The Small GTPase RhoB Regulates TNFα Signaling in Endothelial Cells

PLoS ONE

Volumn 8, Issue 9, 2013, Pages

  Kroon, Jeffrey ^a   Tol, Simon ^a   van Amstel, Sven ^a   Elias, Judith A ^a   Fernandez Borja, Mar ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE P38; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; RHOB GUANINE NUCLEOTIDE BINDING PROTEIN; SMALL INTERFERING RNA; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA RECEPTOR;

ARTICLE; CELL TRANSPORT; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENDOCYTOSIS; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; INFLAMMATION; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; UPREGULATION;

ENDOCYTOSIS; ENZYME ACTIVATION; GENE SILENCING; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; INFLAMMATION MEDIATORS; MITOGEN-ACTIVATED PROTEIN KINASES; NF-KAPPA B; RHOB GTP-BINDING PROTEIN; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84884659377     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0075031     Document Type: Article

References (52)

1. Bradley JR, (2008) TNF-mediated inflammatory disease. J Pathol 214: 149-160.
2. Hehlgans T, Pfeffer K, (2005) The intriguing biology of the tumour necrosis factor/tumour necrosis factor receptor superfamily: players, rules and the games. Immunology 115: 1-20.
3. Karin M, Gallagher E, (2009) TNFR signaling: ubiquitin-conjugated TRAFfic signals control stop-and-go for MAPK signaling complexes. Immunol Rev 228: 225-240.
4. Schneider-Brachert W, Tchikov V, Neumeyer J, Jakob M, Winoto-Morbach S, et al. (2004) Compartmentalization of TNF receptor 1 signaling: internalized TNF receptosomes as death signaling vesicles. Immunity 21: 415-428.
5. Tsujimoto M, Yip YK, Vilcek J, (1985) Tumor necrosis factor: specific binding and internalization in sensitive and resistant cells. Proc Natl Acad Sci U S A 82: 7626-7630.
6. Schutze S, Tchikov V, Schneider-Brachert W, (2008) Regulation of TNFR1 and CD95 signalling by receptor compartmentalization. Nat Rev Mol Cell Biol 9: 655-662.
7. Mahul-Mellier AL, Strappazzon F, Petiot A, Chatellard-Causse C, Torch S, et al. (2008) Alix and ALG-2 are involved in tumor necrosis factor receptor 1-induced cell death. J Biol Chem 283: 34954-34965.
8. Dodeller F, Gottar M, Huesken D, Iourgenko V, Cenni B, (2008) The lysosomal transmembrane protein 9B regulates the activity of inflammatory signaling pathways. J Biol Chem 283: 21487-21494.
9. Liao W, Xiao Q, Tchikov V, Fujita K, Yang W, et al. (2008) CARP-2 is an endosome-associated ubiquitin ligase for RIP and regulates TNF-induced NF-kappaB activation. Curr Biol 18: 641-649.
10. Woo CH, Kim TH, Choi JA, Ryu HC, Lee JE, et al. (2006) Inhibition of receptor internalization attenuates the TNFalpha-induced ROS generation in non-phagocytic cells. Biochem Biophys Res Commun 351: 972-978.
11. Jahner D, Hunter T, (1991) The ras-related gene rhoB is an immediate-early gene inducible by v-Fps, epidermal growth factor, and platelet-derived growth factor in rat fibroblasts. Mol Cell Biol 11: 3682-3690.
12. Fritz G, Kaina B, Aktories K, (1995) The ras-related small GTP-binding protein RhoB is immediate-early inducible by DNA damaging treatments. J Biol Chem 270: 25172-25177.
13. Kajimoto H, Hashimoto K, Bonnet SN, Haromy A, Harry G, et al. (2007) Oxygen activates the Rho/Rho-kinase pathway and induces RhoB and ROCK-1 expression in human and rabbit ductus arteriosus by increasing mitochondria-derived reactive oxygen species: a newly recognized mechanism for sustaining ductal constriction. Circulation 115: 1777-1788.
14. Wheeler AP, Ridley AJ, (2004) Why three Rho proteins? RhoA, RhoB, RhoC, and cell motility. Exp Cell Res 301: 43-49.
