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Volumn 67, Issue , 2013, Pages 459-475

Experimental approaches for defining functional roles of microbes in the human gut

Author keywords

Flora; Gain of function; Loss of function; Metagenomics; Microbiome; Sequencing

Indexed keywords

GENOMIC DNA; RIBOSOME RNA; RNA 16S;

EID: 84884503949     PISSN: 00664227     EISSN: 15453251     Source Type: Book Series    
DOI: 10.1146/annurev-micro-092412-155642     Document Type: Article
Times cited : (38)

References (101)
  • 6
    • 33846015876 scopus 로고    scopus 로고
    • Functional genomic and metabolic studies of the adaptations of a prominent adult human gut symbiont, Bacteroides thetaiotaomicron, to the suckling period
    • Bjursell MK, Martens EC, Gordon JI. 2006. Functional genomic and metabolic studies of the adaptations of a prominent adult human gut symbiont, Bacteroides thetaiotaomicron, to the suckling period. J. Biol. Chem. 281:36269-79
    • (2006) J. Biol. Chem. , vol.281 , pp. 36269-36279
    • Bjursell, M.K.1    Martens, E.C.2    Gordon, J.I.3
  • 7
    • 70449703996 scopus 로고    scopus 로고
    • What are the consequences of the disappearing human microbiota?
    • Blaser MJ, Falkow S. 2009. What are the consequences of the disappearing human microbiota? Nat. Rev. Microbiol. 7:887-94
    • (2009) Nat. Rev. Microbiol. , vol.7 , pp. 887-894
    • Blaser, M.J.1    Falkow, S.2
  • 8
    • 79956078164 scopus 로고    scopus 로고
    • Commensal Bacteroides species induce colitis in host-genotype-specific fashion in a mouse model of inflammatory bowel disease
    • Bloom SM, Bijanki VN, Nava GM, Sun L, Malvin NP, et al. 2011. Commensal Bacteroides species induce colitis in host-genotype-specific fashion in a mouse model of inflammatory bowel disease. Cell Host Microbe 9:390-403
    • (2011) Cell Host Microbe , vol.9 , pp. 390-403
    • Bloom, S.M.1    Bijanki, V.N.2    Nava, G.M.3    Sun, L.4    Malvin, N.P.5
  • 9
    • 53649098280 scopus 로고    scopus 로고
    • Vancomycin-resistant enterococci exploit antibiotic-induced innate immune deficits
    • Brandl K, Plitas G, Mihu CN, Ubeda C, Jia T, et al. 2008. Vancomycin-resistant enterococci exploit antibiotic-induced innate immune deficits. Nature 455:804-7
    • (2008) Nature , vol.455 , pp. 804-807
    • Brandl, K.1    Plitas, G.2    Mihu, C.N.3    Ubeda, C.4    Jia, T.5
  • 10
    • 80052965474 scopus 로고    scopus 로고
    • Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in amouse via the vagus nerve
    • Bravo JA, Forsythe P, ChewMV, Escaravage E, SavignacHM, et al. 2011. Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in amouse via the vagus nerve. Proc. Natl. Acad. Sci. USA 108:16050-55
    • (2011) Proc. Natl. Acad. Sci. USA , vol.108 , pp. 16050-16055
    • Bravo, J.A.1    Forsythe, P.2    Chew, M.V.3    Escaravage, E.4    Savignac, H.M.5
  • 11
    • 84860490976 scopus 로고    scopus 로고
    • The MetaCyc database of metabolic pathways and enzymes and the BioCyc collection of pathway/genome databases
    • Caspi R, Altman T, Dreher K, Fulcher CA, Subhraveti P, et al. 2012. The MetaCyc database of metabolic pathways and enzymes and the BioCyc collection of pathway/genome databases. Nucleic Acids Res. 40:D742-53
    • (2012) Nucleic Acids Res , vol.40
    • Caspi, R.1    Altman, T.2    Dreher, K.3    Fulcher, C.A.4    Subhraveti, P.5
  • 12
    • 84867283741 scopus 로고    scopus 로고
    • Functional screening of antibiotic resistance genes from human gut microbiota reveals a novel gene fusion
    • Cheng G, Hu Y, Yin Y, Yang X, Xiang C, et al. 2012. Functional screening of antibiotic resistance genes from human gut microbiota reveals a novel gene fusion. FEMS Microbiol. Lett. 336:11-16
    • (2012) FEMS Microbiol. Lett. , vol.336 , pp. 11-16
    • Cheng, G.1    Hu, Y.2    Yin, Y.3    Yang, X.4    Xiang, C.5
  • 14
    • 84865477413 scopus 로고    scopus 로고
    • Antibiotics in early life alter the murine colonic microbiome and adiposity
    • Cho I, Yamanishi S, Cox L, Methe BA, Zavadil J, et al. 2012. Antibiotics in early life alter the murine colonic microbiome and adiposity. Nature 488:621-26
    • (2012) Nature , vol.488 , pp. 621-626
    • Cho, I.1    Yamanishi, S.2    Cox, L.3    Methe, B.A.4    Zavadil, J.5
  • 15
    • 84862637797 scopus 로고    scopus 로고
