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Volumn 5, Issue 2, 2013, Pages 169-182

Melanoma immunotherapy: Historical precedents, recent successes and future prospects

Author keywords

cancer immunotherapy; cancer testis antigens; Canvaxin ; CTLA 4; immunotherapy; interferon; melanoma; PD 1; T cell therapy; vaccines

Indexed keywords

ALPHA2B INTERFERON; CISPLATIN; INTERLEUKIN 2; IPILIMUMAB; MELACINE; ONAMELATUCEL L; PEGINTERFERON ALPHA; PEGINTERFERON ALPHA2A; PEGINTERFERON ALPHA2B; SIPULEUCEL T; TEMOZOLOMIDE; TGN 1412; VELIMOGENE ALIPLASMID; VEMURAFENIB;

EID: 84874024364     PISSN: 1750743X     EISSN: 17507448     Source Type: Journal    
DOI: 10.2217/imt.12.162     Document Type: Review
Times cited : (29)

References (128)
  • 1
    • 0000161413 scopus 로고
    • The treatment of malignant tumors by repeated inoculations of erysipelas: With a report of ten original cases
    • Coley WB. The treatment of malignant tumors by repeated inoculations of erysipelas: with a report of ten original cases. Am. J. Med. Sci. (105), 273-290 (1893).
    • (1893) Am. J. Med. Sci. , vol.105 , pp. 273-290
    • Coley, W.B.1
  • 2
    • 84255197842 scopus 로고    scopus 로고
    • Cancer immunotherapy comes of age
    • Mellman I, Coukos G, Dranoff G. Cancer immunotherapy comes of age. Nature 480(7378), 480-489 (2011).
    • (2011) Nature , vol.480 , Issue.7378 , pp. 480-489
    • Mellman, I.1    Coukos, G.2    Dranoff, G.3
  • 3
    • 84866743713 scopus 로고    scopus 로고
    • Combination delivery of TGF-beta inhibitor and IL-2 by nanoscale liposomal polymeric gels enhances tumour immunotherapy
    • Park J, Wrzesinski SH, Stern E et al. Combination delivery of TGF-beta inhibitor and IL-2 by nanoscale liposomal polymeric gels enhances tumour immunotherapy. Nat. Mater. 11(10), 895-905 (2012).
    • (2012) Nat. Mater. , vol.11 , Issue.10 , pp. 895-905
    • Park, J.1    Wrzesinski, S.H.2    Stern, E.3
  • 4
    • 0001486440 scopus 로고
    • Immunity to transplantable tumours
    • Woglom WH. Immunity to transplantable tumours. Cancer Res. 4, 129-138 (1929).
    • (1929) Cancer Res. , vol.4 , pp. 129-138
    • Woglom, W.H.1
  • 5
    • 0005984244 scopus 로고
    • Actively acquired tolerance of foreign cells
    • Billingham RE, Brent L, Medawar PB. Actively acquired tolerance of foreign cells. Nature 172(4379), 603-606 (1953).
    • (1953) Nature , vol.172 , Issue.4379 , pp. 603-606
    • Billingham, R.E.1    Brent, L.2    Medawar, P.B.3
  • 6
    • 0000540265 scopus 로고
    • Immunity to methylcholanthrene-induced tumours in inbred rats following atrophy and regression of the implanted tumours
    • Baldwin RW. Immunity to methylcholanthrene-induced tumours in inbred rats following atrophy and regression of the implanted tumours. Br. J. Cancer 9(4), 652-657 (1955).
    • (1955) Br. J. Cancer , vol.9 , Issue.4 , pp. 652-657
    • Baldwin, R.W.1
  • 7
    • 84965157146 scopus 로고
    • Antigenic properties of methylcholanthrene-induced tumors in mice of the strain of origin
    • Foley EJ. Antigenic properties of methylcholanthrene-induced tumors in mice of the strain of origin. Cancer Res. 13(12), 835-837 (1953).
    • (1953) Cancer Res. , vol.13 , Issue.12 , pp. 835-837
    • Foley, E.J.1
  • 8
    • 78651120598 scopus 로고
    • Demonstration of resistance against methylcholanthrene-induced sarcomas in the primary autochthonous host
    • Klein G, Sjogren HO, Klein E, Hellstrom KE. Demonstration of resistance against methylcholanthrene-induced sarcomas in the primary autochthonous host. Cancer Res. 20, 1561-1572 (1960).
    • (1960) Cancer Res. , vol.20 , pp. 1561-1572
    • Klein, G.1    Sjogren, H.O.2    Klein, E.3    Hellstrom, K.E.4
  • 9
    • 70449193189 scopus 로고
    • Immunity to methylcholanthrene-induced sarcomas
    • Prehn RT, Main JM. Immunity to methylcholanthrene-induced sarcomas. J. Natl Cancer Inst. 18(6), 769-778 (1957).
    • (1957) J. Natl Cancer Inst. , vol.18 , Issue.6 , pp. 769-778
    • Prehn, R.T.1    Main, J.M.2
  • 10
    • 0014191608 scopus 로고
    • Immunological aspects of malignant disease
    • Burnet FM. Immunological aspects of malignant disease. Lancet 1(7501), 1171-1174 (1967).
    • (1967) Lancet , vol.1 , Issue.7501 , pp. 1171-1174
    • Burnet, F.M.1
  • 11
    • 0001415346 scopus 로고
    • About the current state of cancer research
    • Ehrlich P. [About the current state of cancer research]. Ned. Tijdschr. Geneeskd. 5, 273-290 (1909).
    • (1909) Ned. Tijdschr. Geneeskd. , vol.5 , pp. 273-290
    • Ehrlich, P.1
  • 14
    • 0028201732 scopus 로고
    • Tolerance, danger, and the extended family
    • Matzinger P. Tolerance, danger, and the extended family. Annu. Rev. Immunol. 12, 991-1045 (1994).
    • (1994) Annu. Rev. Immunol. , vol.12 , pp. 991-1045
    • Matzinger, P.1
  • 16
    • 0029924107 scopus 로고    scopus 로고
    • Human tumor antigens recognized by T lymphocytes
    • Boon T, van der Bruggen P. Human tumor antigens recognized by T lymphocytes. J. Exp. Med. 183(3), 725-729 (1996).
    • (1996) J. Exp. Med. , vol.183 , Issue.3 , pp. 725-729
    • Boon, T.1    Van Der Bruggen, P.2
  • 18
    • 0033103021 scopus 로고    scopus 로고
    • A new era for cancer immunotherapy based on the genes that encode cancer antigens
    • Rosenberg SA. A new era for cancer immunotherapy based on the genes that encode cancer antigens. Immunity 10(3), 281-287 (1999).
    • (1999) Immunity , vol.10 , Issue.3 , pp. 281-287
    • Rosenberg, S.A.1
  • 20
    • 0029643982 scopus 로고
    • Genetic instability and tumor cell variation: Implications for immunotherapy
    • Fenton RG, Longo DL. Genetic instability and tumor cell variation: implications for immunotherapy. J. Natl Cancer Inst. 87(4), 241-243 (1995).
    • (1995) J. Natl Cancer Inst. , vol.87 , Issue.4 , pp. 241-243
    • Fenton, R.G.1    Longo, D.L.2
  • 21
    • 0033592960 scopus 로고    scopus 로고
    • The onset and extent of genomic instability in sporadic colorectal tumor progression
    • Stoler DL, Chen N, Basik M et al. The onset and extent of genomic instability in sporadic colorectal tumor progression. Proc. Natl Acad. Sci. USA 96(26), 15121-15126 (1999).
    • (1999) Proc. Natl Acad. Sci. USA , vol.96 , Issue.26 , pp. 15121-15126
    • Stoler, D.L.1    Chen, N.2    Basik, M.3
  • 22
    • 0030048724 scopus 로고    scopus 로고
    • Peptide-pulsed dendritic cells induce antigen-specific CTL-mediated protective tumor immunity
    • Celluzzi CM, Mayordomo JI, Storkus WJ, Lotze MT, Falo LD Jr. Peptide-pulsed dendritic cells induce antigen-specific CTL-mediated protective tumor immunity. J. Exp. Med. 183(1), 283-287 (1996).
