Hypoxic-Ischemic Encephalopathy: Pathobiology and Therapy of the Postresuscitation Syndrome in Children

Pediatric Critical Care

Volumn , Issue , 2006, Pages 904-928

  Clark, Robert S B ^a   Lai, Yichen ^b   Hickey, Robert W ^b   Safar, Peter J ^a   Kochanek, Patrick M ^a,c  

^a UNIVERSITY OF PITTSBURGH   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c University of Pittsburgh ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84884453898     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-032301808-1.50061-4     Document Type: Chapter

References (248)

1. Hypothermia after Cardiac Arrest Study Group Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest. N Engl J Med 2002, 346:549-556.
2. Bernard SA, Gray TW, Buist MD, et al. Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia. N Engl J Med 2002, 346:557-563.
3. Nolan JP, Morley PT, Vanden Hoek TL, et al. Therapeutic hypothermia after cardiac arrest: an advisory statement by the advanced life support task force of the International Liaison Committee on Resuscitation. Circulation 2003, 108:118-121.
4. Safar P Cerebral resuscitation after cardiac arrest: a review. Circulation 1986, 74:111-138.
5. O'Rourke PP Outcome of children who are apneic and pulseless in the emergency room. Crit Care Med 1986, 14:466-468.
6. Young KD, Seidel JS Pediatric cardiopulmonary resuscitation: a collective review. Ann Emerg Med 1999, 33:195-205.
7. Reis AG, Nadkarni V, Perondi MB, et al. A prospective investigation into the epidemiology of in-hospital pediatric cardiopulmonary resuscitation using the international Utstein reporting style. Pediatrics 2002, 109:200-209.
8. Odden JP, Stiris T, Hansen TW, et al. Cerebral blood flow during experimental hypoxaemia and ischaemia in the newborn piglet. Acta Paediatr Scand Suppl 1989, 360:13-19.
9. Odden JP, Farstad T, Roll EB, et al. Cerebral blood flow autoregulation after moderate hypoxemia in the newborn piglet. Biol Neonate 1994, 65:367-377.
10. Fink EL, Alexander H, Marco CD, et al. Experimental model of pediatric asphyxial cardiopulmonary arrest in rats. Pediatr Crit Care Med 2004, 5:139-144.
11. Agnew DM, Koehler RC, Guerguerian AM, et al. Hypothermia for 24 hours after asphyxic cardiac arrest in piglets provides striatal neuroprotection that is sustained 10 days after rewarming. Pediatr Res 2003, 54:253-262.
12. Goldberg MP, Monyer H, Choi DW Hypoxic neuronal injury in vitro depends on extracellular glutamine. Neurosci Lett 1988, 94:52-57.
13. Bodsch W, Barbier A, Oehmichen M, et al. Recovery of monkey brain after prolonged ischemia. II. Protein synthesis and morphological alterations. J Cereb Blood Flow Metab 1986, 6:22-33.
14. Vaagenes P, Safar P, Moossy J, et al. Asphyxiation versus ventricular fibrillation cardiac arrest in dogs. Differences in cerebral resuscitation effects-a preliminary study. Resuscitation 1997, 35:41-52.
15. Siesjo BK, Wieloch T Cerebral metabolism in ischaemia: neurochemical basis for therapy. BJA: Brit J Anaesth 1985, 57:47-62.
16. Pellerin L, Magistretti PJ Glutamate uptake into astrocytes stimulates aerobic glycolysis: A mechanism coupling neuronal activity to glucose utilization. Proc Natl Acad Sci USA 1994, 91:10625-10629.
17. Liou AK, Clark RS, Henshall DC, et al. To die or not to die for neurons in ischemia, traumatic brain injury and epilepsy: a review on the stress-activated signaling pathways and apoptotic pathways. Prog Neurobiol 2003, 69:103-142.
18. Choi DW Ischemia-induced neuronal apoptosis. Curr Opin Neurobiol 1996, 6:667-672.
19. Portera-Cailliau C, Price DL, Martin LJ Excitotoxic neuronal death in the immature brain is an apoptosis-necrosis morphological continuum. J Comp Neurol 1997, 378:70-87.
20. Bralet J, Schreiber L, Bouvier C Effect of acidosis and anoxia on iron delocalization from brain homogenates. Biochem Pharmacol 1992, 43:979-983.
21. du Plessis AJ, Volpe JJ Perinatal brain injury in the preterm and term newborn. Curr Opin Neurol 2002, 15:151-157.
22. Siesjo BK, Bengtsson F Calcium fluxes, calcium antagonists, and calcium-related pathology in brain ischemia, hypoglycemia, and spreading depression: a unifying hypothesis. J Cereb Blood Flow Metab 1989, 9:127-140.
23. Katz LM, Callaway CW, Kagan VE, et al. Electron spin resonance measure of brain antioxidant activity during ischemia/reperfusion. Neuroreport 1998, 9:1587-1593.
24. Choi DW, Maulucci-Gedde M, Kriegstein AR Glutamate neurotoxicity in cortical cell culture. J Neurosci 1987, 7:357-368.
25. Newell DW, Malouf AT, Franck JE Glutamate-mediated selective vulnerability to ischemia is present in organotypic cultures of hippocampus. Neurosci Lett 1990, 116:325-330.
26. Brierley JB, Meldrum BS, Brown AW The threshold and neuropathology of cerebral 'anoxic-ischemic' cell change. Arch Neurol 1973, 29:367-374.
27. Buja LM, Eigenbrodt ML, Eigenbrodt EH Apoptosis and necrosis, Basic types and mechanisms of cell death. Arch Pathol Lab Med 1993, 117:1208-1214.
28. Kerr JF, Wyllie AH, Currie AR Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer 1972, 26:239-257.
29. Cao G, Pei W, Lan J, et al. Caspase-activated DNase/DFF40 mediates apoptotic DNA fragmentation in transient cerebral ischemia and in neuronal cultures, J. Neurosci 2001, 21:4678-4690.
30. Du L, Zhang X, Han YY, et al. Intra-mitochondrial poly-ADP-ribosylation contributes to NAD+ depletion and cell death induced by oxidative stress. J Biol Chem 2003, 278:18426-18433.
