The orbitofrontal cortex, impulsivity, and addiction

Annals of the New York Academy of Sciences

Volumn 1121, Issue , 2007, Pages 639-655

  Winstanley, Catharine A ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Cocaine; Delay discounting; Dopamine; Five choice serial reaction time task; Serotonin; FosB

Indexed keywords

COCAINE; DOPAMINE; SEROTONIN;

ATTENTION DEFICIT DISORDER; BEHAVIOR DISORDER; BRAIN DYSFUNCTION; BRAIN FUNCTION; COGNITIVE DEFECT; CONFERENCE PAPER; DISRUPTIVE BEHAVIOR; DRUG DEPENDENCE; HUMAN; IMPULSE CONTROL DISORDER; IMPULSIVENESS; MOLECULAR DYNAMICS; NERVE CELL; NERVE CELL NETWORK; NEUROBIOLOGY; NEUROCHEMISTRY; NUCLEUS ACCUMBENS; ORBITAL CORTEX;

EID: 37549003556     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1196/annals.1401.024     Document Type: Conference Paper

References (72)

1. EVERITT, B.J. & T.W. ROBBINS. 2005. Neural systems of reinforcement for drug addiction: from actions to habits to compulsion. Nat. Neurosci. 8: 1481-1489.
2. JENTSCH, J.D. & J.R. TAYLOR. 1999. Impulsivity resulting from frontostriatal dysfunction in drug abuse: implications for the control of behavior by reward-related stimuli. Psychopharmacology 146: 373-390.
3. ROGERS, R.D. & T.W. ROBBINS. 2001. Investigating the neurocognitive deficits associated with chronic drug misuse. Curr. Opin. Neurobiol. 11: 250-257.
4. WISE, R.A. 1996. Neurobiology of addiction. Curr. Opin. Neurobiol. 6: 243-251.
5. BARRATT, E.S. 1994. Impulsiveness and aggression. In Violence and Mental Disorder. J. Monahan & H.J. Steadman, Eds.: 61-79. University of Chicago Press. Chicago.
6. EYSENCK, S.B.G. 1993. The I7: development of a measure of impulsivity and its relationship to the superfactors of personality. In The Impulsive Client: Theory, Research and Treatment. W.G. McCown, J.L. Johnson & M.B. Shure, Eds.: 141-149. American Psychological Association. Washington, DC.
7. EVENDEN, J.L. 1999. Varieties of impulsivity. Psychopharmacology 146: 348-361.
8. DARUNA, J.H. & P.A. BARNES. 1993. A neurodevelopmental view of impulsivity. In The Impulsive Client: Theory, Research and Treatment. W.G. McCown, J.L. Johnson & M.B. Shure, Eds.: 23. American Psychological Association. Washington, DC.
9. MOELLER, F.G. et al. 2001. Psychiatric aspects of impulsivity. Am. J. Psychiatry 158: 1783-1793.
10. WINSTANLEY, C.A., D.M. EAGLE & T.W. ROBBINS. 2006. Behavioral models of impulsivity in relation to ADHD: translation between clinical and preclinical studies. Clin. Psychol. Rev. 26: 379-395.
11. SOLANTO, M.V. et al. 2001. The ecological validity of delay aversion and response inhibition as measures of impulsivity in AD/HD: a supplement to the NIMH multi-modal treatment study of AD/HD. J. Abnorm. Child Psychol. 29: 215-228.
12. CARLI, M. et al. 1983. Effects of lesions to ascending noradrenergic neurons on performance of a 5-choice serial reaction time task in rats - implications for theories of dorsal noradrenergic bundle function based on selective attention and arousal. Behav. Brain Res. 9: 361-380.
13. ROSVOLD, H.E. et al. 1956. A continuous performance test of brain damage. J. Consult. Psychol. 20: 343-350.
14. EVENDEN, J.L. & C.N. RYAN. 1996. The pharmacology of impulsive behaviour in rats: the effects of drugs on response choice with varying delays of reinforcement. Psychopharmacology 128: 161-170.
