Protein domain mimetics as in vivo modulators of hypoxia-inducible factor signaling

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 39, 2013, Pages 15602-15607

  Kushal, Swati ^a   Lao, Brooke Bullock ^a   Henchey, Laura K ^b   Dubey, Ramin ^a   Mesallati, Hanah ^a   Traaseth, Nathaniel J ^b   Olenyuk, Bogdan Z ^a   Arora, Paramjit S ^b  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b NEW YORK UNIVERSITY   (United States)

Author keywords

Helix mimetics; Hydrogen bond surrogate helices; Rational design; Synthetic inhibitors of transcription

Indexed keywords

GLUCOSE TRANSPORTER 1; HISTONE ACETYLTRANSFERASE PCAF; HYPOXIA INDUCIBLE FACTOR 1ALPHA; VASCULOTROPIN;

AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; BACTERIAL GROWTH; CANCER GROWTH; CELL TYPE; CELL VIABILITY; COMPLEX FORMATION; CONTROLLED STUDY; DOWN REGULATION; GENE EXPRESSION; HETERONUCLEAR SINGLE QUANTUM COHERENCE; HUMAN; HUMAN CELL; HYDROGEN BOND; IN VITRO STUDY; IN VIVO STUDY; KIDNEY CARCINOMA; MOUSE; NONHUMAN; POLARIZATION; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN FOLDING; PROTEIN MICROARRAY; PROTEIN PROTEIN INTERACTION; PROTEIN SYNTHESIS; SIGNAL TRANSDUCTION; TUMOR GROWTH;

HELIX MIMETICS; HYDROGEN BOND SURROGATE HELICES; RATIONAL DESIGN; SYNTHETIC INHIBITORS OF TRANSCRIPTION;

AMINO ACID SEQUENCE; ANIMALS; ANTINEOPLASTIC AGENTS; CELL HYPOXIA; DOWN-REGULATION; FEMALE; GENE EXPRESSION PROFILING; HELA CELLS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1; LIGANDS; MICE; MICE, INBRED BALB C; MOLECULAR SEQUENCE DATA; P300-CBP TRANSCRIPTION FACTORS; PEPTIDES; PROTEIN BINDING; PROTEIN MULTIMERIZATION; PROTEIN STABILITY; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; RESPONSE ELEMENTS; SIGNAL TRANSDUCTION; TRANSCRIPTION, GENETIC; VASCULAR ENDOTHELIAL GROWTH FACTOR A; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84884640689     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1312473110     Document Type: Article

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