31. Zhu C, Qiu L, Wang X, et al. Involvement of apoptosis-inducing factor in neuronal cell death after hypoxia-ischemia in the neonatal rat brain. J Neurochem 2003, 86:306-317.
32. Zhang X, Chen J, Graham SH, et al. Intranuclear localization of apoptosis-inducing factor (AIF) and large scale DNA fragmentation after traumatic brain injury in rats and in neuronal cultures exposed to peroxynitrite. J Neurochem 2002, 82:181-191.
33. Nitatori T, Sato N, Waguri S, et al. Delayed neuronal death in the CA1 pyramidal cell layer of the gerbil hippocampus following transient ischemia is apoptosis. J Neurosci 1995, 15:1001-1011.
34. Li Y, Chopp M, Jiang N, et al. Temporal profile of in situ DNA fragmentation after transient middle cerebral artery occlusion in the rat. J Cereb Blood Flow Metab 1995, 15:389-397.
35. Cheng Y, Deshmukh M, D'Costa A, et al. Caspase inhibitor affords neuroprotection with delayed administration in a rat model of neonatal hypoxic-ischemic brain injury. J Clin Invest 1998, 101:1992-1999.
36. MacManus JP, Buchan AM Apoptosis after experimental stroke: fact or fashion?. J Neurotrauma 2000, 17:899-914.
37. Deshpande J, Bergstedt K, Linden T, et al. Ultrastructural changes in the hippocampal CA1 region following transient cerebral ischemia: evidence against programmed cell death. Exp Brain Res 1992, 88:91-105.
38. Lemaire C, Andreau K, Souvannavong V, et al. Inhibition of caspase activity induces a switch from apoptosis to necrosis. FEBS Lett 1998, 425:266-270.
39. Kloner RA, Przyklenk K, Whittaker P Deleterious effects of oxygen radicals in ischemia/reperfusion. Resolved and unresolved issues. Circulation 1989, 80:1115-1127.
40. Siesjo BK, Agardh CD, Bengtsson F Free radicals and brain damage. Cerebrovasc Brain Metab Rev 1989, 1:165-211.
41. Opie LH Reperfusion injury and its pharmacologic modification. Circulation 1989, 80:1049-1062.
42. Hallenbeck JM Prevention of postischemic impairment of microvascular perfusion. Neurology 1977, 27:3-10.
43. Rothman S Synaptic release of excitatory amino acid neurotransmitter mediates anoxic neuronal death. J Neurosci 1984, 4:1884-1891.
44. Dugan LL, Choi DW Excitotoxicity, free radicals, and cell membrane changes. Ann Neurol 1994, 35(Suppl):S17-S21.
45. Lipton SA, Rosenberg PA Excitatory amino acids as a final common pathway for neurologic disorders. N Engl J Med 1994, 330:613-622.
46. + channels and Na(+)-Ca2+ exchanger. J Neurosci 1992, 12:430-439.
47. Bellamy R, Safar P, Tisherman SA, et al. Suspended animation for delayed resuscitation. Crit Care Med 1996, 24:S24-S47.
48. Lafon-Cazal M, Pietri S, Culcasi M, et al. NMDA-dependent superoxide production and neurotoxicity. Nature 1993, 364:535-537.
49. Bartus RT, Baker KL, Heiser AD, et al. Postischemic administration of AK275, a calpain inhibitor, provides substantial protection against focal ischemic brain damage. J Cereb Blood Flow Metab 1994, 14:537-544.
50. Gill R, Soriano M, Blomgren K, et al. Role of caspase-3 activation in cerebral ischemia-induced neurodegeneration in adult and neonatal brain. J Cereb Blood Flow Metab 2002, 22:420-430.
51. Kontos HA Oxygen radicals from arachidonate metabolism in abnormal vascular responses. Am Rev Respir Dis 1987, 136:474-477.
52. Betz AL, Randall J, Martz D Xanthine oxidase is not a major source of free radicals in focal cerebral ischemia. Am J Physiol 1991, 260:H563-H568.
53. Lindsay S, Liu TH, Xu JA, et al. Role of xanthine dehydrogenase and oxidase in focal cerebral ischemic injury to rat. Am J Physiol 1991, 261:H2051-H2057.
54. Komara JS, Nayini NR, Bialick HA, et al. Brain iron delocalization and lipid peroxidation following cardiac arrest. Ann Emerg Med 1986, 15:384-389.
55. Garthwaite J, Garthwaite G, Palmer RM, et al. NMDA receptor activation induces nitric oxide synthesis from arginine in rat brain slices. Eur J Pharmacol 1989, 172:413-416.
56. Beckman JS, Beckman TW, Chen J, et al. Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. Proc Natl Acad Sci U S A 1990, 87:1620-1624.
57. Gilman SC, Bonner MJ, Pellmar TC Free radicals enhance basal release of D-[3H]aspartate from cerebral cortical synaptosomes. J Neurochem 1994, 62:1757-1763.
58. Krause GS, DeGracia DJ, Skjaerlund JM, et al. Assessment of free radical-induced damage in brain proteins after ischemia and reperfusion. Resuscitation 1992, 23:59-69.
59. Bromont C, Marie C, Bralet J Increased lipid peroxidation in vulnerable brain regions after transient forebrain ischemia in rats. Stroke 1989, 20:918-924.
60. Oliver CN, Starke-Reed PE, Stadtman ER, et al. Oxidative damage to brain proteins, loss of glutamine synthetase activity, and production of free radicals during ischemia/reperfusion-induced injury to gerbil brain. Proc Natl Acad Sci U S A 1990, 87:5144-5147.
61. White BC, Tribhuwan RC, Vander Laan DJ, et al. Brain mitochondrial DNA is not damaged by prolonged cardiac arrest or reperfusion. J Neurochem 1992, 58:1716-1722.
62. Cochrane CG Mechanisms of oxidant injury of cells. Mol Aspects Med 1991, 12:137-147.
63. Hockenbery DM, Oltvai ZN, Yin XM, et al. Bcl-2 functions in an antioxidant pathway to prevent apoptosis. Cell 1993, 75:241-251.
64. Nagayama T, Lan J, Henshall DC, et al. Induction of oxidative DNA damage in the peri-infarct region after permanent focal cerebral ischemia. J Neurochem 2000, 75:1716-1728.
