinase pathway in signaling via the T cell costimulatory receptor 4-1BB
    • Cannons J.L., et al. Role of the stress kinase pathway in signaling via the T cell costimulatory receptor 4-1BB. J. Immunol. 163 (1999) 2990-2998
    • (1999) J. Immunol. , vol.163 , pp. 2990-2998
    • Cannons, J.L.1
  • 31
    • 35448936377 scopus 로고    scopus 로고
    • Adoptively transferred tumor-specific T cells stimulated ex vivo using herpes simplex virus amplicons encoding 4-1BBL persist in the host and show antitumor activity in vivo
    • Yi K.H., et al. Adoptively transferred tumor-specific T cells stimulated ex vivo using herpes simplex virus amplicons encoding 4-1BBL persist in the host and show antitumor activity in vivo. Cancer Res. 67 (2007) 10027-10037
    • (2007) Cancer Res. , vol.67 , pp. 10027-10037
    • Yi, K.H.1
  • 32
    • 22544437564 scopus 로고    scopus 로고
    • + memory T cells and their capacity for secondary expansion
    • + memory T cells and their capacity for secondary expansion. J. Immunol. 175 (2005) 1665-1676
    • (2005) J. Immunol. , vol.175 , pp. 1665-1676
    • Hendriks, J.1
  • 33
    • 0032535119 scopus 로고    scopus 로고
    • NK1.1 cells express 4-1BB (CDw137) costimulatory molecule and are required for tumor immunity elicited by anti-4-1BB monoclonal antibodies
    • Melero I., et al. NK1.1 cells express 4-1BB (CDw137) costimulatory molecule and are required for tumor immunity elicited by anti-4-1BB monoclonal antibodies. Cell. Immunol. 190 (1998) 167-172
    • (1998) Cell. Immunol. , vol.190 , pp. 167-172
    • Melero, I.1
  • 34
    • 0037108355 scopus 로고    scopus 로고
    • + cytolytic T cells and responsiveness to IL-2 but not cytolytic activity
    • + cytolytic T cells and responsiveness to IL-2 but not cytolytic activity. J. Immunol. 169 (2002) 4230-4236
    • (2002) J. Immunol. , vol.169 , pp. 4230-4236
    • Wilcox, R.A.1
  • 35
    • 0036104604 scopus 로고    scopus 로고
    • Gene therapy for cancer using single-chain Fv fragments specific for 4-1BB
    • Ye Z., et al. Gene therapy for cancer using single-chain Fv fragments specific for 4-1BB. Nat. Med. 8 (2002) 343-348
    • (2002) Nat. Med. , vol.8 , pp. 343-348
    • Ye, Z.1
  • 36
    • 40949132423 scopus 로고    scopus 로고
    • Interleukin-15 liver gene transfer increases the number and function of IKDCs and NK cells
    • Arina A., et al. Interleukin-15 liver gene transfer increases the number and function of IKDCs and NK cells. Gene Ther. 15 (2008) 473-483
    • (2008) Gene Ther. , vol.15 , pp. 473-483
    • Arina, A.1
  • 37
    • 35748943227 scopus 로고    scopus 로고
    • + interferon-producing killer dendritic cells are activated natural killer cells
    • + interferon-producing killer dendritic cells are activated natural killer cells. J. Exp. Med. 204 (2007) 2569-2578
    • (2007) J. Exp. Med. , vol.204 , pp. 2569-2578
    • Vosshenrich, C.A.1
  • 38
    • 35748942920 scopus 로고    scopus 로고
    • Putative IKDCs are functionally and developmentally similar to natural killer cells, but not to dendritic cells
    • Caminschi I., et al. Putative IKDCs are functionally and developmentally similar to natural killer cells, but not to dendritic cells. J. Exp. Med. 204 (2007) 2579-2590
    • (2007) J. Exp. Med. , vol.204 , pp. 2579-2590
    • Caminschi, I.1
  • 39
    • 35748972077 scopus 로고    scopus 로고
    • + cells identify them as a subset of NK cells
    • + cells identify them as a subset of NK cells. J. Exp. Med. 204 (2007) 2561-2568
    • (2007) J. Exp. Med. , vol.204 , pp. 2561-2568
    • Blasius, A.L.1
  • 40
    • 42149174964 scopus 로고    scopus 로고
    • 4-1BB engagement costimulates NKT cell activation and exacerbates NKT cell ligand-induced airway hyperresponsiveness and inflammation
