Improved cerebral resuscitation from cardiac arrest in dogs with mild hypothermia plus blood flow promotion

Stroke

Volumn 27, Issue 1, 1996, Pages 105-113

  Safar, Peter ^a,b   Xiao, Feng ^a   Radovsky, Ann ^a   Tanigawa, Koichi ^a   Ebmeyer, Uwe ^a   Bircher, Nicholas ^a   Alexander, Henry ^a   Stezoski, S William ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

cardiopulmonary resuscitation; cerebral blood flow; dogs; heart arrest; hemodilution; hypothermia

Indexed keywords

ADRENALIN; ATROPINE; BICARBONATE; DEXTRAN; DIAZEPAM; HEPARIN; MORPHINE; NEOSTIGMINE; NORADRENALIN; PANCURONIUM;

ANIMAL MODEL; ARTICLE; BRAIN BLOOD FLOW; BRAIN INJURY; BRAIN ISCHEMIA; CLINICAL PROTOCOL; DOG; HEART ARREST; HEMODILUTION; HYPOTHERMIA; MALE; NEUROLOGICAL COMPLICATION; NONHUMAN; PRIORITY JOURNAL; RESUSCITATION; TREATMENT OUTCOME;

EID: 0030039658     PISSN: 00392499     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.STR.27.1.105     Document Type: Article

References (57)

