Development of long-acting bioadhesive vaginal gels of oxybutynin: Formulation, in vitro and in vivo evaluations

International Journal of Pharmaceutics

Volumn 457, Issue 1, 2013, Pages 25-39

  Tuǧcu Demiröz, Fatmanur ^a   Acartürk, Füsun ^a   Erdoǧan, Deniz ^a  

^a GAZI UNIVERSITY   (Turkey)

Author keywords

Bioadhesive vaginal gel; Chitosan; HPMC; Overactive bladder; Oxybutynin; Poloxamer 407

Indexed keywords

CHITOSAN; HYDROXYPROPYLMETHYLCELLULOSE; OXYBUTYNIN; POLOXAMER; UNCLASSIFIED DRUG; UROPAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CONFORMATIONAL TRANSITION; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; COVALENT BOND; DRUG BIOAVAILABILITY; DRUG DIFFUSION; DRUG DOSAGE FORM COMPARISON; DRUG FORMULATION; DRUG SCREENING; EXPERIMENTAL RABBIT; FEMALE; GEL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HISTOLOGY; HYDROPHILICITY; IN VITRO STUDY; IN VIVO STUDY; MUCOADHESION; NONHUMAN; OVERACTIVE BLADDER; PH MEASUREMENT; PRIORITY JOURNAL; VAGINA MUCOSA; VAGINAL DRYNESS; VISCOSITY;

ACETONITRILE (PUBCHEM CID: 6342); BIOADHESIVE VAGINAL GEL; CHITOSAN; GLACIAL ACETIC ACID (PUBCHEM CID: 176); GLUTARALDEHYDE (PUBCHEM CID: 3485); HEXANE (PUBCHEM CID: 8058); HPMC; OSMIUM TETROXIDE (PUBCHEM CID: 30318); OVERACTIVE BLADDER; OXYBUTYNIN; OXYBUTYNIN HYDROCHLORIDE (PUBCHEM CID: 91505); POLOXAMER (PUBCHEM CID: 24751); POLOXAMER 407; PROPIVERINE (PUBCHEM CID: 4942);

ADHESIVENESS; ANIMALS; CHITOSAN; DELAYED-ACTION PREPARATIONS; FEMALE; MANDELIC ACIDS; MUCOUS MEMBRANE; RABBITS; URINARY BLADDER, OVERACTIVE; UROLOGICAL AGENTS; VAGINA; VAGINAL CREAMS, FOAMS, AND JELLIES;

EID: 84884747217     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2013.09.003     Document Type: Article

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