    • Gut immune maturation depends on colonization with a host-specific microbiota
    • Chung H, Pamp SJ, Hill JA, Surana NK, Edelman SM, et al. 2012. Gut immune maturation depends on colonization with a host-specific microbiota. Cell 149:1578-93
    • (2012) Cell , vol.149 , pp. 1578-1593
    • Chung, H.1    Pamp, S.J.2    Hill, J.A.3    Surana, N.K.4    Edelman, S.M.5
  • 16
    • 33846072878 scopus 로고    scopus 로고
    • The ribosomal database project (RDP-II): Introducing myRDP space and quality controlled public data
    • Cole JR, Chai B, Farris RJ, Wang Q, Kulam-Syed-Mohideen AS, et al. 2007. The ribosomal database project (RDP-II): introducing myRDP space and quality controlled public data. Nucleic Acids Res. 35:D169-72
    • (2007) Nucleic Acids Res. , vol.35
    • Cole, J.R.1    Chai, B.2    Farris, R.J.3    Wang, Q.4    Kulam-Syed-Mohideen, A.S.5
  • 17
    • 84868152309 scopus 로고    scopus 로고
    • Context matters-the complex interplay between resistome genotypes and resistance phenotypes
    • Dantas G, Sommer MO. 2012. Context matters-the complex interplay between resistome genotypes and resistance phenotypes. Curr. Opin. Microbiol. 15:577-82
    • (2012) Curr. Opin. Microbiol. , vol.15 , pp. 577-582
    • Dantas, G.1    Sommer, M.O.2
  • 18
    • 84867528871 scopus 로고    scopus 로고
    • Diversity of individual dynamic patterns of emergence of resistance to quinolones in Escherichia coli from the fecal flora of healthy volunteers exposed to ciprofloxacin
    • de Lastours V, Cambau E, Guillard T, Marcade G, Chau F, Fantin B. 2012. Diversity of individual dynamic patterns of emergence of resistance to quinolones in Escherichia coli from the fecal flora of healthy volunteers exposed to ciprofloxacin. J. Infect. Dis. 206:1399-406
    • (2012) J. Infect. Dis. , vol.206 , pp. 1399-1406
    • De Lastours, V.1    Cambau, E.2    Guillard, T.3    Marcade, G.4    Chau, F.5    Fantin, B.6
  • 19
    • 84864754089 scopus 로고    scopus 로고
    • Role of the intestinal microbiome in health and disease: From correlation to causation
    • de VosWM, de Vos EA. 2012. Role of the intestinal microbiome in health and disease: from correlation to causation. Nutr. Rev. 70(Suppl. 1):S45-56
    • (2012) Nutr. Rev , vol.70 , Issue.SUPPL. 1
    • De Vos, W.M.1    De Vos, E.A.2
  • 20
    • 79959677612 scopus 로고    scopus 로고
    • The gut as reservoir of antibiotic resistance: Microbial diversity of tetracycline resistance in mother and infant
    • de Vries LE, Vallès Y, AgersøY, Vaishampayan PA, Garcá-Montaner A, et al. 2011. The gut as reservoir of antibiotic resistance: microbial diversity of tetracycline resistance in mother and infant. PLoS One 6:e21644
    • (2011) PLoS One , vol.6
    • De Vries, L.E.1    Vallès, Y.2    Agersø, Y.3    Vaishampayan, P.A.4    Garcá-Montaner, A.5
  • 21
    • 56849106496 scopus 로고    scopus 로고
    • The pervasive effects of an antibiotic on the human gut microbiota, as revealed by deep 16S rRNA sequencing
    • Dethlefsen L, Huse S, SoginML, Relman DA. 2008. The pervasive effects of an antibiotic on the human gut microbiota, as revealed by deep 16S rRNA sequencing. PLoS Biol. 6:e280
    • (2008) PLoS Biol. , vol.6
    • Dethlefsen, L.1    Huse, S.2    Sogin, M.L.3    Relman, D.A.4
  • 22
    • 79952756960 scopus 로고    scopus 로고
    • Incomplete recovery and individualized responses of the human distal gut microbiota to repeated antibiotic perturbation
    • Dethlefsen L, Relman DA. 2011. Incomplete recovery and individualized responses of the human distal gut microbiota to repeated antibiotic perturbation. Proc. Natl. Acad. Sci. USA 108(Suppl. 1):4554-61
    • (2011) Proc. Natl. Acad. Sci. USA , vol.108 , Issue.SUPPL. 1 , pp. 4554-4561
    • Dethlefsen, L.1    Relman, D.A.2
  • 24
    • 79957576718 scopus 로고    scopus 로고
    • NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis
    • Elinav E, Strowig T, Kau AL, Henao-Mejia J, Thaiss CA, et al. 2011. NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis. Cell 145:745-57
    • (2011) Cell , vol.145 , pp. 745-757
    • Elinav, E.1    Strowig, T.2    Kau, A.L.3    Henao-Mejia, J.4    Thaiss, C.A.5
  • 25
    • 84864752706 scopus 로고    scopus 로고
    • The impact of nutrition on the human microbiome
    • Flint HJ. 2012. The impact of nutrition on the human microbiome. Nutr. Rev. 70(Suppl. 1):S10-13
    • (2012) Nutr. Rev , vol.70 , Issue.SUPPL. 1
