Coronary anatomy to predict physiology fundamental limits

Circulation: Cardiovascular Imaging

Volumn 6, Issue 5, 2013, Pages 817-832

  Johnson, Nils P ^a   Kirkeeide, Richard L ^a   Gould, K Lance ^a  

^a UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

Author keywords

Cardiovascular; Coronary circulation; Coronary stenosis; Models; Myocardial fractional flow reserve

Indexed keywords

ANATOMY; ARTERY OCCLUSION; ARTICLE; COMPUTED TOMOGRAPHIC ANGIOGRAPHY; CONVENTIONAL ANGIOGRAPHY; CORONARY ARTERY BLOOD FLOW; CORONARY ARTERY DISEASE; FRACTIONAL FLOW RESERVE; HEART OUTPUT; HUMAN; INTRAVASCULAR ULTRASOUND; LEFT CORONARY ARTERY; OPTICAL COHERENCE TOMOGRAPHY; PHYSIOLOGY; POTENTIAL DIFFERENCE; PREDICTION; PRIORITY JOURNAL; REVASCULARIZATION;

CORONARY CIRCULATION; CORONARY STENOSIS; MODELS, CARDIOVASCULAR; MYOCARDIAL FRACTIONAL FLOW RESERVE;

ANIMALS; CARDIAC CATHETERIZATION; CORONARY ANGIOGRAPHY; CORONARY CIRCULATION; CORONARY STENOSIS; CORONARY VESSELS; DIAGNOSTIC IMAGING; FRACTIONAL FLOW RESERVE, MYOCARDIAL; HUMANS; MODELS, CARDIOVASCULAR; MYOCARDIAL PERFUSION IMAGING; PREDICTIVE VALUE OF TESTS; PROGNOSIS; REPRODUCIBILITY OF RESULTS; SEVERITY OF ILLNESS INDEX; TOMOGRAPHY, OPTICAL COHERENCE; TOMOGRAPHY, X-RAY COMPUTED; ULTRASONOGRAPHY, INTERVENTIONAL;

EID: 84884467331     PISSN: 19419651     EISSN: 19420080     Source Type: Journal    
DOI: 10.1161/CIRCIMAGING.113.000373     Document Type: Article

References (115)

1. Gould KL, Lipscomb K, Hamilton GW. Physiologic basis for assessing critical coronary stenosis. Instantaneous flow response and regional distribution during coronary hyperemia as measures of coronary flow reserve. Am J Cardiol. 1974; 33: 87-94.
2. Silver N. The Signal and the Noise: Why So Many Predictions Fail-but Some Don't. New York, NY: Penguin Press; 2012.
3. Keane D, Haase J, Slager CJ, Montauban van Swijndregt E, Lehmann KG, Ozaki Y, di Mario C, Kirkeeide R, Serruys PW. Comparative validation of quantitative coronary angiography systems: results and implications from a multicenter study using a standardized approach. Circulation. 1995; 91: 2174-2183.
4. Bezerra HG, Costa MA, Guagliumi G, Rollins AM, Simon DI. Intracoronary optical coherence tomography: a comprehensive review clinical and research applications. JACC Cardiovasc Interv. 2009; 2: 1035-1046.
5. Voros S, Rinehart S, Qian Z, Joshi P, Vazquez G, Fischer C, Belur P, Hulten E, Villines TC. Coronary atherosclerosis imaging by coronary CT angiography: current status, correlation with intravascular interrogation and meta-analysis. JACC Cardiovasc Imaging. 2011; 4: 537-548.
6. van der Voort PH, van Hagen E, Hendrix G, van Gelder B, Bech JW, Pijls NH. Comparison of intravenous adenosine to intracoronary papaverine for calculation of pressure-derived fractional flow reserve. Cathet Cardiovasc Diagn. 1996; 39: 120-125. (Pubitemid 26365875)
7. Nair PK, Marroquin OC, Mulukutla SR, Khandhar S, Gulati V, Schindler JT, Lee JS. Clinical utility of regadenoson for assessing fractional flow reserve. JACC Cardiovasc Interv. 2011; 4: 1085-1092.
8. Bech GJ, De Bruyne B, Pijls NH, de Muinck ED, Hoorntje JC, Escaned J, Stella PR, Boersma E, Bartunek J, Koolen JJ, Wijns W. Fractional flow reserve to determine the appropriateness of angioplasty in moderate coronary stenosis: a randomized trial. Circulation. 2001; 103: 2928-2934. (Pubitemid 32578130)
9. Berry C, van 't Veer M, Witt N, Kala P, Bocek O, Pyxaras SA, McClure JD, Fearon WF, Barbato E, Tonino PA, De Bruyne B, Pijls NH, Oldroyd KG. VERIFY (VERification of Instantaneous Wave-Free Ratio and Fractional Flow Reserve for the Assessment of Coronary Artery Stenosis Severity in EverydaY Practice): a multicenter study in consecutive patients. J Am Coll Cardiol. 2013; 61: 1421-1427.