15. Adamson P, Paterson HF, Hall A, (1992) Intracellular localization of the P21rho proteins. J Cell Biol 119: 617-627.
16. Gampel A, Parker PJ, Mellor H, (1999) Regulation of epidermal growth factor receptor traffic by the small GTPase rhoB. Curr Biol 9: 955-958.
17. Huang M, Duhadaway JB, Prendergast GC, Laury-Kleintop LD, (2007) RhoB regulates PDGFR-beta trafficking and signaling in vascular smooth muscle cells. Arterioscler Thromb Vasc Biol 27: 2597-2605.
18. Lajoie-Mazenc I, Tovar D, Penary M, Lortal B, Allart S, et al. (2008) MAP1A light chain-2 interacts with GTP-RhoB to control epidermal growth factor (EGF)-dependent EGF receptor signaling. J Biol Chem 283: 4155-4164.
19. Neel NF, Lapierre LA, Goldenring JR, Richmond A, (2007) RhoB plays an essential role in CXCR2 sorting decisions. J Cell Sci 120: 1559-1571.
20. Rondanino C, Rojas R, Ruiz WG, Wang E, Hughey RP, et al. (2007) RhoB-dependent modulation of postendocytic traffic in polarized Madin-Darby canine kidney cells. Traffic 8: 932-949.
21. Sandilands E, Akbarzadeh S, Vecchione A, McEwan DG, Frame MC, et al. (2007) Src kinase modulates the activation, transport and signalling dynamics of fibroblast growth factor receptors. EMBO Rep 8: 1162-1169.
22. Sandilands E, Cans C, Fincham VJ, Brunton VG, Mellor H, et al. (2004) RhoB and actin polymerization coordinate Src activation with endosome-mediated delivery to the membrane. Dev Cell 7: 855-869.
23. Fernandez-Borja M, Janssen L, Verwoerd D, Hordijk P, Neefjes J, (2005) RhoB regulates endosome transport by promoting actin assembly on endosomal membranes through Dia1. J Cell Sci 118: 2661-2670.
24. Wallar BJ, Deward AD, Resau JH, Alberts AS, (2007) RhoB and the mammalian Diaphanous-related formin mDia2 in endosome trafficking. Exp Cell Res 313: 560-571.
25. Garcia-Mata R, Wennerberg K, Arthur WT, Noren NK, Ellerbroek SM, et al. (2006) Analysis of activated GAPs and GEFs in cell lysates. Methods Enzymol 406: 425-437.
26. van der Pouw Kraan TC, Boeije LC, de Groot ER, Stapel SO, Snijders A, et al. (1997) Reduced production of IL-12 and IL-12-dependent IFN-gamma release in patients with allergic asthma. J Immunol 158: 5560-5565.
27. Engel ME, Datta PK, Moses HL, (1998) RhoB is stabilized by transforming growth factor beta and antagonizes transcriptional activation. J Biol Chem 273: 9921-9926.
28. Fritz G, Kaina B, (2001) Transcriptional activation of the small GTPase gene rhoB by genotoxic stress is regulated via a CCAAT element. Nucleic Acids Res 29: 792-798.
29. Westmark CJ, Bartleson VB, Malter JS, (2005) RhoB mRNA is stabilized by HuR after UV light. Oncogene 24: 502-511.
30. Kishore N, Sommers C, Mathialagan S, Guzova J, Yao M, et al. (2003) A selective IKK-2 inhibitor blocks NF-kappa B-dependent gene expression in interleukin-1 beta-stimulated synovial fibroblasts. J Biol Chem 278: 32861-32871.
31. Adini I, Rabinovitz I, Sun JF, Prendergast GC, Benjamin LE, (2003) RhoB controls Akt trafficking and stage-specific survival of endothelial cells during vascular development. Genes Dev 17: 2721-2732.
32. Canguilhem B, Pradines A, Baudouin C, Boby C, Lajoie-Mazenc I, et al. (2005) RhoB protects human keratinocytes from UVB-induced apoptosis through epidermal growth factor receptor signaling. J Biol Chem 280: 43257-43263.
33. Mannam P, Zhang X, Shan P, Zhang Y, Shinn AS, et al. (2013) Endothelial MKK3 is a critical mediator of lethal murine endotoxemia and acute lung injury. J Immunol 190: 1264-1275.
34. Su X, Ao L, Zou N, Song Y, Yang X, et al. (2008) Post-transcriptional regulation of TNF-induced expression of ICAM-1 and IL-8 in human lung microvascular endothelial cells: an obligatory role for the p38 MAPK-MK2 pathway dissociated with HSP27. Biochim Biophys Acta 1783: 1623-1631.
