Protective effect of ginseng against gamma-irradiation-induced oxidative stress and endothelial dysfunction in rats

EXCLI Journal

Volumn 12, Issue , 2013, Pages 766-777

  Mansour, Heba Hosny ^a  

^a NATIONAL CENTER FOR RADIATION RESEARCH AND TECHNOLOGY   (Egypt)

Author keywords

Asymmetric dimethylarginine; Gamma radiation; Ginseng; Nitric oxide; Oxidative stress; Rats

Indexed keywords

CREATINE KINASE; GINSENG EXTRACT; GLUTATHIONE PEROXIDASE; LACTATE DEHYDROGENASE; MALONALDEHYDE; N(G),N(G) DIMETHYLARGININE; NITRITE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CARDIOTOXICITY; CONTROLLED STUDY; CREATINE KINASE BLOOD LEVEL; CREATININE BLOOD LEVEL; DRUG EFFICACY; DRUG MECHANISM; DRUG RESPONSE; ENDOTHELIAL DYSFUNCTION; ENZYME ACTIVITY; GAMMA IRRADIATION; LACTATE DEHYDROGENASE BLOOD LEVEL; MALE; NEPHROTOXICITY; NONHUMAN; OXIDATIVE STRESS; RADIATION DOSE; RADIATION INJURY; RAT; TREATMENT DURATION; UREA BLOOD LEVEL;

EID: 84884255853     PISSN: None     EISSN: 16112156     Source Type: Journal    
DOI: None     Document Type: Article

References (75)

