Oxygen activates the rho/rho-kinase pathway and induces RhoB and ROCK-1 expression in human and rabbit ductus arteriosus by increasing mitochondria-derived reactive oxygen species: A newly recognized mechanism for sustaining ductal constriction

Circulation

Volumn 115, Issue 13, 2007, Pages 1777-1788

  Kajimoto, Hidemi ^a   Hashimoto, Kyoko ^a   Bonnet, Sandra N ^a   Haromy, Alois ^a   Harry, Gwyneth ^a   Moudgil, Rohit ^a   Nakanishi, Toshio ^b   Rebeyka, Ivan ^a   Thébaud, Bernard ^a   Michelakis, Evangelos D ^a   Archer, Stephen L ^a,c  

^a UNIVERSITY OF ALBERTA   (Canada)

^b TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

^c UNIVERSITY OF CHICAGO   (United States)

Author keywords

Calcium; Cardiovascular diseases; Congenital heart disease; Ductus arteriosus, patent; Muscle, smooth; Oxygen; Prematurity

Indexed keywords

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; ADENOSINE TRIPHOSPHATASE (CALCIUM); CALCIUM; CALCIUM CHANNEL L TYPE; ENDOTHELIN; FASUDIL; HYDROGEN PEROXIDE; NIFEDIPINE; OXYGEN; PHENYLEPHRINE; POTASSIUM CHLORIDE; PROTEIN KINASE; REACTIVE OXYGEN METABOLITE; RHO ASSOCIATED COILED COIL FORMING PROTEIN KINASE 1; RHO FACTOR; RHO KINASE; RHO KINASE INHIBITOR; RHOB GUANINE NUCLEOTIDE BINDING PROTEIN; UNCLASSIFIED DRUG; 1 (5 ISOQUINOLINESULFONYL) 2 METHYLPIPERAZINE; AMIDE; CALCIUM CHANNEL BLOCKING AGENT; DRUG DERIVATIVE; PROTEIN SERINE THREONINE KINASE; PYRIDINE DERIVATIVE; RHO-ASSOCIATED KINASE; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; SIGNAL PEPTIDE; SUPEROXIDE;

ANIMAL TISSUE; AORTA; ARTICLE; CONTROLLED STUDY; DUCTUS ARTERIOSUS; DUCTUS ARTERIOSUS OBLITERATION; ENZYME ACTIVATION; ENZYME LOCALIZATION; EXTRACELLULAR SPACE; FEMALE; HEART MITOCHONDRION; HUMAN; HUMAN TISSUE; HYPOPLASTIC LEFT HEART SYNDROME; MALE; MOLECULAR MIMICRY; NEWBORN; NONHUMAN; OXIDATION REDUCTION REACTION; OXYGEN TENSION; PATENT DUCTUS ARTERIOSUS; POSITIVE FEEDBACK; PREMATURITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PULMONARY ARTERY; RABBIT; SARCOPLASMIC RETICULUM; SMOOTH MUSCLE FIBER; UPREGULATION; VASOCONSTRICTION; ANIMAL; BIOSYNTHESIS; BLOOD; CALCIUM SIGNALING; DRUG ANTAGONISM; DRUG EFFECT; ENZYME INDUCTION; ENZYMOLOGY; FEEDBACK SYSTEM; FETUS HEART; GENETICS; GESTATIONAL AGE; METABOLISM; ORGAN CULTURE TECHNIQUE; PATHOLOGY; PHYSIOLOGY; PRESSURE;

1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE; AMIDES; ANIMALS; ANIMALS, NEWBORN; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS, L-TYPE; CALCIUM SIGNALING; DUCTUS ARTERIOSUS; ENZYME ACTIVATION; ENZYME INDUCTION; FEEDBACK, BIOCHEMICAL; FEMALE; FETAL HEART; GESTATIONAL AGE; HUMANS; HYDROGEN PEROXIDE; HYPOPLASTIC LEFT HEART SYNDROME; INFANT, NEWBORN; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MITOCHONDRIA, HEART; NIFEDIPINE; ORGAN CULTURE TECHNIQUES; OXIDATION-REDUCTION; OXYGEN; PARTIAL PRESSURE; PHENYLEPHRINE; PROTEIN-SERINE-THREONINE KINASES; PYRIDINES; RABBITS; REACTIVE OXYGEN SPECIES; RHOA GTP-BINDING PROTEIN; RHOB GTP-BINDING PROTEIN; SUPEROXIDES; VASOCONSTRICTION;

EID: 34247216078     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.106.649566     Document Type: Article

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