    • (1996) J. Exp. Med. , vol.183 , Issue.1 , pp. 283-287
    • Celluzzi, C.M.1    Mayordomo, J.I.2    Storkus, W.J.3    Lotze, M.T.4    Falo Jr., L.D.5
  • 23
    • 0028347936 scopus 로고
    • Murine dendritic cells pulsed in vitro with tumor antigen induce tumor resistance in vivo
    • Flamand V, Sornasse T, Thielemans K et al. Murine dendritic cells pulsed in vitro with tumor antigen induce tumor resistance in vivo. Eur. J. Immunol. 24(3), 605-610 (1994).
    • (1994) Eur. J. Immunol. , vol.24 , Issue.3 , pp. 605-610
    • Flamand, V.1    Sornasse, T.2    Thielemans, K.3
  • 24
    • 0028793675 scopus 로고
    • Bone marrow-derived dendritic cells pulsed with synthetic tumour peptides elicit protective and therapeutic antitumour immunity
    • Mayordomo JI, Zorina T, Storkus WJ et al. Bone marrow-derived dendritic cells pulsed with synthetic tumour peptides elicit protective and therapeutic antitumour immunity. Nat. Med. 1(12), 1297-1302 (1995).
    • (1995) Nat. Med. , vol.1 , Issue.12 , pp. 1297-1302
    • Mayordomo, J.I.1    Zorina, T.2    Storkus, W.J.3
  • 25
    • 0031941423 scopus 로고    scopus 로고
    • Vaccination of melanoma patients with peptide-or tumor lysate-pulsed dendritic cells
    • Nestle FO, Alijagic S, Gilliet M et al. Vaccination of melanoma patients with peptide-or tumor lysate-pulsed dendritic cells. Nat. Med. 4(3), 328-332 (1998).
    • (1998) Nat. Med. , vol.4 , Issue.3 , pp. 328-332
    • Nestle, F.O.1    Alijagic, S.2    Gilliet, M.3
  • 26
    • 0035953308 scopus 로고    scopus 로고
    • IFNgamma and lymphocytes prevent primary tumour development and shape tumour immunogenicity
    • Shankaran V, Ikeda H, Bruce AT et al. IFNgamma and lymphocytes prevent primary tumour development and shape tumour immunogenicity. Nature 410(6832), 1107-1111 (2001).
    • (2001) Nature , vol.410 , Issue.6832 , pp. 1107-1111
    • Shankaran, V.1    Ikeda, H.2    Bruce, A.T.3
  • 27
    • 0035320526 scopus 로고    scopus 로고
    • A fresh look at tumor immunosurveillance and immunotherapy
    • Smyth MJ, Godfrey DI, Trapani JA. A fresh look at tumor immunosurveillance and immunotherapy. Nat. Immunol. 2(4), 293-299 (2001).
    • (2001) Nat. Immunol. , vol.2 , Issue.4 , pp. 293-299
    • Smyth, M.J.1    Godfrey, D.I.2    Trapani, J.A.3
  • 28
    • 0037383526 scopus 로고    scopus 로고
    • Cancer immunotherapy: The past, the present and the future
    • Parish CR. Cancer immunotherapy: the past, the present and the future. Immunol. Cell Biol. 81(2), 106-113 (2003).
    • (2003) Immunol. Cell Biol. , vol.81 , Issue.2 , pp. 106-113
    • Parish, C.R.1
  • 29
    • 0033056073 scopus 로고    scopus 로고
    • Characterization of circulating T cells specific for tumor-associated antigens in melanoma patients
    • Lee PP, Yee C, Savage PA et al. Characterization of circulating T cells specific for tumor-associated antigens in melanoma patients. Nat. Med. 5(6), 677-685 (1999).
    • (1999) Nat. Med. , vol.5 , Issue.6 , pp. 677-685
    • Lee, P.P.1    Yee, C.2    Savage, P.A.3
  • 33
    • 84859588335 scopus 로고    scopus 로고
    • Efficacy of vaccination with recombinant vaccinia and fowlpox vectors expressing NY-ESO-1 antigen in ovarian cancer and melanoma patients
    • Odunsi K, Matsuzaki J, Karbach J et al. Efficacy of vaccination with recombinant vaccinia and fowlpox vectors expressing NY-ESO-1 antigen in ovarian cancer and melanoma patients. Proc. Natl Acad. Sci. USA 109(15), 5797-5802 (2012).
    • (2012) Proc. Natl Acad. Sci. USA , vol.109 , Issue.15 , pp. 5797-5802
    • Odunsi, K.1    Matsuzaki, J.2    Karbach, J.3
  • 34
    • 54449097809 scopus 로고    scopus 로고
    • Helper Tcell responses and clinical activity of a melanoma vaccine with multiple peptides from MAGE and melanocytic differentiation antigens
    • Slingluff CL Jr, Petroni GR, Olson W et al. Helper Tcell responses and clinical activity of a melanoma vaccine with multiple peptides from MAGE and melanocytic differentiation antigens. J. Clin. Oncol. 26(30), 4973-4980 (2008).
    • (2008) J. Clin. Oncol. , vol.26 , Issue.30 , pp. 4973-4980
    • Slingluff Jr., C.L.1    Petroni, G.R.2    Olson, W.3
  • 35
    • 80052432557 scopus 로고    scopus 로고
    • Tcell immune function in tumor, skin, and peripheral blood of advanced stage melanoma patients: Implications for immunotherapy
    • Tjin EP, Konijnenberg D, Krebbers G et al. Tcell immune function in tumor, skin, and peripheral blood of advanced stage melanoma patients: implications for immunotherapy. Clin. Cancer Res. 17(17), 5736-5747 (2011).
    • (2011) Clin. Cancer Res. , vol.17 , Issue.17 , pp. 5736-5747
    • Tjin, E.P.1    Konijnenberg, D.2    Krebbers, G.3
  • 36
    • 69549103141 scopus 로고    scopus 로고
    • Feedback control of regulatory T cell homeostasis by dendritic cells in vivo
    • Darrasse-Jeze G, Deroubaix S, Mouquet H et al. Feedback control of regulatory T cell homeostasis by dendritic cells in vivo. J. Exp. Med. 206(9), 1853-1862 (2009).
    • (2009) J. Exp. Med. , vol.206 , Issue.9 , pp. 1853-1862
    • Darrasse-Jeze, G.1    Deroubaix, S.2    Mouquet, H.3
  • 37
    • 35348968837 scopus 로고    scopus 로고
    • Disruption of E-cadherin-mediated adhesion induces a functionally distinct pathway of dendritic cell maturation
    • Jiang A, Bloom O, Ono S et al. Disruption of E-cadherin-mediated adhesion induces a functionally distinct pathway of dendritic cell maturation. Immunity 27(4), 610-624 (2007).
    • (2007) Immunity , vol.27 , Issue.4 , pp. 610-624
    • Jiang, A.1    Bloom, O.2    Ono, S.3
  • 39
    • 0034614886 scopus 로고    scopus 로고
    • The induction of tolerance by dendritic cells that have captured apoptotic cells
    • Steinman RM, Turley S, Mellman I, Inaba K. The induction of tolerance by dendritic cells that have captured apoptotic cells. J. Exp. Med. 191(3), 411-416 (2000).
    • (2000) J. Exp. Med. , vol.191 , Issue.3 , pp. 411-416
    • Steinman, R.M.1    Turley, S.2    Mellman, I.3    Inaba, K.4
  • 40
    • 33747135818 scopus 로고    scopus 로고
    • Therapeutic potential of immunostimulatory monoclonal antibodies
    • Gray JC, Johnson PW, Glennie MJ. Therapeutic potential of immunostimulatory monoclonal antibodies. Clin. Sci. (Lond.) 111(2), 93-106 (2006).
