Inhibition of protein kinase C promotes neuronal survival in low potassium through an Akt-dependent pathway

Neurotoxicity Research

Volumn 6, Issue 4, 2004, Pages 281-289

  Zhu, Daming ^a   Jiang, Xueying ^a   Wu, Xuan ^a   Tian, Feng ^a   Mearow, Karen ^b   Lipsky, Robert H ^c   Marini, Ann M ^a  

^a UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES   (United States)

^b MEMORIAL UNIVERSITY OF NEWFOUNDLAND   (Canada)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

BDNF; Low potassium; Phosphatidylinositol 3 kinase Akt; PKC; PKC ; Rat cerebellar granule neurons

Indexed keywords

AKT1 PROTEIN, RAT; ONCOPROTEIN; POTASSIUM; PROTEIN KINASE B; PROTEIN KINASE C; PROTEIN KINASE INHIBITOR; PROTEIN SERINE THREONINE KINASE;

ANIMAL; ARTICLE; CELL CULTURE; CELL SURVIVAL; COMPARATIVE STUDY; DRUG ANTAGONISM; DRUG EFFECT; METABOLISM; NERVE CELL; PHYSIOLOGY; RAT; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT;

ANIMALS; CELL SURVIVAL; CELLS, CULTURED; NEURONS; POTASSIUM; PROTEIN KINASE C; PROTEIN KINASE INHIBITORS; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION;

EID: 21644431803     PISSN: 10298428     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF03033438     Document Type: Article

References (47)