    • Flint, H.J.1
  • 26
    • 33748776559 scopus 로고    scopus 로고
    • Automated protein function prediction-the genomic challenge
    • Friedberg I. 2006. Automated protein function prediction-the genomic challenge. Brief Bioinform. 7:225-42
    • (2006) Brief Bioinform. , vol.7 , pp. 225-242
    • Friedberg, I.1
  • 27
    • 70349742524 scopus 로고    scopus 로고
    • The key role of segmented filamentous bacteria in the coordinated maturation of gut helper T cell responses
    • Gaboriau-Routhiau V, Rakotobe S, Lécuyer E, Mulder I, Lan A, et al. 2009. The key role of segmented filamentous bacteria in the coordinated maturation of gut helper T cell responses. Immunity 31:677-89
    • (2009) Immunity , vol.31 , pp. 677-689
    • Gaboriau-Routhiau, V.1    Rakotobe, S.2    Lécuyer, E.3    Mulder, I.4    Lan, A.5
  • 28
    • 79955079817 scopus 로고    scopus 로고
    • Genome-scale identification of resistance functions in Pseudomonas aeruginosa using Tn-seq
    • Gallagher LA, Shendure J, Manoil C. 2011. Genome-scale identification of resistance functions in Pseudomonas aeruginosa using Tn-seq. mBio 2:e00315-10
    • (2011) MBio , vol.2
    • Gallagher, L.A.1    Shendure, J.2    Manoil, C.3
  • 29
    • 67650069479 scopus 로고    scopus 로고
    • Perturbation of the small intestine microbial ecology by streptomycin alters pathology in a Salmonella enterica serovar Typhimurium murine model of infection
    • Garner CD, Antonopoulos DA, Wagner B, Duhamel GE, Keresztes I, et al. 2009. Perturbation of the small intestine microbial ecology by streptomycin alters pathology in a Salmonella enterica serovar Typhimurium murine model of infection. Infect. Immun. 77:2691-702
    • (2009) Infect. Immun. , vol.77 , pp. 2691-2702
    • Garner, C.D.1    Antonopoulos, D.A.2    Wagner, B.3    Duhamel, G.E.4    Keresztes, I.5
  • 30
    • 70349510646 scopus 로고    scopus 로고
    • Tracking insertion mutants within libraries by deep sequencing and a genome-wide screen for Haemophilus genes required in the lung
    • Gawronski JD, Wong SM, Giannoukos G, Ward DV, Akerley BJ. 2009. Tracking insertion mutants within libraries by deep sequencing and a genome-wide screen for Haemophilus genes required in the lung. Proc. Natl. Acad. Sci. USA 106:16422-27
    • (2009) Proc. Natl. Acad. Sci. USA , vol.106 , pp. 16422-16427
    • Gawronski, J.D.1    Wong, S.M.2    Giannoukos, G.3    Ward, D.V.4    Akerley, B.J.5
  • 32
    • 79957924860 scopus 로고    scopus 로고
    • Our unindicted coconspirators: Human metabolism from a microbial perspective
    • Goodman AL, Gordon JI. 2010. Our unindicted coconspirators: human metabolism from a microbial perspective. Cell Metabol. 12:111-16
    • (2010) Cell Metabol. , vol.12 , pp. 111-116
    • Goodman, A.L.1    Gordon, J.I.2
  • 33
    • 79955025122 scopus 로고    scopus 로고
    • Extensive personal human gut microbiota culture collections characterized and manipulated in gnotobiotic mice
    • Goodman AL, Kallstrom G, Faith JJ, Reyes A, Moore A, et al. 2011. Extensive personal human gut microbiota culture collections characterized and manipulated in gnotobiotic mice. Proc. Natl. Acad. Sci. USA 108:6252-57
    • (2011) Proc. Natl. Acad. Sci. USA , vol.108 , pp. 6252-6257
    • Goodman, A.L.1    Kallstrom, G.2    Faith, J.J.3    Reyes, A.4    Moore, A.5
  • 34
    • 69949123813 scopus 로고    scopus 로고
    • Identifying genetic determinants needed to establish a human gut symbiont in its habitat
    • Goodman AL, McNulty NP, Zhao Y, Leip D, Mitra RD, et al. 2009. Identifying genetic determinants needed to establish a human gut symbiont in its habitat. Cell Host Microbe 6:279-89
    • (2009) Cell Host Microbe , vol.6 , pp. 279-289
    • Goodman, A.L.1    McNulty, N.P.2    Zhao, Y.3    Leip, D.4    Mitra, R.D.5
  • 35
    • 84860541398 scopus 로고    scopus 로고
    • Identifying microbial fitness determinants by insertion sequencing using genome-wide transposon mutant libraries
    • Goodman AL, WuM, Gordon JI. 2011. Identifying microbial fitness determinants by insertion sequencing using genome-wide transposon mutant libraries. Nat. Protoc. 6:1969-80
    • (2011) Nat. Protoc , vol.6 , pp. 1969-1980
    • Goodman, A.L.1    Wu, M.2    Gordon, J.I.3
  • 36
    • 84861964370 scopus 로고    scopus 로고
    • Is it time for a metagenomic basis of therapeutics?
