Dissociable effects of kappa-opioid receptor activation on impulsive phenotypes in wistar rats

Neuropsychopharmacology

Volumn 38, Issue 11, 2013, Pages 2278-2285

  Walker, Brendan M ^a   Kissler, Jessica L ^a  

^a Graduate Program in Neuroscience   (United States)

Author keywords

Alcohol; Delay discounting; Dependence; Impulsivity; Kappa opioid receptor; Stop signal reaction time task

Indexed keywords

3,4 DICHLORO N METHYL N [2 (1 PYRROLIDINYL)CYCLOHEXYL]BENZENEACETAMIDE; DYNORPHIN; KAPPA OPIATE RECEPTOR; NEUROTRANSMITTER; NORBINALTORPHIMINE;

AFFECT; ALCOHOL CONSUMPTION; ALCOHOLISM; AMYGDALOID NUCLEUS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DECISION MAKING; DRUG RESPONSE; IMPULSE CONTROL DISORDER; IMPULSIVENESS; MALE; MOTIVATION; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; RAT;

3,4-DICHLORO-N-METHYL-N-(2-(1-PYRROLIDINYL)-CYCLOHEXYL)-BENZENEACETAMIDE, (TRANS)-ISOMER; ANALGESICS, NON-NARCOTIC; ANIMALS; CONDITIONING, OPERANT; DOSE-RESPONSE RELATIONSHIP, DRUG; IMPULSIVE BEHAVIOR; INFUSIONS, INTRAVENTRICULAR; MALE; NALTREXONE; NARCOTIC ANTAGONISTS; PHENOTYPE; RATS; RECEPTORS, OPIOID, KAPPA;

EID: 84884287545     PISSN: 0893133X     EISSN: 1740634X     Source Type: Journal    
DOI: 10.1038/npp.2013.129     Document Type: Article

References (61)

