Role of caspase-3 activation in cerebral ischemia-induced neurodegeneration in adult and neonatal brain

Journal of Cerebral Blood Flow and Metabolism

Volumn 22, Issue 4, 2002, Pages 420-430

  Gill, Ramanjit ^a   Soriano, Marc ^a   Blomgren, Klas ^a   Hagberg, Henrik ^a   Wybrecht, Remy ^a   Miss, Marie Therese ^a   Hoefer, Sandra ^a   Adam, Geo ^a   Niederhauser, Olivier ^a   Kemp, John A ^a   Loetscher, Hansruedi ^a  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

Apoptosis; Caspase 3; Cerebral ischemia; Cytochrome c; Mitochondria; Neonatal hypoxia

Indexed keywords

ASPARTYLGLUTAMYLVALYLASPARTIC ACID; CALCIUM ION; CASPASE 3; CASPASE INHIBITOR; COUMARIN DERIVATIVE; CYSTEINE PROTEINASE; CYTOCHROME C; DEOXYADENOSINE TRIPHOSPHATE; ENZYME PRECURSOR; GRANZYME B; KETONE DERIVATIVE; PEPTIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN HYPOXIA; BRAIN ISCHEMIA; BRAIN MITOCHONDRION; CONTROLLED STUDY; CYTOSOL; ENZYME ACTIVATION; ENZYME SUBSTRATE; MALE; MOUSE; NERVE DEGENERATION; NEUROPROTECTION; NEWBORN; NEWBORN HYPOXIA; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN LOCALIZATION; RAT;

EID: 0036208147     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004647-200204000-00006     Document Type: Article

References (54)

1. Mammalian cell death proteases: A family of highly conserved aspartate specific cysteine proteases
2. Evaluation of brain damage in a rat model of neonatal hypoxic-ischemia
3. Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development
4. Apoptotic features of selective neuronal death in ischemia, epilepsy and gp 120 toxicity
5. Induction of caspase-3-like protease may mediate delayed neuronal death in the hippocampus after transient cerebral ischemia
6. Caspase inhibitor affords neuroprotection with delayed administration in a rat model of neonatal hypoxic-ischemic brain injury
7. Electron microscopic evidence against apoptosis as the mechanism of neuronal death in global ischemia
8. Attenuation of delayed neuronal death after mild focal ischemia in mice by inhibition of the caspase family
9. Internucleosomal cleavage of DNA as the sole criterion for apoptosis may be artifactual
10. The neuroprotective actions of 2,3-dihydroxy-6-nitro-7-sulfamoyl- benzo(F)quinoxaline (NBQX) in a rat focal ischemia model
11. The neuroprotective effect of the glycine site antagonist 3R-(+)-cis-4-methyl-HA966 (L-687,414) in a rat model of focal ischemia
12. Does caspase activation play a role in neuronal damage following focal ischemia induced by permanent middle cerebral artery occlusion?
13. Activation of CPP-32 protease in hippocampal neurons following ischemia and epilepsy
14. Inhibition of caspases prevents cell death of hippocampal CA1 neurons, but not impairment of hippocampal long-term potentiation following global ischemia
15. In situ detection of fragmented DNA (TUNEL assay) fails to discriminate among apoptosis, necrosis, and autolytic cell death: A cautionary note
16. Mitochondria and apoptosis
17. Differential requirement for caspase 9 in apoptotic pathways in vivo
18. Inhibition of interleukin 1beta converting enzyme family proteases reduces ischemic and excitotoxic neuronal damage
19. Disturbances of cerebral protein synthesis and ischemic cell death
20. Involvement of caspase-3 in cell death after hypoxia-ischemia declines during brain maturation
21. Blockade of NMDA receptors and apoptotic neurodegeneration in the developing brain
22. Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics
23. The release of cytochrome c from mitochondria: A primary site for Bcl-2 regulation of apoptosis
24. Immunohistochemical analysis of in vivo patterns of expression of CPP32 (caspase-3), a cell death protease
25. Decreased apoptosis in the brain and premature lethality in CPP32- deficient mice
26. Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9
27. Induction of apoptotic program in cell-free extracts: Requirement for dATP and cytochrome c
28. An ICE inhibitor, z-VAD-DCB attenuates ischemic brain damage in the rat
29. Gene expression induced by cerebral ischemia: An apoptotic perspective
30. Activation and cleavage of caspase-3 in apoptosis induced by experimental cerebral ischemia
31. Cloning and expression of a rat brain interleukin-1beta-converting enzyme (ICE)-related protease (IRP) and its possible role in apoptosis of cultured cerebellar granule neurons
32. Transient global forebrain ischemia induces a prolonged expression of the caspase-3 mRNA in rat hippocampal CA 1 pyramidal neurons
33. Cell death during development of the nervous system
34. The glutamate antagonist MK-801 reduces focal ischemic brain damage in the rat
35. DNA fragmentation follows delayed neuronal death in CA1 neurons exposed to transient global ischemia in the rat
36. Impairment of mitochondrial respiration after cerebral hypoxia-ischemia in immature rats: Relationship to activation of caspase-3 and neuronal injury
37. Temporal profile of neuronal damage in a model of transient forebrain ischemia
38. Synthesis of P1 aspartate-based peptide acyloxymethyl and fluromethyl ketones as inhibitors of interleukin-1 beta-converting enzyme
39. The influence of immaturity on hypoxic-ischemic brain damage in the rat
40. Cytochrome c and dATP-mediated oligomerization of Apaf-1 is a prerequisite for procaspase-9 activation
41. Caspases as treatment targets in stroke and neurodegenerative diseases
42. Models for studying long-term recovery following forebrain ischemia in the rat. Part II: A 2-vessel occlusion model
43. Granule-mediated killing: Pathways for granzyme B-initiated apoptosis
44. Focal cerebral ischemia in the rat. Part I: Description of technique and early neuropathological consequences following middle cerebral artery occlusion
45. Caspases: Enemies within
46. Ultrastructural morphological changes are not characteristic of apoptotic cell death following focal cerebral ischemia in the rat
47. Increased expression of cyclin G1 and p21WAF1/CIP1 in neurons following transient forebrain ischemia: Comparison with early DNA damage
48. Caspase-8 and caspase-3 are expressed by different populations of cortical neurons undergoing delayed cell death after focal stroke in the rat
49. Differential expression of apoptotic protease-activating factor-1 and caspase-3 genes and susceptibility to apoptosis during brain development and after traumatic brain injury
50. Prevention of apoptosis by Bc1-2: Release of cytochrome c from mitochondria blocked
51. Granzyme B mimics apical caspases: Description of a unified pathway for transactivation of executioner caspase-3 and -7
52. Apaf1 is required for mitochondrial pathways of apoptosis and brain development
53. Correlation between caspase-3 activation and three different markers of DNA damage in neonatal cerebral hypoxia-ischemia
54. Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3