    • Haiser HJ, Turnbaugh PJ. 2012. Is it time for a metagenomic basis of therapeutics? Science 336:1253-55
    • (2012) Science , vol.336 , pp. 1253-1255
    • Haiser, H.J.1    Turnbaugh, P.J.2
  • 37
    • 10344227692 scopus 로고    scopus 로고
    • Metagenomics: Application of genomics to uncultured microorganisms
    • Handelsman J. 2004. Metagenomics: application of genomics to uncultured microorganisms. Microbiol. Mol. Biol. Rev. 68:669-85
    • (2004) Microbiol. Mol. Biol. Rev. , vol.68 , pp. 669-685
    • Handelsman, J.1
  • 38
    • 77954051526 scopus 로고    scopus 로고
    • Reversible microbial colonization of germ-freemice reveals the dynamics of IgA immune responses
    • Hapfelmeier S, Lawson MA, Slack E, Kirundi JK, Stoel M, et al. 2010. Reversible microbial colonization of germ-freemice reveals the dynamics of IgA immune responses. Science 328:1705-9
    • (2010) Science , vol.328 , pp. 1705-1709
    • Hapfelmeier, S.1    Lawson, M.A.2    Slack, E.3    Kirundi, J.K.4    Stoel, M.5
  • 39
    • 77950847866 scopus 로고    scopus 로고
    • Transfer of carbohydrate-active enzymes from marine bacteria to Japanese gut microbiota
    • Hehemann JH, Correc G, Barbeyron T, Helbert W, Czjzek M, Michel G. 2010. Transfer of carbohydrate-active enzymes from marine bacteria to Japanese gut microbiota. Nature 464:908-12
    • (2010) Nature , vol.464 , pp. 908-912
    • Hehemann, J.H.1    Correc, G.2    Barbeyron, T.3    Helbert, W.4    Czjzek, M.5    Michel, G.6
  • 40
    • 0035793372 scopus 로고    scopus 로고
    • Molecular analysis of commensal host-microbial relationships in the intestine
    • Hooper LV, Wong MH, Thelin A, Hansson L, Falk PG, Gordon JI. 2001. Molecular analysis of commensal host-microbial relationships in the intestine. Science 291:881-84
    • (2001) Science , vol.291 , pp. 881-884
    • Hooper, L.V.1    Wong, M.H.2    Thelin, A.3    Hansson, L.4    Falk, P.G.5    Gordon, J.I.6
  • 42
    • 84862276328 scopus 로고    scopus 로고
    • Structure, function and diversity of the healthy human microbiome
    • Human Microbiome Project Consortium
    • Human Microbiome Project Consortium. 2012. Structure, function and diversity of the healthy human microbiome. Nature 486:207-14
    • (2012) Nature , vol.486 , pp. 207-214
  • 43
    • 70350343544 scopus 로고    scopus 로고
    • Induction of intestinal Th17 cells by segmented filamentous bacteria
    • Ivanov II, Atarashi K, Manel N, Brodie EL, Shima T, et al. 2009. Induction of intestinal Th17 cells by segmented filamentous bacteria. Cell 139:485-98
    • (2009) Cell , vol.139 , pp. 485-498
    • Ivanov, I.I.1    Atarashi, K.2    Manel, N.3    Brodie, E.L.4    Shima, T.5
  • 45
    • 35448965272 scopus 로고    scopus 로고
    • Transfer of an ampicillin resistance gene between two Escherichia coli strains in the bowel microbiota of an infant treated with antibiotics
    • Karami N, Martner A, Enne VI, Swerkersson S, Adlerberth I, Wold AE. 2007. Transfer of an ampicillin resistance gene between two Escherichia coli strains in the bowel microbiota of an infant treated with antibiotics. J. Antimicrobiol. Chemother. 60:1142-45
    • (2007) J. Antimicrobiol. Chemother. , vol.60 , pp. 1142-1145
    • Karami, N.1    Martner, A.2    Enne, V.I.3    Swerkersson, S.4    Adlerberth, I.5    Wold, A.E.6
  • 47
    • 84862207235 scopus 로고    scopus 로고
    • Human gut-on-a-chip inhabited by microbial flora that experiences intestinal peristalsis-like motions and flow
    • Kim HJ, Huh D, Hamilton G, Ingber DE. 2012. Human gut-on-a-chip inhabited by microbial flora that experiences intestinal peristalsis-like motions and flow. Lab Chip 12:2165-74
    • (2012) Lab Chip , vol.12 , pp. 2165-2174
    • Kim, H.J.1    Huh, D.2    Hamilton, G.3    Ingber, D.E.4
  • 49
    • 84864614787 scopus 로고    scopus 로고
    • Host remodeling of the gut microbiome and metabolic changes during pregnancy
    • Koren O, Goodrich JK, Cullender TC, Spor A, Laitinen K, et al. 2012. Host remodeling of the gut microbiome and metabolic changes during pregnancy. Cell 150:470-80