1. Ainslie G (1975). Specious reward: a behavioral theory of impulsiveness and impulse control. Psychol Bull 82: 463-496.
2. American Psychiatric Association (2000). Diagnostic and Statistical Manual of Mental Disorders DSM-IV-TR. American Psychiatric Association: Washington, DC.
3. Aragues M, Jurado R, Quinto R, Rubio G (2011). Laboratory paradigms of impulsivity and alcohol dependence: a review. Eur Addict Res 17: 64-71.
4. Badanich KA, Becker HC, Woodward JJ (2011). Effects of chronic intermittent ethanol exposure on orbitofrontal and medial prefrontal cortex-dependent behaviors in mice. Behav Neurosci 125: 879-891.
5. Bals-Kubik R, Herz A, Shippenberg TS (1989). Evidence that the aversive effects of opioid antagonists and kappa-agonists are centrally mediated. Psychopharmacology (Berl) 98: 203-206.
6. Bazov I, Kononenko O, Watanabe H, Kuntic V, Sarkisyan D, Taqi MM et al (2013). The endogenous opioid system in human alcoholics: molecular adaptations in brain areas involved in cognitive control of addiction. Addict Biol 18: 161-169.
7. Bencherif B, Wand GS, McCaul ME, Kim YK, Ilgin N, Dannals RF et al (2004). Mu-opioid receptor binding measured by [11C]carfentanil positron emission tomography is related to craving and mood in alcohol dependence. Biol Psychiatry 55: 255-262.
8. Berger AL, Williams AM, McGinnis MM, Walker BM (2013). Affective cue-induced escalation of alcohol self-administration and increased 22-kHz ultrasonic vocalizations during alcohol withdrawal: role of kappa-opioid receptors. Neuropsychopharmacology 38: 647-654.
9. Boettiger CA, Kelley EA, Mitchell JM, D'Esposito M, Fields HL (2009). Now or Later? An fMRI study of the effects of endogenous opioid blockade on a decision-making network. Pharmacol Biochem Behav 93: 291-299.
10. Bruchas MR, Yang T, Schreiber S, Defino M, Kwan SC, Li S et al (2007). Long-acting kappa opioid antagonists disrupt receptor signaling and produce noncompetitive effects by activating c-Jun N-terminal kinase. J Biol Chem 282: 29803-29811.
11. Cardinal RN (2006). Neural systems implicated in delayed and probabilistic reinforcement. Neural Netw 19: 1277-1301.
12. Chartoff E, Sawyer A, Rachlin A, Potter D, Pliakas A, Carlezon WA (2012). Blockade of kappa opioid receptors attenuates the development of depressive-like behaviors induced by cocaine withdrawal in rats. Neuropharmacology 62: 167-176.
13. Crews FT, Boettiger CA (2009). Impulsivity, frontal lobes and risk for addiction. Pharmacol Biochem Behav 93: 237-247.
14. D'Addario C, Caputi FF, Rimondini R, GandolfiO, Del BE, Candeletti S et al (2013). Different alcohol exposures induce selective alterations on the expression of dynorphin and nociceptin systems related genes in rat brain. Addict Biol 18: 425-433.
15. de Wit H (2009). Impulsivity as a determinant and consequence of drug use: a review of underlying processes. Addict Biol 14: 22-31.
16. Deehan GA Jr, McKinzie DL, Carroll FI, McBride WJ, Rodd ZA (2012). The long-lasting effects of JDTic, a kappa opioid receptor antagonist, on the expression of ethanol-seeking behavior and the relapse drinking of female alcohol-preferring (P) rats. Pharmacol Biochem Behav 101: 581-587.
17. Dougherty DM, Mathias CW, Marsh-Richard DM, Furr RM, Nouvion SO, Dawes MA (2009). Distinctions in behavioral impulsivity: implications for substance abuse research. Addict Disord Their Treat 8: 61-73.
18. Duann JR, Ide JS, Luo X, Li CS (2009). Functional connectivity delineates distinct roles of the inferior frontal cortex and presupplementary motor area in stop signal inhibition. J Neurosci 29: 10171-10179.
19. Eagle DM, Robbins TW (2003a). Inhibitory control in rats performing a stop-signal reaction-time task: effects of lesions of the medial striatum and d-amphetamine. Behav Neurosci 117: 1302-1317.
20. Eagle DM, Robbins TW (2003b). Lesions of the medial prefrontal cortex or nucleus accumbens core do not impair inhibitory control in rats performing a stop-signal reaction time task. Behav Brain Res 146: 131-144.
21. Evenden JL, Ryan CN (1996). The pharmacology of impulsive behaviour in rats: the effects of drugs on response choice with varying delays of reinforcement. Psychopharmacology (Berl) 128: 161-170.
22. Fernandez-Serrano MJ, Perez-Garcia M, Verdejo-Garcia A (2011). What are the specific vs generalized effects of drugs of abuse on neuropsychological performance? Neurosci Biobehav Rev 35: 377-406.
23. Goldstein M, Brendel G, Tuescher O, Pan H, Epstein J, Beutel M et al (2007). Neural substrates of the interaction of emotional stimulus processing and motor inhibitory control: an emotional linguistic go/no-go fMRI study. Neuroimage 36: 1026-1040.
24. Grant BF, Harford TC (1995). Comorbidity between DSM-IV alcohol use disorders and major depression: results of a national survey. Drug Alcohol Depend 39: 197-206.
25. Heilig M, Koob GF (2007). A key role for corticotropin-releasing factor in alcohol dependence. Trends Neurosci 30: 399-406.
26. Kim SW (1998). Opioid antagonists in the treatment of impulsecontrol disorders. J Clin Psychiatry 59: 159-164.
27. Kissler JL, Sirohi S, Reis DJ, Jansen HT, Quock RM, Smith DG et al (2013). The one-two punch of alcoholism: role of central amygdala dynorphins/kappa-opioid receptors. Biol Psychiatry pii S0006-3223: 00267-00269.
28. Knoll AT, Muschamp JW, Sillivan SE, Ferguson D, Dietz DM, Meloni EG et al (2011). Kappa opioid receptor signaling in the basolateral amygdala regulates conditioned fear and anxiety in rats. Biol Psychiatry 70: 425-433.
29. Land BB, Bruchas MR, Lemos JC, Xu M, Melief EJ, Chavkin C (2008). The dysphoric component of stress is encoded by activation of the dynorphin kappa-opioid system. J Neurosci 28: 407-414.
30. Love TM, Stohler CS, Zubieta JK (2009). Positron emission tomography measures of endogenous opioid neurotransmission and impulsiveness traits in humans. Arch Gen Psychiatry 66: 1124-1134.