65. Bayir H, Kagan VE, Tyurina YY, et al. Assessment of antioxidant reserves and oxidative stress in cerebrospinal fluid after severe traumatic brain injury in infants and children. Pediatr Res 2002, 51:571-578.
66. Shiu GK, Nemmer JP, Nemoto EM Reassessment of brain free fatty acid liberation during global ischemia and its attenuation by barbiturate anesthesia. J Neurochem 1983, 40:880-884.
67. Ikeda M, Yoshida S, Busto R, et al. Polyphosphoinositides as a probable source of brain free fatty acids accumulated at the onset of ischemia. J Neurochem 1986, 47:123-132.
68. Abe K, Kogure K, Yamamoto H, et al. Mechanism of arachidonic acid liberation during ischemia in gerbil cerebral cortex. J Neurochem 1987, 48:503-509.
69. Bazan NG Involvement of acachidonic acid and platelet-activating factor in the response of the nervous system to ischemia and convulsions. Lipid mediators in ischemic brain damage and experimental epilepsy 1990, Karger, Basel. p. kon. N.G. Bazan (Ed.).
70. Simon RP, Cho H, Gwinn R, et al. The temporal profile of 72-kDa heat-shock protein expression following global ischemia. J Neurosci 1991, 11:881-889.
71. Seidberg N, Clark RS, Zhang X et al: Alterations in inducible 72 kilodalton heat shock protein and the chaperone cofactor BAG-1 in human brain after head injury, J Neurochem in press, 2002.
72. Murphy SJ, Song D, Welsh FA, et al. Regional expression of heat shock protein 72 mRNA following mild and severe hypoxia in neonatal piglet brain. Adv Exper Med Biol 1999, 471:155-163.
73. Chopp M, Chen H, Ho KL, et al. Transient hyperthermia protects against subsequent forebrain ischemic cell damage in the rat. Neurology 1989, 39:1396-1398.
74. Ota A, Ikeda T, Xia XY, et al. Hypoxic-ischemic tolerance induced by hyperthermic pretreatment in newborn rats. J Soc Gynecol Invest 2000, 7:102-105.
75. Lowenstein DH, Chan PH, Miles MF The stress protein response in cultured neurons: characterization and evidence for a protective role in excitotoxicity. Neuron 1991, 7:1053-1060.
76. Hoehn B, Ringer TM, Xu L, et al. Overexpression of HSP72 after induction of experimental stroke protects neurons from ischemic damage. J Cereb Blood Flow Metab 2001, 21:1303-1309.
77. Tsuchiya D, Hong S, Matsumori Y, et al. Overexpression of rat heat shock protein 70 is associated with reduction of early mitochondrial cytochrome C release and subsequent DNA fragmentation after permanent focal ischemia. J Cereb Blood Flow Metab 2003, 23:718-727.
78. Kelly S, Zhang ZJ, Zhao H, et al. Gene transfer of HSP72 protects cornu ammonis 1 region of the hippocampus neurons from global ischemia: influence of Bcl-2. Annals of Neurology 2002, 52:160-167.
79. Kane DJ, Ord T, Anton R, et al. Expression of bcl-2 inhibits necrotic neural cell death. J Neurosci Res 1995, 40:269-275.
80. Chen J, Graham SH, Chan PH, et al. bcl-2 is expressed in neurons that survive focal ischemia in the rat. Neuroreport 1995, 6:394-398.
81. Shimazaki K, Ishida A, Kawai N Increase in bcl-2 oncoprotein and the tolerance to ischemia-induced neuronal death in the gerbil hippocampus. Neurosci Res 1994, 20:95-99.
82. Krajewski S, Mai JK, Krajewska M, et al. Upregulation of bax protein levels in neurons following cerebral ischemia. J Neurosci 1995, 15:6364-6376.
83. Linnik MD, Zahos P, Geschwind MD, et al. Expression of bcl-2 from a defective herpes simplex virus-1 vector limits neuronal death in focal cerebral ischemia. Stroke 1995, 26:1670-1674. discussion 1675.
84. Chen Y, Ginis I, Hallenbeck JM The protective effect of ceramide in immature rat brain hypoxia-ischemia involves up-regulation of bcl-2 and reduction of TUNEL-positive cells. J Cereb Blood Flow Metab 2001, 21:34-40.
85. Cao G, Pei W, Ge H, et al. In Vivo Delivery of a Bcl-xL Fusion Protein Containing the TAT Protein Transduction Domain Protects against Ischemic Brain Injury and Neuronal Apoptosis. J Neurosci 2002, 22:5423-5431.
86. Clark RS, Kochanek PM, Chen M, et al. Increases in Bcl-2 and cleavage of Caspase-1 and Caspase-3 in human brain after head injury. FASEB J 1999, 13:813-821.
87. Phillis JW, Smith-Barbour M, O'Regan MH, et al. Amino acid and purine release in rat brain following temporary middle cerebral artery occlusion. Neurochem Res 1994, 19:1125-1130.
88. Morii S, Ngai AC, Ko KR, et al. Role of adenosine in regulation of cerebral blood flow: effects of theophylline during normoxia and hypoxia. Am J Physiol 1987, 253:H165-H175.
89. Laudignon N, Beharry K, Farri E, et al. The role of adenosine in the vascular adaptation of neonatal cerebral blood flow during hypotension. J Cereb Blood Flow Metab 1991, 11:424-431.
90. Ruth VJ, Park TS, Gonzales ER, et al. Adenosine and cerebrovascular hyperemia during insulin-induced hypoglycemia in newborn piglet. Am J Physiol 1993, 265:H1762-H1768.
91. Miller LP, Hsu C Therapeutic potential for adenosine receptor activation in ischemic brain injury. J Neurotrauma 1992, 9(Suppl 2):S563-S5677.
92. Rudolphi KA, Schubert P, Parkinson FE, et al. Neuroprotective role of adenosine in cerebral ischaemia. Trends Pharmacol Sci 1992, 13:439-445.
93. Snyder JV, Nemoto EM, Carroll RG, et al. Global ischemia in dogs: intracranial pressures, brain blood flow and metabolism. Stroke 1975, 6:21-27.