10. Arumugham P, Figueredo VM, Patel PB, Morris DL. Comparison of intravenous adenosine and intravenous regadenoson for the measurement of pressure-derived coronary fractional flow reserve. EuroIntervention. 2013; 8: 1166-1171.
11. De Bruyne B, Bartunek J, Sys SU, Pijls NH, Heyndrickx GR, Wijns W. Simultaneous coronary pressure and flow velocity measurements in humans. Feasibility, reproducibility, and hemodynamic dependence of coronary flow velocity reserve, hyperemic flow versus pressure slope index, and fractional flow reserve. Circulation. 1996; 94: 1842-1849. (Pubitemid 26349295)
12. Barbato E, Bartunek J, Aarnoudse W, Vanderheyden M, Staelens F, Wijns W, Heyndrickx GR, Pijls NH, De Bruyne B. Alpha-adrenergic receptor blockade and hyperaemic response in patients with intermediate coronary stenoses. Eur Heart J. 2004; 25: 2034-2039. (Pubitemid 39486023)
13. Lespérance J, Campeau L, Reiber JH, Bois M, Dyrda I, Laurier J, Hudon G. Validation of coronary artery saphenous vein bypass graft diameter measurements using quantitative angiography. Int J Card Imaging. 1996; 12: 299-303. (Pubitemid 27006925)
14. Reiber JH, Serruys PW, Kooijman CJ, Wijns W, Slager CJ, Gerbrands JJ, Schuurbiers JC, den Boer A, Hugenholtz PG. Assessment of short-, medium-, and long-term variations in arterial dimensions from computer-assisted quantitation of coronary cineangiograms. Circulation. 1985; 71: 280-288. (Pubitemid 15157088)
15. Brown G, Albers JJ, Fisher LD, Schaefer SM, Lin JT, Kaplan C, Zhao XQ, Bisson BD, Fitzpatrick VF, Dodge HT. Regression of coronary artery disease as a result of intensive lipid-lowering therapy in men with high levels of apolipoprotein B. N Engl J Med. 1990; 323: 1289-1298. (Pubitemid 20364735)
16. White CW, Campeau L, Canner P, Domanski M, Forrester JS, Gobel FL, Herd JA, Hoogwerf BJ, Hunninghake DB, Knatterud GL, LoPresti F; Post CABG Investigators. Lessons from the post coronary artery bypass graft study in evaluating and controlling technical variability in angio-graphic trials: Post CABG Investigators. Am J Cardiol. 2001; 87: 40-43. (Pubitemid 32013082)
17. Yong AS, Ng AC, Brieger D, Lowe HC, Ng MK, Kritharides L. Three-dimensional and two-dimensional quantitative coronary angiography, and their prediction of reduced fractional flow reserve. Eur Heart J. 2011; 32: 345-353.
18. Tuinenburg JC, Koning G, Hekking E, Desjardins C, Harel F, Bilodeau L, van Weert AW, Lespérance J, Reiber JH. One core laboratory at two international sites, is that feasible? An inter-core laboratory and intra-observer variability study. Catheter Cardiovasc Interv. 2002; 56: 333-340. (Pubitemid 34693889)
19. Shin DH, Koo BK, Waseda K, Park KW, Kim HS, Corral M, Lansky A, Honda Y, Fearon WF, Fitzgerald PJ. Discrepancy in the assessment of jailed side branch lesions by visual estimation and quantitative coronary angiographic analysis: comparison with fractional flow reserve. Catheter Cardiovasc Interv. 2011; 78: 720-726.
20. Sirnes PA, Myreng Y, Mølstad P, Golf S. Reproducibility of quantitative coronary analysis, assessment of variability due to frame selection, different observers, and different cinefilmless laboratories. Int J Card Imaging. 1996; 12: 197-203.
21. Popma JJ, Lansky AJ, Yeh W, Kennard ED, Keller MB, Merritt AJ, DeFalco RA, Desai A, Pacera JH, Schnabel JF, Niedermeyer V, Baim DS, Detre KM. Reliability of the quantitative angiographic measurements in the New Approaches to Coronary Intervention (NACI) registry: a comparison of clinical site and repeated angiographic core laboratory readings. Am J Cardiol. 1997; 80: 19K-25K. (Pubitemid 28012259)
22. Syvänne M, Nieminen MS, Frick MH. Accuracy and precision of quantitative arteriography in the evaluation of coronary artery disease after coronary bypass surgery: a validation study. Int J Card Imaging. 1994; 10: 243-252.
23. Sarno G, Garg S, Onuma Y, Girasis C, Tonino P, Morel MA, van Es GA, Pijls N, Serruys PW. Bifurcation lesions: Functional assessment by fractional flow reserve vs. anatomical assessment using conventional and dedicated bifurcation quantitative coronary angiogram. Catheter Cardiovasc Interv. 2010; 76: 817-823.
24. Lespérance J, Waters D. Measuring progression and regression of coronary atherosclerosis in clinical trials: problems and progress. Int J Card Imaging. 1992; 8: 165-173.