1. Abdel-Wahhab MA, Ahmed HH. Protective effect of Korean panax ginseng against chromium VI toxicity and free radicals generation in rats. J Ginseng Res 2004;28: 11-17.
2. Attele AS, Wu JA, Yuan CS. Ginseng pharmacology. Biochem Pharmacol 1999; 58:1685-1693.
3. Barakat IAH, Abbas OA, Ayad S, Hassan AM. Evaluation of radioprotective effects of wheat germ oil in male rats. J Am Sci 2011;7:664-673.
4. Beltowski J, Kêdra A. Asymmetric dime-thylarginine (ADMA) as a target for phar-macotherapy. Pharmacol Rep 2006;59: 159-178.
5. Bhosle SM, Huilgol NG, Mishra KP. Enhancement of radiation-induced oxidative stress and cytotoxicity in tumor cells by el-lagic acid. Clin Chim Acta 2005;359:89-100.
6. Block KI, Mead MN. Immune system effects of Echinacea, ginseng, and astragalus: A review. Interg Cancer Ther 2003;2:247-267.
7. Boerma M, Hauer-Jensen M. Preclinical research into basic mechanisms of radiation-induced heart disease. Cardiol Res Pract 2011;2011:1-8.
8. Bonsenes RW, Taussky HN. On the colori-metric determination of creatinine by the Jaffe reaction. J Biol Chem 1945;158:587-591.
9. Buege JA, Aust SD. Microsomal lipid pe-roxidation. Methods Enzymol 1978;52: 302-310.
10. Busch M, Fleck C, Wolf G, Stein G. Asymmetrical (ADMA) and symmetrical dimethylarginine (SDMA) as potential risk factors for cardiovascular and renal outcome in chronic kidney disease - possible candidates for paradoxical epidemiology? Amino Acids 2006;30:225-232.
11. Choi KT. Botanical characteristics, pharmacological effects and medicinal components of Korean panax ginseng C A Meyer. Acta Pharmacol Sin 2008;29:1109-1118.
12. Ellman GL. Tissue sulfhydryl groups. Arch Biochem Biophys 1959;17:214-226.
13. Gadkariem EA, Al-Ashban RA, Babikir LB, Al-Joher HI. Toxicity study of Korean ginseng herbal medicine. Res J Pharmacol 2010;4(4):86-90.
14. Gorbunov NV, Pogue-Geile KL, Epperly MW, Bigbee WL, Draviam R, Day BW et al. Activation of the nitric oxide synthase 2 pathway in the response of bone marrow stromal cells to high doses of ionizing radiation. Radiat Res 2000;154:73-86.
15. Hallet CJ, Cook JG. Reduced nicotinamide adenine dinucleotide-coupled reaction for emergency blood urea estimation. Clin Chim Acta 1971;35:33-37.
16. Han SW, Kim H. Ginsenosides stimulate endogenous production of NO in rat kidney. Int J Biochem Cell Biol 1996;28:573-580.
17. Han Y, Son SJ, Akhalaia M, Platonov A, Son HJ, Lee KH et al. Modulation of radiation-induced disturbances of antioxidant defense systems by ginsan. Evid based Complement Alternat Med 2005;2:529-536.
18. Hare JM, Stamler JS. NO/redox disequilibrium in the failing heart and cardiovascular system. J Clin Invest 2005;115:509-517.
19. Hwanga I, Ahna G, Parka E, Haa D, Songb J, Jeea Y. An acidic polysaccharide of Panax ginseng ameliorates experimental autoimmune encephalomyelitis and induces regulatory T cells. Immunol Lett 2011;138: 169-178
20. Ibuki Y, Goto R. Enhancement of NO production from resident peritoneal macro-phages by in vitro gamma-irradiation and its relationship to reactive oxygen intermediates. Free Radic Biol Med 1997;22:1029-1035.
21. IFCC. Measurement of lactate dehydrogen-ase in serum. J Clin Chem Clin Biochem 1980;18:521.
22. Kang KS, Kim HY, Baek SH, Yoo HH, Park JH, Yokozawa T. Study on the hydro-xyl radical scavenging activity changes of ginseng and ginsenoside-Rb2 by heat processing. Biol Pharm Bull 2007;30:724-728.
23. Kiani AN, Mahoney JA, Petri M. Asymmetric dimethylarginine is a marker of poor prognosis and coronary calcium in systemic lupus erythematosus. J Rheumatol 2007;34: 1502-1505.
24. Kim TH, Lee SM. The effects of ginseng total saponin, panaxadiol and panaxatriol on ischemia/reperfusion injury in isolated rat heart. Food Chem Toxicol 2010;48: 1516-20.
25. Kim HJ, Lee SG, Chae IG, Kim MJ, Im NK, Yu MH et al. Antioxidant effects of fermented red ginseng extracts in strepto-zotocin-induced diabetic rats. J Ginseng Res 2011;35:129-137.
26. Kitts D, Wijewickreme AN, Hu C. Antioxi-dant properties of a North American ginseng extract. Mol Cell Biochem 2000;203: 1-10.
27. Kregel KC, Zhang HJ. An integrated view of oxidative stress in aging: basic mechanisms, functional effects, and pathological considerations. Am J Physiol Regul Integr Comp Physiol 2007;292:18-36
28. Kumar M, Sharma MK, Saxena PS, Kumar A. Radioprotective effect of panax ginseng on the phosphatases and lipid peroxidation level in testes of Swiss albino mice. Biol Pharm Bull 2003;26:308-312.