94. Cerchiari EL, Hoel TM, Safar P, et al. Protective effects of combined superoxide dismutase and deferoxamine on recovery of cerebral blood flow and function after cardiac arrest in dogs. Stroke 1987, 18:869-878.
95. Rosenberg AA Cerebral blood flow and O2 metabolism after asphyxia in neonatal lambs. Pediatr Res 1986, 20:778-782.
96. Michenfelder JD, Milde JH Postischemic canine cerebral blood flow appears to be determined by cerebral metabolic needs. J Cereb Blood Flow Metab 1990, 10:71-76.
97. Wolfson SK, Safar P, Reich H, et al. Dynamic heterogeneity of cerebral hypoperfusion after prolonged cardiac arrest in dogs measured by the stable xenon/CT technique: a preliminary study. Resuscitation 1992, 23:1-20.
98. Sterz F, Leonov Y, Safar P, et al. Multifocal cerebral blood flow by Xe-CT and global cerebral metabolism after prolonged cardiac arrest in dogs. Reperfusion with open-chest CPR or cardiopulmonary bypass. Resuscitation 1992, 24:27-47.
99. Steen PA, Gisvold SE, Milde JH, et al. Nimodipine improves outcome when given after complete cerebral ischemia in primates. Anesthesiology 1985, 62:406-414.
100. Karinen P, Koivukangas P, Ohinmaa A, et al. Cost-effectiveness analysis of nimodipine treatment after aneurysmal subarachnoid hemorrhage and surgery. Neurosurgery 1999, 45:780-784. discussion 784-785.
101. Horn J, de Haan RJ, Vermeulen M, et al. Very Early Nimodipine Use in Stroke (VENUS): a randomized, double-blind, placebo-controlled trial. Stroke 2001, 32:461-465.
102. Safar P, Xiao F, Radovsky A, et al. Improved cerebral resuscitation from cardiac arrest in dogs with mild hypothermia plus blood flow promotion. Stroke 1996, 27:105-113.
103. Beckstead JE, Tweed WA, Lee J, et al. Cerebral blood flow and metabolism in man following cardiac arrest. Stroke 1978, 9:569-573.
104. Cohan SL, Mun SK, Petite J, et al. Cerebral blood flow in humans following resuscitation from cardiac arrest. Stroke 1989, 20:761-765.
105. Bergsneider M, Hovda DA, Shalmon E, et al. Cerebral hyperglycolysis following severe traumatic brain injury in humans: a positron emission tomography study. J Neurosurg 1997, 86:241-251.
106. Mujsce DJ, Christensen MA, Vannucci RC Cerebral blood flow and edema in perinatal hypoxic-ischemic brain damage. Pediatr Res 1990, 27:450-453.
107. Ashwal S, Schneider S, Tomasi L, et al. Prognostic implications of hyperglycemia and reduced cerebral blood flow in childhood near-drowning. Neurology 1990, 40:820-823.
108. Beyda DH The prognostic value of measuring regional cerebral blood flow in the neuro-compromised paediatric patient. Current problems in neurology: impact of functional imaging 1987, J Libbey, London. J. Wade (Ed.).
109. Jacobs MM, Phibbs RH Prevention, recognition, and treatment of perinatal asphyxia. Clin Perinatol 1989, 16:785-807.
110. Nemoto EM, Bleyaert AL, Stezoski SW, et al. Global brain ischemia: a reproducible monkey model. Stroke 1977, 8:558-564.
111. Katz L, Ebmeyer U, Safar P, et al. Outcome model of asphyxial cardiac arrest in rats. J Cereb Blood Flow Metab 1995, 15:1032-1039.
112. Ng T, Graham DI, Adams JH, et al. Changes in the hippocampus and the cerebellum resulting from hypoxic insults: frequency and distribution. Acta Neuropathol (Berl) 1989, 78:438-443.
113. Kinney HC, Korein J, Panigrahy A, et al. Neuropathological findings in the brain of Karen Ann Quinlan. The role of the thalamus in the persistent vegetative state. N Engl J Med 1994, 330:1469-1475.
114. Fisher B, Peterson B, Hicks G Use of brainstem auditory-evoked response testing to assess neurologic outcome following near drowning in children. Crit Care Med 1992, 20:578-585.
115. Zaritsky A Cardiopulmonary resuscitation in children. Clin Chest Med 1987, 8:561-571.
116. Earnest MP, Yarnell PR, Merrill SL, et al. Long-term survival and neurologic status after resuscitation from out-of-hospital cardiac arrest. Neurology 1980, 30:1298-1302.
117. Biggart MJ, Bohn DJ Effect of hypothermia and cardiac arrest on outcome of near-drowning accidents in children. J Pediatr 1990, 117:179-183.
118. Robertson CM, Joffe AR, Moore AJ, et al. Neurodevelopmental outcome of young pediatric intensive care unit survivors of serious brain injury. Pediatr Crit Care Med 2002, 3:345-350.
119. Lewis JK, Minter MG, Eshelman SJ, et al. Outcome of pediatric resuscitation. Ann Emerg Med 1983, 12:297-299.
120. Torphy DE, Minter MG, Thompson BM Cardiorespiratory arrest and resuscitation of children. Am J Dis Child 1984, 138:1099-1102.
121. Levy DE, Caronna JJ, Singer BH, et al. Predicting outcome from hypoxic-ischemic coma. JAMA 1985, 253:1420-1426.
122. Edgren E, Hedstrand U, Nordin M, et al. Prediction of outcome after cardiac arrest. Crit Care Med 1987, 15:820-825.
123. Mullie A, Verstringe P, Buylaert W, et al. Predictive value of Glasgow coma score for awakening after out-of-hospital cardiac arrest. Cerebral Resuscitation Study Group of the Belgian Society for Intensive Care. Lancet 1988, 1:137-140.
124. Sirbaugh PE, Pepe PE, Shook JE, et al. A prospective, population-based study of the demographics, epidemiology, management, and outcome of out-of-hospital pediatric cardiopulmonary arrest.[comment][erratum appears in Ann Emerg Med 1999 Mar;33(3):358]. Ann Emerg Med 1999, 33:174-184.