25. Herrington DM, Siebes M, Sokol DK, Siu CO, Walford GD. Variability in measures of coronary lumen dimensions using quantitative coronary angiography. J Am Coll Cardiol. 1993; 22: 1068-1074. (Pubitemid 23285756)
26. Moer R, van Weert AW, Myreng Y, Mølstad P. Variability of quantitative coronary angiography: an evaluation of on-site versus core laboratory analysis. Int J Cardiovasc Imaging. 2003; 19: 457-464. (Pubitemid 37521320)
27. Steigen TK, Claudio C, Abbott D, Schulzer M, Burton J, Tymchak W, Buller CE, John Mancini GB. Angiographic core laboratory reproduc-ibility analyses: implications for planning clinical trials using coronary angiography and left ventriculography end-points. Int J Cardiovasc Imaging. 2008; 24: 453-462.
28. Mintz GS, Griffin J, Chuang YC, Pichard AD, Kent KM, Satler LF, Popma JJ, Leon MB. Reproducibility of the intravascular ultrasound assessment of stent implantation in saphenous vein grafts. Am J Cardiol. 1995; 75: 1267-1270.
29. Blessing E, Hausmann D, Sturm M, Wolpers HG, Amende I, Mügge A. Intravascular ultrasound and stent implantation: intraobserver and interobserver variability. Am Heart J. 1999; 137: 368-371. (Pubitemid 29070151)
30. Peters RJ, Kok WE, Rijsterborgh H, van Dijk M, Koch KT, Piek JJ, David GK, Visser CA. Reproducibility of quantitative measurements from intracoronary ultrasound images: beat-to-beat variability and influence of the cardiac cycle. Eur Heart J. 1996; 17: 1593-1599. (Pubitemid 26345151)
31. Gaster AL, Korsholm L, Thayssen P, Pedersen KE, Haghfelt TH. Reproducibility of intravascular ultrasound and intracoronary Doppler measurements. Catheter Cardiovasc Interv. 2001; 53: 449-458. (Pubitemid 32729241)
32. Bocksch W, Wellnhofer E, Schartl M, Dreysse S, Klimek W, Franke R, Musci M, Hetzer R, Fleck E. Reproducibility of serial intravascular ultrasound measurements in patients with angiographically silent coronary artery disease after heart transplantation. Coron Artery Dis. 2000; 11: 555-562.
33. Gonzalo N, Garcia-Garcia HM, Serruys PW, Commissaris KH, Bezerra H, Gobbens P, Costa M, Regar E. Reproducibility of quantitative optical coherence tomography for stent analysis. EuroIntervention. 2009; 5: 224-232.
34. Jamil Z, Tearney G, Bruining N, Sihan K, van Soest G, Ligthart J, van Domburg R, Bouma B, Regar E. Interstudy reproducibility of the second generation, Fourier domain optical coherence tomography in patients with coronary artery disease and comparison with intravascular ultrasound: a study applying automated contour detection. Int J Cardiovasc Imaging. 2013; 29: 39-51.
35. Fedele S, Biondi-Zoccai G, Kwiatkowski P, Di Vito L, Occhipinti M, Cremonesi A, Albertucci M, Materia L, Paoletti G, Prati F. Reproducibility of coronary optical coherence tomography for lumen and length measurements in humans (the CLI-VAR [Centro per la Lotta contro l'Infarto-VARiability] study). Am J Cardiol. 2012; 110: 1106-1112.
36. Tanimoto S, Rodriguez-Granillo G, Barlis P, de Winter S, Bruining N, Hamers R, Knappen M, Verheye S, Serruys PW, Regar E. A novel approach for quantitative analysis of intracoronary optical coherence tomography: high inter-observer agreement with computer-assisted contour detection. Catheter Cardiovasc Interv. 2008; 72: 228-235.
37. Okamura T, Gonzalo N, Gutiérrez-Chico JL, Serruys PW, Bruining N, de Winter S, Dijkstra J, Commossaris KH, van Geuns RJ, van Soest G, Ligthart J, Regar E. Reproducibility of coronary Fourier domain optical coherence tomography: quantitative analysis of in vivo stented coronary arteries using three different software packages. EuroIntervention. 2010; 6: 371-379.
38. Hutcheon JA, Chiolero A, Hanley JA. Random measurement error and regression dilution bias. BMJ. 2010; 340: c2289.
39. Levine GN, Bates ER, Blankenship JC, Bailey SR, Bittl JA, Cercek B, Chambers CE, Ellis SG, Guyton RA, Hollenberg SM, Khot UN, Lange RA, Mauri L, Mehran R, Moussa ID, Mukherjee D, Nallamothu BK, Ting HH; American College of Cardiology Foundation; American Heart Association Task Force on Practice Guidelines; Society for Cardiovascular Angiography and Interventions. 2011 ACCF/AHA/SCAI guideline for percutaneous coronary intervention: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines and the Society for Cardiovascular Angiography and Interventions. J Am Coll Cardiol. 2011; 58: e44-122.
