HTLV-1 bZIP Factor Induces Inflammation through Labile Foxp3 Expression

PLoS Pathogens

Volumn 9, Issue 9, 2013, Pages

  Yamamoto Taguchi, Nanae ^a   Satou, Yorifumi ^a   Miyazato, Paola ^a   Ohshima, Koichi ^b   Nakagawa, Masanori ^c   Katagiri, Koko ^d   Kinashi, Tatsuo ^e   Matsuoka, Masao ^a  

^a KYOTO UNIVERSITY   (Japan)

^b KURUME UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

^d KITASATO UNIVERSITY   (Japan)

^e KANSAI MEDICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BASIC LEUCINE ZIPPER TRANSCRIPTION FACTOR; CD103 ANTIGEN; CD18 ANTIGEN; CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CCR7; CHEMOKINE RECEPTOR CXCR3; CXCL9 CHEMOKINE; GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; INTERCELLULAR ADHESION MOLECULE 1; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; TRANSCRIPTION FACTOR FOXP3; FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, HUMAN; FOXP3 PROTEIN, MOUSE; HBZ PROTEIN, HUMAN T-CELL LEUKEMIA VIRUS TYPE I; RECOMBINANT PROTEIN; VIRUS PROTEIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CD4+ T LYMPHOCYTE; CELL ADHESION; CELL MIGRATION; CHRONIC INFLAMMATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DNA SEQUENCE; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; FLUORESCENCE ACTIVATED CELL SORTING; GENE EXPRESSION; HISTOLOGY; HUMAN; HUMAN CELL; HUMAN T CELL LEUKEMIA VIRUS 1; HUMAN T CELL LEUKEMIA VIRUS INFECTION; LYMPHOCYTIC INFILTRATION; MALE; MOUSE; NONHUMAN; REGULATORY T LYMPHOCYTE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPINAL CORD DISEASE; TROPICAL SPASTIC PARAPARESIS; ANIMAL; CELL CULTURE; CELL MOTION; DNA METHYLATION; GENETICS; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; METABOLISM; MONONUCLEAR CELL; PARAPARESIS, TROPICAL SPASTIC; PATHOLOGY; PATHOPHYSIOLOGY; SECRETION (PROCESS); SPLEEN; THYMUS; TRANSGENIC MOUSE; VIROLOGY;

ANIMALS; BASIC-LEUCINE ZIPPER TRANSCRIPTION FACTORS; CELL ADHESION; CELL MOVEMENT; CELLS, CULTURED; DNA METHYLATION; FORKHEAD TRANSCRIPTION FACTORS; HTLV-I INFECTIONS; HUMAN T-LYMPHOTROPIC VIRUS 1; HUMANS; INTERFERON-GAMMA; LEUKOCYTES, MONONUCLEAR; LYMPHOCYTE ACTIVATION; MALE; MICE, TRANSGENIC; PARAPARESIS, TROPICAL SPASTIC; RECOMBINANT PROTEINS; SPLEEN; T-LYMPHOCYTES, REGULATORY; THYMUS GLAND; VIRAL PROTEINS;

EID: 84884687562     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1003630     Document Type: Article

References (47)