    • (2006) Clin. Sci. (Lond.) , vol.111 , Issue.2 , pp. 93-106
    • Gray, J.C.1    Johnson, P.W.2    Glennie, M.J.3
  • 41
    • 33748416499 scopus 로고    scopus 로고
    • Cytokine storm in a Phase 1 trial of the anti-CD28 monoclonal antibody TGN1412
    • Suntharalingam G, Perry MR, Ward S et al. Cytokine storm in a Phase 1 trial of the anti-CD28 monoclonal antibody TGN1412. N. Engl. J. Med. 355(10), 1018-1028 (2006).
    • (2006) N. Engl. J. Med. , vol.355 , Issue.10 , pp. 1018-1028
    • Suntharalingam, G.1    Perry, M.R.2    Ward, S.3
  • 42
    • 0033991158 scopus 로고    scopus 로고
    • Escape of human solid tumors from Tcell recognition: Molecular mechanisms and functional significance
    • Marincola FM, Jaffee EM, Hicklin DJ, Ferrone S. Escape of human solid tumors from Tcell recognition: molecular mechanisms and functional significance. Adv. Immunol. 74, 181-273 (2000).
    • (2000) Adv. Immunol. , vol.74 , pp. 181-273
    • Marincola, F.M.1    Jaffee, E.M.2    Hicklin, D.J.3    Ferrone, S.4
  • 44
    • 0037126021 scopus 로고    scopus 로고
    • Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade
    • Iwai Y, Ishida M, Tanaka Y, Okazaki T, Honjo T, Minato N. Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade. Proc. Natl Acad. Sci. USA 99(19), 12293-12297 (2002).
    • (2002) Proc. Natl Acad. Sci. USA , vol.99 , Issue.19 , pp. 12293-12297
    • Iwai, Y.1    Ishida, M.2    Tanaka, Y.3    Okazaki, T.4    Honjo, T.5    Minato, N.6
  • 45
    • 84863393080 scopus 로고    scopus 로고
    • Intratumor heterogeneity and branched evolution revealed by multiregion sequencing
    • Gerlinger M, Rowan AJ, Horswell S et al. Intratumor heterogeneity and branched evolution revealed by multiregion sequencing. N. Engl. J Med. 366(10), 883-892 (2012).
    • (2012) N. Engl. J Med. , vol.366 , Issue.10 , pp. 883-892
    • Gerlinger, M.1    Rowan, A.J.2    Horswell, S.3
  • 46
    • 0036813331 scopus 로고    scopus 로고
    • Cancer/testis antigens: An expanding family of targets for cancer immunotherapy
    • Scanlan MJ, Gure AO, Jungbluth AA, Old LJ, Chen YT. Cancer/testis antigens: an expanding family of targets for cancer immunotherapy. Immunol. Rev. 188, 22-32 (2002).
    • (2002) Immunol. Rev. , vol.188 , pp. 22-32
    • Scanlan, M.J.1    Gure, A.O.2    Jungbluth, A.A.3    Old, L.J.4    Chen, Y.T.5
  • 47
    • 0030013334 scopus 로고    scopus 로고
    • Serological analysis of Melan-A(MART-1), a melanocyte-specific protein homogeneously expressed in human melanomas
    • Chen YT, Stockert E, Jungbluth A et al. Serological analysis of Melan-A(MART-1), a melanocyte-specific protein homogeneously expressed in human melanomas. Proc. Natl Acad. Sci. USA 93(12), 5915-5919 (1996).
    • (1996) Proc. Natl Acad. Sci. USA , vol.93 , Issue.12 , pp. 5915-5919
    • Chen, Y.T.1    Stockert, E.2    Jungbluth, A.3
  • 48
    • 84862903106 scopus 로고    scopus 로고
    • Safety and activity of anti-PD-L1 antibody in patients with advanced cancer
    • Brahmer JR, Tykodi SS, Chow LQ et al. Safety and activity of anti-PD-L1 antibody in patients with advanced cancer. N. Engl. J. Med. 366(26), 2455-2465 (2012).
    • (2012) N. Engl. J. Med. , vol.366 , Issue.26 , pp. 2455-2465
    • Brahmer, J.R.1    Tykodi, S.S.2    Chow, L.Q.3
  • 49
    • 84862859820 scopus 로고    scopus 로고
    • Safety, activity, and immune correlates of anti-PD-1 antibody in cancer
    • Topalian SL, Hodi FS, Brahmer JR et al. Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. N. Engl. J. Med. 366(26), 2443-2454 (2012).
    • (2012) N. Engl. J. Med. , vol.366 , Issue.26 , pp. 2443-2454
    • Topalian, S.L.1    Hodi, F.S.2    Brahmer, J.R.3
  • 50
    • 0020314507 scopus 로고
    • Development of long-term cell lines and lymphoid clones reactive against murine and human tumors: A new approach to the adoptive immunotherapy of cancer
    • Rosenberg SA, Eberlein TJ, Grimm EA, Lotze MT, Mazumder A, Rosenstein M. Development of long-term cell lines and lymphoid clones reactive against murine and human tumors: A new approach to the adoptive immunotherapy of cancer. Surgery 92(2), 328-336 (1982).
    • (1982) Surgery , vol.92 , Issue.2 , pp. 328-336
    • Rosenberg, S.A.1    Eberlein, T.J.2    Grimm, E.A.3    Lotze, M.T.4    Mazumder, A.5    Rosenstein, M.6
  • 51
    • 0028266553 scopus 로고
    • Treatment of 283 consecutive patients with metastatic melanoma or renal cell cancer using high-dose bolus interleukin 2
    • Rosenberg SA, Yang JC, Topalian SL et al. Treatment of 283 consecutive patients with metastatic melanoma or renal cell cancer using high-dose bolus interleukin 2. JAMA 271(12), 907-913 (1994).
    • (1994) JAMA , vol.271 , Issue.12 , pp. 907-913
    • Rosenberg, S.A.1    Yang, J.C.2    Topalian, S.L.3
  • 52
    • 0033024863 scopus 로고    scopus 로고
    • High-dose recombinant interleukin 2 therapy for patients with metastatic melanoma: Analysis of 270 patients treated between 1985 and 1993
    • Atkins MB, Lotze MT, Dutcher JP et al. High-dose recombinant interleukin 2 therapy for patients with metastatic melanoma: analysis of 270 patients treated between 1985 and 1993. J. Clin. Oncol. 17(7), 2105-2116 (1999).
    • (1999) J. Clin. Oncol. , vol.17 , Issue.7 , pp. 2105-2116
    • Atkins, M.B.1    Lotze, M.T.2    Dutcher, J.P.3
  • 53
    • 34548337157 scopus 로고    scopus 로고
    • Single-agent interleukin-2 in the treatment of metastatic melanoma: A systematic review
    • Petrella T, Quirt I, Verma S et al. Single-agent interleukin-2 in the treatment of metastatic melanoma: A systematic review. Cancer Treat. Rev. 33(5), 484-496 (2007).
    • (2007) Cancer Treat. Rev. , vol.33 , Issue.5 , pp. 484-496
    • Petrella, T.1    Quirt, I.2    Verma, S.3
  • 54
    • 34548539872 scopus 로고    scopus 로고
    • More support for the judicious use of high-dose interleukin-2 in patients with advanced melanoma
    • Mcdermott DF, Atkins MB. More support for the judicious use of high-dose interleukin-2 in patients with advanced melanoma. J. Clin. Oncol. 25(25), 3791-3793 (2007).
    • (2007) J. Clin. Oncol. , vol.25 , Issue.25 , pp. 3791-3793
    • McDermott, D.F.1    Atkins, M.B.2
  • 55
    • 0342894822 scopus 로고    scopus 로고
    • Interferon alfa-2a and interleukin-2 with or without cisplatin in metastatic melanoma: A randomized trial of the European Organization for Research and Treatment of Cancer Melanoma Cooperative Group
    • Keilholz U, Goey SH, Punt CJ et al. Interferon alfa-2a and interleukin-2 with or without cisplatin in metastatic melanoma: A randomized trial of the European Organization for Research and Treatment of Cancer Melanoma Cooperative Group. J. Clin. Oncol. 15(7), 2579-2588 (1997).