29. Lanza V, Fadda P, Iannone C, Negri R. Low-dose ionizing radiation stimulates transcription and production of endothelin by human vein endothelial cells. Radiat Res 2007;168:193-198.
30. Lawrence RA, Burk RF. Glutathione perox-idase activity in selenium-deficient rat liver. Biochem Biophys Res Commun 1976;71: 952-958.
31. Lee DCW, Lau ASY. Effects of Panax ginseng on tumor necrosis factor-α-mediated inflammation: A mini-review. Molecules 2011;16:2802-2816.
32. Lee TK, Johnke RM, Allison RR, O'Brien KF, Dobbs LJ. The radioprotective potential of ginseng. Mutagenesis 2005;20:237-243.
33. Lee HJ, Kim SR, Kim JC, Kang CM, Lee YS, Jo SK et al. In vivo radioprotective effect of Panax ginseng C.A. Meyer and identification of active ginsenosides. Phytother Res 2006;20:392-395.
34. Lee TK, O'Brien KF, Wang W, Chao Sheng C, Wang T, Johnke RM et al. American ginseng modifies 137Cs-induced DNA damage and oxidative stress in human lymphocytes. Open Nuclear Med J 2009;1:1-8.
35. Lee TK, O'Brien KF, Wang W, Johnke RM, Sheng C, Benhabib SM et al. Radio-protective effect of American ginseng on human lymphocytes at 90 minutes postirra-diation: A study of 40 cases. J Altern Complement Med 2010a;16:561-567.
36. Lee SY, Kim YK, Park N, Kim CS, Lee CY, Park SU. Chemical constituents and biological activities of the berry of Panax ginseng. J Med Plants Res 2010b;5:349-353.
37. Maas R, Schulze F, Baumert J, Lowel H, Hamraz K, Schwedhelm E et al. Asymmetric dimethylarginine, smoking, and risk of coronary heart disease in apparently healthy men: prospective analysis from the population-based monitoring of trends and determinants in cardiovascular disease. Clin Chem 2007;53:693-701.
38. Mansour HH, Hafez HF. Protective effect of Withania somnifera against radiation-induced hepatotoxicity in rats. Ecotoxicol Environ Saf 2012;80:14-19.
39. Maurya DK, Devasagayam TPA, Nair CKK. Some novel approaches for radiopro-tection and the beneficial effect of natural products. Indian J Exp Biol 2006;44:93-114.
40. Minami M, Yoshikawa H. A simplified assay method of superoxide dismutase activity for clinical use. Clin Chim Acta 1979; 92:337-342.
41. Miranda KM, Espey MG, Wink DA. A rapid, simple spectrophotometric method for simultaneous detection of nitrate and nitrite. Nitric Oxide 2001;5:62-71.
42. Ostrau C, Hülsenbeck J, Herzog M, Schad A, Torzewski M, Lackner KJ et al. Lova-statin attenuates ionizing radiation-induced normal tissue damage in vivo. Radiother Oncol 2009;92:492-499.
43. Pan C, Huo Y, An X, Singh G, Chen M, Yang Z et al. Panax notoginseng and its components decreased hypertension via stimulation of endothelial-dependent vessel dilatation. Vasc Pharmacol 2012;56:150-158.
44. Park E, Hwang I, Song J, Jee Y. Acidic polysaccharide of Panax ginseng as a defense against small intestinal damage by whole-body gamma irradiation of mice. Acta Histochem 2011;113:19-23.
45. Pradeep K, Ko KC, Choi MH, Kang JA, Chung YJ, Park SH. Protective effect of hesperidin, a citrus flavanoglycone, against γ-radiation-induced tissue damage in Spra-gue-Dawley rats. J Med Food 2012;15: 419-427.
46. Prasad NR, Menon VP, Vasudev V, Puga-lendi KV. Radioprotective effect of sesamol on γ-radiation induced DNA damage, lipid peroxidation and antioxidants levels in cultured human lymphocytes. Toxicology 2005;209:225-235.
47. Ramadan LA, Moustafa AMA, El-Sayed EM. A possible protecting activity of dilti-azem against irradiation hazards on the cardiac muscle. Az J Pharm Sci 1997;19:1-8.
48. Ramadan LA, Shouman SA, Sayed-Ahmed MM, El-Habit OH. Modulation of radiation-induced organs toxicity by cremophor-el in experimental animals. Pharmacol Res 2001;43:185-191.
49. Ramesh T, Kim SW, Sung JH, Hwang SY, Sohn SH, Yoo SK et al. Effect of fermented Panax ginseng extract (GINST) on oxida-tive stress and antioxidant activities in major organs of aged rats. Exp Gerontol 2012; 47:77-84.
50. Razavi HM, Hamilton JA, Feng Q. Modulation of apoptosis by nitric oxide: implications in myocardial ischemia and heart failure. Pharmacol Ther 2005;147:160-162.
51. Reiter RJ, Tan DX, Manchester LC, Qi W. Biochemical reactivity of melatonin with reactive oxygen and nitrogen species. A review of the evidence. Cell Biochem Bio-phys 2001;34:237-256.
52. Sathyasaikumar KV, Swapna I, Reddy PVB, Murthy RK, Dutta GA, Senthilkumaran B et al. Fulminant hepatic failure in rats induces oxidative stress differentially in cerebral cortex, cerebellum and pons medulla. Neurochem Res 2007; 32:517-524.
53. Schnabel R, Blankenberg S, Lubos E, Lackner KJ, Rupprecht HJ, Espinola-Klein C et al. Asymmetric dimethylarginine and the risk of cardiovascular events and death in patients with coronary artery disease: results from the AtheroGene Study. Circ Res 2005;97:e53-e59.