    • (2012) Cell , vol.150 , pp. 470-480
    • Koren, O.1    Goodrich, J.K.2    Cullender, T.C.3    Spor, A.4    Laitinen, K.5
  • 52
    • 73249130761 scopus 로고    scopus 로고
    • Simultaneous assay of every Salmonella Typhi gene using one million transposon mutants
    • Langridge GC, Phan MD, Turner DJ, Perkins TT, Parts L, et al. 2009. Simultaneous assay of every Salmonella Typhi gene using one million transposon mutants. Genome Res. 19:2308-16
    • (2009) Genome Res. , vol.19 , pp. 2308-2316
    • Langridge, G.C.1    Phan, M.D.2    Turner, D.J.3    Perkins, T.T.4    Parts, L.5
  • 53
    • 31944451507 scopus 로고    scopus 로고
    • In vivo transfer of the vanA resistance gene from an Enterococcus faecium isolate of animal origin to an E. faecium isolate of human origin in the intestines of human volunteers
    • Lester CH, Frimodt-Møller N, Sørensen TL, Monnet DL, Hammerum AM. 2006. In vivo transfer of the vanA resistance gene from an Enterococcus faecium isolate of animal origin to an E. faecium isolate of human origin in the intestines of human volunteers. Antimicrob. Agents Chemother. 50:596-99
    • (2006) Antimicrob. Agents Chemother. , vol.50 , pp. 596-599
    • Lester, C.H.1    Frimodt-Møller, N.2    Sørensen, T.L.3    Monnet, D.L.4    Hammerum, A.M.5
  • 55
    • 33748713890 scopus 로고    scopus 로고
    • UniFrac-an online tool for comparing microbial community diversity in a phylogenetic context
    • LozuponeC, HamadyM, Knight R. 2006. UniFrac-an online tool for comparing microbial community diversity in a phylogenetic context. BMC Bioinforma. 7:371
    • (2006) BMC Bioinforma , vol.7 , pp. 371
    • Lozupone, C.1    Hamady, M.2    Knight, R.3
  • 57
    • 65249149643 scopus 로고    scopus 로고
    • Characterizing a model human gut microbiota composed of members of its two dominant bacterial phyla
    • Mahowald MA, Rey FE, Seedorf H, Turnbaugh PJ, Fulton RS, et al. 2009. Characterizing a model human gut microbiota composed of members of its two dominant bacterial phyla. Proc. Natl. Acad. Sci. USA 106:5859-64
    • (2009) Proc. Natl. Acad. Sci. USA , vol.106 , pp. 5859-5864
    • Mahowald, M.A.1    Rey, F.E.2    Seedorf, H.3    Turnbaugh, P.J.4    Fulton, R.S.5
  • 58
    • 55249108031 scopus 로고    scopus 로고
    • Mucosal glycan foraging enhances fitness and transmission of a saccharolytic human gut bacterial symbiont
    • Martens EC, Chiang HC, Gordon JI. 2008. Mucosal glycan foraging enhances fitness and transmission of a saccharolytic human gut bacterial symbiont. Cell Host Microbe 4:447-57
    • (2008) Cell Host Microbe , vol.4 , pp. 447-457
    • Martens, E.C.1    Chiang, H.C.2    Gordon, J.I.3
  • 59
    • 38349078772 scopus 로고    scopus 로고
    • Probiotic modulation of symbiotic gut microbial-host metabolic interactions in a humanized microbiome mouse model
    • Martin FP, Wang Y, Sprenger N, Yap IK, Lundstedt T, et al. 2008. Probiotic modulation of symbiotic gut microbial-host metabolic interactions in a humanized microbiome mouse model. Mol. Syst. Biol. 4:157
    • (2008) Mol. Syst. Biol. , vol.4 , pp. 157
    • Martin, F.P.1    Wang, Y.2    Sprenger, N.3    Yap, I.K.4    Lundstedt, T.5
  • 60
    • 80054960299 scopus 로고    scopus 로고
    • The impact of a consortium of fermented milk strains on the gut microbiome of gnotobiotic mice and monozygotic twins
    • McNulty NP, Yatsunenko T, Hsiao A, Faith JJ, Muegge BD, et al. 2011. The impact of a consortium of fermented milk strains on the gut microbiome of gnotobiotic mice and monozygotic twins. Sci. Transl. Med. 3:106ra06
    • (2011) Sci. Transl. Med , vol.3
    • McNulty, N.P.1    Yatsunenko, T.2    Hsiao, A.3    Faith, J.J.4    Muegge, B.D.5
  • 61
    • 84864106655 scopus 로고    scopus 로고
    • Functional metagenomic investigations of the human intestinal microbiota
    • Moore AM, Munck C, Sommer MOA, Dantas G. 2011. Functional metagenomic investigations of the human intestinal microbiota. Front. Microbiol. 2:188