15. CARDINAL, R.N. et al. 2001. Impulsive choice induced in rats by lesions of the nucleus accumbens core. Science 292: 2499-2501.
16. MUIR, J.L., B.J. EVERITT & T.W. ROBBINS. 1996. The cerebral cortex of the rat and visual attentional function: dissociable effects of mediofrontal, cingulate, anterior dorsolateral, and parietal cortex lesions on a five-choice serial reaction time task. Cereb. Cortex 6: 470-481.
17. CHRISTAKOU, A., T.W. ROBBINS & B.J. EVERITT. 2004. Prefrontal-ventral striatal systems involved in affective modulation of attentional performance: implications for corticostriatal circuitry function. J. Neurosci. 24: 773-780.
18. GOMEZ, R. 2003. Underlying processes in the poor response inhibition of children with Attention-Deficit/Hyperactivity Disorder. J. Atten. Disord. 6: 111-122.
19. BECHARA, A. et al. 1994. Insensitivity to future consequences following damage to human prefrontal cortex. Cognition 50: 7-15.
20. CAVEDINI, P. et al. 2002. Frontal lobe dysfunction in pathological gambling patients. Biol. Psychiatry 51: 334-341.
21. BECHARA, A. et al. 2001. Decision-making deficits, linked to a dysfunctional ventromedial prefrontal cortex, revealed in alcohol and stimulant abusers. Neuropsychologia 39: 376-389.
22. BECHARA, A. et al. 1999. Different contributions of the human amygdala and ventromedial prefrontal cortex to decision-making. J. Neurosci. 19: 5473-5481.
23. VOLKOW, N.D. & J.S. FOWLER. 2000. Addiction, a disease of compulsion and drive: involvement of the orbitofrontal cortex. Cereb. Cortex 10: 318-325.
24. VOLKOW, N.D., J.S. FOWLER & G.-J. WANG. 2004. The addicted human brain viewed in the light of imaging studies: brain circuits and treatment strategies. Neuropharmacology 47: 3-13.
25. VOLKOW, N.D. et al. 2002. Role of dopamine, the frontal cortex and memory circuits in drug addiction: insight from imaging studies. Neurobiol. Learn. Mem. 78: 610-624.
26. MOELLER, F.G. et al. 2004. P300 event-related potential amplitude and impulsivity in cocaine-dependent subjects. Neuropsychobiology 50: 167-173.
27. PETRY, N.M. 2002. Discounting of delayed rewards in substance abusers: relationship to antisocial personality disorder. Psychopharmacology 162: 425-432.
28. KIRBY, K.N. & N.M. PETRY. 2004. Heroin and cocaine abusers have higher discount rates for delayed rewards than alcoholics or non-drug-using controls. Addiction 99: 461-471.
29. DALLEY, J.W. et al. 2007. Nucleus accumbens D2/3 receptors predict trait impulsivity and cocaine reinforcement. Science 315: 1267-1270.
30. VOLKOW, N.D. et al. 1996. Cocaine addiction: hypothesis derived from imaging studies with PET. J. Addict. Dis. 15: 55-71.
31. WINSTANLEY, C.A. et al. 2004. Contrasting roles for basolateral amygdala and orbitofrontal cortex in impulsive choice. J. Neurosci. 24: 4718-4722.
32. SCHOENBAUM, G., A.A. CHIBA & M. GALLAGHER. 1999. Neural encoding in orbitofrontal cortex and basolateral amygdala during olfactory discrimination learning. J. Neurosci. 19: 1876-1884.
33. COLE, B.J. & T.W. ROBBINS. 1987. Amphetamine impairs the discriminative performance of rats with dorsal noradrenergic bundle lesions on a 5-choice serial reaction time task: new evidence for central dopaminergic-noradrenergic interactions. Psychopharmacology 91: 458-466.