    • (1997) J. Clin. Oncol. , vol.15 , Issue.7 , pp. 2579-2588
    • Keilholz, U.1    Goey, S.H.2    Punt, C.J.3
  • 56
    • 0031718717 scopus 로고    scopus 로고
    • Results of interleukin-2-based treatment in advanced melanoma: A case record-based analysis of 631 patients
    • Keilholz U, Conradt C, Legha SS et al. Results of interleukin-2-based treatment in advanced melanoma: A case record-based analysis of 631 patients. J. Clin. Oncol. 16(9), 2921-2929 (1998).
    • (1998) J. Clin. Oncol. , vol.16 , Issue.9 , pp. 2921-2929
    • Keilholz, U.1    Conradt, C.2    Legha, S.S.3
  • 57
    • 0037087755 scopus 로고    scopus 로고
    • Cisplatin, dacarbazine with or without subcutaneous interleukin-2, and interferon alpha-2b in advanced melanoma outpatients: Results from an Italian multicenter Phase III randomized clinical trial
    • Ridolfi R, Chiarion-Sileni V, Guida M et al. Cisplatin, dacarbazine with or without subcutaneous interleukin-2, and interferon alpha-2b in advanced melanoma outpatients: results from an Italian multicenter Phase III randomized clinical trial. J. Clin. Oncol. 20(6), 1600-1607 (2002).
    • (2002) J. Clin. Oncol. , vol.20 , Issue.6 , pp. 1600-1607
    • Ridolfi, R.1    Chiarion-Sileni, V.2    Guida, M.3
  • 58
    • 27244432257 scopus 로고    scopus 로고
    • Dacarbazine, cisplatin, and interferon-alfa-2b with or without interleukin-2 in metastatic melanoma: A randomized Phase III trial (18951) of the European Organisation for Research and Treatment of Cancer Melanoma Group
    • Keilholz U, Punt CJ, Gore M et al. Dacarbazine, cisplatin, and interferon-alfa-2b with or without interleukin-2 in metastatic melanoma: A randomized Phase III trial (18951) of the European Organisation for Research and Treatment of Cancer Melanoma Group. J. Clin. Oncol. 23(27), 6747-6755 (2005).
    • (2005) J. Clin. Oncol. , vol.23 , Issue.27 , pp. 6747-6755
    • Keilholz, U.1    Punt, C.J.2    Gore, M.3
  • 59
    • 54049149389 scopus 로고    scopus 로고
    • A Phase 2 trial of sequential temozolomide chemotherapy followed by high-dose interleukin 2 immunotherapy for metastatic melanoma
    • Tarhini AA, Kirkwood JM, Gooding WE, Moschos S, Agarwala SS. A Phase 2 trial of sequential temozolomide chemotherapy followed by high-dose interleukin 2 immunotherapy for metastatic melanoma. Cancer 113(7), 1632-1640 (2008).
    • (2008) Cancer , vol.113 , Issue.7 , pp. 1632-1640
    • Tarhini, A.A.1    Kirkwood, J.M.2    Gooding, W.E.3    Moschos, S.4    Agarwala, S.S.5
  • 60
    • 66849095271 scopus 로고    scopus 로고
    • Serum vascular endothelial growth factor and fibronectin predict clinical response to high-dose interleukin-2 therapy
    • Sabatino M, Kim-Schulze S, Panelli MC et al. Serum vascular endothelial growth factor and fibronectin predict clinical response to high-dose interleukin-2 therapy. J. Clin. Oncol. 27(16), 2645-2652 (2009).
    • (2009) J. Clin. Oncol. , vol.27 , Issue.16 , pp. 2645-2652
    • Sabatino, M.1    Kim-Schulze, S.2    Panelli, M.C.3
  • 62
    • 77954327720 scopus 로고    scopus 로고
    • Long-term pegylated interferon-alpha and its potential in the treatment of melanoma
    • Dummer R, Mangana J. Long-term pegylated interferon-alpha and its potential in the treatment of melanoma. Biologics 3, 169-182 (2009).
    • (2009) Biologics , vol.3 , pp. 169-182
    • Dummer, R.1    Mangana, J.2
  • 63
    • 0034769960 scopus 로고    scopus 로고
    • Viruses and interferons
    • Sen GC. Viruses and interferons. Annu. Rev. Microbiol. 55, 255-281 (2001).
    • (2001) Annu. Rev. Microbiol. , vol.55 , pp. 255-281
    • Sen, G.C.1
  • 64
    • 0030030347 scopus 로고    scopus 로고
    • Interferon alfa-2b adjuvant therapy of high-risk resected cutaneous melanoma: The Eastern Cooperative Oncology Group Trial EST 1684
    • Kirkwood JM, Strawderman MH, Ernstoff MS, Smith TJ, Borden EC, Blum RH. Interferon alfa-2b adjuvant therapy of high-risk resected cutaneous melanoma: the Eastern Cooperative Oncology Group Trial EST 1684. J. Clin. Oncol. 14(1), 7-17 (1996).
    • (1996) J. Clin. Oncol. , vol.14 , Issue.1 , pp. 7-17
    • Kirkwood, J.M.1    Strawderman, M.H.2    Ernstoff, M.S.3    Smith, T.J.4    Borden, E.C.5    Blum, R.H.6
  • 65
    • 25844465690 scopus 로고    scopus 로고
    • Post-surgery adjuvant therapy with intermediate doses of interferon alfa 2b versus observation in patients with stage IIb/III melanoma (EORTC 18952): Randomised controlled trial
    • Eggermont AM, Suciu S, Mackie R et al. Post-surgery adjuvant therapy with intermediate doses of interferon alfa 2b versus observation in patients with stage IIb/III melanoma (EORTC 18952): randomised controlled trial. Lancet 366(9492), 1189-1196 (2005).
    • (2005) Lancet , vol.366 , Issue.9492 , pp. 1189-1196
    • Eggermont, A.M.1    Suciu, S.2    MacKie, R.3
  • 66
    • 46749103710 scopus 로고    scopus 로고
    • Adjuvant therapy with pegylated interferon alfa-2b versus observation alone in resected stage III melanoma: Final results of EORTC 18991, a randomised Phase III trial
    • Eggermont AM, Suciu S, Santinami M et al. Adjuvant therapy with pegylated interferon alfa-2b versus observation alone in resected stage III melanoma: final results of EORTC 18991, a randomised Phase III trial. Lancet 372(9633), 117-126 (2008).
    • (2008) Lancet , vol.372 , Issue.9633 , pp. 117-126
    • Eggermont, A.M.1    Suciu, S.2    Santinami, M.3
  • 67
    • 0034013092 scopus 로고    scopus 로고
    • Adjuvant interferon in the treatment of melanoma
    • Kirkwood JM. Adjuvant interferon in the treatment of melanoma. Br. J. Cancer 82(10), 1755-1756 (2000).
    • (2000) Br. J. Cancer , vol.82 , Issue.10 , pp. 1755-1756
    • Kirkwood, J.M.1
  • 68
    • 77950576363 scopus 로고    scopus 로고
    • Interferon alpha adjuvant therapy in patients with high-risk melanoma: A systematic review and meta-analysis
    • Mocellin S, Pasquali S, Rossi CR, Nitti D. Interferon alpha adjuvant therapy in patients with high-risk melanoma: A systematic review and meta-analysis. J. Natl Cancer Inst. 102(7), 493-501 (2010).