    • (2011) Front. Microbiol. , vol.2 , pp. 188
    • Moore, A.M.1    Munck, C.2    Sommer, M.O.A.3    Dantas, G.4
  • 62
    • 56649117672 scopus 로고    scopus 로고
    • MmeI: A minimal Type II restriction-modification system that only modifies one DNA strand for host protection
    • Morgan RD, Bhatia TK, Lovasco L, Davis TB. 2008. MmeI: a minimal Type II restriction-modification system that only modifies one DNA strand for host protection. Nucleic Acids Res. 36:6558-70
    • (2008) Nucleic Acids Res. , vol.36 , pp. 6558-6570
    • Morgan, R.D.1    Bhatia, T.K.2    Lovasco, L.3    Davis, T.B.4
  • 63
    • 43949122957 scopus 로고    scopus 로고
    • Mice as clinically relevant models for the study of cytochrome P450- dependent metabolism
    • Muruganandan S, Sinal CJ. 2008. Mice as clinically relevant models for the study of cytochrome P450- dependent metabolism. Clin. Pharmacol. Ther. 83:818-28
    • (2008) Clin. Pharmacol. Ther. , vol.83 , pp. 818-828
    • Muruganandan, S.1    Sinal, C.J.2
  • 66
    • 84867074831 scopus 로고    scopus 로고
    • A metagenome-wide association study of gut microbiota in type 2 diabetes
    • Qin J, Li Y, Cai Z, Li S, Zhu J, et al. 2012. A metagenome-wide association study of gut microbiota in type 2 diabetes. Nature 490:55-60
    • (2012) Nature , vol.490 , pp. 55-60
    • Qin, J.1    Li, Y.2    Cai, Z.3    Li, S.4    Zhu, J.5
  • 67
    • 77950251400 scopus 로고    scopus 로고
    • A human gut microbial gene catalogue established by metagenomic sequencing
    • Qin J, Li R, Raes J, Arumugam M, Burgdorf KS, et al. 2010. A human gut microbial gene catalogue established by metagenomic sequencing. Nature 464:59-65
    • (2010) Nature , vol.464 , pp. 59-65
    • Qin, J.1    Li, R.2    Raes, J.3    Arumugam, M.4    Burgdorf, K.S.5
  • 68
    • 33749997498 scopus 로고    scopus 로고
    • Reciprocal gut microbiota transplants from zebrafish and mice to germ-free recipients reveal host habitat selection
    • Rawls JF, Mahowald MA, Ley RE, Gordon JI. 2006. Reciprocal gut microbiota transplants from zebrafish and mice to germ-free recipients reveal host habitat selection. Cell 127:423-33
    • (2006) Cell , vol.127 , pp. 423-433
    • Rawls, J.F.1    Mahowald, M.A.2    Ley, R.E.3    Gordon, J.I.4
  • 69
    • 4344587758 scopus 로고    scopus 로고
    • Uncultured soil bacteria are a reservoir of new antibiotic resistance genes
    • Riesenfeld CS, Goodman RM, Handelsman J. 2004. Uncultured soil bacteria are a reservoir of new antibiotic resistance genes. Environ. Microbiol. 6:981-89
    • (2004) Environ. Microbiol. , vol.6 , pp. 981-989
    • Riesenfeld, C.S.1    Goodman, R.M.2    Handelsman, J.3
  • 71
    • 79952759738 scopus 로고    scopus 로고
    • Antibiotic administration alters the community structure of the gastrointestinal microbiota
    • Robinson CJ, Young VB. 2010. Antibiotic administration alters the community structure of the gastrointestinal microbiota. Gut Microbes 1:279-84
    • (2010) Gut Microbes , vol.1 , pp. 279-284
    • Robinson, C.J.1    Young, V.B.2
  • 72
    • 0020312528 scopus 로고
    • Utilization of chondroitin sulfate by Bacteroides thetaiotaomicron growing in carbohydrate-limited continuous culture
    • Salyers AA, O'Brien M, Kotarski SF. 1982. Utilization of chondroitin sulfate by Bacteroides thetaiotaomicron growing in carbohydrate-limited continuous culture. J. Bacteriol. 150:1008-15
    • (1982) J. Bacteriol. , vol.150 , pp. 1008-1015
    • Salyers, A.A.1    Obrien, M.2    Kotarski, S.F.3
  • 73
    • 0017341656 scopus 로고
    • Microbial ecology of the gastrointestinal tract
    • Savage DC. 1977. Microbial ecology of the gastrointestinal tract. Annu. Rev. Microbiol. 31:107-33
    • (1977) Annu. Rev. Microbiol. , vol.31 , pp. 107-133
    • Savage, D.C.1
  • 74
    • 0032412057 scopus 로고    scopus 로고
    • Resident enteric bacteria are necessary for development of spontaneous colitis and immune system activation in interleukin-10- deficient mice
