Regulatory T cell-like activity of Foxp3+ adult T cell leukemia cells

International Immunology

Volumn 18, Issue 2, 2006, Pages 269-277

  Chen, Shuming ^a   Ishii, Naoto ^a   Ine, Shouji ^a   Ikeda, Syuichi ^b   Fujimura, Taku ^a   Ndhlovu, Lishomwa C ^a   Soroosh, Pejman ^a   Tada, Kohtaro ^a   Harigae, Hideo ^a   Kameoka, Junichi ^a   Kasai, Noriyuki ^a   Sasaki, Takeshi ^a   Sugamura, Kazuo ^a  

^a TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b Sasebo Shiritsu Sogo Hospital   (Japan)

Author keywords

ATL; Foxp3; HTLV 1; Regulatory T cell

Indexed keywords

ANTIBIOTIC AGENT; ANTIFUNGAL AGENT; RETROVIRUS VECTOR; TRANSCRIPTION FACTOR FOXP3;

ADULT; AGED; ARTICLE; CELL CONTACT; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN T CELL LEUKEMIA VIRUS 1; LEUKEMIA CELL; LYMPHOCYTE PROLIFERATION; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REGULATORY T LYMPHOCYTE; SKIN INFECTION; T CELL LEUKEMIA; T LYMPHOCYTE; THRUSH;

ADULT; AGED; CELL LINE, TUMOR; FEMALE; FORKHEAD TRANSCRIPTION FACTORS; GENE PRODUCTS, TAX; HUMAN T-LYMPHOTROPIC VIRUS 1; HUMANS; IMMUNOCOMPROMISED HOST; LEUKEMIA, T-CELL; LYMPHOCYTE ACTIVATION; MALE; MIDDLE AGED; PHENOTYPE; T-LYMPHOCYTES, REGULATORY;

EID: 31544442501     PISSN: 09538178     EISSN: 14602377     Source Type: Journal    
DOI: 10.1093/intimm/dxh366     Document Type: Article

References (27)