35. Llado A, Timpson P, Vila de MS, Moreto J, Pol A, et al. (2008) Protein kinase Cdelta and calmodulin regulate epidermal growth factor receptor recycling from early endosomes through Arp2/3 complex and cortactin. Mol Biol Cell 19: 17-29.
36. Rolfe BE, Worth NF, World CJ, Campbell JH, Campbell GR, (2005) Rho and vascular disease. Atherosclerosis 183: 1-16.
37. Kim BK, Kim HM, Chung KS, Kim DM, Park SK, et al. (2011) Upregulation of RhoB via c-Jun N-terminal kinase signaling induces apoptosis of the human gastric carcinoma NUGC-3 cells treated with NSC12618. Carcinogenesis 32: 254-261.
38. Kim DM, Won M, Chung CS, Kim S, Yim HJ, et al. (2010) JNK-mediated transcriptional upregulation of RhoB is critical for apoptosis of HCT-116 colon cancer cells by a novel diarylsulfonylurea derivative. Apoptosis 15: 1540-1548.
39. Kamon H, Kawabe T, Kitamura H, Lee J, Kamimura D, et al. (2006) TRIF-GEFH1-RhoB pathway is involved in MHCII expression on dendritic cells that is critical for CD4 T-cell activation. EMBO J 25: 4108-4119.
40. Nwariaku FE, Rothenbach P, Liu Z, Zhu X, Turnage RH, et al. (2003) Rho inhibition decreases TNF-induced endothelial MAPK activation and monolayer permeability. J Appl Physiol 95: 1889-1895.
41. Teramoto H, Crespo P, Coso OA, Igishi T, Xu N, et al. (1996) The small GTP-binding protein rho activates c-Jun N-terminal kinases/stress-activated protein kinases in human kidney 293T cells. Evidence for a Pak-independent signaling pathway. J Biol Chem 271: 25731-25734.
42. Kotlyarov A, Neininger A, Schubert C, Eckert R, Birchmeier C, et al. (1999) MAPKAP kinase 2 is essential for LPS-induced TNF-alpha biosynthesis. Nat Cell Biol 1: 94-97.
43. Kyriakis JM, Avruch J, (2001) Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. Physiol Rev 81: 807-869.
44. Lasa M, Mahtani KR, Finch A, Brewer G, Saklatvala J, et al. (2000) Regulation of cyclooxygenase 2 mRNA stability by the mitogen-activated protein kinase p38 signaling cascade. Mol Cell Biol 20: 4265-4274.
45. Neininger A, Kontoyiannis D, Kotlyarov A, Winzen R, Eckert R, et al. (2002) MK2 targets AU-rich elements and regulates biosynthesis of tumor necrosis factor and interleukin-6 independently at different post-transcriptional levels. J Biol Chem 277: 3065-3068.
46. Saklatvala J, Dean J, Clark A (2003) Control of the expression of inflammatory response genes. Biochem Soc Symp 95-106.
47. Winzen R, Kracht M, Ritter B, Wilhelm A, Chen CY, et al. (1999) The p38 MAP kinase pathway signals for cytokine-induced mRNA stabilization via MAP kinase-activated protein kinase 2 and an AU-rich region-targeted mechanism. EMBO J 18: 4969-4980.
48. Wysk M, Yang DD, Lu HT, Flavell RA, Davis RJ, (1999) Requirement of mitogen-activated protein kinase kinase 3 (MKK3) for tumor necrosis factor-induced cytokine expression. Proc Natl Acad Sci U S A 96: 3763-3768.
49. Delcroix JD, Valletta JS, Wu C, Hunt SJ, Kowal AS, et al. (2003) NGF signaling in sensory neurons: evidence that early endosomes carry NGF retrograde signals. Neuron 39: 69-84.
50. Pelkmans L, Zerial M, (2005) Kinase-regulated quantal assemblies and kiss-and-run recycling of caveolae. Nature 436: 128-133.
51. Miaczynska M, Pelkmans L, Zerial M, (2004) Not just a sink: endosomes in control of signal transduction. Curr Opin Cell Biol 16: 400-406.
52. Bradley JR, Johnson DR, Pober JS, (1993) Four different classes of inhibitors of receptor-mediated endocytosis decrease tumor necrosis factor-induced gene expression in human endothelial cells. J Immunol 150: 5544-5555.