31. Mague SD, Pliakas AM, Todtenkopf MS, Tomasiewicz HC, Zhang Y, Stevens WC Jr et al (2003). Antidepressant-like effects of kappa-opioid receptor antagonists in the forced swim test in rats. J Pharmacol Exp Ther 305: 323-330.
32. Mansour A, Fox CA, Meng F, Akil H, Watson SJ (1994). Kappa 1 receptor mRNA distribution in the rat CNS: comparison to kappa receptor binding and prodynorphin mRNA. Mol Cell Neurosci 5: 124-144.
33. Mansour A, Khachaturian H, Lewis ME, Akil H, Watson SJ (1987). Autoradiographic differentiation of mu, delta, and kappa opioid receptors in the rat forebrain and midbrain. J Neurosci 7: 2445-2464.
34. Mazur JE (1989). Theories of probabilistic reinforcement. J Exp Anal Behav 51: 87-99.
35. Mitchell JM, Fields HL, D'Esposito M, Boettiger CA (2005). Impulsive responding in alcoholics. Alcohol Clin Exp Res 29: 2158-2169.
36. Myrick H, Anton RF, Li X, Henderson S, Randall PK, Voronin K (2008). Effect of naltrexone and ondansetron on alcohol cueinduced activation of the ventral striatum in alcohol-dependent people. Arch Gen Psychiatry 65: 466-475.
37. National Research Council (1996). Guide for the Care and Use of Laboratory Animals. National Academy Press: Washington, D.C, USA.
38. Nealey KA, Smith AW, Davis SM, Smith DG, Walker BM (2011). kappa-opioid receptors are implicated in the increased potency of intra-accumbens nalmefene in ethanol-dependent rats. Neuropharmacology 61: 35-42.
39. Nemeth CL, Paine TA, Rittiner JE, Beguin C, Carroll FI, Roth BL et al (2010). Role of kappa-opioid receptors in the effects of salvinorin A and ketamine on attention in rats. Psychopharmacology (Berl) 210: 263-274.
40. Paine TA, Tomasiewicz HC, Zhang K, Carlezon WA Jr (2007). Sensitivity of the five-choice serial reaction time task to the effects of various psychotropic drugs in Sprague-Dawley rats. Biol Psychiatry 62: 687-693.
41. Paxinos G, Watson C (2007). The Rat Brain in Stereotaxic Coordinates. Elsevier, Academic Press: San Diego.
42. Pessoa L, Padmala S, Kenzer A, Bauer A (2012). Interactions between cognition and emotion during response inhibition. Emotion 12: 192-197.
43. Petry NM (2001). Delay discounting of money and alcohol in actively using alcoholics, currently abstinent alcoholics, and controls. Psychopharmacology (Berl) 153: 243-250.
44. Roberts AJ, Heyser CJ, Cole M, Griffin P, Koob GF (2000). Excessive ethanol drinking following a history of dependence: animal model of allostasis. Neuropsychopharmacology 22: 581-594.
45. Roy A, DeJong J, Lamparski D, George T, Linnoila M (1991). Depression among alcoholics. Relationship to clinical and cerebrospinal fluid variables. Arch Gen Psychiatry 48: 428-432.
46. Sabino V, Cottone P, Blasio A, Iyer MR, Steardo L, Rice KC et al (2011). Activation of sigma-receptors induces binge-like drinking in Sardinian alcohol-preferring rats. Neuropsychopharmacology 36: 1207-1218.
47. Schmaal L, Joos L, Koeleman M, Veltman DJ, van den Brink W, Goudriaan AE (2013). Effects of modafinil on neural correlates of response inhibition in alcohol-dependent patients. Biol Psychiatry 73: 211-218.
48. Schuckit MA, Tipp JE, Bergman M, Reich W, Hesselbrock VM, Smith TL (1997a). Comparison of induced and independent major depressive disorders in 2,945 alcoholics. Am J Psychiatry 154: 948-957.
49. Schuckit MA, Tipp JE, Bucholz KK, Nurnberger JI Jr, Hesselbrock VM, Crowe RR et al (1997b). The life-time rates of three major mood disorders and four major anxiety disorders in alcoholics and controls. Addiction 92: 1289-1304.
50. Sirohi S, Bakalkin G, Walker BM (2012). Alcohol-induced plasticity in the dynorphin/kappa-opioid receptor system. Front Mol Neurosci 5: 95.
51. Solomon RL, Corbit JD (1974). An opponent-process theory of motivation. I. Temporal dynamics of affect. Psychol Rev 81: 119-145.
52. Substance Abuse and Mental Health Services Administration (2005). Results from the 2004 National Survey on Drug Use and Health. Office of Applied Studies, DHHS Publication: Rockville, MD, USA.
53. Swann NC, Cai W, Conner CR, Pieters TA, Claffey MP, George JS et al (2012). Roles for the pre-supplementary motor area and the right inferior frontal gyrus in stopping action: electrophysiological responses and functional and structural connectivity. Neuroimage 59: 2860-2870.
54. Todtenkopf MS, Marcus JF, Portoghese PS, Carlezon WA Jr (2004). Effects of kappa-opioid receptor ligands on intracranial selfstimulation in rats. Psychopharmacology (Berl) 172: 463-470.
55. Walker BM (2012). Conceptualizing withdrawal-induced escalation of alcohol self-administration as a learned, plasticity-dependent process. Alcohol 46: 339-348.
56. Walker BM, Koob GF (2008). Pharmacological evidence for a motivational role of kappa-opioid systems in ethanol dependence. Neuropsychopharmacology 33: 643-652.
57. Walker BM, Valdez GR, McLaughlin JP, Bakalkin G (2012). Targeting dynorphin/kappa opioid receptor systems to treat alcohol abuse and dependence. Alcohol 46: 359-370.
58. Walker BM, Zorrilla EP, Koob GF (2011). Systemic kappa-opioid receptor antagonism by nor-binaltorphimine reduces dependenceinduced excessive alcohol self-administration in rats. Addict Biol 16: 116-119.
59. Williams AM, Reis DJ, Powell AS, Neira LJ, Nealey KA, Ziegler CE et al (2012). The effect of intermittent alcohol vapor or pulsatile heroin on somatic and negative affective indices during spontaneous withdrawal in Wistar rats. Psychopharmacology (Berl) 223: 75-88.
60. Winstanley CA (2007). The orbitofrontal cortex, impulsivity, and addiction: probing orbitofrontal dysfunction at the neural, neurochemical, and molecular level. Ann N Y Acad Sci 1121: 639-655.
61. Winstanley CA, Eagle DM, Robbins TW (2006). Behavioral models of impulsivity in relation to ADHD: translation between clinical and preclinical studies. Clin Psychol Rev 26: 379-395.