34. VAN GAALEN, M.M. et al. 2006. Behavioral disinhibition requires dopamine receptor activation. Psychopharmacology (Berl.) 187: 73-85.
35. ROBBINS, T.W. & B.J. SAHAKIAN. 1979. "Paradoxical" effects of psychomotor stimulant drugs in hyperactive children from the standpoint of behavioural pharmacology. Neuropharmacology 18: 931-950.
36. CARDINAL, R.N., T.W. ROBBINS & B.J. EVERITT. 2000. The effects of d-amphetamine, chlordiazepoxide, alpha- flupenthixol and behavioural manipulations on choice of signalled and unsignalled delayed reinforcement in rats. Psychopharmacology 152: 362-375.
37. VAN GAALEN, M.M. et al. 2006. Critical involvement of dopaminergic neurotransmission in impulsive decision making. Biol. Psychiatry 60: 66-73.
38. WADE, T.R., H. DE WIT & J.B. RICHARDS. 2000. Effects of dopaminergic drugs on delayed reward as a measure of impulsive behavior in rats. Psychopharmacology 150: 90-101.
39. WINSTANLEY, C.A. et al. 2003. Global 5-HT depletion attenuates the ability of amphetamine to decrease impulsive choice in rats. Psychopharmacology 170: 320-331.
40. WINSTANLEY, C.A. et al. 2005. Interactions between serotonin and dopamine in the control of impulsive choice in rats: therapeutic implications for impulse control disorders. Neuropsychopharmacology 30: 669-682.
41. USLANER, J.M. & T.E. ROBINSON. 2006. Subthalamic nucleus lesions increase impulsive action and decrease impulsive choice - mediation by enhanced incentive motivation? Eur. J. Neurosci. 24: 2345-2354.
42. COLE, B.J. & T.W. ROBBINS. 1989. Effects of 6-Hydroxydopamine lesions of the nucleus accumbens septi on performance of a 5-choice serial reaction time task in rats - Implications for theories of selective attention and arousal. Behav. Brain Res. 33: 165-179.
43. HARRISON, A.A., B.J. EVERITT & T.W. ROBBINS. 1997. Central 5-HT depletion enhances impulsive responding without affecting the accuracy of attentional performance: interactions with dopaminergic mechanisms. Psychopharmacology 133: 329-342.
44. DALLEY, J.W. et al. 2002. Deficits in impulse control associated with tonically-elevated serotonergic function in rat prefrontal cortex. Neuropsychopharmacology 26: 716-728.
45. KHERAMIN, S. et al. 2004. Effects of orbital prefrontal cortex dopamine depletion on inter-temporal choice: a quantitative analysis. Psychopharmacology 175: 206-214.
46. WINSTANLEY, C.A. et al. 2006. Double dissociation between serotonergic and dopaminergic modulation of medial prefrontal and orbitofrontal cortex during a test of impulsive choice. Cereb. Cortex 16: 106-114.
47. WINSTANLEY, C.A. et al. 2007. ΔFosB induction in orbitofrontal cortex regulates tolerance to cocaine-induced cognitive dysfunction. J. Neurosci. 27: 10497-10507.
48. DALLEY, J.W. et al. 2005. Attentional and motivational deficits in rats withdrawn from intravenous self-administration of cocaine or heroin. Psychopharmacology (Berl.) 182: 579-587.
49. ROBINSON, T.E. & B. KOLB. 2004. Structural plasticity associated with exposure to drugs of abuse. Neuropharmacology 47(Suppl 1): 33-46.
50. KOOB, G.F. 1996. Drug addiction: the yin and yang of hedonic homeostasis. Neuron. 16: 893-896.
51. ADINOFF, B. et al. 2001. Limbic responsiveness to procaine in cocaine-addicted subjects. Am. J. Psychiatry 158: 390-398.
52. KREEK, M.J. et al. 2004. Evolving perspectives on neurobiological research on the addictions: celebration of the 30th anniversary of NIDA. Neuropharmacology 47(Suppl 1): 324-344.