125. Safar P, Bircher N, Pretto E, et al. Reappraisal of mouth-to-mouth ventilation. Ann Emerg Med 1998, 31:653-654.
126. Becker LB, Berg RA, Pepe PE, et al. A reappraisal of mouth-to-mouth ventilation during bystander-initiated cardiopulmonary resuscitation: a statement for Healthcare Professionals from the Ventilation Working Group of the Basic Life Support and Pediatric Life Support Subcommittees, American Heart Association. Ann Emerg Med 1997, 30:654-666.
127. Scollo-Lavizzari G, Bassetti C Prognostic value of EEG in post-anoxic coma after cardiac arrest. Eur Neurol 1987, 26:161-170.
128. Meynaar IA, Straaten HM, van der Wetering J, et al. Serum neuron-specific enolase predicts outcome in post-anoxic coma: a prospective cohort study. Inten Care Med 2003, 29:189-195.
129. Martens P, Raabe A, Johnsson P Serum S-100 and neuron-specific enolase for prediction of regaining consciousness after global cerebral ischemia. Stroke 1998, 29:2363-2366.
130. Zingler VC, Krumm B, Bertsch T, et al. Early prediction of neurological outcome after cardiopulmonary resuscitation: a multimodal approach combining neurobiochemical and electrophysiological investigations may provide high prognostic certainty in patients after cardiac arrest. Eur Neurol 2003, 49:79-84.
131. Madl C, Grimm G, Kramer L, et al. Early prediction of individual outcome after cardiopulmonary resuscitation. Lancet 1993, 341:855-858.
132. Miller JR, Myers RE Neuropathology of systemic circulatory arrest in adult monkeys. Neurology 1972, 22:888-904.
133. Ment LR, Stewart WB, Duncan CC, et al. Beagle pup model of perinatal asphyxia: nimodipine studies. Stroke 1987, 18:599-605.
134. Kirsch JR, Helfaer MA, Blizzard K, et al. Age-related cerebrovascular response to global ischemia in pigs. Am J Physiol 1990, 259:H1551-H1558.
135. Roland EH, Hill A, Norman MG, et al. Selective brainstem injury in an asphyxiated newborn. Ann Neurol 1988, 23:89-92.
136. van Lookeren Campagne M, Verheul JB, Nicolay K, et al. Early evolution and recovery from excitotoxic injury in the neonatal rat brain: a study combining magnetic resonance imaging, electrical impedance, and histology. J Cereb Blood Flow Metab 1994, 14:1011-1023.
137. Johnston MV Developmental aspects of NMDA receptor agonists and antagonists in the central nervous system. Psychopharmacol Bull 1994, 30:567-575.
138. Ikonomidou C, Bosch F, Miksa M, et al. Blockade of NMDA receptors and apoptotic neurodegeneration in the developing brain. Science 1999, 283:70-74.
139. Finger S, Almli CR Brain damage and neuroplasticity: mechanisms of recovery or development?. Brain Res 1985, 357:177-186.
140. Hicks SP, D'Amato CJ Motor-sensory and visual behavior after hemispherectomy in newborn and mature rats. Exp Neurol 1970, 29:416-438.
141. Hoffman WE, Braucher E, Pelligrino DA, et al. Brain lactate and neurologic outcome following incomplete ischemia in fasted, nonfasted, and glucose-loaded rats. Anesthesiology 1990, 72:1045-1050.
142. Kalimo H, Rehncrona S, Soderfeldt B, et al. Brain lactic acidosis and ischemic cell damage: 2. Histopathology. J Cereb Blood Flow Metab 1981, 1:313-327.
143. Rehncrona S, Rosen I, Siesjo BK Brain lactic acidosis and ischemic cell damage: 1. Biochemistry and neurophysiology. J Cereb Blood Flow Metab 1981, 1:297-311.
144. Simon R, Shiraishi K N-methyl-D-aspartate antagonist reduces stroke size and regional glucose metabolism. Ann Neurol 1990, 27:606-611.
145. Kraig RP, Petito CK, Plum F, et al. Hydrogen ions kill brain at concentrations reached in ischemia. J Cereb Blood Flow Metab 1987, 7:379-386.
146. Myerburg RJ, Estes D, Zaman L, et al. Outcome of resuscitation from bradyarrhythmic or asystolic prehospital cardiac arrest. J Am Coll Cardiol 1984, 4:1118-1122.
147. Martin LJ, Brambrink A, Koehler RC, et al. Primary sensory and forebrain motor systems in the newborn brain are preferentially damaged by hypoxia-ischemia. J Comp Neurol 1997, 377:262-285.
148. Brown CG, Werman HA Adrenergic agonists during cardiopulmonary resuscitation. Resuscitation 1990, 19:1-16.
149. Berg RA, Otto CW, Kern KB, et al. A randomized, blinded trial of high-dose epinephrine versus standard-dose epinephrine in a swine model of pediatric asphyxial cardiac arrest. Crit Care Med 1996, 24:1695-1700.
150. Voelckel WG, Lurie KG, McKnite S, et al. Effects of epinephrine and vasopressin in a piglet model of prolonged ventricular fibrillation and cardiopulmonary resuscitation. Crit Care Med 2002, 30:957-962.
151. Goetting MG, Paradis NA High-dose epinephrine improves outcome from pediatric cardiac arrest. Ann Emerg Med 1991, 20:22-26.
152. Sutton-Tyrrell K, Snyder JV, Kelsey S, et al. Risk monitoring of randomized trials in emergency medicine: experience of the Brain Resuscitation Clinical Trial II. Am J Emerg Med 1991, 9:112-117.
153. Vandycke C, Martens P High dose versus standard dose epinephrine in cardiac arrest - a meta-analysis. Resuscitation 2000, 45:161-166.
154. Dean JM, McComb JG Intracranial pressure monitoring in severe pediatric near-drowning. Neurosurgery 1981, 9:627-630.
155. Nussbaum E, Galant SP Intracranial pressure monitoring as a guide to prognosis in the nearly drowned, severely comatose child. J Pediatr 1983, 102:215-218.
156. Frewen TC, Sumabat WO, Han VK, et al. Cerebral resuscitation therapy in pediatric near-drowning. J Pediatr 1985, 106:615-617.
157. Sarnaik AP, Preston G, Lieh-Lai M, et al. Intracranial pressure and cerebral perfusion pressure in near-drowning. Crit Care Med 1985, 13:224-227.