40. Kern MJ, Lerman A, Bech JW, De Bruyne B, Eeckhout E, Fearon WF, Higano ST, Lim MJ, Meuwissen M, Piek JJ, Pijls NH, Siebes M, Spaan JA; American Heart Association Committee on Diagnostic and Interventional Cardiac Catheterization, Council on Clinical Cardiology. Physiological assessment of coronary artery disease in the cardiac catheterization laboratory: a scientific statement from the American Heart Association Committee on Diagnostic and Interventional Cardiac Catheterization, Council on Clinical Cardiology. Circulation. 2006; 114: 1321-1341. (Pubitemid 44402059)
41. Park SJ, Kang SJ, Ahn JM, Shim EB, Kim YT, Yun SC, Song H, Lee JY, Kim WJ, Park DW, Lee SW, Kim YH, Lee CW, Mintz GS, Park SW. Visual-functional mismatch between coronary angiography and fractional flow reserve. JACC Cardiovasc Interv. 2012; 5: 1029-1036.
42. Saad M, Toelg R, Khattab AA, Kassner G, Abdel-Wahab M, Richardt G. Determination of haemodynamic significance of intermediate coronary lesions using three-dimensional coronary reconstruction. EuroIntervention. 2009; 5: 573-579.
43. Kang SJ, Lee JY, Ahn JM, Song HG, Kim WJ, Park DW, Yun SC, Lee SW, Kim YH, Mintz GS, Lee CW, Park SW, Park SJ. Intravascular ultrasound-derived predictors for fractional flow reserve in intermediate left main disease. JACC Cardiovasc Interv. 2011; 4: 1168-1174.
44. Reith S, Battermann S, Jaskolka A, Lehmacher W, Hoffmann R, Marx N, Burgmaier M. Relationship between optical coherence tomography derived intraluminal and intramural criteria and haemodynamic relevance as determined by fractional flow reserve in intermediate coronary stenoses of patients with type 2 diabetes. Heart. 2013; 99: 700-707.
45. Bartúnek J, Sys SU, Heyndrickx GR, Pijls NH, De Bruyne B. Quantitative coronary angiography in predicting functional significance of stenoses in an unselected patient cohort. J Am Coll Cardiol. 1995; 26: 328-334.
46. Koo BK, Yang HM, Doh JH, Choe H, Lee SY, Yoon CH, Cho YK, Nam CW, Hur SH, Lim HS, Yoon MH, Park KW, Na SH, Youn TJ, Chung WY, Ma S, Park SK, Kim HS, Tahk SJ. Optimal intravascular ultrasound criteria and their accuracy for defining the functional significance of intermediate coronary stenoses of different locations. JACC Cardiovasc Interv. 2011; 4: 803-811.
47. Kang SJ, Ahn JM, Song H, Kim WJ, Lee JY, Park DW, Yun SC, Lee SW, Kim YH, Lee CW, Park SW, Park SJ. Usefulness of minimal luminal coronary area determined by intravascular ultrasound to predict functional significance in stable and unstable angina pectoris. Am J Cardiol. 2012; 109: 947-953.
48. Koh JS, Koo BK, Kim JH, Yang HM, Park KW, Kang HJ, Kim HS, Oh BH, Park YB. Relationship between fractional flow reserve and angio-graphic and intravascular ultrasound parameters in ostial lesions: major epicardial vessel versus side branch ostial lesions. JACC Cardiovasc Interv. 2012; 5: 409-415.
49. Ahn JM, Lee JY, Kang SJ, Kim YH, Song HG, Oh JH, Park JS, Kim WJ, Lee SW, Lee CW, Kim JJ, Park SW, Park SJ. Functional assessment of jailed side branches in coronary bifurcation lesions using fractional flow reserve. JACC Cardiovasc Interv. 2012; 5: 155-161.
50. Takagi A, Tsurumi Y, Ishii Y, Suzuki K, Kawana M, Kasanuki H. Clinical potential of intravascular ultrasound for physiological assessment of coronary stenosis: relationship between quantitative ultrasound tomography and pressure-derived fractional flow reserve. Circulation. 1999; 100: 250-255. (Pubitemid 29340130)
51. Fischer JJ, Samady H, McPherson JA, Sarembock IJ, Powers ER, Gimple LW, Ragosta M. Comparison between visual assessment and quantitative angiography versus fractional flow reserve for native coronary narrowings of moderate severity. Am J Cardiol. 2002; 90: 210-215. (Pubitemid 34804552)
52. Iguchi T, Hasegawa T, Nishimura S, Nakata S, Kataoka T, Ehara S, Hanatani A, Shimada K, Yoshiyama M. Impact of lesion length on functional significance in intermediate coronary lesions. Clin Cardiol. 2013; 36: 172-177.
53. Koo BK, Kang HJ, Youn TJ, Chae IH, Choi DJ, Kim HS, Sohn DW, Oh BH, Lee MM, Park YB, Choi YS, Tahk SJ. Physiologic assessment of jailed side branch lesions using fractional flow reserve. J Am Coll Cardiol. 2005; 46: 633-637.
54. Lee CH, Tai BC, Soon CY, Low AF, Poh KK, Yeo TC, Lim GH, Yip J, Omar AR, Teo SG, Tan HC. New set of intravascular ultrasound-derived anatomic criteria for defining functionally significant stenoses in small coronary arteries (results from Intravascular Ultrasound Diagnostic Evaluation of Atherosclerosis in Singapore [IDEAS] study). Am J Cardiol. 2010; 105: 1378-1384.