    • Sellon RK, Tonkonogy S, Schultz M, Dieleman LA, Grenther W, et al. 1998. Resident enteric bacteria are necessary for development of spontaneous colitis and immune system activation in interleukin-10- deficient mice. Infect. Immun. 66:5224-31
    • (1998) Infect. Immun. , vol.66 , pp. 5224-5231
    • Sellon, R.K.1    Tonkonogy, S.2    Schultz, M.3    Dieleman, L.A.4    Grenther, W.5
  • 75
    • 0033802036 scopus 로고    scopus 로고
    • Characterization of four outer membrane proteins involved in binding starch to the cell surface of Bacteroides thetaiotaomicron
    • Shipman JA, Berleman JE, Salyers AA. 2000. Characterization of four outer membrane proteins involved in binding starch to the cell surface of Bacteroides thetaiotaomicron. J. Bacteriol. 182:5365-72
    • (2000) J. Bacteriol. , vol.182 , pp. 5365-5372
    • Shipman, J.A.1    Berleman, J.E.2    Salyers, A.A.3
  • 76
    • 0345148490 scopus 로고    scopus 로고
    • Physiological characterization of SusG, an outer membrane protein essential for starch utilization by Bacteroides thetaiotaomicron
    • Shipman JA, Cho KH, Siegel HA, Salyers AA. 1999. Physiological characterization of SusG, an outer membrane protein essential for starch utilization by Bacteroides thetaiotaomicron. J. Bacteriol. 181:7206-11
    • (1999) J. Bacteriol. , vol.181 , pp. 7206-7211
    • Shipman, J.A.1    Cho, K.H.2    Siegel, H.A.3    Salyers, A.A.4
  • 78
    • 23944515241 scopus 로고    scopus 로고
    • Persistence of resistant Staphylococcus epidermidis after single course of clarithromycin
    • Sj ölundM, Tano E, Blaser MJ, Andersson DI, Engstrand L. 2005. Persistence of resistant Staphylococcus epidermidis after single course of clarithromycin. Emerg. Infect. Dis. 11:1389-93
    • (2005) Emerg. Infect. Dis. , vol.11 , pp. 1389-1393
    • Sjölund, M.1    Tano, E.2    Blaser, M.J.3    Andersson, D.I.4    Engstrand, L.5
  • 79
    • 0141462552 scopus 로고    scopus 로고
    • Long-term persistence of resistant Enterococcus species after antibiotics to eradicate Helicobacter pylori
    • Sj ölundM, Wreiber K, Andersson DI, Blaser MJ, Engstrand L. 2003. Long-term persistence of resistant Enterococcus species after antibiotics to eradicate Helicobacter pylori. Ann. Intern. Med. 139:483-87
    • (2003) Ann. Intern. Med. , vol.139 , pp. 483-487
    • Sjölund, M.1    Wreiber, K.2    Andersson, D.I.3    Blaser, M.J.4    Engstrand, L.5
  • 80
    • 77954976246 scopus 로고    scopus 로고
    • Microfluidic dissolved oxygen gradient generator biochip as a useful tool in bacterial biofilm studies
    • Skolimowski M, Nielsen MW, Emneus J, Molin S, Taboryski R, et al. 2010. Microfluidic dissolved oxygen gradient generator biochip as a useful tool in bacterial biofilm studies. Lab Chip 10:2162-69
    • (2010) Lab Chip , vol.10 , pp. 2162-2169
    • Skolimowski, M.1    Nielsen, M.W.2    Emneus, J.3    Molin, S.4    Taboryski, R.5
  • 81
    • 34249284197 scopus 로고    scopus 로고
    • Use of axenic animals in studying the adaptation of mammals to their commensal intestinal microbiota
    • Smith K, McCoy KD, MacPherson AJ. 2007. Use of axenic animals in studying the adaptation of mammals to their commensal intestinal microbiota. Semin. Immunol. 19:59-69
    • (2007) Semin. Immunol. , vol.19 , pp. 59-69
    • Smith, K.1    McCoy, K.D.2    Macpherson, A.J.3
  • 82
    • 77955043924 scopus 로고    scopus 로고
    • The human microbiome harbors a diverse reservoir of antibiotic resistance genes
    • Sommer MO, Church GM, Dantas G. 2010. The human microbiome harbors a diverse reservoir of antibiotic resistance genes. Virulence 1:299-303
    • (2010) Virulence , vol.1 , pp. 299-303
    • Sommer, M.O.1    Church, G.M.2    Dantas, G.3
  • 83
    • 80053927489 scopus 로고    scopus 로고
    • Antibiotics and the resistantmicrobiome
    • SommerMO, Dantas G. 2011. Antibiotics and the resistantmicrobiome. Curr. Opin.Microbiol. 14:556-63
    • (2011) Curr. Opin.Microbiol. , vol.14 , pp. 556-563
    • Sommer, M.O.1    Dantas, G.2
  • 84
    • 69549086653 scopus 로고    scopus 로고
