JNK-mediated transcriptional upregulation of RhoB is critical for apoptosis of HCT-116 colon cancer cells by a novel diarylsulfonylurea derivative

Apoptosis

Volumn 15, Issue 12, 2010, Pages 1540-1548

  Kim, Dong Myung ^a,b   Won, Misun ^b   Chung, Chung Sook ^b   Kim, Semi ^b   Yim, Hyeon Joo ^a   Jung, Sang Hun ^c   Jeong, Shinwu ^a  

^a LG Chemical Ltd   (South Korea)

^b Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

^c Chungnam National University   (South Korea)

Author keywords

Anti cancer agent; Apoptosis; Diarylsulfonylurea; HDAC1; RhoB; SAPK JNK

Indexed keywords

5,6 DICHLOROBENZIMIDAZOLE RIBOSIDE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; ANTINEOPLASTIC AGENT; ETHYL [2 METHYL 4 [(2 OXO 4 PHENYLIMIDAZOLLIDIN 1 YL)SULFONYL]PHENYL]CARBAMATE; HISTONE DEACETYLASE 1; JANUS KINASE 1; JANUS KINASE 2; LUCIFERASE; MESSENGER RNA; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROCASPASE 3; PROTEIN P53; RHOB GUANINE NUCLEOTIDE BINDING PROTEIN; SULFONYLUREA DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CANCER INHIBITION; COLON ADENOCARCINOMA; COLON CANCER; CONTROLLED STUDY; DRUG POTENCY; ENZYME ACTIVATION; FEMALE; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; REPORTER GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA SYNTHESIS; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION; TUMOR XENOGRAFT; UPREGULATION; WESTERN BLOTTING;

ANIMALS; ANTHRACENES; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE, TUMOR; COLORECTAL NEOPLASMS; DICHLORORIBOFURANOSYLBENZIMIDAZOLE; FEMALE; FLOW CYTOMETRY; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LUCIFERASES; MICE; MICE, INBRED BALB C; NEOPLASM TRANSPLANTATION; PLASMIDS; RHOB GTP-BINDING PROTEIN; SIGNAL TRANSDUCTION; SULFONYLUREA COMPOUNDS; TRANSCRIPTION, GENETIC; UP-REGULATION;

EID: 78649945643     PISSN: 13608185     EISSN: 1573675X     Source Type: Journal    
DOI: 10.1007/s10495-010-0531-7     Document Type: Article

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