55. Waksman R, Legutko J, Singh J, Orlando Q, Marso S, Schloss T, Tugaoen J, DeVries J, Palmer N, Haude M, Swymelar S, Torguson R. FIRST: Fractional Flow Reserve and Intravascular Ultrasound Relationship Study. J Am Coll Cardiol. 2013; 61: 917-923.
56. Gonzalo N, Gonzalo N, Escaned J, Alfonso F, Nolte C, Rodriguez V, Jimenez-Quevedo P, Bañuelos C, Fernández-Ortiz A, Fernández-Ortiz A, Garcia E, Hernandez-Antolin R, Macaya C. Morphometric assessment of coronary stenosis relevance with optical coherence tomography: a comparison with fractional flow reserve and intravascular ultrasound. J Am Coll Cardiol. 2012; 59: 1080-1089.
57. Kang SJ, Lee JY, Ahn JM, Mintz GS, Kim WJ, Park DW, Yun SC, Lee SW, Kim YH, Lee CW, Park SW, Park SJ. Validation of intravascular ultrasound-derived parameters with fractional flow reserve for assessment of coronary stenosis severity. Circ Cardiovasc Interv. 2011; 4: 65-71.
58. Chen SL, Xu B, Chen JB, Xu T, Ye F, Zhang JJ, Kwan TW, Tian NL, Liu ZZ, Lin S. Diagnostic accuracy of quantitative angiographic and intravascular ultrasound parameters predicting the functional significance of single de novo lesions. Int J Cardiol. December 26, 2012. http://www. internationaljournalofcardiology.com/article/S0167-5273%2812%2901638-5/abstract. doi:10.1016/j.ijcard.2012.12.010.
59. Kwan TW, Yang S, Xu B, Chen J, Xu T, Ye F, Zhang JJ, Tian NL, Liu ZZ, Chen SL. Optimized quantitative angiographic and intravascular ultrasound parameters predicting the functional significance of single de novo lesions in the left anterior descending artery. Chin Med J (Engl). 2012; 125: 4249-4253.
60. Ben-Dor I, Torguson R, Deksissa T, Bui AB, Xue Z, Satler LF, Pichard AD, Waksman R. Intravascular ultrasound lumen area parameters for assessment of physiological ischemia by fractional flow reserve in intermediate coronary artery stenosis. Cardiovasc Revasc Med. 2012; 13: 177-182.
61. Ben-Dor I, Torguson R, Gaglia MA Jr, Gonzalez MA, Maluenda G, Bui AB, Xue Z, Satler LF, Suddath WO, Lindsay J, Pichard AD, Waksman R. Correlation between fractional flow reserve and intravascular ultrasound lumen area in intermediate coronary artery stenosis. EuroIntervention. 2011; 7: 225-233.
62. Briguori C, Anzuini A, Airoldi F, Gimelli G, Nishida T, Adamian M, Corvaja N, Di Mario C, Colombo A. Intravascular ultrasound criteria for the assessment of the functional significance of intermediate coronary artery stenoses and comparison with fractional flow reserve. Am J Cardiol. 2001; 87: 136-141. (Pubitemid 32057220)
63. Jasti V, Ivan E, Yalamanchili V, Wongpraparut N, Leesar MA. Correlations between fractional flow reserve and intravascular ultrasound in patients with an ambiguous left main coronary artery stenosis. Circulation. 2004; 110: 2831-2836. (Pubitemid 39473605)
64. Shiono Y, Kitabata H, Kubo T, Masuno T, Ohta S, Ozaki Y, Sougawa H, Orii M, Shimamura K, Ishibashi K, Komukai K, Yamano T, Tanimoto T, Ino Y, Yamaguchi T, Hirata K, Mizukoshi M, Imanishi T, Akasaka T. Optical coherence tomography-derived anatomical criteria for functionally significant coronary stenosis assessed by fractional flow reserve. Circ J. 2012; 76: 2218-2225.
65. Mittal N, Zhou Y, Linares C, Ung S, Kaimovitz B, Molloi S, Kassab GS. Analysis of blood flow in the entire coronary arterial tree. Am J Physiol Heart Circ Physiol. 2005; 289: H439-H446. (Pubitemid 40934131)
66. Kirkeeide RL, Gould KL, Parsel L. Assessment of coronary stenoses by myocardial perfusion imaging during pharmacologic coronary vasodilation, VII: validation of coronary flow reserve as a single integrated functional measure of stenosis severity reflecting all its geometric dimensions. J Am Coll Cardiol. 1986; 7: 103-113. (Pubitemid 16132462)
67. Wilson RF, Laughlin DE, Ackell PH, Chilian WM, Holida MD, Hartley CJ, Armstrong ML, Marcus ML, White CW. Transluminal, subselective measurement of coronary artery blood flow velocity and vasodilator reserve in man. Circulation. 1985; 72: 82-92. (Pubitemid 15069580)
68. Gould KL, Kirkeeide R, Johnson NP. Coronary branch steal: experimental validation and clinical implications of interacting stenosis in branching coronary arteries. Circ Cardiovasc Imaging. 2010; 3: 701-709.
