Specific detection and imaging of enzyme activity by signal-amplifiable self-assembling 19Fa MRI probes

Chemistry - A European Journal

Volumn 19, Issue 38, 2013, Pages 12875-12883

  Matsuo, Kazuya ^a   Kamada, Rui ^a   Mizusawa, Keigo ^a   Imai, Hirohiko ^a   Takayama, Yuki ^a   Narazaki, Michiko ^a   Matsuda, Tetsuya ^a   Takaoka, Yousuke ^a   Hamachi, Itaru ^a,b  

^a KYOTO UNIVERSITY   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

enzyme activity; imaging agents; magnetic resonance imaging; NMR spectroscopy; self assembly; signal amplification

Indexed keywords

DRUG DISCOVERY RESEARCHES; ENZYMATIC ACTIVITIES; IMAGING AGENT; MATRIX METALLOPROTEINASES; MEDICAL DIAGNOSTICS; NANOMOLAR CONCENTRATION; NONINVASIVE VISUALIZATION; SIGNAL AMPLIFICATIONS;

AGGREGATES; CELL CULTURE; DIAGNOSIS; ENZYME ACTIVITY; ENZYME INHIBITION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROBES; SELF ASSEMBLY; SIGNAL DETECTION; TUMORS;

MAGNETIC RESONANCE IMAGING;

FLUORESCENT DYE; FLUORINE; MATRIX METALLOPROTEINASE; PEPTIDE;

ARTICLE; CHEMISTRY; CONFOCAL MICROSCOPY; ENZYME ACTIVITY; ENZYME SPECIFICITY; HELA CELL; HUMAN; IMAGING AGENTS; METABOLISM; MOLECULAR PROBE; NUCLEAR MAGNETIC RESONANCE; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; SELF-ASSEMBLY; SIGNAL AMPLIFICATION;

ENZYME ACTIVITY; IMAGING AGENTS; MAGNETIC RESONANCE IMAGING; NMR SPECTROSCOPY; SELF-ASSEMBLY; SIGNAL AMPLIFICATION;

FLUORESCENT DYES; FLUORINE RADIOISOTOPES; HELA CELLS; HUMANS; MAGNETIC RESONANCE IMAGING; MATRIX METALLOPROTEINASES; MICROSCOPY, CONFOCAL; MOLECULAR PROBES; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PEPTIDES; SUBSTRATE SPECIFICITY;

EID: 84884285714     PISSN: 09476539     EISSN: 15213765     Source Type: Journal    
DOI: 10.1002/chem.201300817     Document Type: Article

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