1. Hinuma, Y., Nagata, K., Hanaoka, M. et al. 1981. Adult T-cell leukemia: antigen in an ATL cell line and detection of antibodies to the antigen in human sera. Proc. Natl. Acad. Sci. USA 78:6476.
2. Uchiyama, T. 1997. Human T cell leukemia virus type I (HTLV-I) and human diseases. Annu. Rev. Immunol. 15:15.
3. Shimoyama, M. 1991. Diagnostic criteria and classification of clinical subtypes of adult T-cell leukaemia-lymphoma. A report from the Lymphoma Study Group (1984-87). Br. J. Haematol. 79:428.
4. Matsuoka, M. 2003. Human T-cell leukemia virus type I and adult T-cell leukemia. Oncogene 22:5131.
5. Yasunaga, J., Sakai, T., Nosaka, K. et al. 2001. Impaired production of naive T lymphocytes in human T-cell leukemia virus type I-infected individuals: Its implications in the immunodeficient state. Blood 97:3177.
6. Sugamura, K., Fujii, M., Kannagi, M., Sakitani, M., Takeuchi, M. and Hinuma, Y. 1984. Cell surface phenotypes and expression of viral antigens of various human cell lines carrying human T-cell leukemia virus. Int. J. Cancer 34:221.
7. Sakaguchi, S. 2004. Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses. Annu. Rev. Immunol. 22:531.
8. Shevach, E. M. 2002. CD4+ CD25+ suppressor T cells: More questions than answers, Nat. Rev. Immunol. 2:389.
9. Ndhlovu, L. C., Takeda, I., Sugamura, K. and Ishii, N. 2004. Expanding role of T-cell costimulators in regulatory T-cell function: Recent advances in accessory molecules expressed on both regulatory and nonregulatory T cells. Crit. Rev. Immunol. 24:251.
10. Karube, K., Ohshima, K., Tsuchiya, T. et al. 2004. Expression of FoxP3, a key molecule in CD4CD25 regulatory T cells, in adult T-cell leukaemia/ lymphoma cells. Br. J. Haematol. 126:81.
11. Ishida, T., Iida, S., Akatsuka, Y. et al. 2004. The CC chemokine receptor 4 as a novel specific molecular target for immunotherapy in adult T-cell leukemia/lymphoma. Clin. Cancer Res. 10:7529.
12. Matsubara, Y., Hori, T., Morita, R., Sakaguchi, S. and Uchiyama, T. 2005. Phenotypic and functional relationship between adult T-cell leukemia cells and regulatory T cells. Leukemia 19:482.
13. Kohno, T., Yamada, Y., Akamatsu, N. et al. 2005. Possible origin of adult T-cell leukemia/lymphoma cells from human T lymphotropic virus type-1-infected regulatory T cells. Cancer Sci. 96:527.
14. Sugamura, K., Nakai, S., Fujii, M. and Hinuma, Y. 1985. Interleukin 2 inhibits in vitro growth of human T cell lines carrying retrovirus. J. Exp. Med. 161:1243.
15. Miyoshi, I., Kubonishi, I., Yoshimoto, S. and Shiraishi, Y. 1981. A T-cell line derived from normal human cord leukocytes by co-culturing with human leukemic T-cells. Gann 72:978.
16. Maeda, M., Shimizu, A., Ikuta, K. et al. 1985. Origin of human T-lymphotrophic virus I-positive T cell lines in adult T cell leukemia. Analysis of T cell receptor gene rearrangement. J. Exp. Med. 162:2169.
17. Ishii, N., Asao, H., Kimura, Y. et al. 1994. Impairment of ligand binding and growth signaling of mutant IL-2 receptor gamma-chains in patients with X-linked severe combined immunodeficiency. J. Immunol. 153:1310.
18. Nagata, K., Ohtani, K., Nakamura, M. and Sugamura, K. 1989. Activation of endogenous c-fos proto-oncogene expression by human T-cell leukemia virus type I-encoded p40tax protein in the human T-cell line, Jurkat. J. Virol. 63:3220.
19. Mori, N., Gill, P. S., Mougdil, T., Murakami, S., Eto, S. and Prager, D. 1996. Interleukin-10 gene expression in adult T-cell leukemia. Blood 88:1035.
20. Niitsu, Y., Urushizaki, Y., Koshida, Y. et al. 1988. Expression of TGF-beta gene in adult T cell leukemia. Blood 71:263.
21. Walker, M. R., Kasprowicz, D. J., Gersuk, V. H. et al. 2003. Induction of FoxP3 and acquisition of T regulatory activity by stimulated human CD4+CD25- T cells. J. Clin. Invest. 112: 1437.
22. Zheng, S. G., Wang, J. H., Gray, J. D., Soucier, H. and Horwitz, D. A. 2004. Natural and induced CD4+CD25+ cells educate CD4+CD25- cells to develop suppressive activity: The role of IL-2, TGF-beta, and IL-10. J. Immunol. 172:5213.
23. Yagi, H., Nomura, T., Nakamura, K. et al. 2004. Crucial role of FOXP3 in the development and function of human CD25+CD4+ regulatory T cells. Int. Immunol. 16:1643.
24. Miura, S., Ohtani, K., Numata, N. et al. 1991. Molecular cloning and characterization of a novel glycoprotein, gp34, that is specifically induced by the human T-cell leukemia virus type I transactivator p40tax. Mol. Cell. Biol. 11:1313.
25. Higashimura, N., Takasawa, N., Tanaka, Y., Nakamura, M. and Sugamura, K. 1996. Induction of OX40, a receptor of gp34, on T cells by trans-acting transcriptional activator, Tax, of human T-cell leukemia virus type 1. Jpn. J. Cancer Res. 87:227.
26. Hori, S., Nomura, T. and Sakaguchi, S. 2003. Control of regulatory T cell development by the transcription factor Foxp3. Science 299:1057.
27. Allan, S. E., Passerini, L., Bacchetta, R., Crellin, N., Dai, M., Orban, P. C., Ziegler, S. F, Roncarolo, M. G., and Levings, M. K. 2005. The role of 2 FOXP3 isoforms in the generation of human CD4+ Tregs. J. Clin. Invest. 115:3276.