69. Johnson NP, Kirkeeide RL, Gould KL. Is discordance of coronary flow reserve and fractional flow reserve due to methodology or clinically relevant coronary pathophysiology? JACC Cardiovasc Imaging. 2012; 5: 193-202.
70. Johnson NP, Kirkeeide RL, Asrress KN, Fearon WF, Lockie T, Marques KM, Pyxaras SA, Rolandi MC, van 't Veer M, De Bruyne B, Piek JJ, Pijls NH, Redwood S, Siebes M, Spaan JA, Gould KL. Does the instantaneous wave-free ratio approximate the fractional flow reserve? J Am Coll Cardiol. 2013; 61: 1428-1435.
71. Gould KL, Kirkeeide RL, Buchi M. Coronary flow reserve as a physiologic measure of stenosis severity. J Am Coll Cardiol. 1990; 15: 459-474. (Pubitemid 20067508)
72. Gould KL. Pressure-flow characteristics of coronary stenoses in unsedated dogs at rest and during coronary vasodilation. Circ Res. 1978; 43: 242-253. (Pubitemid 9004286)
73. Siebes M, Verhoeff BJ, Meuwissen M, de Winter RJ, Spaan JA, Piek JJ. Single-wire pressure and flow velocity measurement to quantify coronary stenosis hemodynamics and effects of percutaneous interventions. Circulation. 2004; 109: 756-762. (Pubitemid 38222896)
74. Seiler C, Fleisch M, Meier B. Direct intracoronary evidence of collateral steal in humans. Circulation. 1997; 96: 4261-4267. (Pubitemid 28007453)
75. Spaan JA, Piek JJ, Hoffman JI, Siebes M. Physiological basis of clinically used coronary hemodynamic indices. Circulation. 2006; 113: 446-455. (Pubitemid 43803207)
76. De Bruyne B, Pijls NH, Barbato E, Bartunek J, Bech JW, Wijns W, Heyndrickx GR. Intracoronary and intravenous adenosine 5'-triphosphate, adenosine, papaverine, and contrast medium to assess fractional flow reserve in humans. Circulation. 2003; 107: 1877-1883. (Pubitemid 36444128)
77. Chareonthaitawee P, Kaufmann PA, Rimoldi O, Camici PG. Heterogeneity of resting and hyperemic myocardial blood flow in healthy humans. Cardiovasc Res. 2001; 50: 151-161. (Pubitemid 32244395)
78. Sdringola S, Johnson NP, Kirkeeide RL, Cid E, Gould KL. Impact of unexpected factors on quantitative myocardial perfusion and coronary flow reserve in young, asymptomatic volunteers. JACC Cardiovasc Imaging. 2011; 4: 402-412.
79. De Bruyne B, Baudhuin T, Melin JA, Pijls NH, Sys SU, Bol A, Paulus WJ, Heyndrickx GR, Wijns W. Coronary flow reserve calculated from pressure measurements in humans: validation with positron emission tomography. Circulation. 1994; 89: 1013-1022. (Pubitemid 24076525)
80. Tron C, Kern MJ, Donohue TJ, Bach RG, Aguirre FV, Caracciolo EA, Moore JA. Comparison of quantitative angiographically derived and measured translesion pressure and flow velocity in coronary artery disease. Am J Cardiol. 1995; 75: 111-117.
81. Di Mario C, Gil R, de Feyter PJ, Schuurbiers JC, Serruys PW. Utilization of translesional hemodynamics: comparison of pressure and flow methods in stenosis assessment in patients with coronary artery disease. Cathet Cardiovasc Diagn. 1996; 38: 189-201. (Pubitemid 26181025)
82. Danzi GB, Pirelli S, Mauri L, Testa R, Ciliberto GR, Massa D, Lotto AA, Campolo L, Parodi O. Which variable of stenosis severity best describes the significance of an isolated left anterior descending coronary artery lesion? Correlation between quantitative coronary angiography, intracoronary Doppler measurements and high dose dipyridamole echo-cardiography. J Am Coll Cardiol. 1998; 31: 526-533. (Pubitemid 28144116)
83. Emanuelsson H, Dohnal M, Lamm C, Tenerz L. Initial experiences with a miniaturized pressure transducer during coronary angioplasty. Cathet Cardiovasc Diagn. 1991; 24: 137-143.
84. Wilson RF, White CW. Intracoronary papaverine: an ideal coronary vasodilator for studies of the coronary circulation in conscious humans. Circulation. 1986; 73: 444-451. (Pubitemid 16133022)
85. Wilson RF, Wyche K, Christensen B V, Zimmer S, Laxson DD. Effects of adenosine on human coronary arterial circulation. Circulation. 1990; 82: 1595-1606. (Pubitemid 20367962)
86. Kim HJ, Vignon-Clementel IE, Coogan JS, Figueroa CA, Jansen KE, Taylor CA. Patient-specific modeling of blood flow and pressure in human coronary arteries. Ann Biomed Eng. 2010; 38: 3195-3209.