1. Balazs R, V Gallo and A Kingsbury (1988a) Effect of depolarization on the maturation of cerebellar granule cells in culture. Brain Res. 468, 269-276.
2. Balazs R, OS Jorgensen and N Hack (1988b) N-methyl-D-aspartate promotes the survival of cerebellar granule cells in culture. Neuroscience 27, 437-451.
3. Batistatou A and LA Greene (1993) Internucleosomal DNA cleavage and neuronal cell survival/death. J. Cell. Biol. 122, 523-532.
4. Bhave SV, L Ghoda and PL Hoffman (1999) Brain-derived neurotrophic factor mediates the anti-apoptotic effect of NMDA in cerebellar granule neurons, signal transduction cascades and site of ethanol action. J. Neurosci. 19, 3277-3286.
5. Blair LA, KK Bence-Hanulec, S Mehta, T Franke, D Kaplan and J Marshall (1999) Akt-dependent potentiation of L channels by insulin-like growth factor-1 is required for neuronal survival. J. Neurosci. 19, 1940-1951.
6. Corbit KC, J-W Soh, K Yoshida, EM Eves, IB Weinstein and MR Rosner (2000) Different protein kinase C isoforms determine growth factor specificity in neuronal cells. Mol. Cell. Biol. 20, 5392-5403.
7. D'Mello SR, C Galli, T Ciotti and P Calissano (1993) Induction of apoptosis in cerebellar granule neurons by low potassium: Inhibition of death by insulin-like growth factor I and cAMP. Proc. Natl. Acad. Sci. USA 90, 10989-10993.
8. D'Mello SR, K Borodezt and SP Soltoff (1997) Insulin-like growth factor and potassium depolarization maintain neuronal survival by distinct pathways: Possible involvement of PI 3-kinase in IGF-1 signaling. J. Neurosci. 17, 1548-1560.
9. Dekker LV and PJ Parker (1994) Protein kinase C-a question of specificity. Trends Biochem. Sci. 19, 73-77.
10. Ditlevsen DK, LB Kohler, MV Pedersen, M Risell, K Kolkova, M Meyer, V Berezin and E Bock (2003) The role of phosphatidylinositol 3-kinase in neural cell adhesion molecule-mediated neu-ronal differentiation and survival. J. Neurochem. 84, 546-556.
11. Dodge ME, M Rahimtula and KM Mearow (2002) Factors contributing to neurotrophin-independent survival of adult sensory neurons. Brain Res. 953, 144-156.
12. Doornbos RP, M Theelen, PC van der Hoeven, WJ van Blitterswijk, AJ Verkleij and PM van Bergen en Henegouwen (1999) Protein kinase Czeta is a negative regulator of protein kinase B activity. J. Biol. Chem. 274, 8589-8596.
13. Dudek H, SR Datta, TF Franke, MJ Birnbaum, R Yao, GM Cooper, RA Segal, DR Kaplan and ME Greenberg (1997) Regulation of neuronal survival by the serine-threonine protein kinase Akt. Science 275, 661-665.
14. Gallo V, A Kingsbury, R Balazs and OS Jorgensen (1987) The role of depolarization in the survival and differentiation of cerebellar granule cells in culture. J. Neurosci. 7, 2203-2213.
15. Ghourmari AM, R Wehrlé, CI De Zeeuw, C Sotelo and I Dusart (2002) Inhibition of protein kinase C prevents purkinje cell death but does not affect axonal regeneration. J. Neurosci. 22, 3531-3542.
16. Gonzalez MI, PG Bannerman and MB Robinson (2003) Phorbol myristate acetate-dependent interaction of protein kinase Cα and the neuronal glutamate transporter EAAC1. J. Neurosci. 23, 5589-5593.
17. Ha KS, KM Kim, YG Kwon, SK Bai, WD Nam, YM Yoo, PK Kim, HT Chung, TR Billiar and YM Kim (2003) Nitric oxide prevents 6-hydroxydopamine-induced apoptosis in PC12 cells through cGMP-dependent PI3 kinase/Akt activation. FASEB J. 17, 1036-1047.
18. Hamabe W, R Fujita and H Ueda (2003) Neuronal necrosis inhibition by insulin through protein kinase C-activation. J. Pharmacol. Exp. Ther. 307, 205-212.
19. Ichikawa D, A Tabuchi, A Taoka, T Tsuchiya and M Tsuda (1998) Attenuation of cell death mediated by membrane depolarization different from that by exogenous BDNF in cultured mouse cere-bellar granule cells. Mol. Brain Res. 56, 218-226.
20. Kaplan DR and FD Miller (2000) Neurotrophin signal transduction in the nervous system. Curr. Opin. Neurobiol. 10, 381-391.
21. Kaplan DR, BL Hempstead, D Martin-Zanca, MV Chao and LF Parada (1991) The trk proto-oncogene product, a signal transducing receptor for nerve growth factor. Science 252, 554-558.
22. Kubo T, T Nonomura, Y Enokido and H Hatanaka (1995) Brain-derived neurotrophic factor (BDNF) can prevent apoptosis of rat cerebellar granule neurons in culture. Dev. Brain Res. 85, 249-258.
23. Kumari S, X Liu, T Nguyen, X Zhang and SR D'Mello (2001) Distinct phosphorylation patterns underlie Akt activation by different survival factors in neurons. Mol. Brain Res. 96, 157-162.