158. Vanicky I, Marsala M, Murar J, et al. Prolonged postischemic hyperventilation reduces acute neuronal damage after 15 min of cardiac arrest in the dog. Neurosci Lett 1992, 135:167-170.
159. Muizelaar JP, Marmarou A, Ward JD, et al. Adverse effects of prolonged hyperventilation in patients with severe head injury: a randomized clinical trial. J Neurosurg 1991, 75:731-739.
160. Miller CL, Lampard DG, Alexander K, et al. Local cerebral blood flow following transient cerebral ischemia. I. Onset of impaired reperfusion within the first hour following global ischemia. Stroke 1980, 11:534-541.
161. Todd MM, Tommasino C, Shapiro HM Cerebrovascular effects of prolonged hypocarbia and hypercarbia after experimental global ischemia in cats. Crit Care Med 1985, 13:720-723.
162. Cold GE Does acute hyperventilation provoke cerebral oligaemia in comatose patients after acute head injury?. Acta Neurochir (Wien) 1989, 96:100-106.
163. Arai T, Tsukahara I, Nitta K, et al. Effects of mannitol on cerebral circulation after transient complete cerebral ischemia in dogs. Crit Care Med 1986, 14:634-637.
164. Muizelaar JP, Ward JD, Marmarou A, et al. Cerebral blood flow and metabolism in severely head-injured children. Part 2: Autoregulation. J Neurosurg 1989, 71:72-76.
165. Moolten SE Albumin therapy for brain swelling in cardiac arrest: a proposal. Mt Sinai J Med 1979, 46:277-287.
166. Cole F Use of human serum albumini n cerebral edema following cardiac arrest, report of a case. JAMA 1951, 147:1563-1564.
167. Belayev L, Saul I, Huh PW, et al. Neuroprotective effect of high-dose albumin therapy against global ischemic brain injury in rats. Brain Res 1999, 845:107-111.
168. Breil M, Krep H, Sinn D, et al. Hypertonic saline improves myocardial blood flow during CPR, but is not enhanced further by the addition of hydroxy ethyl starch. Resuscitation 2003, 56:307-317.
169. Lubchenco LO, Bard H Incidence of hypoglycemia in newborn infants classified by birth weight and gestational age. Pediatrics 1971, 47:831-838.
170. Chiaretti A, Piastra M, Pulitano S, et al. Prognostic factors and outcome of children with severe head injury: an 8-year experience. Childs Nerv Syst 2002, 18:129-136.
171. Bleyaert AL, Sands PA, Safar P, et al. Augmentation of postischemic brain damage by severe intermittent hypertension. Crit Care Med 1980, 8:41-47.
172. Bohn DJ, Biggar WD, Smith CR, et al. Influence of hypothermia, barbiturate therapy, and intracranial pressure monitoring on morbidity and mortality after near-drowning. Crit Care Med 1986, 14:529-534.
173. Phelps C Principles of Treatment. Traumatic Injuries of the Brain and Its Membranes 1897, 223. D. Appleton and Company, New York. M. Critchley (Ed.).
174. Rosomoff HL, Holaday DA Cerebral blood flow and cerebral oxygen consumption during hypothermia. Am J Physiol 1954, 179:85-88.
175. Yager JY, Asselin J Effect of mild hypothermia on cerebral energy metabolism during the evolution of hypoxic-ischemic brain damage in the immature rat. Stroke 1996, 27:919-926.
176. Busto R, Dietrich WD, Globus MY, et al. Small differences in intraischemic brain temperature critically determine the extent of ischemic neuronal injury. J Cereb Blood Flow Metab 1987, 7:729-738.
177. Hickey RW, Ferimer H, Alexander HL, et al. Delayed, spontaneous hypothermia reduces neuronal damage after asphyxial cardiac arrest in rats. Crit Care Med 2000, 28:3511-3516.
178. Leonov Y, Sterz F, Safar P, et al. Mild cerebral hypothermia during and after cardiac arrest improves neurologic outcome in dogs. J Cereb Blood Flow Metab 1990, 10:57-70.
179. Weinrauch V, Safar P, Tisherman S, et al. Beneficial effect of mild hypothermia and detrimental effect of deep hypothermia after cardiac arrest in dogs. Stroke 1992, 23:1454-1462.
180. Tisherman SA, Rodriguez A, Safar P Therapeutic hypothermia in traumatology. Surg Clin N Am 1999, 79:1269-1289.
181. Xiao F, Safar P, Alexander H Peritoneal cooling for mild cerebral hypothermia after cardiac arrest in dogs. Resuscitation 1995, 30:51-59.
182. Behringer W, Safar P, Wu X, et al. Veno-venous extracorporeal blood shunt cooling to induce mild hypothermia in dog experiments and review of cooling methods. Resuscitation 2002, 54:89-98.
183. Bernard S, Buist M, Monteiro O, et al. Induced hypothermia using large volume, ice-cold intravenous fluid in comatose survivors of out-of-hospital cardiac arrest: a preliminary report. Resuscitation 2003, 56:9-13.
184. Frank SM, Raja SN, Bulcao C, et al. Age-related thermoregulatory differences during core cooling in humans. Am J Physiol - Reg Integ Comp Physiol 2000, 279:R349-R354.
185. Hickey RW, Kochanek PM, Ferimer H, et al. Hypothermia and hyperthermia in children after resuscitation from cardiac arrest. Pediatrics 2000, 106:118-122.
186. Minamisawa H, Smith ML, Siesjo BK The effect of mild hyperthermia and hypothermia on brain damage following 5, 10, and 15 minutes of forebrain ischemia. Ann Neurol 1990, 28:26-33.
187. Battin MR, Penrice J, Gunn TR, et al. Treatment of term infants with head cooling and mild systemic hypothermia (35.0 degrees C and 34.5 degrees C) after perinatal asphyxia. Pediatrics 2003, 111:244-251.
188. Kuroiwa T, Bonnekoh P, Hossmann KA Therapeutic window of CA1 neuronal damage defined by an ultrashort-acting barbiturate after brain ischemia in gerbils. Stroke 1990, 21:1489-1493.
