In vitro and in vivo characteristics of a thermogelling rectal delivery system of etodolac

AAPS PharmSciTech

Volumn 10, Issue 3, 2009, Pages 724-731

  Barakat, Nahla S ^a  

^a KING SAUD UNIVERSITY   (Saudi Arabia)

Author keywords

Anti inflammatory effect; Etodolac; Mucoadhesive polymers; Poloxamer gel; Safety study

Indexed keywords

CARBOMER; ETODOLAC; HYDROXYETHYLCELLULOSE; HYDROXYPROPYLMETHYLCELLULOSE; METHYLCELLULOSE; PLACEBO; POLOXAMER; POVIDONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG DOSAGE FORM COMPARISON; DRUG EFFICACY; DRUG FORMULATION; DRUG RELEASE; DRUG SAFETY; GEL; GELATION; IN VITRO STUDY; IN VIVO STUDY; MALE; NONHUMAN; PAW EDEMA; PHYSICAL CHEMISTRY; RAT; SUPPOSITORY; SUSPENSION;

ADHESIVENESS; ADMINISTRATION, RECTAL; ALGORITHMS; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CELL SURVIVAL; CHEMISTRY, PHARMACEUTICAL; ETODOLAC; EXCIPIENTS; GELS; INTESTINAL MUCOSA; IRRITANTS; MALE; POLOXAMER; RATS; RATS, SPRAGUE-DAWLEY; RECTUM; SUPPOSITORIES; TEMPERATURE;

EID: 70449527563     PISSN: None     EISSN: 15309932     Source Type: Journal    
DOI: 10.1208/s12249-009-9261-y     Document Type: Article

References (26)