1. Matsuoka M, Jeang KT, (2007) Human T-cell leukaemia virus type 1 (HTLV-1) infectivity and cellular transformation. Nat Rev Cancer 7: 270-280.
2. Gessain A, Jouannelle A, Escarmant P, Calender A, Schaffar-Deshayes L, et al. (1984) HTLV antibodies in patients with non-Hodgkin lymphomas in Martinique. Lancet 1: 1183-1184.
3. Osame M, Usuku K, Izumo S, Ijichi N, Amitani H, et al. (1986) HTLV-I associated myelopathy, a new clinical entity. Lancet 1: 1031-1032.
4. Nakao K, Ohba N, Matsumoto M, (1989) Noninfectious anterior uveitis in patients infected with human T-lymphotropic virus type I. Jpn J Ophthalmol 33: 472-481.
5. Mochizuki M, Yamaguchi K, Takatsuki K, Watanabe T, Mori S, et al. (1992) HTLV-I and uveitis. Lancet 339: 1110.
6. Sugimoto M, Nakashima H, Watanabe S, Uyama E, Tanaka F, et al. (1987) T-lymphocyte alveolitis in HTLV-I-associated myelopathy. Lancet 2: 1220.
7. LaGrenade L, Hanchard B, Fletcher V, Cranston B, Blattner W, (1990) Infective dermatitis of Jamaican children: a marker for HTLV-I infection. Lancet 336: 1345-1347.
8. Morgan OS, Rodgers-Johnson P, Mora C, Char G, (1989) HTLV-1 and polymyositis in Jamaica. Lancet 2: 1184-1187.
9. Matsuura E, Yamano Y, Jacobson S, (2010) Neuroimmunity of HTLV-I Infection. J Neuroimmune Pharmacol 5: 310-325.
10. Satou Y, Yasunaga J, Yoshida M, Matsuoka M, (2006) HTLV-I basic leucine zipper factor gene mRNA supports proliferation of adult T cell leukemia cells. Proc Natl Acad Sci U S A 103: 720-725.
11. Arnold J, Zimmerman B, Li M, Lairmore MD, Green PL, (2008) Human T-cell leukemia virus type-1 antisense-encoded gene, Hbz, promotes T-lymphocyte proliferation. Blood 112: 3788-3797.
12. Satou Y, Yasunaga J, Zhao T, Yoshida M, Miyazato P, et al. (2011) HTLV-1 bZIP Factor Induces T-Cell Lymphoma and Systemic Inflammation In Vivo. PLoS Pathog 7: e1001274.
13. Zhao T, Satou Y, Sugata K, Miyazato P, Green PL, et al. (2011) HTLV-1 bZIP factor enhances TGF-{beta} signaling through p300 coactivator. Blood 118: 1865-1876.
14. Sakaguchi S, Yamaguchi T, Nomura T, Ono M, (2008) Regulatory T cells and immune tolerance. Cell 133: 775-787.
15. Gavin M, Rudensky A, (2003) Control of immune homeostasis by naturally arising regulatory CD4+ T cells. Current opinion in immunology 15: 690-696.
16. Zhou X, Bailey-Bucktrout SL, Jeker LT, Penaranda C, Martinez-Llordella M, et al. (2009) Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo. Nature immunology 10: 1000-1007.
17. Miyao T, Floess S, Setoguchi R, Luche H, Fehling HJ, et al. (2012) Plasticity of foxp3(+) T cells reflects promiscuous foxp3 expression in conventional T cells but not reprogramming of regulatory T cells. Immunity 36: 262-275.
18. Rubtsov YP, Niec RE, Josefowicz S, Li L, Darce J, et al. (2010) Stability of the regulatory T cell lineage in vivo. Science 329: 1667-1671.
19. Hori S, Nomura T, Sakaguchi S, (2003) Control of regulatory T cell development by the transcription factor Foxp3. Science 299: 1057-1061.
20. Thornton AM, Korty PE, Tran DQ, Wohlfert EA, Murray PE, et al. (2010) Expression of Helios, an Ikaros transcription factor family member, differentiates thymic-derived from peripherally induced Foxp3+ T regulatory cells. Journal of immunology 184: 3433-3441.
21. Himmel ME, MacDonald KG, Garcia RV, Steiner TS, Levings MK, (2013) Helios+ and Helios- cells coexist within the natural FOXP3+ T regulatory cell subset in humans. J Immunol 190: 2001-2008.
22. Gottschalk RA, Corse E, Allison JP, (2012) Expression of Helios in peripherally induced Foxp3+ regulatory T cells. J Immunol 188: 976-980.
23. Akimova T, Beier UH, Wang L, Levine MH, Hancock WW, (2011) Helios expression is a marker of T cell activation and proliferation. PLoS One 6: e24226.
24. Zheng Y, Josefowicz S, Chaudhry A, Peng XP, Forbush K, et al. (2010) Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate. Nature 463: 808-812.
25. O'Shea JJ, Paul WE, (2010) Mechanisms underlying lineage commitment and plasticity of helper CD4+ T cells. Science 327: 1098-1102.
26. Virgin HW, Wherry EJ, Ahmed R, (2009) Redefining chronic viral infection. Cell 138: 30-50.
27. Bangham CR, Osame M, (2005) Cellular immune response to HTLV-1. Oncogene 24: 6035-6046.
