Therapy-resistant acute lymphoblastic leukemia (ALL) cells inactivate FOXO3 to escape apoptosis induction by TRAIL and Noxa

Oncotarget

Volumn 4, Issue 7, 2013, Pages 995-1007

  Ausserlechner, Michael J ^a,b   Salvador, Christina ^a   Deutschmann, Andrea ^a,b   Bodner, Martin ^a,b   Viola, Giampietro ^c   Bortolozzi, Roberta ^c   Basso, Giuseppe ^c   Hagenbuchner, Judith ^a,b   Obexer, Petra ^a,b  

^a INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^b TYROLEAN CANCER RESEARCH INSTITUTE   (Austria)

^c UNIVERSITY OF PADOVA   (Italy)

Author keywords

BH3 only proteins; FOXO3 FKHRL1; p16 INK4A; T ALL; TRAIL

Indexed keywords

CASPASE 8; CYCLIN DEPENDENT KINASE INHIBITOR 2A; CYTOKINE RESPONSE MODIFIER A; PHOSPHATIDYLINOSITOL 3 KINASE; PREDNISONE; PROTEIN BID; PROTEIN KINASE B; PROTEIN NOXA; TRANSCRIPTION FACTOR FKHRL1; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND;

ACUTE LYMPHOBLASTIC LEUKEMIA; APOPTOSIS; ARTICLE; CANCER RESISTANCE; CELLULAR DISTRIBUTION; CHILD; CHILDHOOD LEUKEMIA; CONTROLLED STUDY; FEEDBACK SYSTEM; HUMAN; HUMAN CELL; LEUKEMIA CELL; SIGNAL TRANSDUCTION;

ADOLESCENT; APOPTOSIS; CHILD; CHILD, PRESCHOOL; CYCLIN-DEPENDENT KINASE INHIBITOR P16; FORKHEAD TRANSCRIPTION FACTORS; HUMANS; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-BCL-2; SIGNAL TRANSDUCTION; TNF-RELATED APOPTOSIS-INDUCING LIGAND; TRANSFECTION;

EID: 84884264381     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.953     Document Type: Article

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