87. Pijls NH, van Son JA, Kirkeeide RL, De Bruyne B, Gould KL. Experimental basis of determining maximum coronary, myocardial, and collateral blood flow by pressure measurements for assessing functional stenosis severity before and after percutaneous transluminal coronary angioplasty. Circulation. 1993; 87: 1354-1367. (Pubitemid 23110406)
88. Pijls NH, De Bruyne B, Smith L, Aarnoudse W, Barbato E, Bartunek J, Bech GJ, Van De Vosse F. Coronary thermodilution to assess flow reserve: validation in humans. Circulation. 2002; 105: 2482-2486. (Pubitemid 34568968)
89. Chapman CB, Fraser RS. Studies on the effect of exercise on cardiovascular function, I: cardiac output and mean circulation time. Circulation. 1954; 9: 57-62.
90. Sorensen SG, Groves BM, Horwitz LD, Chaudhuri TK. Regional myocardial blood flow in man during dipyridamole coronary vasodilation. Chest. 1985; 87: 735-739. (Pubitemid 15063772)
91. Tello R, Hartnell GG, Hill TC, Cerel A, Finn JP, Kamalesh M, Cohen M, Lewis S. First-pass evaluation of myocardial output during dipyridamole stress using turbo-FLASH magnetic resonance imaging. Invest Radiol. 1996; 31: 690-695. (Pubitemid 26376446)
92. Meuwissen M, Chamuleau SA, Siebes M, Schotborgh CE, Koch KT, de Winter RJ, Bax M, de Jong A, Spaan JA, Piek JJ. Role of variability in microvascular resistance on fractional flow reserve and coronary blood flow velocity reserve in intermediate coronary lesions. Circulation. 2001; 103: 184-187. (Pubitemid 32095399)
93. Seiler C, Kirkeeide RL, Gould KL. Measurement from arteriograms of regional myocardial bed size distal to any point in the coronary vascular tree for assessing anatomic area at risk. J Am Coll Cardiol. 1993; 21: 783-797. (Pubitemid 23076298)
94. Koo BK, Erglis A, Doh JH, Daniels DV, Jegere S, Kim HS, Dunning A, DeFrance T, Lansky A, Leipsic J, Min JK. Diagnosis of ischemia-causing coronary stenoses by noninvasive fractional flow reserve computed from coronary computed tomographic angiograms: results from the prospective multicenter DISCOVER-FLOW (Diagnosis of Ischemia-Causing Stenoses Obtained Via Noninvasive Fractional Flow Reserve) study. J Am Coll Cardiol. 2011; 58: 1989-1997.
95. Min JK, Leipsic J, Pencina MJ, Berman DS, Koo BK, van Mieghem C, Erglis A, Lin FY, Dunning AM, Apruzzese P, Budoff MJ, Cole JH, Jaffer FA, Leon MB, Malpeso J, Mancini GB, Park SJ, Schwartz RS, Shaw LJ, Mauri L. Diagnostic accuracy of fractional flow reserve from anatomic CT angiography. JAMA. 2012; 308: 1237-1245.
96. Takayama T, Hodgson JM. Prediction of the physiologic severity of coronary lesions using 3D IVUS: validation by direct coronary pressure measurements. Catheter Cardiovasc Interv. 2001; 53: 48-55. (Pubitemid 32405747)
97. Morris PD, Ryan D, Morton AC, Lycett R, Lawford PV, Hose DR, Gunn JP. Virtual fractional flow reserve from coronary angiography: modeling the significance of coronary lesions: results from the VIRTU-1 (VIRTUal Fractional Flow Reserve From Coronary Angiography) study. JACC Cardiovasc Interv. 2013; 6: 149-157.
98. Guagliumi G, Sirbu V, Petroff C, Capodanno D, Musumeci G, Yamamoto H, Elbasiony A, Brushett C, Matiashvili A, Lortkipanidze N, Valsecchi O, Bezerra HG, Schmitt JM. Volumetric assessment of lesion severity with optical coherence tomography: relationship with fractional flow. EuroIntervention. 2013; 8: 1172-1181.
