Vaginal permeability and enzymatic activity studies in normal and ovariectomized rabbits

Pharmaceutical Research

Volumn 13, Issue 5, 1996, Pages 779-783

  Acartürk, Füsun ^a   Robinson, Joseph R ^b  

^a GAZI UNIVERSITY   (Turkey)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

Enkephalin derivative; Enzymatic activity; Ovariectomized rabbits; Vaginal permeability

Indexed keywords

AMINOPEPTIDASE; CYTOSOL AMINOPEPTIDASE; ENKEPHALIN DERIVATIVE; ENKEPHALIN[2 DEXTRO ALANINE 4 METHYLPHENYLALANINE 5 GLYCINE];

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOLOGICAL MODEL; CONTROLLED STUDY; DIFFUSION; DRUG PENETRATION; ENZYME ACTIVITY; FEMALE; INTRAVAGINAL DRUG ADMINISTRATION; NONHUMAN; OVARIECTOMY; PERMEABILITY; PRIORITY JOURNAL; RABBIT; TISSUE HOMOGENATE; VAGINA EPITHELIUM;

AMINOPEPTIDASES; ANIMALS; ENKEPHALINS; ESTROGENS; FEMALE; HUMANS; HYDROGEN-ION CONCENTRATION; MODELS, BIOLOGICAL; OVARIECTOMY; PERMEABILITY; POSTMENOPAUSE; RABBITS; VAGINA;

EID: 0029938238     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1016016120392     Document Type: Article

References (15)

1. K. Knuth, M. Amiji, and J. R. Robinson. Hydrogel delivery systems for vaginal and oral applications. Formulation and biological considerations. Adv. Drug Delivery Rev. 11:137-167 (1993).
2. J. L. Richardson and L. Illum. Routes of delivery: case studies. The vaginal route of peptide and protein drug delivery. Adv. Drug Delivery Rev. 8:341-366 (1992).
3. M. J. Durrani, A. Kusai, N. F. H. Ho, J. L. Fox, and W. I. Higuchi. Topical vaginal drug delivery in guinea pig. I. Effect of estrous cycle on the vaginal membrane permeability of vidarabine. Int. J. Pharm. 24:209-218 (1985).
4. H. Okada, T. Yashiki, and H. Mima. Vaginal absorption of a potent luteinizing hormone-releasing hormone analogue (leuprolide) in rats. III: Effect of estrous cycle on vaginal absorption of hydrophilic model compounds. J. Pharm. Sci. 72:173-176 (1983).
5. J. L. Richardson, P. S. Minhas, N. W. Thomas, and L. Illum. Vaginal administration of gentamicin to rats. Pharmaceutical and morphological studies using absorption enhancers. Int. J. Pharm. 56:29-35 (1989).
6. 2]-LH-RH Ethylamide on serum LH levels in ovariectomized, steroid-blocked rats. Proceed. Soc. Exp. Biolog. Med. 148:1009-1012 (1975).
7. D. C. Corbo, J. Liu, and Y. W. Chien. Drug absorption through mucosal membranes: Effect of mucosal route and penetrant hydrophilicity. Pharm. Res. 6:848-852 (1989).
8. Fishman, W. H. and G. W. Mitchell. Studies on vaginal enzymology. Ann. N.Y. Acad. Sci. 83:105-121 (1959).
9. R. T. Havran and G. Oster. Trypsin-like activity in the vaginal epithelial cells of the rat. J. Histochem. Cytochem. 25:1178-1186 (1977).
10. S. D. Kashi and V. H. L. Lee. Enkephalin hydrolysis in homogenates of various absorptive mucosae of the albino rabbit: Similarities in rates and involvement of aminopeptidases. Life Sciences 38:2019-2028 (1986).
11. R. E. Stratford and V. H. Lee. Aminopeptidase activity in homogenates of various absorptive mucosae in the albino rabbit: Implications for peptide delivery. Int. J. Pharm. 30:73-82 (1986).
12. M. M. Bradford. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72:248-254 (1976).
13. V. D. Ramirez and C. Beyer. The ovarian cycle of the rabbit: Its neuroendocrine control. In E. Knobil, J. Neil (eds.), The Physiology of Reproduction, Raven Press, Ltd., New York, 1988, pp 1873-1892.
14. P. Langguth, Merkle, H. P., and G. Amidon. Oral absorption of peptides: The effect of absorption site and enzyme inhibition on the systemic availability of metkephamid. Pharm. Res. 11:528-535 (1994).
15. M. Furuhjelm, E. Karlgren, and K. Carlstrom. Intravaginal administration of conjugated estrogens in premenopausal and postmenopausal women. Im. J. Gynaecol. Obstet. 17:335-339 (1980).