    • (2010) J. Natl Cancer Inst. , vol.102 , Issue.7 , pp. 493-501
    • Mocellin, S.1    Pasquali, S.2    Rossi, C.R.3    Nitti, D.4
  • 69
    • 44849131339 scopus 로고    scopus 로고
    • Adjuvant low-dose interferon {alpha}2a with or without dacarbazine compared with surgery alone: A prospective-randomized Phase III DeCOG trial in melanoma patients with regional lymph node metastasis
    • Garbe C, Radny P, Linse R et al. Adjuvant low-dose interferon {alpha}2a with or without dacarbazine compared with surgery alone: A prospective- randomized Phase III DeCOG trial in melanoma patients with regional lymph node metastasis. Ann. Oncol. 19(6), 1195-1201 (2008).
    • (2008) Ann. Oncol. , vol.19 , Issue.6 , pp. 1195-1201
    • Garbe, C.1    Radny, P.2    Linse, R.3
  • 70
    • 7144264391 scopus 로고    scopus 로고
    • Adjuvant interferon alfa-2a treatment in resected primary stage II cutaneous melanoma. Austrian Malignant Melanoma Cooperative Group
    • Pehamberger H, Soyer HP, Steiner A et al. Adjuvant interferon alfa-2a treatment in resected primary stage II cutaneous melanoma. Austrian Malignant Melanoma Cooperative Group. J. Clin. Oncol. 16(4), 1425-1429 (1998).
    • (1998) J. Clin. Oncol. , vol.16 , Issue.4 , pp. 1425-1429
    • Pehamberger, H.1    Soyer, H.P.2    Steiner, A.3
  • 71
    • 0033085746 scopus 로고    scopus 로고
    • 3year treatment with recombinant interferon-alpha as adjuvant therapy of cutaneous malignant melanoma
    • Ascierto PA, Palmieri G, Parasole R, Daponte A, Castello G. 3year treatment with recombinant interferon-alpha as adjuvant therapy of cutaneous malignant melanoma. Int. J. Mol. Med. 3(3), 303-306 (1999).
    • (1999) Int. J. Mol. Med. , vol.3 , Issue.3 , pp. 303-306
    • Ascierto, P.A.1    Palmieri, G.2    Parasole, R.3    Daponte, A.4    Castello, G.5
  • 72
    • 84871920160 scopus 로고    scopus 로고
    • Real-life experience with pegylated interferon and conventional interferon in adjuvant melanoma therapy
    • Rozati S, Naef L, Levesque MP, French LE, Dummer R. Real-life experience with pegylated interferon and conventional interferon in adjuvant melanoma therapy. J. Immunother. 36(1), 52-56 (2013).
    • (2013) J. Immunother. , vol.36 , Issue.1 , pp. 52-56
    • Rozati, S.1    Naef, L.2    Levesque, M.P.3    French, L.E.4    Dummer, R.5
  • 73
    • 84869212118 scopus 로고    scopus 로고
    • Long-term results of the randomized Phase III trial EORTC 18991 of adjuvant therapy with pegylated interferon alfa-2b versus observation in resected stage III melanoma
    • Eggermont AM, Suciu S, Testori A et al. Long-term results of the randomized Phase III trial EORTC 18991 of adjuvant therapy with pegylated interferon alfa-2b versus observation in resected stage III melanoma. J. Clin. Oncol. 30(31), 3810 (2012).
    • (2012) J. Clin. Oncol. , vol.30 , Issue.31 , pp. 3810
    • Eggermont, A.M.1    Suciu, S.2    Testori, A.3
  • 74
    • 77954801079 scopus 로고    scopus 로고
    • Improved survival with ipilimumab in patients with metastatic melanoma
    • Hodi FS, O'Day SJ, Mcdermott DF et al. Improved survival with ipilimumab in patients with metastatic melanoma. N. Engl. J. Med. 363(8), 711-723 (2010).
    • (2010) N. Engl. J. Med. , vol.363 , Issue.8 , pp. 711-723
    • Hodi, F.S.1    O'day, S.J.2    McDermott, D.F.3
  • 75
    • 84862494584 scopus 로고    scopus 로고
    • Assessment of association between BRAF-V600E mutation status in melanomas and clinical response to ipilimumab
    • Shahabi V, Whitney G, Hamid O et al. Assessment of association between BRAF-V600E mutation status in melanomas and clinical response to ipilimumab. Cancer Immunol. Immunother. 61(5), 733-737 (2012).
    • (2012) Cancer Immunol. Immunother. , vol.61 , Issue.5 , pp. 733-737
    • Shahabi, V.1    Whitney, G.2    Hamid, O.3
  • 76
    • 84856598992 scopus 로고    scopus 로고
    • Melanoma in 2011: A new paradigm tumor for drug development
    • Eggermont AM, Robert C. Melanoma in 2011: A new paradigm tumor for drug development. Nat. Rev. Clin. Oncol. 9(2), 74-76 (2012).
    • (2012) Nat. Rev. Clin. Oncol. , vol.9 , Issue.2 , pp. 74-76
    • Eggermont, A.M.1    Robert, C.2
  • 77
    • 84860446616 scopus 로고    scopus 로고
    • Ipilimumab in patients with melanoma and brain metastases: An open-label, Phase 2 trial
    • Margolin K, Ernstoff MS, Hamid O et al. Ipilimumab in patients with melanoma and brain metastases: an open-label, Phase 2 trial. Lancet Oncol. 13(5), 459-465 (2012).
    • (2012) Lancet Oncol. , vol.13 , Issue.5 , pp. 459-465
    • Margolin, K.1    Ernstoff, M.S.2    Hamid, O.3
  • 78
    • 79952272922 scopus 로고    scopus 로고
    • CTLA4-blocking immunotherapy with ipilimumab for advanced melanoma
    • Tarhini AA, Kirkwood JM. CTLA4-blocking immunotherapy with ipilimumab for advanced melanoma. Oncology (Williston Park) 24(14), 1302, 1304 (2010).
    • (2010) Oncology (Williston Park) , vol.24 , Issue.14 , pp. 1302
    • Tarhini, A.A.1    Kirkwood, J.M.2
  • 79
    • 32644454916 scopus 로고    scopus 로고
    • Prognostic significance of autoimmunity during treatment of melanoma with interferon
    • Gogas H, Ioannovich J, Dafni U et al. Prognostic significance of autoimmunity during treatment of melanoma with interferon. N. Engl. J. Med. 354(7), 709-718 (2006).
    • (2006) N. Engl. J. Med. , vol.354 , Issue.7 , pp. 709-718
    • Gogas, H.1    Ioannovich, J.2    Dafni, U.3
  • 80
    • 73149092567 scopus 로고    scopus 로고
    • Guidelines for the evaluation of immune therapy activity in solid tumors: Immune-related response criteria
    • Wolchok JD, Hoos A, O'Day S et al. Guidelines for the evaluation of immune therapy activity in solid tumors: immune-related response criteria. Clin. Cancer Res. 15(23), 7412-7420 (2009).
    • (2009) Clin. Cancer Res. , vol.15 , Issue.23 , pp. 7412-7420
    • Wolchok, J.D.1    Hoos, A.2    O'day, S.3
  • 81
    • 73149111448 scopus 로고    scopus 로고
    • Do we need a different set of response assessment criteria for tumor immunotherapy? Clin
    • Ribas A, Chmielowski B, Glaspy JA. Do we need a different set of response assessment criteria for tumor immunotherapy? Clin. Cancer Res. 15(23), 7116-7118 (2009).
    • (2009) Cancer Res. , vol.15 , Issue.23 , pp. 7116-7118
    • Ribas, A.1    Chmielowski, B.2    Glaspy, J.A.3
  • 83
    • 74949143594 scopus 로고    scopus 로고
    • Final version of 2009 AJCC melanoma staging and classification
    • Balch CM, Gershenwald JE, Soong SJ et al. Final version of 2009 AJCC melanoma staging and classification. J. Clin. Oncol. 27(36), 6199-6206 (2009).
    • (2009) J. Clin. Oncol. , vol.27 , Issue.36 , pp. 6199-6206
    • Balch, C.M.1    Gershenwald, J.E.2    Soong, S.J.3
  • 84
    • 0025147441 scopus 로고
    • Treatment of metastatic melanoma with an autologous tumor-cell vaccine: Clinical and immunologic results in 64 patients
    • Berd D, Maguire HC, Jr, Mccue P, Mastrangelo MJ. Treatment of metastatic melanoma with an autologous tumor-cell vaccine: clinical and immunologic results in 64 patients. J. Clin. Oncol. 8(11), 1858-1867 (1990).
