Porcine vaginal mucosa as an in vitro permeability model for human vaginal mucosa

International Journal of Pharmaceutics

Volumn 305, Issue 1-2, 2005, Pages 105-111

  Van Eyk, Armorél D ^a   Van Der Bijl, Pieter ^a  

^a UNIVERSITY OF STELLENBOSCH   (South Africa)

Author keywords

Human; Mucosa; Permeability; Porcine; Vaginal

Indexed keywords

ARECOLINE; ESTRADIOL; LIQUID NITROGEN; OXYTOCIN; TRITIUM; VASOPRESSIN; WATER;

AGED; ANIMAL TISSUE; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; CRYOPRESERVATION; DIFFUSION COEFFICIENT; DRUG DIFFUSION; DRUG PENETRATION; FEMALE; HUMAN; HUMAN TISSUE; IN VITRO STUDY; MEMBRANE MODEL; MEMBRANE PERMEABILITY; NONHUMAN; PRIORITY JOURNAL; STATISTICAL SIGNIFICANCE; STEADY STATE; SWINE; TISSUE SECTION; VAGINA MUCOSA;

ANIMALS; ARECOLINE; ESTRADIOL; FEMALE; HUMANS; MODELS, ANIMAL; MUCOUS MEMBRANE; OXYTOCIN; PERMEABILITY; REGRESSION ANALYSIS; RHEOLOGY; SPECIES SPECIFICITY; SWINE; VAGINA;

EID: 27644562361     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2005.09.002     Document Type: Article

References (23)

1. N.J. Alexander, E. Baker, M. Kaptein, U. Karck, L. Miller, and E. Zampaglione Why consider vaginal drug administration Fertil. Steril. 82 2004 1 12
2. S. Asthana, N.H. Greig, H.W. Halloway, K.C. Raffaele, A. Berardi, M.B. Schapiro, S.I. Rapoport, and T.T. Soncrant Clinical pharmacokinetics of arecoline in subjects with Alzheimer's disease Clin. Pharm. Ther. 60 1996 276 282
3. L-L.H. Chen, D.J. Chetty, and Y.W. Chien A mechanistic analysis to characterize oramucosal permeation properties Int. J. Pharm. 184 1999 63 72
4. C.C. Davis, M.J. Kremer, P.M. Schlievert, and C.A. Squier Penetration of toxic shock syndrome toxin-1 across porcine vaginal mucosa ex vivo: permeability characteristics, toxin distribution, and tissue damage Am. J. Obstet. Gynecol. 189 2003 1785 1791
5. W.O. Foye, T.L. Lemke, and D.A. Williams Principles of Medicinal Chemistry fourth ed. 1995 Williams & Wilkens Baltimore http://www.neurosci. pharm.utoledo.edu/MBC3320/vasopressin.htm
6. D. Harris, and J.R. Robinson Drug delivery via the mucous membranes of the oral cavity J. Pharm. Sci. 81 1992 1 10
7. A. Hussain, and F. Ahsan Review. The vagina as a route for systemic drug delivery J. Control. Release 103 2005 301 313
8. M. Justin-Temu, F. Damian, R. Kinget, and G. van den Mooter Intravaginal gels as drug delivery systems J. Womens Health 13 2004 834 844
9. M.J. Kremer, P.W. Wertz, and C.A. Squier Permeability and barrier function of three porcine non-keratinized mucosae J. Dent. Res. 80 2001 851
10. C.H. Lee, and Y.W. Chien In vitro permeation study of a mucoadhesive drug delivery system for controlled delivery of nonoxynol-9 Pharm. Dev. Technol. 1 1996 135 145
11. H. Motulsky Intuitive biostatistics Graphpad Software 1995 Oxford University Press New York
12. H.M. Nielsen, and M.R. Rassing TR146 cells grown on filters as a model of human buccal epithelium. IV. Permeability of water, mannitol, testosterone and β-adrenoceptor antagonists. Comparison to human, monkey and porcine buccal mucosa Int. J. Pharm. 194 2000 155 167
13. M.L. Peterson, K. Ault, M.J. Kremer, A.J. Klingelhutz, C.C. Davis, C.A. Squier, and P.M. Schlievert The innate immune system is activated by stimulation of vaginal epithelial cells with Staphylococcus aureus and toxic shock syndrome toxin 1 Infect. Immun. 73 2005 2164 2174
14. G. Sandri, S. Rossi, F. Ferrari, M.C. Bonferoni, C. Muzzarelli, and C. Caramella Assessment of chitosan derivatives as buccal and vaginal penetration enhancers Eur. J. Pharm. Sci. 21 2004 351 359
15. I.O.C. Thompson, P. van der Bijl, C.W. van Wyk, and A.D. van Eyk A comparative light-microscopic, electron-microscopic and chemical study of human vaginal and buccal epithelium Arch. Oral Biol. 46 2001 1091 1098
16. P. van der Bijl, I.O.C. Thompson, and C.A. Squier Comparative permeability of human vaginal and buccal mucosa to water Eur. J. Oral Sci. 105 1997 571 575
17. P. van der Bijl, and A.D. van Eyk Human vaginal mucosa as a model of buccal mucosa for in vitro permeability studies: an overview Curr. Drug Deliv. 1 2004 129 135
18. P. van der Bijl, A.D. van Eyk, and I.O.C. Thompson Permeation of 17β-estradiol through human vaginal and buccal mucosa Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod. 85 1998 393 398
19. P. van der Bijl, A.D. van Eyk, and I.O.C. Thompson Diffusion rates of vasopressin through human vaginal and buccal mucosa Eur. J. Oral Sci. 106 1998 958 962
20. P. van der Bijl, A.D. van Eyk, C.W. van Wyk, and I.A. Stander Diffusion of reduced arecoline and arecaidine through human vaginal and buccal mucosa J. Oral Pathol. Med. 30 2001 200 205
21. A.D. van Eyk, and P. van der Bijl Comparative permeability of various chemical markers through human vaginal and buccal mucosa as well as porcine buccal and mouth floor mucosa Arch. Oral Biol. 49 2004 387 392
22. P.W. Wertz, and C.A. Squier Cellular and molecular basis of barrier function in oral epithelium Crit. Rev. Ther. Drug Carrier Syst. 8 1991 237 269
23. A. Williams Theoretical aspects of transdermal drug delivery A. Williams Transdermal and Topical Drug Delivery 2003 Pharmaceutical Press London 35 40