24. 2+-MAPK/ERK pathways. J. Neurochem. 87, 508-521.
25. Lamballe F, R Klein and M Barbacid (1991) TrkC, a new member of the trk family of tyrosine protein kinases, is a receptor for neurotrophin-3. Cell 66, 967-979.
26. Li J, S Dokka, L Wang, X Shi, V Castranova, Y Yan, M Costa and C Huang (2004) Activation of PKCα is required for vanadate-induced phosphorylation of protein kinase B (Akt), but not p70S6k in mouse epidermal JB6 cells. Mol. Cell. Biochem. 255, 217-225.
27. Lin Y and JB Long (1996) Acute or prolonged exposure to 1-aminocyclopropane-carboxylic acid protects spinal neurons against NMDA toxicity. Eur. J. Pharmacol. 318, 491-496.
28. Lin WW, CW Wang and DM Chuang (1997) Effects of depolarization and NMDA antagonists on the role survival of cerebellar granule cells: A pivotal role for protein kinase C isoforms. J. Neurochem. 68, 2577-2586.
29. Marini AM, JP Schwartz and IJ Kopin (1989) The neurotoxicity of 1-methyl-4-phenylpyridinium in cultured cerebellar granule cells. J. Neurosci. 9, 3665-3672.
30. Marini AM and SM Paul (1992) N-Methyl-D-aspartate receptor-mediated neuroprotection in cerebellar granule cells requires new RNA and protein synthesis. Proc. Natl. Acad. Sci. USA 89, 6555-6559.
31. Marini AM, SJ Rabin, RH Lipsky and I Mocchetti (1998) Activity-dependent release of brain-derived neurotrophic factor underlies the neuroprotective effect of N-Methyl-D-aspartate. J. Biol. Chem. 273, 29394-29399.
32. Matsumoto M, W Ogawa, Y Hino, K Furukawa, Y Ono, M Takahashi, M Ohba, T Kuroki and M Kasuga (2001) Inhibition of insulin-induced activation of Akt by a kinase-deficient mutant of the epsilon isozyme of protein kinase C. J. Biol. Chem. 276, 14400-14406.
33. + deprivation in cerebellar granule cells. J. Neurochem. 78, 199-206.
34. Poser S, S Impey, Z Xia and DR Storm (2003) Brain-derived neurotrophic factor protection of cortical neurons from serum withdrawal-induced apoptosis is inhibited by cAMP. J. Neurosci. 23, 4420-4427.
35. Shankar SL, K O'Guin, M Cammer, FA McMorris, TN Stitt, RS Basch, B Varnum and B Shafit-Zagardo (2003) The growth arrest-specific gene product Gas6 promotes the survival of human oligodendrocytes via a phosphatidylinositol 3-kinase-dependent pathway. J. Neurosci. 23, 4208-4218.
36. +-induced apoptosis of cere-bellar granule neurons Brain Res. Dev. Brain Res. 101, 197-206.
37. +-induced apoptosis of cerebellar granule neurons via Akt kinase activation. FEBS Lett. 437, 221-224.
38. Subramaniam S, J Strelau and K Unsicker (2003) Growth differential factor-15 prevents low potassium-induced cell death of cerebellar granule neurons by differential regulation of Akt and ERK pathways. J. Biol. Chem. 278, 8904-8912.
39. Tanaka S and T Koike (2001) Activation of protein kinase C delays apoptosis of nerve growth factor-deprived rat sympathetic neurons through a Ca(2+)-influx dependent mechanism. Neurosci. Lett. 313, 9-12.
40. Tanaka Y, MV Gavrielides, Y Mitsuuchi and T Fujii (2003) Protein kinase C promotes apoptosis in LNCaP prostate cancer cells through activation of p38 MAPK and inhibition of the Akt survival pathway. J. Biol. Chem. 278, 33753-33762.
41. Taylor CW (2002) Controlling calcium entry. Cell 111, 767-769.
42. Wen HC, WC Huang, A Ali, JR Woodgett and WW Lin (2003) Negative regulation of phosphatidylinositol 3-kinase and Akt signalling pathway by PKC. Cell Signal. 15, 37-45.
43. Yan G-M, B Ni, M Weller, KA Wood and SM Paul (1994) Depolarization or glutamate receptor activation blocks apoptotic cell death of cultured cerebellar granule neurons. Brain Res. 656, 43-51.
44. Yu O and DM Chuang (1997) Neurotrophin protection against toxicity induced by low potassium and nitroprusside in cultured cerebellar granule neurons. J. Neurochem. 68, 68-77.
45. Zhang L, T Himi, I Morita and S Murota (2000) Hepatocyte growth factor protects cultured rat cerebellar granule neurons from apoptosis via the phosphatidylinotositol-3 kinase/Akt pathway. J. Neurosci. Res. 59, 489-496.
46. Zhong M, Z Lu and DA Foster (2002) Downregulation PKC delta provides a PI3K/Akt-independent survival signal that overcomes apoptotic signals generated by c-Src overexpression. Oncogene 21, 1071-1078.
47. + and IGF-1 protect cerebellar granule neurons via distinct signaling pathways. J. Neurosci. Res. 75, 794-806.