Novel anthranilamide-pyrazolo[1,5-a]pyrimidine conjugates modulate the expression of p53-MYCN associated micro RNAs in neuroblastoma cells and cause cell cycle arrest and apoptosis

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 20, 2013, Pages 5699-5706

  Ramaiah, M Janaki ^a   Pushpavalli, Sreerangam N C V L ^a   Lavanya, A ^a   Bhadra, Kaustav ^a   Haritha, V ^a   Patel, Nibedita ^a   Tamboli, Jaki R ^a   Kamal, Ahmed ^a   Bhadra, Utpal ^b   Pal Bhadra, Manika ^a  

^a INDIAN INSTITUTE OF CHEMICAL TECHNOLOGY   (India)

^b CENTRE FOR CELLULAR AND MOLECULAR BIOLOGY   (India)

Author keywords

Apoptosis; IMR 32 cells; miR 34; Neuroblastoma; p53

Indexed keywords

AKT1 PROTEIN; ANTHRANILAMIDE PYRAZOLO[1,5 A]PYRIMIDINE DERIVATIVE; CASPASE; MICRORNA; MICRORNA 107; MICRORNA 200B; MICRORNA 34A; MICRORNA 542 5P; MICRORNA 605; MYCN ONCOPROTEIN; ONCOPROTEIN; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE B; PROTEIN MDM2; PROTEIN P21; PROTEIN P53; PYRIMIDINE DERIVATIVE; ROSCOVITINE; TRANSCRIPTION FACTOR E2F1; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; DOWN REGULATION; DROSOPHILA; DRUG CONJUGATION; DRUG CYTOTOXICITY; G2 PHASE CELL CYCLE CHECKPOINT; GENE EXPRESSION; HUMAN; HUMAN CELL; IN VIVO STUDY; NEUROBLASTOMA CELL; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION;

3-(4,5-DIMETHYL THIAZOL-2-YL)-2,5 DIPHENYL TETRAZOLIUM BROMIDE; APOPTOSIS; IMR-32 CELLS; MICRORNA; MIR-34; MIRNA; MTT; MYCN; N-MYC; NEUROBLASTOMA; P53; REVERSE TRANSCRIPTION PCR; RT-PCR;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CELL LINE, TUMOR; CYCLIN-DEPENDENT KINASE INHIBITOR P21; G2 PHASE CELL CYCLE CHECKPOINTS; GENE EXPRESSION REGULATION, NEOPLASTIC; HELA CELLS; HUMANS; M PHASE CELL CYCLE CHECKPOINTS; MICRORNAS; NEUROBLASTOMA; NUCLEAR PROTEINS; ONCOGENE PROTEINS; ORTHO-AMINOBENZOATES; PROTO-ONCOGENE PROTEINS C-MDM2; PURINES; PYRAZOLES; PYRIMIDINES; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84884289800     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.08.018     Document Type: Article

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