Substantial neuroprotection against K+ deprivation-induced apoptosis in primary cerebellar granule neurons by novel dimer bis(propyl)-cognitin via the activation of VEGFR-2 signaling pathway

CNS Neuroscience and Therapeutics

Volumn 19, Issue 10, 2013, Pages 764-772

  Hu, Sheng Quan ^a   Cui, Wei ^a   Xu, Da Ping ^a   Mak, Shing Hung ^a   Tang, Jing ^b   Choi, Chung Lit ^a   Pang, Yuan Ping ^b   Han, Yi Fan ^a  

^a HONG KONG POLYTECHNIC UNIVERSITY   (Hong Kong)

^b MAYO CLINIC CANCER CENTER   (United States)

Author keywords

Akt; Apoptosis; Bis(propyl) cognitin; Extracellular signal regulated kinase; VEGFR 2

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; BIS(PROPYL) COGNITIN; GLYCOGEN SYNTHASE KINASE 3BETA; MITOGEN ACTIVATED PROTEIN KINASE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NEUROPROTECTIVE AGENT; PROTEIN KINASE B; UNCLASSIFIED DRUG; VASCULOTROPIN RECEPTOR 2; VATALANIB;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG INHIBITION; GENE SWITCHING; GRANULE CELL; IC 50; NEUROPROTECTION; NEWBORN; NONHUMAN; POTASSIUM DEFICIENCY; RANDOMIZED CONTROLLED TRIAL; RAT; SIGNAL TRANSDUCTION;

AKT; APOPTOSIS; BIS(PROPYL)-COGNITIN; EXTRACELLULAR SIGNAL-REGULATED KINASE; K+ DEPRIVATION; VEGFR-2;

ANIMALS; APOPTOSIS; CELL SURVIVAL; CELLS, CULTURED; CEREBELLUM; DOSE-RESPONSE RELATIONSHIP, DRUG; NEURONS; NEUROPROTECTIVE AGENTS; POTASSIUM; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; TACRINE; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2;

EID: 84884814549     PISSN: 17555930     EISSN: 17555949     Source Type: Journal    
DOI: 10.1111/cns.12141     Document Type: Article

References (38)