189. Steen PA, Michenfelder JD Mechanisms of barbiturate protection. Anesthesiology 1980, 53:183-185.
190. Detre K, Abramson N, Safar P, et al. Collaborative randomized clinical study of cardiopulmonary-cerebral resuscitation. Crit Care Med 1981, 9:395-396.
191. Albers GW, Goldberg MP, Choi DW N-methyl-D-aspartate antagonists: ready for clinical trial in brain ischemia?. Ann Neurol 1989, 25:398-403.
192. Guerguerian AM, Brambrink AM, Traystman RJ, et al. Altered expression and phosphorylation of N-methyl-D-aspartate receptors in piglet striatum after hypoxia-ischemia. Brain Res Mol Brain Res 2002, 104:66-80.
193. Buchan A, Li H, Pulsinelli WA The N-methyl-D-aspartate antagonist, MK-801, fails to protect against neuronal damage caused by transient, severe forebrain ischemia in adult rats. J Neurosci 1991, 11:1049-1056.
194. Brambrink AM, Martin LJ, Hanley DF, et al. Effects of the AMPA receptor antagonist NBQX on outcome of newborn pigs after asphyxic cardiac arrest. J Cereb Blood Flow Metab 1999, 19:927-938.
195. + channel modulator and glutamate release inhibitor in cultured rat cerebellar neurons and in gerbil global brain ischemia. Stroke 1994, 25:2476-2482.
196. Davis SM, Lees KR, Albers GW, et al. Selfotel in acute ischemic stroke: possible neurotoxic effects of an NMDA antagonist. Stroke 2000, 31:347-354.
197. Grotta JC, Picone CM, Earls R, et al. Calcium-calmodulin binding in ischemic rat neurons after calcium channel blocker therapy. Stroke 1990, 21:948-952.
198. Forsman M, Aarseth HP, Nordby HK, et al. Effects of nimodipine on cerebral blood flow and cerebrospinal fluid pressure after cardiac arrest: correlation with neurologic outcome. Anesth Analg 1989, 68:436-443.
199. Roine RO, Kajaste S, Kaste M Neuropsychological sequelae of cardiac arrest. JAMA 1993, 269:237-242.
200. Helfaer MA, Kirsch JR, Haun SE, et al. Polyethylene glycol-conjugated superoxide dismutase fails to blunt postischemic reactive hyperemia. Am J Physiol 1991, 261:H548-H553.
201. Lim KH, Connolly M, Rose D, et al. Prevention of reperfusion injury of the ischemic spinal cord: use of recombinant superoxide dismutase. Ann Thorac Surg 1986, 42:282-286.
202. Hayashi M, Slater TF Inhibitory effects of ebselen on lipid peroxidation in rat liver microsomes. Free Radic Res Commun 1986, 2:179-185.
203. Kramer K, Voss HP, Grimbergen JA, et al. Glutathione mobilization during cerebral ischemia and reperfusion in the rat. Gen Pharmacol 1992, 23:105-108.
204. Ikeda Y, Anderson JH, Long DM Oxygen free radicals in the genesis of traumatic and peritumoral brain edema. Neurosurgery 1989, 24:679-685.
205. Liu TH, Beckman JS, Freeman BA, et al. Polyethylene glycol-conjugated superoxide dismutase and catalase reduce ischemic brain injury. Am J Physiol 1989, 256:H589-H593.
206. Chan PH Antioxidant-dependent amelioration of brain injury: role of CuZn-superoxide dismutase. J Neurotrauma 1992, 9(Suppl 2):S417-S423.
207. Kuribayashi Y, Naritomi H, Sasaki M, et al. Effects of L-ascorbic acid 2-[3, 4-dihydro-2, 5, 7, 8-tetramethyl-2-(4, 8, 12-trimethyltridecyl)-2H-1- benzopyran-6yl-hydrogen phosphate] potassium salt on cerebral energy state and consciousness recovery following transient forebrain ischemia in gerbils. Arzneimittelforschung 1994, 44:995-998.
208. Hara H, Kato H, Kogure K Protective effect of alpha-tocopherol on ischemic neuronal damage in the gerbil hippocampus. Brain Res 1990, 510:335-338.
209. Perkins WJ, Milde LN, Milde JH, et al. Pretreatment with U74006F improves neurologic outcome following complete cerebral ischemia in dogs. Stroke 1991, 22:902-909.
210. Hall ED, Pazara KE, Braughler JM, et al. Nonsteroidal lazaroid U78517F in models of focal and global ischemia. Stroke 1990, 21:III83-III87.
211. Rosenthal RE, Chanderbhan R, Marshall G, et al. Prevention of post-ischemic brain lipid conjugated diene production and neurological injury by hydroxyethyl starch-conjugated deferoxamine. Free Radic Biol Med 1992, 12:29-33.
212. Kotake Y Pharmacologic properties of phenyl N-tert-butylnitrone. Antiox Redox Signal 1999, 1:481-499.
213. Lewen A, Skoglosa Y, Clausen F, et al. Paradoxical increase in neuronal DNA fragmentation after neuroprotective free radical scavenger treatment in experimental traumatic brain injury. J Cereb Blood Flow Metab 2001, 21:344-350.
214. Behringer W, Safar P, Kentner R, et al. Antioxidant Tempol enhances hypothermic cerebral preservation during prolonged cardiac arrest in dogs. J Cereb Blood Flow Metab 2002, 22:105-117.
215. Agardh CD, Zhang H, Smith ML, et al. Free radical production and ischemic brain damage: influence of postischemic oxygen tension. Int J Dev Neurosci 1991, 9:127-138.
216. Zwemer CF, Whitesall SE, D'Alecy LG Cardiopulmonary-cerebral resuscitation with 100% oxygen exacerbates neurological dysfunction following nine minutes of normothermic cardiac arrest in dogs. Resuscitation 1994, 27:159-170.
217. Vento M, Asensi M, Sastre J, et al. Oxidative stress in asphyxiated term infants resuscitated with 100% oxygen. J Pediatr 2003, 142:240-246.
218. Rosenthal RE, Silbergleit R, Hof PR, et al. Hyperbaric oxygen reduces neuronal death and improves neurological outcome after canine cardiac arrest. Stroke 2003, 34:1311-1316.
