Thermosensitive and mucoadhesive in situ gel based on poloxamer as new carrier for rectal administration of nimesulide

International Journal of Pharmaceutics

Volumn 430, Issue 1-2, 2012, Pages 114-119

  Yuan, Yuan ^a   Cui, Ying ^a   Zhang, Li ^a   Zhu, Hui Ping ^b   Guo, Yi Sha ^a   Zhong, Bo ^a   Hu, Xia ^a   Zhang, Ling ^a   Wang, Xiao Hui ^a   Chen, Li ^a  

^a MEDICAL COLLEGE OF CHINESE PEOPLE'S ARMED POLICE FORCES   (China)

^b UNIVERSITY OF TEXAS AT AUSTIN   (United States)

Author keywords

In situ gel; Mucoadhesive polymer; Nimesulide; Rectal drug delivery; Thermosensitive

Indexed keywords

ALGINIC ACID; DRUG CARRIER; HYDROXYPROPYLMETHYLCELLULOSE; MACROGOL; MACROGOL 4000; NIMESULIDE; POLOXAMER;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG FORMULATION; DRUG HALF LIFE; DRUG RELEASE; DRUG RETENTION; DRUG SAFETY; GELATION; HEAT SENSITIVITY; MALE; MAXIMUM PLASMA CONCENTRATION; MUCOADHESION; MUCOSA INFLAMMATION; NONHUMAN; PRIORITY JOURNAL; RABBIT; TRANSITION TEMPERATURE;

ADHESIVENESS; ADMINISTRATION, RECTAL; ALGINATES; ANIMALS; AREA UNDER CURVE; CHEMISTRY, PHARMACEUTICAL; CYCLOOXYGENASE 2 INHIBITORS; DRUG CARRIERS; DRUG COMPOUNDING; GELS; GLUCURONIC ACID; HEXURONIC ACIDS; MALE; MUCOUS MEMBRANE; POLOXAMER; POLYETHYLENE GLYCOLS; RABBITS; RECTUM; SOLUBILITY; SULFONAMIDES; TECHNOLOGY, PHARMACEUTICAL; TRANSITION TEMPERATURE;

EID: 84860728306     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2012.03.054     Document Type: Article

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