Microparticulated anti-HIV vaginal gel: In vitro-in vivo drug release and vaginal irritation study

Pharmaceutical Development and Technology

Volumn 16, Issue 5, 2011, Pages 466-473

  Chatterjee, Arkendu ^a   Kumar, Lalit ^a   Bhowmik, Benoy Brata ^a   Gupta, Amlan ^b  

^a HIMALAYAN PHARMACY INSTITUTE   (India)

^b SIKKIM MANIPAL INSTITUTE OF MEDICAL SCIENCES   (India)

Author keywords

Gel; Irritation; Microparticle; Zidovudine

Indexed keywords

CARBOMER; CARBOPOL 940; ETHYL CELLULOSE; ZIDOVUDINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DELIVERY SYSTEM; DRUG DIFFUSION; DRUG DOSAGE FORM COMPARISON; DRUG EFFICACY; DRUG ELIMINATION; DRUG FORMULATION; DRUG HALF LIFE; DRUG SAFETY; DRUG SOLUBILITY; DRUG TRANSPORT; ENCAPSULATION; EXPERIMENTAL RABBIT; FEMALE; FIRST PASS EFFECT; GEL; HISTOPATHOLOGY; IN VITRO STUDY; IN VIVO STUDY; MAXIMUM PLASMA CONCENTRATION; MICROPARTICULATED BIOADHESIVE GEL; NONHUMAN; PLASMA CONCENTRATION-TIME CURVE; PRIORITY JOURNAL; RAT; SINGLE DRUG DOSE; SURFACE PROPERTY; SUSPENSION; TIME TO MAXIMUM PLASMA CONCENTRATION; UTERUS CONTRACTION; VAGINA DISCHARGE; VAGINA DISEASE; VAGINAL IRRITATION;

ADMINISTRATION, INTRAVAGINAL; ADMINISTRATION, ORAL; ANIMALS; AREA UNDER CURVE; CELLULOSE; DELAYED-ACTION PREPARATIONS; DIFFUSION; FEMALE; HIV INFECTIONS; HUMANS; RABBITS; RATS; RATS, WISTAR; TIME FACTORS; VAGINAL CREAMS, FOAMS, AND JELLIES; ZIDOVUDINE;

EID: 80052884601     PISSN: 10837450     EISSN: 10979867     Source Type: Journal    
DOI: 10.3109/10837450.2010.485318     Document Type: Article

References (26)