    • (1990) J. Clin. Oncol. , vol.8 , Issue.11 , pp. 1858-1867
    • Berd, D.1    Maguire Jr., H.C.2    McCue, P.3    Mastrangelo, M.J.4
  • 85
    • 0036896972 scopus 로고    scopus 로고
    • Prolonged survival after complete resection of disseminated melanoma and active immunotherapy with a therapeutic cancer vaccine
    • Hsueh EC, Essner R, Foshag LJ et al. Prolonged survival after complete resection of disseminated melanoma and active immunotherapy with a therapeutic cancer vaccine. J. Clin. Oncol. 20(23), 4549-4554 (2002).
    • (2002) J. Clin. Oncol. , vol.20 , Issue.23 , pp. 4549-4554
    • Hsueh, E.C.1    Essner, R.2    Foshag, L.J.3
  • 86
    • 82455172010 scopus 로고    scopus 로고
    • Therapeutic cancer vaccines: Why so few randomised Phase III studies reflect the initial optimism of Phase II studies
    • Dalgleish AG. Therapeutic cancer vaccines: why so few randomised Phase III studies reflect the initial optimism of Phase II studies. Vaccine 29(47), 8501-8505 (2011).
    • (2011) Vaccine , vol.29 , Issue.47 , pp. 8501-8505
    • Dalgleish, A.G.1
  • 87
    • 34548249596 scopus 로고    scopus 로고
    • An international, randomized, Phase III trial of bacillus Calmette-Guerin (BCG) plus allogeneic melanoma vaccine (MCV) or placebo after complete resection of melanoma metastatic to regional or distant sites
    • Morton DL, Mozillo N, Thompson JF et al. An international, randomized, Phase III trial of bacillus Calmette-Guerin (BCG) plus allogeneic melanoma vaccine (MCV) or placebo after complete resection of melanoma metastatic to regional or distant sites. J. Clin. Oncol. 25(18S), 8508 (2007).
    • (2007) J. Clin. Oncol. , vol.25 , Issue.18 S , pp. 8508
    • Morton, D.L.1    Mozillo, N.2    Thompson, J.F.3
  • 88
    • 0037496082 scopus 로고    scopus 로고
    • Melacine: An allogeneic melanoma tumor cell lysate vaccine
    • Sosman JA, Sondak VK. Melacine: an allogeneic melanoma tumor cell lysate vaccine. Expert Rev. Vaccines 2(3), 353-368 (2003).
    • (2003) Expert Rev. Vaccines , vol.2 , Issue.3 , pp. 353-368
    • Sosman, J.A.1    Sondak, V.K.2
  • 90
    • 0029080474 scopus 로고
    • Exposing the immunology of naked DNA vaccines
    • Pardoll DM, Beckerleg AM. Exposing the immunology of naked DNA vaccines. Immunity 3(2), 165-169 (1995).
    • (1995) Immunity , vol.3 , Issue.2 , pp. 165-169
    • Pardoll, D.M.1    Beckerleg, A.M.2
  • 92
    • 0033848628 scopus 로고    scopus 로고
    • High-dose recombinant interleukin-2 therapy in patients with metastatic melanoma: Long-term survival update
    • Atkins MB, Kunkel L, Sznol M, Rosenberg SA. High-dose recombinant interleukin-2 therapy in patients with metastatic melanoma: long-term survival update. Cancer J. Sci. Am. 6(Suppl. 1), S11-S14 (2000).
    • (2000) Cancer J. Sci. Am. , vol.6 , Issue.SUPPL. 1
    • Atkins, M.B.1    Kunkel, L.2    Sznol, M.3    Rosenberg, S.A.4
  • 93
    • 14644390867 scopus 로고    scopus 로고
    • Rapid and strong human CD8+ T cell responses to vaccination with peptide, IFA, and CpG oligodeoxynucleotide 7909
    • Speiser DE, Lienard D, Rufer N et al. Rapid and strong human CD8+ T cell responses to vaccination with peptide, IFA, and CpG oligodeoxynucleotide 7909. J. Clin. Invest. 115(3), 739-746 (2005).
    • (2005) J. Clin. Invest. , vol.115 , Issue.3 , pp. 739-746
    • Speiser, D.E.1    Lienard, D.2    Rufer, N.3
  • 94
    • 84255186425 scopus 로고    scopus 로고
    • Targeted delivery of TLR ligands to human and mouse dendritic cells strongly enhances adjuvanticity
    • Tacken PJ, Zeelenberg IS, Cruz LJ et al. Targeted delivery of TLR ligands to human and mouse dendritic cells strongly enhances adjuvanticity. Blood 118(26), 6836-6844 (2011).
    • (2011) Blood , vol.118 , Issue.26 , pp. 6836-6844
    • Tacken, P.J.1    Zeelenberg, I.S.2    Cruz, L.J.3
  • 95
    • 47049100427 scopus 로고    scopus 로고
    • Nanoparticles target distinct dendritic cell populations according to their size
    • Manolova V, Flace A, Bauer M, Schwarz K, Saudan P, Bachmann MF. Nanoparticles target distinct dendritic cell populations according to their size. Eur. J. Immunol. 38(5), 1404-1413 (2008).
    • (2008) Eur. J. Immunol. , vol.38 , Issue.5 , pp. 1404-1413
    • Manolova, V.1    Flace, A.2    Bauer, M.3    Schwarz, K.4    Saudan, P.5    Bachmann, M.F.6
  • 96
    • 84868094428 scopus 로고    scopus 로고
    • Nano-particle vaccination combined with TLR-7 and-9 ligands triggers memory and effector CD8(+) Tcell responses in melanoma patients
    • Goldinger SM, Dummer R, Baumgaertner P et al. Nano-particle vaccination combined with TLR-7 and-9 ligands triggers memory and effector CD8(+) Tcell responses in melanoma patients. Eur. J. Immunol. 42(11), 3049-3061 (2012).
    • (2012) Eur. J. Immunol. , vol.42 , Issue.11 , pp. 3049-3061
    • Goldinger, S.M.1    Dummer, R.2    Baumgaertner, P.3
  • 97
    • 77951714425 scopus 로고    scopus 로고
    • Clinical responses in a Phase II study using adoptive transfer of short-term cultured tumor infiltration lymphocytes in metastatic melanoma patients
    • Besser MJ, Shapira-Frommer R, Treves AJ et al. Clinical responses in a Phase II study using adoptive transfer of short-term cultured tumor infiltration lymphocytes in metastatic melanoma patients. Clin. Cancer Res. 16(9), 2646-2655 (2010).
    • (2010) Clin. Cancer Res. , vol.16 , Issue.9 , pp. 2646-2655
    • Besser, M.J.1    Shapira-Frommer, R.2    Treves, A.J.3
  • 98
    • 77954939175 scopus 로고    scopus 로고
    • Prostate cancer as a model for tumour immunotherapy
    • Drake CG. Prostate cancer as a model for tumour immunotherapy. Nat. Rev. Immunol. 10(8), 580-593 (2010).
    • (2010) Nat. Rev. Immunol. , vol.10 , Issue.8 , pp. 580-593
    • Drake, C.G.1
  • 99
    • 0024222522 scopus 로고
    • Current approaches to the adoptive immunotherapy of cancer
    • Yang JC, Rosenberg SA. Current approaches to the adoptive immunotherapy of cancer. Adv. Exp. Med. Biol. 233, 459-467 (1988).
