Continuous low-dose treatment with brain-derived neurotrophic factor or neurotrophin-3 protects striatal medium spiny neurons from mild neonatal hypoxia/ischemia: A stereological study

Neuroscience

Volumn 118, Issue 4, 2003, Pages 1023-1032

  Galvin, K A ^a   Oorschot, D E ^a  

^a UNIVERSITY OF OTAGO   (New Zealand)

Author keywords

BDNF; Cavalieri method; NT 3; Optical disector

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; NEUROTROPHIN 3;

ANESTHESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN HYPOXIA; BRAIN INJURY; BRAIN ISCHEMIA; BRAIN SIZE; BRAIN WEIGHT; CAROTID ARTERY LIGATION; CELL COUNT; COMMON CAROTID ARTERY; CONTROLLED STUDY; CORPUS STRIATUM; DOSE RESPONSE; DRUG EFFECT; DRUG MEGADOSE; FEMALE; IMMUNOHISTOCHEMISTRY; LOW DRUG DOSE; MALE; NERVE CELL NECROSIS; NEUROPROTECTION; NEWBORN; NEWBORN HYPOXIA; NONHUMAN; PERINATAL PERIOD; PRIORITY JOURNAL; RAT; STEREOTAXIC SURGERY; STRIATE CORTEX; WEIGHT GAIN;

EID: 0038066559     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-4522(03)00066-6     Document Type: Article

References (59)