28. Moritoyo T, Reinhart TA, Moritoyo H, Sato E, Izumo S, et al. (1996) Human T-lymphotropic virus type I-associated myelopathy and tax gene expression in CD4+ T lymphocytes. Annals of neurology 40: 84-90.
29. Kubota R, Soldan SS, Martin R, Jacobson S, (2002) Selected cytotoxic T lymphocytes with high specificity for HTLV-I in cerebrospinal fluid from a HAM/TSP patient. Journal of neurovirology 8: 53-57.
30. Dao T, Holan V, Minowada J, (1993) Multiple and heterogeneous patterns of cytokine production in 18 leukemia and in vitro transformed mature T cell lines reflect the individuality of human leukemias. International journal of hematology 57: 139-146.
31. Macnamara A, Rowan A, Hilburn S, Kadolsky U, Fujiwara H, et al. (2010) HLA class I binding of HBZ determines outcome in HTLV-1 infection. PLoS Pathog 6: e1001117.
32. Sun SC, Yamaoka S, (2005) Activation of NF-kappaB by HTLV-I and implications for cell transformation. Oncogene 24: 5952-5964.
33. Zhao T, Yasunaga J, Satou Y, Nakao M, Takahashi M, et al. (2009) Human T-cell leukemia virus type 1 bZIP factor selectively suppresses the classical pathway of NF-kappaB. Blood 113: 2755-2764.
34. Arnulf B, Villemain A, Nicot C, Mordelet E, Charneau P, et al. (2002) Human T cell lymphotropic virus oncoprotein tax represses TGF-{beta}1 signaling in human T cells via c-Jun activation: a potential mechanism of HTLV-I leukemogenesis. Blood 100: 4129-38.
35. Lee DK, Kim BC, Brady JN, Jeang KT, Kim SJ, (2002) Human T-cell Lymphotropic Virus Type 1 Tax Inhibits Transforming Growth Factor-beta Signaling by Blocking the Association of Smad Proteins with Smad-binding Element. J Biol Chem 277: 33766-33775.
36. Sugata K, Satou Y, Yasunaga J, Hara H, Ohshima K, et al. (2012) HTLV-1 bZIP factor impairs cell-mediated immunity by suppressing production of Th1 cytokines. Blood 119: 434-444.
37. Yang XO, Nurieva R, Martinez GJ, Kang HS, Chung Y, et al. (2008) Molecular antagonism and plasticity of regulatory and inflammatory T cell programs. Immunity 29: 44-56.
38. Komatsu N, Mariotti-Ferrandiz ME, Wang Y, Malissen B, Waldmann H, et al. (2009) Heterogeneity of natural Foxp3+ T cells: a committed regulatory T-cell lineage and an uncommitted minor population retaining plasticity. Proc Natl Acad Sci U S A 106: 1903-1908.
39. Xu L, Kitani A, Fuss I, Strober W, (2007) Cutting edge: regulatory T cells induce CD4+CD25-Foxp3- T cells or are self-induced to become Th17 cells in the absence of exogenous TGF-beta. Journal of immunology 178: 6725-6729.
40. Yamano Y, Araya N, Sato T, Utsunomiya A, Azakami K, et al. (2009) Abnormally high levels of virus-infected IFN-gamma+ CCR4+ CD4+ CD25+ T cells in a retrovirus-associated neuroinflammatory disorder. PLoS One 4: e6517.
41. Saito M, Matsuzaki T, Satou Y, Yasunaga J, Saito K, et al. (2009) In vivo expression of the HBZ gene of HTLV-1 correlates with proviral load, inflammatory markers and disease severity in HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP). Retrovirology 6: 19.
42. Karube K, Ohshima K, Tsuchiya T, Yamaguchi T, Kawano R, et al. (2004) Expression of FoxP3, a key molecule in CD4CD25 regulatory T cells, in adult T-cell leukaemia/lymphoma cells. Br J Haematol 126: 81-84.
43. Chen S, Ishii N, Ine S, Ikeda S, Fujimura T, et al. (2006) Regulatory T cell-like activity of Foxp3+ adult T cell leukemia cells. Int Immunol 18: 269-277.
44. Miyara M, Yoshioka Y, Kitoh A, Shima T, Wing K, et al. (2009) Functional delineation and differentiation dynamics of human CD4+ T cells expressing the FoxP3 transcription factor. Immunity 30: 899-911.
45. Satou Y, Utsunomiya A, Tanabe J, Nakagawa M, Nosaka K, et al. (2012) HTLV-1 modulates the frequency and phenotype of FoxP3+CD4+ T cells in virus-infected individuals. Retrovirology 9: 46.
46. Curotto de Lafaille MA, Lafaille JJ, (2009) Natural and adaptive foxp3+ regulatory T cells: more of the same or a division of labor? Immunity 30: 626-635.
47. Kinashi T, Katagiri K, (2005) Regulation of immune cell adhesion and migration by regulator of adhesion and cell polarization enriched in lymphoid tissues. Immunology 116: 164-171.