1. Eisenberg MS, Horwood BT, Cummins RO, Reynolds-Haertle R, Hearne TR. Cardiac arrest and resuscitation: a tale of 29 cities. Ann Emerg Med. 1990;19:179-186.
2. American Heart Association. Guidelines for cardiopulmonary resuscitation and emergency cardiac care. JAMA. 1992;268: 2199-2241.
3. Safar P. Cerebral resuscitation after cardiac arrest: research initiatives and future directions. Ann Emerg Med. 1993;22:324-349.
4. Brain Resuscitation Clinical Trial II Study Group, Abramson NS, Sutton-Tyrrell K, Safar P, et al. A randomized clinical study of a calcium-entry blocker (lidoflazine) in the treatment of comatose survivors of cardiac arrest. N Engl J Med. 1991;324:1225-1231.
5. Safar P. Resuscitation from clinical death: pathophysiologic limits and therapeutic potentials. Crit Care Med. 1988;16:923-941.
6. Leonov Y, Sterz F, Safar P, Radovsky A, Oku K, Tisherman S, Stezoski SW. Mild cerebral hypothermia during and after cardiac arrest improves neurologic outcome in dogs. J Cereb Blood Flow Metab. 1990;10:57-70.
7. Sterz F, Safar P, Tisherman S, Radovsky A, Kuboyama K, Oku K. Mild hypothermic cardiopulmonary resuscitation improves outcome after prolonged cardiac arrest in dogs. Crit Care Med. 1991;19:379-389.
8. Weinrauch V, Safar P, Tisherman S, Kuboyama K, Radovsky A. Beneficial effect of mild hypothermia and detrimental effect of deep hypothermia after cardiac arrest in dogs. Stroke. 1992;23:1454-1462.
9. Kuboyama K, Safar P, Radovsky A, Tisherman SA, Stezoski SW, Alexander H. Delay in cooling negates the beneficial effect of mild resuscitative cerebral hypothermia after cardiac arrest in dogs: a prospective, randomized, controlled study. Crit Care Med. 1993;21: 1348-1358.
10. Leonov Y, Sterz F, Safar P, Radovsky A. Moderate hypothermia after cardiac arrest of 17 minutes in dogs: effect on cerebral and cardiac outcome. Stroke. 1990;21:1600-1606.
11. Dripps RD, ed. The Physiology of Induced Hypothermia. Washington, DC: National Academy of Sciences; 1956.
12. Busto R, Dietrich WD, Globus MY, Ginsberg MD. Postischemic moderate hypothermia inhibits CA1 hippocampal ischemic neuronal injury. Neurosci Lett. 1989;101:299-304.
13. Boris-Moller F, Smith ML, Siesjö BK. Effects of hypothermia on brain ischemia: a comparison of intraischemic and postischemic hypothermia. J Cereb Blood Flow Metab. 1989;9:S276. Abstract.
14. Chopp M, Chen H, Dereski MO, Garcia JH. Mild hypothermic intervention after graded ischemic stress in rats. Stroke. 1991;22: 37-43.
15. Xiao F, Safar P, Katz L, Radovsky A, Ebmeyer U, Sim KM, Neumar R. Mild protective and resuscitative cerebral hypothermia improves outcome after asphyxial cardiac arrest in rats. Resuscitation. 1994;28:521. Abstract P67.
16. Hossmann KA, Lechtape-Gruter H, Hossmann V. The role of cerebral blood flow for the recovery of the brain after prolonged ischemia. J Neurol. 1973;204:281-299.
17. Snyder JV, Nemoto EM, Carroll RG, Safar O. Global ischemia in dogs: intracranial pressures, brain blood flow, and metabolism. Stroke. 1975;6:21-27.
18. Leonov Y, Sterz F, Safar P, Johnson DW, Tisherman SA, Oku K. Hypertension with hemodilution prevents multifocal cerebral hypoperfusion after cardiac arrest in dogs. Stroke. 1992;23:45-53.
19. Oku K, Sterz F, Safar P, Johnson D, Obrist W, Leonov Y, Kuboyama K, Tisherman SA, Stezoski SW. Mild hypothermia after cardiac arrest in dogs does not affect postarrest multifocal cerebral hypoperfusion. Stroke. 1993;24:1590-1598.
20. Nemoto EM, Hossmann KA, Cooper HK. Postischemic hypermetabolism in cat brain. Stroke. 1981;12:666-676.
21. Symon L. Flow thresholds in brain ischemia and the effects of drugs. Br J Anaesth. 1985;57:34-43.
22. Thews G. Implications to physiology and pathology of oxygen diffusion at the capillary level. In: Schade JP, ed. Selective Vulnerability of the Brain in Hypoxaemia. Philadelphia, Pa: FA Davis Co; 1963:27-35.
23. Oku K, Kuboyama K, Safar P, Obrist W, Sterz F, Leonov Y, Tisherman SA. Cerebral and systemic arteriovenous oxygen monitoring after cardiac arrest: inadequate cerebral oxygen delivery. Resuscitation. 1994;27:141-152.
24. Kuboyama K, Safar P, Oku K, Obrist W, Leonov Y, Sterz F, Tisherman SA, Stezoski SW. Mild hypothermia after cardiac arrest in dogs does not affect postarrest cerebral oxygen uptake/delivery mismatching. Resuscitation. 1994;27:231-244.
25. Safar P, Stezoski W, Nemoto EM. Amelioration of brain damage after 12 minutes' cardiac arrest in dogs. Arch Neurol. 1976;33:91-95.
26. Sterz F, Leonov Y, Safar P, Radovsky A, Tisherman S, Oku K. Hypertension with or without hemodilution after cardiac arrest in dogs. Stroke. 1990;21:1178-1184.
27. Ebmeyer U, Safar P, Radovsky A, Sharma C, Tanigawa K, Wang Y, Capone A, Xiao F, Bircher N, Stezoski W, Alexander H. Effective combination treatments for cerebral resuscitation from cardiac arrest in dogs: exploratory studies. Resuscitation. 1994;28:S20. Abstract P57.
28. Safar P, Abramson NS, Angelos M, Cantadore R, Leonov Y, Levine R, Pretto E, Reich H, Sterz F, Stezoski SW, Tisherman S. Emergency cardiopulmonary bypass for resuscitation from prolonged cardiac arrest. Am J Emerg Med. 1990;8:55-67.