1. Allsopp T.E., Kiselev S., Wyatt S., Davies A.M. Role of Bcl-2 in the brain-derived neurotrophic factor survival response. Eur J Neurosci. 7:1995;1266-1272.
2. Almli C.R., Levy T.J., Han B.H., Shah A.R., Gidday J.M., Holtzman D.M. BDNF protects against spatial memory deficits following neonatal hypoxia-ischemia. Exp Neurol. 166:2000;99-114.
3. Altar C.A., Boylan C.B., Jackson C., Hershenson S., Miller J., Wiegand S.J., Lindsay R.M., Hyman C. Brain-derived neurotrophic factor augments rotational behaviour and nigrostriatal dopamine turnover in vivo. Proc Natl Acad Sci USA. 89:1992;11347-11351.
4. Anderson K.D., Alderson R.F., Altar C.A., DiStefano P.S., Corcoran T.L., Lindsay R.M., Weigand S.J. Differential distribution of exogenous BDNF, NGF, and NT-3 in the brain corresponds to the relative abundance and distribution of high-affinity neurotrophin receptors. J Comp Neurol. 357:1995;296-317.
5. Barks J.D., Silverstein F.S., Sims K., Greenamyre J.T., Johnston M.V. Glutamate recognition sites in human fetal brain. Neurosci Lett. 84:1988;131-136.
6. A controlled trial of recombinant methionyl human BDNF in ALS. Neurology. 52:1999;1427-1433.
7. Blaha G.R., Raghupathi R., Saatman K.E., McIntosh T.K. Brain-derived neurotrophic factor administration after traumatic brain injury in the rat does not protect against behavioural or histological deficits. Neuroscience. 99:2000;483-493.
8. Cedarbaum J.M., Stambler N., Brooks B.R., Bradley W. Brain-derived neurotrophic factor in amyotrophic lateral sclerosis a failed drug or a failed trial? Ann Neurol. 44:1998;506-507.
9. Cheng Y., Gidday J.M., Yan Q., Shah A.R., Holtzman D.M. Marked age-dependent neuroprotection by brain-derived neurotrophic factor against neonatal hypoxic-ischemic brain injury. Ann Neurol. 41:1997;521-529.
10. Cochran W.G., Cox G.M. Experimental designs. 1992;John Wiley & Sons, New York.
11. de Torres C., Munell F., Ferrer I., Reventos J., Macaya A. Identification of necrotic cell death by the TUNEL assay in the hypoxic-ischemic neonatal rat brain. Neurosci Lett. 230:1997;1-4.
12. Fryer R.H., Kaplan D.R., Feinstein S.C., Radeke M.J., Grayson D.R., Kromer L.F. Developmental and mature expression of full length and truncated TrkB receptors in the rat forebrain. J Comp Neurol. 374:1996;21-40.
13. Galvin K.A., Oorschot D.E. Postinjury magnesium sulfate treatment is not markedly neuroprotective for striatal medium spiny neurons after perinatal hypoxia/ischemia in the rat. Pediatr Res. 44:1998;740-745.
14. Green A.R., Cross A.J. Techniques for examining neuroprotective drugs in vivo. Int Rev Neurobiol. 40:1997;47-68.
15. Greenamyre T., Penney J.B., Young A.B., Hudson C., Silverstein F.S., Johnston M.V. Evidence of transient perinatal glutamatergic innervation of globus pallidus. J Neurosci. 7:1987;1022-1030.
16. Gundersen H.J.G. Stereology of arbitrary particles a review of unbiased number and size estimators and the presentation of some new ones, in memory of William R . Thompson. J Microsc. 143:1986;3-45.
17. Gundersen H.J.G., Jensen E.B. The efficiency of systematic sampling in stereology and its prediction. J Microsc. 147:1987;229-263.
18. Gundersen H.J.G., Bagger P., Bendsten T.F., Evans S.M., Korbo L., Marcussen N., Moller A., Nielsen K., Nyengaard J.R., Pakkenberg B., Sorenson F.B., Vesterby A., West M.J. The new stereological tools disector, fractionator, nucleator and point-sampled intercepts and their use in pathological research and diagnosis . Acta Path Microbiol Immunol Scand. 96:1988;857-881.
19. Han B.H., Holtzman D.M. BDNF protects the neonatal brain from hypoxic-ischemic injury in vivo via the ERK pathway. J Neurosci. 20:2000;5775-5781.
20. Han B.H., D'Costa A., Back S.A., Parsadanian M., Patel S., Shah A.R., Gidday J.M., Srinivasan A., Deshmukh M., Holtzman D.M. BDNF blocks caspase-3 activation in neonatal ischemia. Neurobiol Dis. 7:2000;38-53.
21. Harada J., Sugimoto M. Inhibitors of interleukin-1 beta-converting enzyme-family proteases (caspases) prevent apoptosis without affecting decreased cellular ability to reduce 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide in cerebellar granule neurons. Brain Res. 793:1998;231-243.
22. Helander K.G. Thickness variations within individual paraffin and glycol methacrylate sections. J Microsc. 132:1983;223-227.
23. Hill A. Current concepts of hypoxic-ischemic cerebral injury in the term newborn. Pediatr Neurol. 7:1991;317-325.
24. Hill I.E., MacManus J.P., Rasquinha I., Tuor U.I. DNA fragmentation indicative of apoptosis following unilateral cerebral hypoxia-ischemia in the neonatal rat. Brain Res. 676:1995;398-403.
25. Jansen E.M., Low W.C. Long-term effects of neonatal ischemic-hypoxic brain injury on sensorimotor and locomotor tasks in rats. Behav Brain Res. 78:1996;189-194.
26. Kirschner P.B., Jenkins B.G., Schulz J.B., Finklestein S.P., Matthews R.T., Rosen B.R., Beal M.F. NGF, BDNF and NT-5 but not NT-3 protect against MPP+ toxicity and oxidative stress in neonatal animals. Brain Res. 713:1996;178-185.
27. Knusel B., Rabin S., Hefti F., Kaplan D.R. Regulated neurotrophin receptor responsiveness during neuronal migration and early differentiation. J Neurosci. 14:1994;1542-1554.
28. Kobayashi S., Ogren S.O., Ebendal T., Olson L. Intraventricular injection of NGF, but not BDNF, induces rapid motor activation that is inhibited by nicotinic receptor antagonists. Exp Brain Res. 116:1997;315-325.
29. Lindsay R.M., Wiegand S.J., Altar C.A., DiStefano P.S. Neurotrophic factors from molecule to man . Trends Neurosci. 17:1994;182-190.
30. 2+ concentration and neurotoxicity and increase antioxidant enzyme activities in hippocampal neurons. J Neurochem. 65:1995;1740-1751.