54. Sena S, Chena S, Fenga B, Wua Y, Luib E, Chakrabartia S. Preventive effects of North American ginseng (Panax quinquefolium) on diabetic nephropathy. Phytomedicine 2012;19:494-505.
55. Sener G, Kabasakal L, Atasoy BM, Erzik C, Velioglu-Ögunc A̧ Cetinel S et al. Ginkgo biloba extract protects against ionizing radiation-induced oxidative organ damage in rats. Pharmacol Res 2006;53: 241-252.
56. Sezen O, Ertekin MV, Demircan B, Karslioǧlu I, Erdoǧan F, Koçer I et al. Vitamin E and L-carnitine, separately or in combination, in the prevention of radiation-induced brain and retinal damages. Neuro-surg Rev 2008;31:205-213.
57. Sibal L, Agarwal SC, Home PD, Boger RH. The role of asymmetric dimethylarginine (ADMA) in endothelial dysfunction and cardiovascular disease. Curr Cardiol Rev 2010;6:82-90.
58. Soloviev AI, Tishkin SM, Parshikov AV, Ivanova IV, Goncharov EV, Gurney AM. Mechanisms of endothelial dysfunction after ionized radiation: selective impairment of the nitric oxide component of endotheli-um dependent vasodilation. Br J Pharmacol 2003;138:837-844.
59. Soucy KG, Lim HK, Attarzadeh DO, San-thanam L, Kim JH, Bhunia AK et al. Dietary inhibition of xanthine oxidase attenuates radiation-induced endothelial dysfunction in rat aorta. J Appl Physiol 2010;108: 1250-1258.
60. Spitz DR, Azzam EI, Li JJ, Gius D. Metabolic oxidation/reduction reactions and cellular responses to ionizing radiation: A unifying concept in stress response biology. Cancer Metast Rev 2004;23:311-322.
61. Sridharan S, Shyamaladevi CS. Protective effect of N-acetylcysteine against gamma ray induced damages in rats biochemical evaluations. Indian J Exp Biol 2002;40: 181-186.
62. Sun Y. Structure and biological activities of the polysaccharides from the leaves, roots and fruits of Panax ginseng C.A. Meyer: An overview. Carbohydrate Polymers 2011; 85:490-499.
63. Swanson JR, Wilkinson JH. Measurement of creatine kinase in serum. In: Cooper GR (ed.): Standard method of clinical chemistry, Vol. 7 (pp 33-42). New York: Academic Press, 1972.
64. Syaifudin M, Song JY, Lee YS, Kang CM. Radio protective effects of ginseng extract in gamma-rays induced chromosomal damages of human lymphocyte. Atom Indonesia 2008;34(1):45-58.
65. Szelid Z, Pokreisz P, Liu X, Vermeersch P, Marsboom G, Gillijns H et al. Cardioselec-tive nitric oxide synthase 3 gene transfer protects against myocardial reperfusion injury. Basic Res Cardiol 2010;105:169-179.
66. Ueda S, Yamagishi S, Matsumoto Y, Fu-kami K, Okuda S. Asymmetric dimethyl-arginine (ADMA) is a novel emerging risk factor for cardiovascular disease and the development of renal injury in chronic kidney disease. Clin Exp Nephrol 2007;11: 115-121.
67. Wang CZ, Mehendale SR, Yuan CS. Commonly used antioxidant botanicals: Active constituents and their potential role in cardiovascular illness. Am J Chin Med. 2007a; 35:543-558.
68. Wang W, Zhao Y, Raybur ER, Hill DL, Wang H, Zhang R. In vitro anti-cancer activity and structure-activity relationships of natural products isolated from fruits of Panax ginseng. Cancer Chemother Pharmacol 2007b;59:589-601.
69. Wang Z, Li M, Wu WK, Tan HM, Geng DF. Ginsenoside Rb1 preconditioning protects against myocardial infarction after regional ischemia and reperfusion by activation of phosphatidylinositol-3-kinase signal transduction. Cardiovasc Drugs Ther 2008; 22:443-52.
70. Wilcox CS. Asymmetric dimethylarginine and reactive oxygen species. Unwelcome twin visitors to the cardiovascular and kidney disease tables. Hypertension 2012; 59: 375-381.
71. Wu Y, Lu X, Xiang FL, Lui EM, Feng Q. North American ginseng protects the heart from ischemia and reperfusion injury via upregulation of endothelial nitric oxide syn-thase. Pharmacol Res 2011;64:195-202.
72. Xie JT, McHendale S, Yuan CS. Ginseng and diabetes. Am J Chin Med 2005;33: 397-404.
73. Yi SW, Sull JW, Hong JS, Linton JA, Ohrr H. Association between ginseng intake and mortality: Kangwha cohort study. J Altern Complement Med 2009;15:921-928.
74. Zhang HA, Wang M, Zhou J, Yao QY, Ma JM, Jiang CL. Protective effect of ginseno-side against acute renal failure and expression of tyrosine hydroxylase in the locus coeruleus. Physiol Res 2010;59:61-70.
75. Zhu D, Wu L, Li CR, Wang XW, Ma YJ, Zhong ZY et al. Ginsenoside Rg1 protects rat cardiomyocyte from hypoxia/reoxy-genation oxidative injury via antioxidant and intracellular calcium homeostasis. J Cell Biochem 2009;108:117-124.