99. Hambrecht R, Walther C, Möbius-Winkler S, Gielen S, Linke A, Conradi K, Erbs S, Kluge R, Kendziorra K, Sabri O, Sick P, Schuler G. Percutaneous coronary angioplasty compared with exercise training in patients with stable coronary artery disease: a randomized trial. Circulation. 2004; 109: 1371-1378. (Pubitemid 38387823)
100. Steg PG, Thuaire C, Himbert D, Carrié D, Champagne S, Coisne D, Khalifé K, Cazaux P, Logeart D, Slama M, Spaulding C, Cohen A, Tirouvanziam A, Montély JM, Rodriguez RM, Garbarz E, Wijns W, Durand-Zaleski I, Porcher R, Brucker L, Chevret S, Chastang C; DECOPI Investigators. DECOPI (DEsobstruction COronaire en PostInfarctus): a randomized multi-centre trial of occluded artery angioplasty after acute myocardial infarction. Eur Heart J. 2004; 25: 2187-2194. (Pubitemid 39592419)
101. Hochman JS, Lamas GA, Buller CE, Dzavik V, Reynolds HR, Abramsky SJ, Forman S, Ruzyllo W, Maggioni AP, White H, Sadowski Z, Carvalho AC, Rankin JM, Renkin JP, Steg PG, Mascette AM, Sopko G, Pfisterer ME, Leor J, Fridrich V, Mark DB, Knatterud GL; Occluded Artery Trial Investigators. Coronary intervention for persistent occlusion after myocardial infarction. N Engl J Med. 2006; 355: 2395-2407. (Pubitemid 44911017)
102. Hueb W, Lopes NH, Gersh BJ, Soares P, Machado LA, Jatene FB, Oliveira SA, Ramires JA. Five-year follow-up of the Medicine, Angioplasty, or Surgery Study (MASS II): a randomized controlled clinical trial of 3 therapeutic strategies for multivessel coronary artery disease. Circulation. 2007; 115: 1082-1089. (Pubitemid 46673170)
103. Boden WE, O'Rourke RA, Teo KK, Hartigan PM, Maron DJ, Kostuk WJ, Knudtson M, Dada M, Casperson P, Harris CL, Chaitman BR, Shaw L, Gosselin G, Nawaz S, Title LM, Gau G, Blaustein AS, Booth DC, Bates ER, Spertus JA, Berman DS, Mancini GB, Weintraub WS; COURAGE Trial Research Group. Optimal medical therapy with or without PCI for stable coronary disease. N Engl J Med. 2007; 356: 1503-1516. (Pubitemid 46588415)
104. Nishigaki K, Yamazaki T, Kitabatake A, Yamaguchi T, Kanmatsuse K, Kodama I, Takekoshi N, Tomoike H, Hori M, Matsuzaki M, Takeshita A, Shimbo T, Fujiwara H; Japanese Stable Angina Pectoris Study Investigators. Percutaneous coronary intervention plus medical therapy reduces the incidence of acute coronary syndrome more effectively than initial medical therapy only among patients with low-risk coronary artery disease a randomized, comparative, multicenter study. JACC Cardiovasc Interv. 2008; 1: 469-479.
105. Frye RL, August P, Brooks MM, Hardison RM, Kelsey SF, MacGregor JM, Orchard TJ, Chaitman BR, Genuth SM, Goldberg SH, Hlatky MA, Jones TL, Molitch ME, Nesto RW, Sako EY, Sobel BE; BARI 2D Study Group. A randomized trial of therapies for type 2 diabetes and coronary artery disease. N Engl J Med. 2009; 360: 2503-2515.
106. Pijls NH, van Schaardenburgh P, Manoharan G, Boersma E, Bech JW, van't Veer M, Bär F, Hoorntje J, Koolen J, Wijns W, de Bruyne B. Percutaneous coronary intervention of functionally nonsignificant stenosis: 5-year follow-up of the DEFER Study. J Am Coll Cardiol. 2007; 49: 2105-2111. (Pubitemid 46771047)
107. Tonino PA, De Bruyne B, Pijls NH, Siebert U, Ikeno F, van' t Veer M, Klauss V, Manoharan G, Engstrøm T, Oldroyd KG, Ver Lee PN, MacCarthy PA, Fearon WF; FAME Study Investigators. Fractional flow reserve versus angiography for guiding percutaneous coronary intervention. N Engl J Med. 2009; 360: 213-224.
108. De Bruyne B, Pijls NH, Kalesan B, Barbato E, Tonino PA, Piroth Z, Jagic N, Möbius-Winkler S, Mobius-Winckler S, Rioufol G, Witt N, Kala P, MacCarthy P, Engström T, Oldroyd KG, Mavromatis K, Manoharan G, Verlee P, Frobert O, Curzen N, Johnson JB, Jüni P, Fearon WF; FAME 2 Trial Investigators. Fractional flow reserve-guided PCI versus medical therapy in stable coronary disease. N Engl J Med. 2012; 367: 991-1001.
109. Gould KL. Does coronary flow trump coronary anatomy? JACC Cardiovasc Imaging. 2009; 2: 1009-1023.
110. Batchvarov V, Malik M. Individual patterns of QT/RR relationship. Card Electrophysiol Rev. 2002; 6: 282-288. (Pubitemid 35276939)
111. Koo BK. A novel non-invasive technology for treatment planning using virtual coronary intervention and CT-derived computed fractional flow reserve (FFRCT). Paper Presented at: EuroPCR; May 16, 2012; Paris, France.
112. Serruys PW, Girasis C, Papadopoulou SL, Onuma Y. Non-invasive fractional flow reserve: scientific basis, methods and perspectives. EuroIntervention. 2012; 8: 511-519.
113. Kern MJ. Use and abuse of IVUS and FFR by Magni V et al. or why you shouldn't believe the saying, "If you want to treat, use IVUS. If you don't, use FFR". Catheter Cardiovasc Interv. 2009; 74: 811-813; author reply 814.
114. Hodgson JM. If you want to stent... do intravascular ultrasound! JACC Cardiovasc Interv. 2010; 3: 818-820.
115. Johnson NP, Davidson CJ. Don't judge a book by its cover: don't judge