53. DACKIS, C.A. et al. 2005. A double-blind, placebo-controlled trial of modafinil for cocaine dependence. Neuropsychopharmacology 30: 205-211.
54. TURNER, D.C. et al. 2003. Cognitive enhancing effects of modafinil in healthy volunteers. Psychopharmacology (Berl.) 165: 260-269.
55. HYMAN, S.E. & R.C. MALENKA. 2001. Addiction and the brain: the neurobiology of compulsion and its persistence. Nat. Rev. Neurosci. 2: 695-703.
56. KALIVAS, P.W. 2004. Glutamate systems in cocaine addiction. Curr. Opin. Pharmacol. 4: 23-29.
57. NESTLER, E.J. 2004. Molecular mechanisms of drug addiction. Neuropharmacology 47(Suppl 1): 24-32.
58. NESTLER, E.J., M. BARROT & D.W. SELF. 2001. DeltaFosB: a sustained molecular switch for addiction. Proc. Natl. Acad. Sci. USA 98: 11042-11046.
59. BIBB, J.A. et al. 2001. Effects of chronic exposure to cocaine are regulated by the neuronal protein Cdk5. Nature 410: 376-380.
60. MULLER, D.L. & E.M. UNTERWALD. 2005. D1 dopamine receptors modulate deltaFosB induction in rat striatum after intermittent morphine administration. J. Pharmacol. Exp. Ther. 314: 148-154.
61. DOUCET, J.P. et al. 1996. Chronic alterations in dopaminergic neurotransmission produce a persistent elevation in deltaFosB-like protein(s) in both the rodent and primate striatum. Eur. J. Neurosci. 8: 365-381.
62. KELZ, M.B. et al. 1999. Expression of the transcription factor deltaFosB in the brain controls sensitivity to cocaine. Nature 401: 272-276.
63. ZACHARIOU, V. et al. 2006. An essential role for DeltaFosB in the nucleus accumbens in morphine action. Nat. Neurosci. 9: 205-211.
64. COLBY, C.R. et al. 2003. Striatal cell type-specific overexpression of DeltaFosB enhances incentive for cocaine. J. Neurosci. 23: 2488-2493.
65. HOMAYOUN, H. & B. MOGHADDAM. 2006. Progression of cellular adaptations in medial prefrontal and orbitofrontal cortex in response to repeated amphetamine. J. Neurosci. 26: 8025-8039.
66. CHU, Z. & J.J. HABLITZ. 1998. Activation of group ImGluRs increases spontaneous IPSC frequency in rat frontal cortex. J. Neurophysiol. 80: 621-627.
67. DUNN, E. et al. 1996. Differential distribution of gamma-aminobutyric acidA receptor subunit (alpha 1, alpha 2, alpha 3, alpha 5 and beta 2 + 3) immunoreactivity in the medial prefrontal cortex of the rat. Neurosci. Lett. 210: 213-217.
68. MAUBACH, K.A., C. CODY & R.S. JONES. 1998. Tachykinins may modify spontaneous epileptiform activity in the rat entorhinal cortex in vitro by activating GABAergic inhibition. Neuroscience 83: 1047-1062.
69. WINSTANLEY, C.A. et al. 2006. Withdrawal from cocaine self-administration increases impulsivity in rats: role for DeltaFosB in the orbitofrontal cortex. Program No. 482.22, 2006 Neuroscience Meeting Planner. Atlanta, GA: Society for Neuroscience, 2006. Online.
70. HUTCHESON, D.M. & B.J. EVERITT. 2003. The effects of selective orbitofrontal cortex lesions on the acquisition and performance of cue-controlled cocaine seeking in rats. Ann. N.Y. Acad Sci. 1003: 410-411.
71. POWELL, K.J. et al. 2006. Neonatal ventral hippocampal lesions produce an elevation of DeltaFosB-like protein(s) in the rodent neocortex. Neuropsychopharmacology 31: 700-711.
72. KALIVAS, P.W. 2001. Drug addiction: to the cortex and beyond! Am. J. Psychiatry 158: 349-350.