1. Merabet J, Tompson D, Levinson SR. Advancing vaginal drug delivery. Expert Opin Drug Deliv 2005;2:769-777. (Pubitemid 41038687)
2. Alexander NJ, Baker E, Kaptein M, Karck U, Miller L, Zampaglione E. Why consider vaginal drug administration. Fertil Steril 2004;82:1-12. (Pubitemid 38968766)
3. Rang HP, Dale MM, Ritter JM. Antiviral drugs. In: Pharmacology. 5th ed. New York: Churchill Livingstone; 2003:624-660.
4. World Health Organization, AIDS epidemic update global over view. 2007:1-50. [http://data.unaids.org/pub/EPISlides/2007/2007-epiupdate-en.pdf]
5. Royce RA, Sena A, Cates W, Cohen MS. Sexual transmission of HIV. N Engl J Med 1997;336:1072-1078. (Pubitemid 27163861)
6. Bhowmik BB, Chatterjee A, Deepak A, Hitendra R, Dharmendra S. Controlled release of anti-HIV biomimetic micro-device in gel for intra-vaginal lubrication and AIDS therapy [abstract]. International Nanotribology Forum, Pelling, Sikkim, India, 10-14 November 2008: p 59.
7. Takuria R, Chatterjee A, Bhowmik BB, Awashti D. Drug release from polymeric vaginal flm for antiretroviral therapy [abstract]. In: International Conference on Fundamental and Translational Research on HIV/AIDS: Global perspectives; Mumbai, India, 5-8 October 2008:S38-39.
8. Chatterjee A, Ghauthaman K. Rahangdale H, Takura R, Bhowmik BB. Microparticulate bioadhesive vaginal gel: Te next generation treatment for of HIV infected women [abstract]. 16th West Bengal state Science & Technology Congress, Burdwan, West Bengal, India; 28 Feb-1 March 2009, HLTH-29.
9. Safari M, Shahbazi M, Ardestani MS. Formulation and in-vitro evaluation of Eudragit L 100 microspheres of piroxicam. Nat Preced 2008: 1-5.
10. Salehi MA. Investigation of efective parameters in intelligence drug delivery systems process with micro-encapsulation method. Int J Chem Sci 2008:6:726-734.
11. Das MK, Rao KR. Evaluation of Zidovudine encapsulated ethyl cellulose microspheres prepared by water-in-oil-in-oil (W/O/O) double emulsion solvent evaporation technique. Acta Polon Pharm 2006;63:141-148. (Pubitemid 351359771)
12. Behera BC, Sahoo SK, Dhal S, Barik BB, Gupta BK. Characterization of glipizide-loaded polymethacrylate micro-sphere prepared by an emulsion solvent evaporation method. Trop J Pharm Res 2008:7:879-885.
13. Vyas SP, Khar RK.Microspheres. In: Targeted and controlled drug delivery novel carrier systems. 1st ed. New Delhi: CBS Publisher and Distributors; 2002:417-457.
14. Bhowmik BB, Sa B, Mukherjee A. Preparation and in vitro characterization of slow release testosterone nanocapsules in alginates. Acta Pharmaceut 2006;56:417-429. (Pubitemid 44863009)
15. Schmolka IR. Preparation and properties of Pluronic PF-127 gels for the treatment of burns. J Biomed Mater Res 1972;6: 571-582.
16. Chaudhari P, Ajab A, Malpure P, Kolsure P, Sanap D. Development and in-vitro evaluation of thermo reversible nasal gel formulations of Rizatriptan benzoate. Ind J Pharm Ed Res 2009;43: 55-62.
17. Higuchi T. Mechanism of rate of sustained-action medication. J Pharm Sci 1963;52:1145-1149.
18. Shoaib MH, Tazeen J, Merchant HA. Evaluation of drug release kinetics from ibuprofen matrix tablets using HPMC. Pak J Pharm Sci 2006;19:119-124.
19. Shankar NB, Kumar NU. Lamivudine loaded microspheres for oral use: Design, development and establishment of in vivo-in vitro correlation. Asi J Pharm Clin Res 2009;2:55-60.
20. Ito Y, Shiroyama K, Yoshimitsu J, Ohashi Y, Sugioka N, Takada K. Pharmacokinetic and pharmacodynamic studies following percutaneous absorption of erythropoietin micropiles to rats. J Control Release 2007;121:176-180. (Pubitemid 47212539)
21. Sharma PK, Palani S, Irchhiaya R. In-vitro and in-vivo release of Zidovudine from diferent liposome gel in rabbit model. Adv Pharmacol Toxicol 2007;8:73-80.
22. Quevedo MA, Teijeiro SA, Brinon MC. Quantitative plasma determination of a novel anti-retroviral derivative of Zidovudine by solid-phase extraction and high-performance liquid chromatog-raphy. Anal Bioanal Chem 2006;385:377-384.
23. Kuksal A, Tiwary AK, Jain NK, Jain S. Formulation and in-vitro, in-vivo evaluation of extended-release matrix tablet of Zidovudine: Infuence of combination of hydrophilic and hydro-phobic matrix formers. AAPS PharmSciTech 2006;7:E1-9.
24. Shargel L, Yu ABC. Applied biopharmaceutics and pharma-cokinetics. 4th ed. New York: McGraw-Hill Medical Publishing Division; 1999:247-279.
25. Eckstein P, Jackson MC, Millman N, Sobrero AJ. Comparison of vaginal tolerance tests of spermicidal preparations in rabbits and monkeys. J Reprod Fertil 1969;20:85-93.
26. Controller of Publication Government of India, Ministry of Health & Family Welfare, Tablet & reagents and solution. In: Indian Pharmacopeia. Vol. 2. 2nd ed. Delhi; 1996:736.