    • (1988) Adv. Exp. Med. Biol. , vol.233 , pp. 459-467
    • Yang, J.C.1    Rosenberg, S.A.2
  • 100
    • 0027471898 scopus 로고
    • Specific activation and targeting of cytotoxic lymphocytes through chimeric single chains consisting of antibody-binding domains and the gamma or zeta subunits of the immunoglobulin and Tcell receptors
    • Eshhar Z, Waks T, Gross G, Schindler DG. Specific activation and targeting of cytotoxic lymphocytes through chimeric single chains consisting of antibody-binding domains and the gamma or zeta subunits of the immunoglobulin and Tcell receptors. Proc. Natl Acad. Sci. USA 90(2), 720-724 (1993).
    • (1993) Proc. Natl Acad. Sci. USA , vol.90 , Issue.2 , pp. 720-724
    • Eshhar, Z.1    Waks, T.2    Gross, G.3    Schindler, D.G.4
  • 101
    • 18344375283 scopus 로고    scopus 로고
    • Immunotherapy and chemotherapy-A practical partnership
    • Lake RA, Robinson BW. Immunotherapy and chemotherapy-a practical partnership. Nat. Rev. Cancer 5(5), 397-405 (2005).
    • (2005) Nat. Rev. Cancer , vol.5 , Issue.5 , pp. 397-405
    • Lake, R.A.1    Robinson, B.W.2
  • 102
    • 62749185585 scopus 로고    scopus 로고
    • Fludarabine modulates immune response and extends in vivo survival of adoptively transferred CD8 T cells in patients with metastatic melanoma
    • Wallen H, Thompson JA, Reilly JZ, Rodmyre RM, Cao J, Yee C. Fludarabine modulates immune response and extends in vivo survival of adoptively transferred CD8 T cells in patients with metastatic melanoma. PLoS ONE 4(3), e4749 (2009).
    • (2009) PLoS ONE , vol.4 , Issue.3
    • Wallen, H.1    Thompson, J.A.2    Reilly, J.Z.3    Rodmyre, R.M.4    Cao, J.5    Yee, C.6
  • 103
    • 84856001071 scopus 로고    scopus 로고
    • Tumor associated antigen specific Tcell populations identified in ex vivo expanded TIL cultures
    • Junker N, Kvistborg P, Kollgaard T, Straten P, Andersen MH, Svane IM. Tumor associated antigen specific Tcell populations identified in ex vivo expanded TIL cultures. Cell. Immunol. 273(1), 1-9 (2012).
    • (2012) Cell. Immunol. , vol.273 , Issue.1 , pp. 1-9
    • Junker, N.1    Kvistborg, P.2    Kollgaard, T.3    Straten, P.4    Andersen, M.H.5    Svane, I.M.6
  • 104
    • 84855182399 scopus 로고    scopus 로고
    • Adoptive cell therapy for patients with melanoma
    • Dudley ME. Adoptive cell therapy for patients with melanoma. J. Cancer 2, 360-362 (2011).
    • (2011) J. Cancer , vol.2 , pp. 360-362
    • Dudley, M.E.1
  • 105
    • 79960299888 scopus 로고    scopus 로고
    • Durable complete responses in heavily pretreated patients with metastatic melanoma using Tcell transfer immunotherapy
    • Rosenberg SA, Yang JC, Sherry RM et al. Durable complete responses in heavily pretreated patients with metastatic melanoma using Tcell transfer immunotherapy. Clin. Cancer Res. 17(13), 4550-4557 (2011).
    • (2011) Clin. Cancer Res. , vol.17 , Issue.13 , pp. 4550-4557
    • Rosenberg, S.A.1    Yang, J.C.2    Sherry, R.M.3
  • 106
    • 50649087258 scopus 로고    scopus 로고
    • Molecular mechanisms of MHC class i abnormalities and APM components in human tumors
    • Seliger B. Molecular mechanisms of MHC class I abnormalities and APM components in human tumors. Cancer Immunol. Immunother. 57(11), 1719-1726 (2008).
    • (2008) Cancer Immunol. Immunother. , vol.57 , Issue.11 , pp. 1719-1726
    • Seliger, B.1
  • 107
    • 80051775476 scopus 로고    scopus 로고
    • T cells with chimeric antigen receptors have potent antitumor effects and can establish memory in patients with advanced leukemia
    • Kalos M, Levine BL, Porter DL et al. T cells with chimeric antigen receptors have potent antitumor effects and can establish memory in patients with advanced leukemia. Sci. Transl Med. 3(95), 95ra73 (2011).
    • (2011) Sci. Transl Med. , vol.3 , Issue.95
    • Kalos, M.1    Levine, B.L.2    Porter, D.L.3
  • 108
    • 79955517235 scopus 로고    scopus 로고
    • CD28 costimulation improves expansion and persistence of chimeric antigen receptor-modified T cells in lymphoma patients
    • Savoldo B, Ramos CA, Liu E et al. CD28 costimulation improves expansion and persistence of chimeric antigen receptor-modified T cells in lymphoma patients. J. Clin. Invest. 121(5), 1822-1826 (2011).
    • (2011) J. Clin. Invest. , vol.121 , Issue.5 , pp. 1822-1826
    • Savoldo, B.1    Ramos, C.A.2    Liu, E.3
  • 109
    • 70149114880 scopus 로고    scopus 로고
    • Gene therapy with human and mouse Tcell receptors mediates cancer regression and targets normal tissues expressing cognate antigen
    • Johnson LA, Morgan RA, Dudley ME et al. Gene therapy with human and mouse Tcell receptors mediates cancer regression and targets normal tissues expressing cognate antigen. Blood 114(3), 535-546 (2009).
    • (2009) Blood , vol.114 , Issue.3 , pp. 535-546
    • Johnson, L.A.1    Morgan, R.A.2    Dudley, M.E.3
  • 110
    • 18544380239 scopus 로고    scopus 로고
    • Tumor-associated B7-H1 promotes Tcell apoptosis: A potential mechanism of immune evasion
    • Dong H, Strome SE, Salomao DR et al. Tumor-associated B7-H1 promotes Tcell apoptosis: A potential mechanism of immune evasion. Nat. Med. 8(8), 793-800 (2002).
    • (2002) Nat. Med. , vol.8 , Issue.8 , pp. 793-800
    • Dong, H.1    Strome, S.E.2    Salomao, D.R.3
  • 111
    • 84858766182 scopus 로고    scopus 로고
    • The blockade of immune checkpoints in cancer immunotherapy
    • Pardoll DM. The blockade of immune checkpoints in cancer immunotherapy. Nat. Rev. Cancer 12(4), 252-264 (2012).
    • (2012) Nat. Rev. Cancer , vol.12 , Issue.4 , pp. 252-264
    • Pardoll, D.M.1
  • 112
    • 84857405450 scopus 로고    scopus 로고
    • Ipilimumab, a promising immunotherapy with increased overall survival in metastatic melanoma? Dermatol
    • Pierard GE, Aubin F, Humbert P. Ipilimumab, a promising immunotherapy with increased overall survival in metastatic melanoma? Dermatol. Res. Pract. 2012, 182157 (2012).
    • (2012) Res. Pract. , vol.2012 , pp. 182157
    • Pierard, G.E.1    Aubin, F.2    Humbert, P.3
  • 113
    • 59849116262 scopus 로고    scopus 로고
    • Immunization with analog peptide in combination with CpG and montanide expands tumor antigen-specific CD8+ T cells in melanoma patients
    • Fourcade J, Kudela P, Andrade Filho PA et al. Immunization with analog peptide in combination with CpG and montanide expands tumor antigen-specific CD8+ T cells in melanoma patients. J. Immunother. 31(8), 781-791 (2008).
    • (2008) J. Immunother. , vol.31 , Issue.8 , pp. 781-791
    • Fourcade, J.1    Kudela, P.2    Andrade Filho, P.A.3
  • 114
    • 74049118785 scopus 로고    scopus 로고
    • Tumorreactive CD8+ Tcell responses after vaccination with NY-ESO-1 peptide, CpG 7909 and Montanide ISA-51: Association with survival
    • Karbach J, Gnjatic S, Bender A et al. Tumorreactive CD8+ Tcell responses after vaccination with NY-ESO-1 peptide, CpG 7909 and Montanide ISA-51: association with survival. Int. J. Cancer 126(4), 909-918 (2010).