31. Memberg S.P., Hall A.K. Proliferation, differentiation, and survival of rat sensory neuron precursors in vitro require specific trophic factors. Mol Cell Neurosci. 6:1995;323-335.
32. Merlio J.P., Ernfors P., Jaber M., Persson H. Molecular cloning of rat trkC and distribution of cells expressing messenger RNAs for members of the trk family in the rat central nervous system. Neuroscience. 51:1992;513-532.
33. Mizuno K., Carnahan J., Nawa H. Brain-derived neurotrophic factor promotes differentiation of striatal GABAergic neurons. Dev Biol. 165:1994;243-256.
34. Nakao N., Brundin P., Funa K., Lindvall O., Odin P. Trophic and protective actions of brain-derived neurotrophic factor on striatal DARPP-32-containing neurons in vitro. Dev Brain Res. 90:1995;92-101.
35. Nakao N., Kokaia Z., Odin P., Lindvall O. Protective effects of BDNF and NT-3 but not PDGF against hypoglycemic injury to cultured striatal neurons. Exp Neurol. 131:1995;1-10.
36. Nawa H., Pelleymounter M.A., Carnahan J. Intraventricular administration of BDNF increases neuropeptide expression in newborn rat brain. J Neurosci. 14:1994;3751-3765.
37. Oorschot D.E. Are you using neuronal densities, synaptic densities or neurochemical densities as your definitive data? There is a better way to go. Prog Neurobiol. 44:1994;233-247.
38. Oorschot D.E. Total number of neurons in the neostriatal, pallidal, subthalamic, and substantia nigral nuclei of the rat basal ganglia a stereological study using the Cavalieri and optical disector methods . J Comp Neurol. 366:1996;580-599.
39. Oorschot D.E., Galvin K.A. The effect of hypoxic-ischemic brain injury on the total number of astrocytes in the rat basal ganglia is there hyperplasia? Proc Aust Neurosci Soc. 6:1995;234.
40. Oorschot DE, Galvin KA (1999) Treatment with neurotrophin-3 or brain-derived neurotrophic factor protects striatal medium-spiny neurons against immature hypoxic/ischemic brain injury in the rat: a stereological study. Proc 29th Soc Neurosci Meeting, Abstract No. 909.11.
41. Oorschot D.E., Peterson D.A., Jones D.G. Neurite outgrowth from, and neuronal survival within, cultured explants of the nervous system a critical review of morphometric and stereological methods, and suggestions for the future . Prog Neurobiol. 37:1991;525-546.
42. Oorschot D.E., Tunstall M.J., Wickens J.R. Local connectivity between striatal spiny projection neurons a re-evaluation . Nicholson L., Faull R.L.M. The basal ganglia VII. 2002;421-434 Plenum Press, New York.
43. Oorschot D.E., Black M.J., Rangi F., Scarr E. Fos expression after immature hypoxic-ischemic brain injury. Exp Neurol. 161:2000;227-233.
44. Pelleymounter M.A., Cullen M.J., Wellman C.L. Characteristics of BDNF-induced weight loss. Exp Neurol. 131:1995;229-238.
45. Purcell W.M., Westgate C., Atterwill C.K. Rat brain mast cells an in vitro paradigm for assessing the toxic effects of neurotrophic therapeutics . Neurotoxicology. 17:1996;845-850.
46. Rice J.E., Vannucci R.C., Brierly J.B. The influence of immaturity on hypoxic-ischemic brain damage in the rat. Ann Neurol. 9:1981;131-141.
47. Romijn H.J., van Marle J., Janszen A.W.J.W. Permanent increase of the GAD67/synaptophysin ratio in rat cerebral cortex nerve endings as a result of hypoxic-ischemic encephalopathy sustained in early postnatal life a confocal laser scanning microscope study . Brain Res. 630:1993;315-329.
48. Sauer H., Wong V., Björklund A. Brain-derived neurotrophic factor and neurotrophin-4/5 modify neurotransmitter related gene expression in the 6-hydroxydopamine-lesioned rat striatum. Neuroscience. 65:1995;927-933.
49. Siesjö B.K. The role of calcium in cell death. Price D.L., Thoenen H., Aguayo A.J. Neurodegenerative disorders: mechanisms and prospects for therapy. 1991;35-39 Wiley, New York.
50. Siuciak J.A., Boylan C., Fritsche M., Altar A., Lindsay R.M. BDNF increases monoaminergic activity in rat brain following intracerebroventricular or intraparenchymal administration. Brain Res. 710:1996;11-20.
51. Skaper S.D., Floreani M., Negro A., Facci L., Giusti P. Neurotrophins rescue cerebellar granule neurons from oxidative stress-mediated apoptotic death selective involvement of the phosphatidylinositol 3-kinase and the mitogen-activated protein kinase pathway . J Neurochem. 70:1998;1859-1868.
52. Spina M.B., Squinto S.P., Miller J., Lindsay R.M., Hyman C. Brain-derived neurotrophic factor protects dopamine neurons against 6-hydroxydopamine and N-methyl-4-phenylpyridinum ion toxicity involvement of the glutathione system . J Neurochem. 59:1992;99-106.
53. Stuart D.A., Oorschot D.E. Embedding, sectioning, immunocytochemical and stereological methods that optimise research on the lesioned adult rat spinal cord. J Neurosci Methods. 61:1995;5-14.
54. Swaab D.F., Uylings H.B.M. Density measures parameters to avoid . Neurobiol Aging. 8:1987;574-576.
55. 2+ ionophore-induced apoptosis of cultured cortical neurons involvement of dual pathways . Neuropharmacol. 38:1999;283-288.
56. Ventimiglia R., Mather P.E., Jones B.E., Lindsay R.M. The neurotrophins BDNF, NT-3 and NT-4/5 promote survival and morphological and biochemical differentiation of striatal neurons in vitro. Eur J Neurosci. 7:1995;213-222.
57. Volpe J.J. Perinatal hypoxic-ischemic brain injury overview . Fukuyama Y., Suzuki Y., Kamoshita S., Casaer P. Fetal and perinatal neurology. 1992;232-252 Karger, Basel.
58. West M.J. Stereological methods for estimating the total number of neurons and synapses issues of precision and bias . Trends Neurosci. 22:1999;51-61.
59. West M.J., Gundersen H.J.G. Unbiased stereological estimation of the number of neurons in the human hippocampus. J Comp Neurol. 296:1990;1-22.