    • Kim D.H., et al. 4-1BB engagement costimulates NKT cell activation and exacerbates NKT cell ligand-induced airway hyperresponsiveness and inflammation. J. Immunol. 180 (2008) 2062-2068
    • (2008) J. Immunol. , vol.180 , pp. 2062-2068
    • Kim, D.H.1
  • 41
    • 4644245852 scopus 로고    scopus 로고
    • CD137-deficient mice have reduced NK/NKT cell numbers and function, are resistant to lipopolysaccharide-induced shock syndromes, and have lower IL-4 responses
    • Vinay D.S., et al. CD137-deficient mice have reduced NK/NKT cell numbers and function, are resistant to lipopolysaccharide-induced shock syndromes, and have lower IL-4 responses. J. Immunol. 173 (2004) 4218-4229
    • (2004) J. Immunol. , vol.173 , pp. 4218-4229
    • Vinay, D.S.1
  • 42
    • 34547628869 scopus 로고    scopus 로고
    • Combined natural killer T-cell based immunotherapy eradicates established tumors in mice
    • Teng M.W., et al. Combined natural killer T-cell based immunotherapy eradicates established tumors in mice. Cancer Res. 67 (2007) 7495-7504
    • (2007) Cancer Res. , vol.67 , pp. 7495-7504
    • Teng, M.W.1
  • 43
    • 38849108168 scopus 로고    scopus 로고
    • + T regulatory cells based on synergy between IL-2 and 4-1BB signaling
    • + T regulatory cells based on synergy between IL-2 and 4-1BB signaling. J. Immunol. 179 (2007) 7295-7304
    • (2007) J. Immunol. , vol.179 , pp. 7295-7304
    • Elpek, K.G.1
  • 45
    • 36349037090 scopus 로고    scopus 로고
    • Rejection of metastatic 4T1 breast cancer by attenuation of Treg cells in combination with immune stimulation
    • Chen L., et al. Rejection of metastatic 4T1 breast cancer by attenuation of Treg cells in combination with immune stimulation. Mol. Ther. 15 (2007) 2194-2202
    • (2007) Mol. Ther. , vol.15 , pp. 2194-2202
    • Chen, L.1
  • 46
    • 34548759728 scopus 로고    scopus 로고
    • Mechanisms involved in synergistic anticancer immunity of anti-4-1BB and anti-CD4 therapy
    • Choi B.K., et al. Mechanisms involved in synergistic anticancer immunity of anti-4-1BB and anti-CD4 therapy. Cancer Res. 67 (2007) 8891-8899
    • (2007) Cancer Res. , vol.67 , pp. 8891-8899
    • Choi, B.K.1
  • 47
    • 42249097689 scopus 로고    scopus 로고
    • OX40 triggering blocks suppression by regulatory T cells and facilitates tumor rejection
    • Piconese S., et al. OX40 triggering blocks suppression by regulatory T cells and facilitates tumor rejection. J. Exp. Med. 205 (2008) 825-839
    • (2008) J. Exp. Med. , vol.205 , pp. 825-839
    • Piconese, S.1
  • 48
    • 38049046025 scopus 로고    scopus 로고
    • Absence of surface expression of CD137 (4-1BB) on myeloid-derived suppressor cells
    • Dubrot J., et al. Absence of surface expression of CD137 (4-1BB) on myeloid-derived suppressor cells. Inmunologia 26 (2007) 121-126
    • (2007) Inmunologia , vol.26 , pp. 121-126
    • Dubrot, J.1
  • 49
    • 34249822498 scopus 로고    scopus 로고
    • Genes that distinguish physiological and pathological angiogenesis
    • Seaman S., et al. Genes that distinguish physiological and pathological angiogenesis. Cancer Cell 11 (2007) 539-554
    • (2007) Cancer Cell , vol.11 , pp. 539-554
    • Seaman, S.1
  • 50
    • 0033571176 scopus 로고    scopus 로고
    • Anti-4-1BB monoclonal antibodies abrogate T cell-dependent humoral immune responses in vivo through the induction of helper T cell anergy
    • Mittler R.S., et al. Anti-4-1BB monoclonal antibodies abrogate T cell-dependent humoral immune responses in vivo through the induction of helper T cell anergy. J. Exp. Med. 190 (1999) 1535-1540
    • (1999) J. Exp. Med. , vol.190 , pp. 1535-1540
    • Mittler, R.S.1
  • 51
    • 34948859589 scopus 로고    scopus 로고