29. Safar P, Gisvold SE, Vaagenes P, Hendrickx HHL, Bar-Joseph G, Bircher N, Stezoski W, Alexander H. Long-term animal models for the study of global brain ischemia. In: Wauquier A, Borgers M, Amery WK, eds. Protection of Tissues Against Hypoxia. Amsterdam, Netherlands: Elsevier Science Publishing Co; 1982:147-170.
30. Nemoto EM, Bleyaert AL, Stezoski SW, Moossy J, Rao GR, Safar P. Global brain ischemia: a reproducible monkey model. Stroke. 1977;8:558-564.
31. Radovsky A, Safar P, Sterz F, Leonov Y, Reich H, Kuboyama K. Regional prevalence and distribution of ischemic neurons in dog brains 96 hours after cardiac arrest of 0 to 20 minutes. Stroke. 1995; 26:2127-2134.
32. Xiao F, Safar P, Radovsky A, Tanigawa K, Wang Y, Ebmeyer U, Capone A, Bircher NG, Alexander H, Stezoski SW. Mild hypothermia (Hth) plus cerebral blood flow (CBF) promotion, but not drugs, give complete functional recovery after 11 min cardiac arrest (CA) in dogs. Crit Care Med. 1995;23:A179. Abstract.
33. Vaagenes P, Cantadore R, Safar P, Moossy J, Rao G, Diven W, Alexander H, Stezoski W. Amelioration of brain damage by lidoflazine after prolonged ventricular fibrillation cardiac arrest in dogs. Crit Care Med. 1984;12:846-855.
34. Cerchiari EL, Safar P, Klein E, Cantadore R, Pinsky M. Cardiovascular function and neurologic outcome after cardiac arrest in dogs: the cardiovascular post-resuscitation syndrome. Resuscitation. 1993;25:9-33.
35. Xiao F, Safar P, Radovsky A, Sterz F, Leonov Y, Weinrauch V, Kuboyama K, Alexander H, Stezoski SW. Improved reproducible outcome model in dogs of cardiac arrest (CA) 11 min for evaluation of cerebral resuscitation potentials. Crit Care Med. 1995;23:A178. Abstract.
36. Sterz F, Safar P, Diven W, Leonov Y, Radovsky A, Oku K. Detoxification with hemabsorption after cardiac arrest does not improve neurologic recovery: review and outcome study in dogs. Resuscitation. 1993;25:137-160.
37. Rosomoff HL, Holaday BA. Cerebral blood flow and cerebral oxygen consumption during hypothermia. Am J Physiol. 1954;179: 85-88.
38. Crumrine RC, Thomas AL, Morgan PF. Attenuation of p53 expression protects against focal ischemic damage in transgenic mice. J Cereb Blood Flow Metab. 1994;14:887-891.
39. Dietrich WD, Busto R, Alonso O, Globus MYT, Ginsberg MD. Intraischemic but not postischemic brain hypothermia protects chronically following global forebrain ischemia in rats. J Cereb Blood Flow Metab. 1993;13:541-549.
40. Goss JR, Styren SD, Miller PD, Kochanek PM, Palmer AM, Marion DW, DeKosky ST. Hypothermia attenuates the normal increase in interleukin-1β3 RNA and nerve growth factor following traumatic brain injury in the rat. J Neurotrauma. 1995;12:159-167.
41. Lin B, Dietrich WD, Busto R, Kraydieh S, Globus MYT, Ginsberg MD. Postischemic brain hypothermia combined with delayed MK-801 treatment protects chronically after global ischemia in rats. Stroke. 1994;25:254. Abstract.
42. Hossmann KA. Hemodynamics of post-ischemic reperfusion of the brain. In: Weinstein PA, Faden AI, eds. Protection of the Brain from Ischemia. Baltimore, Md: Williams & Wilkins Co; 1990:21-33.
43. Spivey WH, Abramson NS, Safar P, Sutton-Tyrrell K, Schoffstaff JM, for the Brain Resuscitation Clinical Trial II Study Group. Correlation of blood pressure with mortality and neurologic recovery in comatose postresuscitation patients. Ann Emerg Med. 1991;20:453. Abstract.
44. Martin DR, Persse D, Brown CG, Jastremski M, Cummins RO, Pepe PE, Gonzalez E, Stueven H. Relation between initial post-resuscitation systolic blood pressure and neurologic outcome following cardiac arrest. Ann Emerg Med. 1993;22:206. Abstract 114.
45. Hossmann KA. Resuscitation potentials after prolonged global cerebral ischemia in cats. Crit Care Med. 1988;16:964-971.
46. Heros RC, Korosue K. Hemodilution for cerebral ischemia. Stroke. 1989;20:423-427.
47. Vanicky I, Marsala M, Murar J, Marsala J. Prolonged postischemic hyperventilation reduces acute neuronal damage after 15 min of cardiac arrest in the dog. Neurosci Lett. 1992;135:167-170.
48. 2 reactivity and autoregulation. Stroke. 1975;6:425-431.
49. Kagstrom E, Smith ML, Siesjö BK. Cerebral circulatory responses to hypercapnia and hypoxia in the recovery period following complete and incomplete cerebral ischemia in the rat. Acta Physiol Scand. 1983;118:281-291.
50. 2 on cerebral microcirculation. J Cereb Blood Flow Metab. 1984;4:343-349.
51. 2 after cerebral ischemia in swine. Am J Physiol. 1991;260(5 pt 2):H1482-H1488.
52. Rehncrona S, Rosen I, Siesjö BK. Excessive cellular acidosis: an important mechanism of neuronal damage in the brain? Acta Physiol Scand. 1980;110:435-437.
53. Katz L, Safar P, Xiao F, Sullivan M, Neumar R, Tisherman S, Sterz F, Klain M, Stezoski W, Alexander H. Mild cerebral cooling after cardiac arrest in dogs and patients. Resuscitation. 1994;28:S10. Abstract O60.
54. Brader E, Jehle D, Safar P. Protective head cooling during cardiac arrest in dogs. Ann Emerg Med. 1985;14:510. Abstract.
55. White RJ. Cerebral hypothermia and circulatory arrest: review and commentary. Mayo Clin Proc. 1978;53:450-458.
56. Coimbra C, Wieloch T. Hypothermia ameliorates neuronal survival when induced 2 hours after ischaemia in the rat. Acta Physiol Scand. 1992;146:543-544.
57. Marion DW, Obrist WD, Carlier PM, Penrod LE, Darby JM. The use of moderate therapeutic hypothermia for patients with severe head injuries: a preliminary report. J Neurosurg. 1993;79: 354-362.