    • (2010) Int. J. Cancer , vol.126 , Issue.4 , pp. 909-918
    • Karbach, J.1    Gnjatic, S.2    Bender, A.3
  • 115
    • 79960732805 scopus 로고    scopus 로고
    • Combination of lentivector immunization and low-dose chemotherapy or PD-1/PD-L1 blocking primes self-reactive T cells and induces anti-tumor immunity
    • Sierro SR, Donda A, Perret R et al. Combination of lentivector immunization and low-dose chemotherapy or PD-1/PD-L1 blocking primes self-reactive T cells and induces anti-tumor immunity. Eur. J. Immunol. 41(8), 2217-2228 (2011).
    • (2011) Eur. J. Immunol. , vol.41 , Issue.8 , pp. 2217-2228
    • Sierro, S.R.1    Donda, A.2    Perret, R.3
  • 117
    • 63449124514 scopus 로고    scopus 로고
    • Anti-programmed death-1 synergizes with granulocyte macrophage colony-stimulating factor-secreting tumor cell immunotherapy providing therapeutic benefit to mice with established tumors
    • Li B, Vanroey M, Wang C, Chen TH, Korman A, Jooss K. Anti-programmed death-1 synergizes with granulocyte macrophage colony-stimulating factor-secreting tumor cell immunotherapy providing therapeutic benefit to mice with established tumors. Clin. Cancer Res. 15(5), 1623-1634 (2009).
    • (2009) Clin. Cancer Res. , vol.15 , Issue.5 , pp. 1623-1634
    • Li, B.1    Vanroey, M.2    Wang, C.3    Chen, T.H.4    Korman, A.5    Jooss, K.6
  • 118
    • 0034788243 scopus 로고    scopus 로고
    • MHC antigens and tumor escape from immune surveillance
    • Garrido F, Algarra I. MHC antigens and tumor escape from immune surveillance. Adv. Cancer Res. 83, 117-158 (2001).
    • (2001) Adv. Cancer Res. , vol.83 , pp. 117-158
    • Garrido, F.1    Algarra, I.2
  • 119
    • 0031080901 scopus 로고    scopus 로고
    • Implications for immunosurveillance of altered HLA class i phenotypes in human tumours
    • Garrido F, Ruiz-Cabello F, Cabrera T et al. Implications for immunosurveillance of altered HLA class I phenotypes in human tumours. Immunol. Today 18(2), 89-95 (1997).
    • (1997) Immunol. Today , vol.18 , Issue.2 , pp. 89-95
    • Garrido, F.1    Ruiz-Cabello, F.2    Cabrera, T.3
  • 120
    • 84861651644 scopus 로고    scopus 로고
    • Regression of melanoma metastases after immunotherapy is associated with activation of antigen presentation and interferon-mediated rejection genes
    • Carretero R, Wang E, Rodriguez AI et al. Regression of melanoma metastases after immunotherapy is associated with activation of antigen presentation and interferon-mediated rejection genes. Int. J. Cancer 131(2), 387-395 (2012).
    • (2012) Int. J. Cancer , vol.131 , Issue.2 , pp. 387-395
    • Carretero, R.1    Wang, E.2    Rodriguez, A.I.3
  • 121
    • 0028364620 scopus 로고
    • HLA class i alleles and responsiveness of melanoma to immunotherapy with interferon-alpha (IFN-alpha) and interleukin-2 (IL-2)
    • Scheibenbogen C, Keilholz U, Mytilineos J, Suciu S, Manasterski M, Hunstein W. HLA class I alleles and responsiveness of melanoma to immunotherapy with interferon-alpha (IFN-alpha) and interleukin-2 (IL-2). Melanoma Res. 4(3), 191-194 (1994).
    • (1994) Melanoma Res. , vol.4 , Issue.3 , pp. 191-194
    • Scheibenbogen, C.1    Keilholz, U.2    Mytilineos, J.3    Suciu, S.4    Manasterski, M.5    Hunstein, W.6
  • 122
    • 0035425425 scopus 로고    scopus 로고
    • Factors associated with response to high-dose interleukin-2 in patients with metastatic melanoma
    • Phan GQ, Attia P, Steinberg SM, White DE, Rosenberg SA. Factors associated with response to high-dose interleukin-2 in patients with metastatic melanoma. J. Clin. Oncol. 19(15), 3477-3482 (2001).
    • (2001) J. Clin. Oncol. , vol.19 , Issue.15 , pp. 3477-3482
    • Phan, G.Q.1    Attia, P.2    Steinberg, S.M.3    White, D.E.4    Rosenberg, S.A.5
  • 123
    • 78650640612 scopus 로고    scopus 로고
    • Messenger RNA-based vaccines with dual activity induce balanced TLR-7 dependent adaptive immune responses and provide antitumor activity
    • Fotin-Mleczek M, Duchardt KM, Lorenz C et al. Messenger RNA-based vaccines with dual activity induce balanced TLR-7 dependent adaptive immune responses and provide antitumor activity. J. Immunother. 34(1), 1-15 (2011).
    • (2011) J. Immunother. , vol.34 , Issue.1 , pp. 1-15
    • Fotin-Mleczek, M.1    Duchardt, K.M.2    Lorenz, C.3
  • 124
    • 1642301553 scopus 로고    scopus 로고
    • Immunostimulating capacities of stabilized RNA molecules
    • Scheel B, Braedel S, Probst J et al. Immunostimulating capacities of stabilized RNA molecules. Eur. J. Immunol. 34(2), 537-547 (2004).
    • (2004) Eur. J. Immunol. , vol.34 , Issue.2 , pp. 537-547
    • Scheel, B.1    Braedel, S.2    Probst, J.3
  • 125
    • 33749624177 scopus 로고    scopus 로고
    • Cancer regression in patients after transfer of genetically engineered lymphocytes
    • Morgan RA, Dudley ME, Wunderlich JR et al. Cancer regression in patients after transfer of genetically engineered lymphocytes. Science 314(5796), 126-129 (2006).
    • (2006) Science , vol.314 , Issue.5796 , pp. 126-129
    • Morgan, R.A.1    Dudley, M.E.2    Wunderlich, J.R.3
  • 126
    • 79952304769 scopus 로고    scopus 로고
    • Tumor regression in patients with metastatic synovial cell sarcoma and melanoma using genetically engineered lymphocytes reactive with NY-ESO-1
    • Robbins PF, Morgan RA, Feldman SA et al. Tumor regression in patients with metastatic synovial cell sarcoma and melanoma using genetically engineered lymphocytes reactive with NY-ESO-1. J. Clin. Oncol. 29(7), 917-924 (2011).
    • (2011) J. Clin. Oncol. , vol.29 , Issue.7 , pp. 917-924
    • Robbins, P.F.1    Morgan, R.A.2    Feldman, S.A.3
  • 127
    • 77957744369 scopus 로고    scopus 로고
    • Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity
    • Sakuishi K, Apetoh L, Sullivan JM, Blazar BR, Kuchroo VK, Anderson AC. Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity. J. Exp. Med. 207(10), 2187-2194 (2010).
    • (2010) J. Exp. Med. , vol.207 , Issue.10 , pp. 2187-2194
    • Sakuishi, K.1    Apetoh, L.2    Sullivan, J.M.3    Blazar, B.R.4    Kuchroo, V.K.5    Anderson, A.C.6
  • 128
    • 84863115998 scopus 로고    scopus 로고
    • Immune inhibitory molecules LAG-3 and PD-1 synergistically regulate Tcell function to promote tumoral immune escape
    • Woo SR, Turnis ME, Goldberg MV et al. Immune inhibitory molecules LAG-3 and PD-1 synergistically regulate Tcell function to promote tumoral immune escape. Cancer Res. 72(4), 917-927 (2012).
    • (2012) Cancer Res. , vol.72 , Issue.4 , pp. 917-927
    • Woo, S.R.1    Turnis, M.E.2    Goldberg, M.V.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.