    • Immune suppression or enhancement by CD137 T cell costimulation during acute viral infection is time dependent
    • Zhang B., et al. Immune suppression or enhancement by CD137 T cell costimulation during acute viral infection is time dependent. J. Clin. Invest. 117 (2007) 3029-3041
    • (2007) J. Clin. Invest. , vol.117 , pp. 3029-3041
    • Zhang, B.1
  • 52
    • 20944446056 scopus 로고    scopus 로고
    • Enhancement of CD4 and CD8 immunity by anti-CD137 (4-1BB) monoclonal antibodies during hepatitis C vaccination with recombinant adenovirus
    • Arribillaga L., et al. Enhancement of CD4 and CD8 immunity by anti-CD137 (4-1BB) monoclonal antibodies during hepatitis C vaccination with recombinant adenovirus. Vaccine 23 (2005) 3493-3499
    • (2005) Vaccine , vol.23 , pp. 3493-3499
    • Arribillaga, L.1
  • 53
    • 33947696816 scopus 로고    scopus 로고
    • Cytokine-mediated disruption of lymphocyte trafficking, hemopoiesis, and induction of lymphopenia, anemia, and thrombocytopenia in anti-CD137-treated mice
    • Niu L., et al. Cytokine-mediated disruption of lymphocyte trafficking, hemopoiesis, and induction of lymphopenia, anemia, and thrombocytopenia in anti-CD137-treated mice. J. Immunol. 178 (2007) 4194-4213
    • (2007) J. Immunol. , vol.178 , pp. 4194-4213
    • Niu, L.1
  • 54
    • 16244408626 scopus 로고    scopus 로고
    • Inhibition of indoleamine 2,3-dioxygenase, an immunoregulatory target of the cancer suppression gene Bin1, potentiates cancer chemotherapy
    • Muller A.J., et al. Inhibition of indoleamine 2,3-dioxygenase, an immunoregulatory target of the cancer suppression gene Bin1, potentiates cancer chemotherapy. Nat. Med. 11 (2005) 312-319
    • (2005) Nat. Med. , vol.11 , pp. 312-319
    • Muller, A.J.1
  • 55
    • 34347398235 scopus 로고    scopus 로고
    • + T cells responding to antigen without requiring knowledge of epitope specificities
    • + T cells responding to antigen without requiring knowledge of epitope specificities. Blood 110 (2007) 201-210
    • (2007) Blood , vol.110 , pp. 201-210
    • Wolfl, M.1
  • 56
    • 34249689632 scopus 로고    scopus 로고
    • CD137 stimulation delivers an antigen-independent growth signal for T lymphocytes with memory phenotype
    • Zhu Y., et al. CD137 stimulation delivers an antigen-independent growth signal for T lymphocytes with memory phenotype. Blood 109 (2007) 4882-4889
    • (2007) Blood , vol.109 , pp. 4882-4889
    • Zhu, Y.1
  • 57
    • 40549112657 scopus 로고    scopus 로고
    • CD137 is expressed in human atherosclerosis and promotes development of plaque inflammation in hypercholesterolemic mice
    • Olofsson P.S., et al. CD137 is expressed in human atherosclerosis and promotes development of plaque inflammation in hypercholesterolemic mice. Circulation 117 (2008) 1292-1301
    • (2008) Circulation , vol.117 , pp. 1292-1301
    • Olofsson, P.S.1
  • 58
    • 1642291001 scopus 로고    scopus 로고
    • Serum concentrations of soluble 4-1BB and 4-1BB ligand correlated with the disease severity in rheumatoid arthritis
    • Jung H.W., et al. Serum concentrations of soluble 4-1BB and 4-1BB ligand correlated with the disease severity in rheumatoid arthritis. Exp. Mol. Med. 36 (2004) 13-22
    • (2004) Exp. Mol. Med. , vol.36 , pp. 13-22
    • Jung, H.W.1
  • 59
    • 34249077931 scopus 로고    scopus 로고
    • Cell surface 4-1BBL mediates sequential signaling pathways 'downstream' of TLR and is required for sustained TNF production in macrophages
    • Kang Y.J., et al. Cell surface 4-1BBL mediates sequential signaling pathways 'downstream' of TLR and is required for sustained TNF production in macrophages. Nat. Immunol. 8 (2007) 601-609
    • (2007) Nat. Immunol. , vol.8 , pp. 601-609
    • Kang, Y.J.1


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