1. Mattson MP. Apoptosis in neurodegenerative disorders. Nat Rev Mol Cell Biol 2000;1:120-129.
2. Ekshyyan O, Aw TY. Apoptosis: a key in neurodegenerative disorders. Curr Neurovasc Res 2004;1:355-371.
3. Mattson MP. Neuronal life-and-death signaling, apoptosis, and neurodegenerative disorders. Antioxid Redox Signal 2006;8:1997-2006.
4. Jana S, Paliwal J. Apoptosis: potential therapeutic targets for new drug discovery. Curr Med Chem 2007;14:2369-2379.
5. Raff MC, Barres BA, Burne JF, Coles HS, Ishizaki Y, Jacobson MD. Programmed cell death and the control of cell survival: lessons from the nervous system. Science 1993;262:695-700.
6. Gallo V, Kingsbury A, Balazs R, Jorgensen OS. The role of depolarization in the survival and differentiation of cerebellar granule cells in culture. J Neurosci 1987;7:2203-2213.
7. Mora A, Sabio G, Gonzalez-Polo RA, et al. Lithium inhibits caspase 3 activation and dephosphorylation of PKB and GSK3 induced by K+ deprivation in cerebellar granule cells. J Neurochem 2001;78:199-206.
8. Severini C, Ciotti MT, Biondini L, et al. TLQP-21, a neuroendocrine VGF-derived peptide, prevents cerebellar granule cells death induced by serum and potassium deprivation. J Neurochem 2008;104:534-544.
9. Zhong J, Deng J, Huang S, Yang X, Lee WH. High K+ and IGF-1 protect cerebellar granule neurons via distinct signaling pathways. J Neurosci Res 2004;75:794-806.
10. Ramiro-Cortes Y, Moran J. Role of oxidative stress and JNK pathway in apoptotic death induced by potassium deprivation and staurosporine in cerebellar granule neurons. Neurochem Int 2009;55:581-592.
11. Atlante A, Bobba A, Paventi G, Pizzuto R, Passarella S. Genistein and daidzein prevent low potassium-dependent apoptosis of cerebellar granule cells. Biochem Pharmacol 2010;79:758-767.
12. Yao L, Li W, She H, et al. Activation of transcription factor MEF2D by bis(3)-cognitin protects dopaminergic neurons and ameliorates Parkinsonian motor defects. J Biol Chem 2012;287:34246-34255.
13. Luo J, Li W, Zhao Y, et al. Pathologically activated neuroprotection via uncompetitive blockade of N-methyl-d-aspartate receptors with fast off-rate by novel multifunctional dimer bis(propyl)-cognitin. J Biol Chem 2010;285:19947-19958.
14. Hu S, Cui W, Mak S, et al. Bis(propyl)-cognitin protects against glutamate-induced neuro-excitotoxicity via concurrent regulation of NO, MAPK/ERK and PI3-K/Akt/GSK3beta pathways. Neurochem Int 2013;62:468-477.
15. Han RW, Zhang RS, Chang M, et al. Reversal of scopolamine-induced spatial and recognition memory deficits in mice by novel multifunctional dimers bis-cognitins. Brain Res 2012;1470:59-68.
16. Carlier PR, Han YF, Chow ES, et al. Evaluation of short-tether bis-THA AChE inhibitors. A further test of the dual binding site hypothesis. Bioorg Med Chem 1999;7:351-357.
17. Hu S, Han R, Mak S, Han Y. Protection against 1-methyl-4-phenylpyridinium ion (MPP+)-induced apoptosis by water extract of ginseng (Panax ginseng C.A. Meyer) in SH-SY5Y cells. J Ethnopharmacol 2011;135:34-42.
18. Barneda-Zahonero B, Minano-Molina A, Badiola N, et al. Bone morphogenetic protein-6 promotes cerebellar granule neurons survival by activation of the MEK/ERK/CREB pathway. Mol Biol Cell 2009;20:5051-5063.
19. Nijhawan D, Honarpour N, Wang X. Apoptosis in neural development and disease. Annu Rev Neurosci 2000;23:73-87.
20. Fu H, Dou J, Li W, et al. Mecamylamine prevents neuronal apoptosis induced by glutamate and low potassium via differential anticholinergic-independent mechanisms. Neuropharmacology 2008;54:755-765.
21. Ishitani R, Sunaga K, Tanaka M, Aishita H, Chuang DM. Overexpression of glyceraldehyde-3-phosphate dehydrogenase is involved in low K+-induced apoptosis but not necrosis of cultured cerebellar granule cells. Mol Pharmacol 1997;51:542-550.
22. See V, Boutillier AL, Bito H, Loeffler JP. Calcium/calmodulin-dependent protein kinase type IV (CaMKIV) inhibits apoptosis induced by potassium deprivation in cerebellar granule neurons. FASEB J 2001;15:134-144.
23. Yeste-Velasco M, Folch J, Casadesus G, Smith MA, Pallas M, Camins A. Neuroprotection by c-Jun NH2-terminal kinase inhibitor SP600125 against potassium deprivation-induced apoptosis involves the Akt pathway and inhibition of cell cycle reentry. Neuroscience 2009;159:1135-1147.
24. Meyer EL, Gahring LC, Rogers SW. Nicotine preconditioning antagonizes activity-dependent caspase proteolysis of a glutamate receptor. J Biol Chem 2002;277:10869-10875.
25. Keck PJ, Hauser SD, Krivi G, et al. Vascular permeability factor, an endothelial cell mitogen related to PDGF. Science 1989;246:1309-1312.
26. Wick A, Wick W, Waltenberger J, Weller M, Dichgans J, Schulz JB. Neuroprotection by hypoxic preconditioning requires sequential activation of vascular endothelial growth factor receptor and Akt. J Neurosci 2002;22:6401-6407.
27. Rosenstein JM, Mani N, Khaibullina A, Krum JM. Neurotrophic effects of vascular endothelial growth factor on organotypic cortical explants and primary cortical neurons. J Neurosci 2003;23:11036-11044.
28. Zachary I. Neuroprotective role of vascular endothelial growth factor: signalling mechanisms, biological function, and therapeutic potential. Neurosignals 2005;14:207-221.
29. Matsuzaki H, Tamatani M, Yamaguchi A, et al. Vascular endothelial growth factor rescues hippocampal neurons from glutamate-induced toxicity: signal transduction cascades. FASEB J 2001;15:1218-1220.
30. Dudek H, Datta SR, Franke TF, et al. Regulation of neuronal survival by the serine-threonine protein kinase Akt. Science 1997;275:661-665.
31. Zhu D, Jiang X, Wu X, et al. Inhibition of protein kinase C promotes neuronal survival in low potassium through an Akt-dependent pathway. Neurotox Res 2004;6:281-289.
32. Zhong J, Yao W, Lee W. Cesium chloride protects cerebellar granule neurons from apoptosis induced by low potassium. Int J Dev Neurosci 2007;25:359-365.
33. Bonni A, Brunet A, West AE, Datta SR, Takasu MA, Greenberg ME. Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms. Science 1999;286:1358-1362.
34. Subramaniam S, Strelau J, Unsicker K. Growth differentiation factor-15 prevents low potassium-induced cell death of cerebellar granule neurons by differential regulation of Akt and ERK pathways. J Biol Chem 2003;278:8904-8912.
35. Oda K, Matsuoka Y, Funahashi A, Kitano H. A comprehensive pathway map of epidermal growth factor receptor signaling. Mol Syst Biol 2005;1:2005.0010.
36. Holmes K, Roberts OL, Thomas AM, Cross MJ. Vascular endothelial growth factor receptor-2: structure, function, intracellular signalling and therapeutic inhibition. Cell Signal 2007;19:2003-2012.
37. Storkebaum E, Lambrechts D, Dewerchin M, et al. Treatment of motoneuron degeneration by intracerebroventricular delivery of VEGF in a rat model of ALS. Nat Neurosci 2005;8:85-92.
38. Takahashi H, Shibuya M. The vascular endothelial growth factor (VEGF)/VEGF receptor system and its role under physiological and pathological conditions. Clin Sci (Lond) 2005;109:227-241.