    • Functional characterization of the antibiotic resistance reservoir in the human microflora
    • Sommer MO, Dantas G, Church GM. 2009. Functional characterization of the antibiotic resistance reservoir in the human microflora. Science 325:1128-31
    • (2009) Science , vol.325 , pp. 1128-1131
    • Sommer, M.O.1    Dantas, G.2    Church, G.M.3
  • 85
    • 0037180433 scopus 로고    scopus 로고
    • Developmental regulation of intestinal angiogenesis by indigenous microbes via Paneth cells
    • Stappenbeck TS, Hooper LV, Gordon JI. 2002. Developmental regulation of intestinal angiogenesis by indigenous microbes via Paneth cells. Proc. Natl. Acad. Sci. USA 99:15451-55
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 15451-15455
    • Stappenbeck, T.S.1    Hooper, L.V.2    Gordon, J.I.3
  • 86
    • 78649270064 scopus 로고    scopus 로고
    • Functional metagenomics to mine the human gut microbiome for dietary fiber catabolic enzymes
    • Tasse L, Bercovici J, Pizzut-Serin S, Robe P, Tap J, et al. 2010. Functional metagenomics to mine the human gut microbiome for dietary fiber catabolic enzymes. Genome Res. 20:1605-12
    • (2010) Genome Res. , vol.20 , pp. 1605-1612
    • Tasse, L.1    Bercovici, J.2    Pizzut-Serin, S.3    Robe, P.4    Tap, J.5
  • 87
    • 84868091529 scopus 로고    scopus 로고
    • Metagenomics: Microbial diversity through a scratched lens
    • Temperton B, Giovannoni SJ. 2012. Metagenomics: microbial diversity through a scratched lens. Curr. Opin. Microbiol. 15:605-12
    • (2012) Curr. Opin. Microbiol. , vol.15 , pp. 605-612
    • Temperton, B.1    Giovannoni, S.J.2
  • 92
    • 70349611730 scopus 로고    scopus 로고
    • Tn-seq: High-throughput parallel sequencing for fitness and genetic interaction studies in microorganisms
    • van Opijnen T, Bodi KL, Camilli A. 2009. Tn-seq: high-throughput parallel sequencing for fitness and genetic interaction studies in microorganisms. Nat. Methods 6:767-72
    • (2009) Nat. Methods , vol.6 , pp. 767-772
    • Van Opijnen, T.1    Bodi, K.L.2    Camilli, A.3
  • 93
    • 80051856839 scopus 로고    scopus 로고
    • The human gut microbiome: Ecology and recent evolutionary changes
    • Walter J, Ley R. 2011. The human gut microbiome: ecology and recent evolutionary changes. Annu. Rev. Microbiol. 65:411-29
    • (2011) Annu. Rev. Microbiol. , vol.65 , pp. 411-429
    • Walter, J.1    Ley, R.2
  • 96
    • 0001271789 scopus 로고
    • Phylogenetic structure of prokaryotic domain: The primary kingdoms
    • Woese CR, Fox GE. 1977. Phylogenetic structure of prokaryotic domain: the primary kingdoms. Proc. Natl. Acad. Sci. USA 74:5088-90
    • (1977) Proc. Natl. Acad. Sci. USA , vol.74 , pp. 5088-5090
    • Woese, C.R.1    Fox, G.E.2
  • 97
    • 0037470975 scopus 로고    scopus 로고
    • A genomic view of the human- Bacteroides thetaiotaomicron symbiosis
    • Xu J, Bjursell MK, Himrod J, Deng S, Carmichael LK, et al. 2003. A genomic view of the human- Bacteroides thetaiotaomicron symbiosis. Science 299:2074-76
    • (2003) Science , vol.299 , pp. 2074-2076
    • Xu, J.1    Bjursell, M.K.2    Himrod, J.3    Deng, S.4    Carmichael, L.K.5
  • 100
    • 84858191432 scopus 로고    scopus 로고
    • Mice with liver composed of human hepatocytes as an animal model for drug testing
    • Yoshizato K, Tateno C, Utoh R. 2012. Mice with liver composed of human hepatocytes as an animal model for drug testing. Curr. Drug Discov. Technol. 9:63-76
    • (2012) Curr. Drug Discov. Technol. , vol.9 , pp. 63-76
    • Yoshizato, K.1    Tateno, C.2    Utoh, R.3
  • 101
    • 1542513850 scopus 로고    scopus 로고
    • Antibiotic-associated diarrhea accompanied by large-scale alterations in the composition of the fecal microbiota
    • Young VB, Schmidt TM. 2004. Antibiotic-associated diarrhea accompanied by large-scale alterations in the composition of the fecal microbiota. J. Clin. Microbiol. 42:1203-6
    • (2004) J. Clin. Microbiol. , vol.42 , pp. 1203-1206
    • Young, V.B.1    Schmidt, T.M.2


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