219. Ramji S, Rasaily R, Mishra PK, et al. Resuscitation of asphyxiated newborns with room air or 100% oxygen at birth: a multicentric clinical trial. Ind Pediatr 2003, 40:510-517.
220. Saugstad OD, Ramji S, Irani SF, et al. Resuscitation of newborn infants with 21% or 100% oxygen: Follow-up at 18 to 24 months. Pediatrics 2003, 112:296-300.
221. Rosenberg AA, Murdaugh E, White CW The role of oxygen free radicals in postasphyxia cerebral hypoperfusion in newborn lambs. Pediatr Res 1989, 26:215-219.
222. Thiringer K, Hrbek A, Karlsson K, et al. Postasphyxial cerebral survival in newborn sheep after treatment with oxygen free radical scavengers and a calcium antagonist. Pediatr Res 1987, 22:62-66.
223. Lei B, Tan X, Cai H, et al. Effect of moderate hypothermia on lipid peroxidation in canine brain tissue after cardiac arrest and resuscitation. Stroke 1994, 25:147-152.
224. Siesjo BK, Bendek G, Koide T, et al. Influence of acidosis on lipid peroxidation in brain tissues in vitro. J Cereb Blood Flow Metab 1985, 5:253-258.
225. Link EM The mechanism of pH-dependent hydrogen peroxide cytotoxicity in vitro. Arch Biochem Biophys 1988, 265:362-372.
226. Chemtob S, Beharry K, Rex J, et al. Prostanoids determine the range of cerebral blood flow autoregulation of newborn piglets. Stroke 1990, 21:777-784.
227. Furlow TW, Hallenbeck JM Indomethacin prevents impaired perfusion of the dogs's brain after global ischemia. Stroke 1987, 9:591-594.
228. Sasaki T, Nakagomi T, Kirino T, et al. Indomethacin ameliorates ischemic neuronal damage in the gerbil hippocampal CA1 sector. Stroke 1988, 19:1399-1403.
229. Nakagomi T, Sasaki T, Kirino T, et al. Effect of cyclooxygenase and lipoxygenase inhibitors on delayed neuronal death in the gerbil hippocampus. Stroke 1989, 20:925-929.
230. Koide T, Wieloch TW, Siesjo BK Chronic dexamethasone pretreatment aggravates ischemic neuronal necrosis. J Cereb Blood Flow Metab 1986, 6:395-404.
231. Hallenbeck JM, Leitch DR, Dutka AJ, et al. Prostaglandin I2, indomethacin, and heparin promote postischemic neuronal recovery in dogs. Ann Neurol 1982, 12:145-156.
232. Minamisawa H, Terashi A, Katayama Y, et al. Brain eicosanoid levels in spontaneously hypertensive rats after ischemia with reperfusion: leukotriene C4 as a possible cause of cerebral edema. Stroke 1988, 19:372-377.
233. Kuhn JE, Steimle CN, Zelenock GB, et al. Ibuprofen improves survival and neurologic outcome after resuscitation from cardiac arrest. Resuscitation 1986, 14:199-212.
234. Jastremski M, Sutton-Tyrrell K, Vaagenes P, et al. Glucocorticoid treatment does not improve neurological recovery following cardiac arrest, Brain Resuscitation Clinical Trial I Study Group. JAMA 1989, 262:3427-3430.
235. Szczepanski A, Moatter T, Carley WW, et al. Induction of cyclooxygenase II in human synovial microvessel endothelial cells by interleukin-1. Inhibition by glucocorticoids. Arthritis Rheum 1994, 37:495-503.
236. Sapolsky RM A mechanism for glucocorticoid toxicity in the hippocampus: increased neuronal vulnerability to metabolic insults. J Neurosci 1985, 5:1228-1232.
237. Toti P, Schurfeld K, et al. Cyclooxygenase-2 immunoreactivity in the ischemic neonatal human brain, An autopsy study. J Submicroscopic Cytol Pathol 2001, 33:245-249.
238. Holtzman DM, Sheldon RA, Jaffe W, et al. Nerve growth factor protects the neonatal brain against hypoxic-ischemic injury. Ann Neurol 1996, 39:114-122.
239. Han BH, Holtzman DM BDNF protects the neonatal brain from hypoxic-ischemic injury in vivo via the ERK pathway. J Neurosci 2000, 20:5775-5781.
240. Galvin KA, Oorschot DE Continuous low-dose treatment with brain-derived neurotrophic factor or neurotrophin-3 protects striatal medium spiny neurons from mild neonatal hypoxia/ischemia: a stereological study. Neuroscience 2003, 118:1023-1032.
241. Pichiule P, Chavez JC, Xu K, et al. Vascular endothelial growth factor upregulation in transient global ischemia induced by cardiac arrest and resuscitation in rat brain. Brain Res Mol Brain Res 1999, 74:83-90.
242. D'Cruz BJ, Fertig KC, Filiano AJ, et al. Hypothermic reperfusion after cardiac arrest augments brain-derived neurotrophic factor activation. J Cereb Blood Flow Metab 2002, 22:843-851.
243. Safar P, Abramson NS, Angelos M, et al. Emergency cardiopulmonary bypass for resuscitation from prolonged cardiac arrest. Am J Emerg Med 1990, 8:55-67.
244. Chen YS, Chao A, Yu HY, et al. Analysis and results of prolonged resuscitation in cardiac arrest patients rescued by extracorporeal membrane oxygenation. J Am Coll Cardiol 2003, 41:197-203.
245. Behringer W, Safar P, Wu X, et al. Survival without brain damage after clinical death of 60-120 mins in dogs using suspended animation by profound hypothermia. Crit Care Med 2003, 31:1523-1531.
246. Nagao K, Hayashi N, Kanmatsuse K, et al. Cardiopulmonary cerebral resuscitation using emergency cardiopulmonary bypass, coronary reperfusion therapy and mild hypothermia in patients with cardiac arrest outside the hospital. J Am Coll Cardiol 2000, 36:776-783.
247. Stegmayr BG Apheresis as therapy for patients with severe sepsis and multiorgan dysfunction syndrome. Therapeutic Apheresis 2001, 5:123-127.
248. Carcillo JA. Management of recalitrant pediatric septic shock. in 4th World Congress on Pediatric Intensive Care. 2003. Boston, MA.