1. YJ Park CS Yong HM Kim JD Rhee YK Oh CK Kim HG Choi 2003 Effect of sodium chloride on the release, absorption, and safety of diclofenac sodium delivered by poloxamer gel Int J Pharm 263 105 111 12954185 10.1016/S0378-5173(03)00362-4 1:CAS:528:DC%2BD3sXmvValtL8%3D (Pubitemid 37087937)
2. CK Kim SW Lee HG Choi MK Lee ZG Gao IS Kim KM Park 1998 Trials of in-situ gelling and mucoadhesive acetaminophen liquid suppository in human subjects Int J Pharm 174 201 207 10.1016/S0378-5173(98)00258-0 1:CAS:528:DyaK1cXmsFGnurk%3D (Pubitemid 28487004)
3. JW Lee JH Park JR Robinson 2000 Bioadhesive-based dosage forms; the next generation J Pharm Sci 89 850 866 10861586 10.1002/1520-6017(200007)89:7<850: :AID-JPS2>3.0.CO;2-G 1:CAS:528:DC%2BD3cXlt1ahtbk%3D (Pubitemid 30691431)
4. JY Chang TK Oh HG Choi YB Kim CK Kim 2002 Rheological evaluation of thermosensitive and mucoadhesive vaginal gels in physiological conditions Int J Pharm 241 155 163 12086731 10.1016/S0378-5173(02)00232-6 1:CAS:528: DC%2BD38XkslSgs7o%3D (Pubitemid 34667075)
5. L Zhang DL Parsons C Navarre UB Kompella 2002 Development and in vitro evaluation of sustained release Poloxamer 407 (P407) gel formulations of ceftiotur J Control Rel 85 73 81 10.1016/S0168-3659(02)00273-0 1:CAS:528:DC%2BD38Xpt12lu7s%3D (Pubitemid 35449455)
6. HG Choi MH Kim MK Lee CK Kim 1999 Effect of additives on the physicochemical properties of liquid suppository Int J Pharm 190 13 19 10528092 10.1016/S0378-5173(99)00225-2 1:CAS:528:DyaK1MXmvVartrc%3D (Pubitemid 29467467)
7. CS Yong JS Choi QZ Quan JD Rhee CK Kim SJ Lim KM Kim P Oh SHG Choi 2001 Effect of sodium chloride on the gelation temperature, gel strength and bioadhesive force of Poloxamer gels containing diclofenac sodium Int J Pharm 226 195 205 11532582 10.1016/S0378-5173(01)00809-2 1:CAS:528:DC%2BD3MXmsV2jtrw%3D (Pubitemid 32800794)
8. S Miyazaki F Suisha N Kawasaki M Shirakawa K Yamatoya D Attwood 1998 Thermally reversible xyloglucan gels as vehicles for rectal drug delivery J Control Rel 56 75 83 10.1016/S0168-3659(98)00079-0 1:CAS:528:DyaK1cXntVGhtbs%3D (Pubitemid 28511128)
9. G Dumortier M Zuber G Courarraze JC Chaumeil JL Grossiord 1991 Rheological study of a thermoreversible morphine gel Drug Dev Ind Pharm 17 1255 1265 10.3109/03639049109043858 1:CAS:528:DyaK3MXksFOjurs%3D
10. Wade A, Weller PJ. Handbook of Excipients, 2nd edn. London, England: The American Pharmaceutical Association (USA) and the Pharmaceutical Press, 306:223-229; 1994.
11. ML Vueba LAE Batista de Carvalho F Veiga JJ Sousa ME Pina 2006 Influence of cellulose ether mixtures on ibuprofen release: MC25, HPC and HPMC K100M Pharm Dev Techn 11 213 228 10.1080/10837450600561349 1:CAS:528:DC%2BD28Xlt1SqtLs%3D (Pubitemid 43879945)
12. HG Choi YK Oh CK Kim 1998 In-situ gelling and mucoadhesive liquid suppository containing acetaminophen: enhanced bioavailability Int J Pharm 165 23 32 10.1016/S0378-5173(97)00385-2 1:CAS:528:DyaK1cXis1Wru74%3D (Pubitemid 28218341)
13. MO Yun HG Choi JH Jung CK Kim 1999 Development of a thermo-reversible insulin liquid suppository with bioavailability enhancement Int J Pharm 189 137 145 10536242 10.1016/S0378-5173(99)00227-6 1:CAS:528:DyaK1MXmvVaqtLk%3D (Pubitemid 29481749)
14. JM Ryu SJ Chung MH Lee CK Kim CK Shim 1999 Increased bioavailability of propranolol in rats by retaining thermally gelling liquid suppositories in the rectum J Control Rel 59 163 172 10.1016/S0168-3659(98)00189-8 1:CAS:528:DyaK1MXjtVyktbs%3D (Pubitemid 29199922)
15. AA Koffi F Agnely M Besnard K Brou JL Grossiord G Ponchel 2008 In vitro and in vivo characteristics of a thermogelling and bioadhesive delivery system intended for rectal administration of quinine in children Eur J Pharm Biopharm 69 167 175 18023982 10.1016/j.ejpb.2007.09.017 1:CAS:528:DC%2BD1cXktlGltL8%3D
16. Z Kokot H Zmidzinska 2001 Solubility and dissolution rate of ibuprofen in ionic and nonionic micellar systems Acta Pol Pharm 58 117 120 11501788 1:CAS:528:DC%2BD3MXlsVOltrc%3D
17. CS Yong YK Oh SH Jung JD Rhee HD Kim CK Kim HG Choi 2004 Preparation of ibuprofen-loaded liquid suppository using eutectic mixture system with menthol Eur J Pharm Sci 23 347 353 15567287 10.1016/j.ejps.2004.08.008 1:CAS:528:DC%2BD2cXhtVamu7nM (Pubitemid 39573385)
18. JA Balfour MM-T Buckley 1991 Etodolac. A reappraisal of its harmacology and therapeutic use in rheumatic diseases and pain states Drugs 42 274 299 1717225 10.2165/00003495-199142020-00008 1:STN:280:DyaK38%2Fgslehsg%3D%3D
19. HG Choi JH Jung JM Ryu SJ Yoon YK Oh CK Kim 1998 Development of in-situ gelling and mucoadhesive acetaminophen liquid suppository Int J Pharm 165 33 44 10.1016/S0378-5173(97)00386-4 1:CAS:528:DyaK1cXis1Wru7w%3D (Pubitemid 28218342)
20. RW Korsmeyer R Gurny EM Doelker P Buri NA Peppas 1983 Mechanism of release from porous hydrophilic polymers Int J Pharm 15 25 35 10.1016/0378-5173(83)90064-9 1:CAS:528:DyaL3sXksVens7Y%3D
21. Kramaric A, Resman A, Kofler B, Zmitek J. Thermoreversible gel as a liquid pharmaceutical carrier for a galenic formulation. European Patent 05551 626 (A1) 1992.
22. CM Lehr JA Bouwatra HE Bodde HE Junginger 1992 A surface energy analysis of mucoadhesion: contact angle measurement on polycarbophil and pig intestinal mucosa in physiologically relevant fluids Pharm Res 9 70 75 1589412 10.1023/A:1018931811189 1:CAS:528:DyaK38XhtFensb8%3D
23. HG Choi JH Jung CS Yong JD Rhee MK Lee JH Han KM Park CK Kim 2000 Formulation and in vivo evaluation of omeprazole buccal adhesive tablet J Control Rel 68 405 412 10.1016/S0168-3659(00)00275-3 1:CAS:528: DC%2BD3cXmtFGktbY%3D (Pubitemid 30676111)
24. CM Lehr JA Bouwstra JJ Tukker HE Junginger 1990 Intestinal transit of bioadhesive microspheres in an in situ loop in the rat: a comparative study with copolymers and blends based on poly (acrylic acid) J Control Rel 13 51 62 10.1016/0168-3659(90)90074-4 1:CAS:528:DyaK3cXlsFymtbo%3D (Pubitemid 20221201)
25. GL Amidon H Lennernas VP Shah JR Crison 1995 A theoretical basis for a biopharmaceutic drug classification: the correlation of in vitro drug product dissolution and in vivo bioavailability Pharm Res 12 413 420 7617530 10.1023/A:1016212804288 1:CAS:528:DyaK2MXksVGqur8%3D
26. JJ Escobar-Chavez M Lopez-Cervantes A Naik YN Kalia D Quintanar-Guerrero A Ganem-Quintanar 2006 Applications of thermo-reversible Pluronic 127 gels in pharmaceutical formulations J Pharm Pharmaceut Sci 9 339 358 1:CAS:528:DC%2BD28XhtlCmsbvF