Vitamin E and L-carnitine, separately or in combination, in the prevention of radiation-induced brain and retinal damages

Neurosurgical Review

Volumn 31, Issue 2, 2008, Pages 205-213

  Sezen, Orhan ^a   Ertekin, Mustafa Vecdi ^b   Demircan, Berna ^b   Karslioǧlu, Ihsan ^c   Erdoǧan, Fazli ^b   Koçer, Ibrahim ^b   Çalik, Ilknur ^b   Gepdiremen, Akçahan ^d  

^a KARADENIZ TECHNICAL UNIVERSITY   (Turkey)

^b ATATURK UNIVERSITY   (Turkey)

^c Gaziantep 25 Aralik Hospital   (Turkey)

^d ONDOKUZ MAYIS UNIVERSITY   (Turkey)

Author keywords

Brain; Gamma irradiation; L carnitine; Oxidative stress; Retina; Vitamin E

Indexed keywords

ALPHA TOCOPHEROL; CARNITINE; CATALASE; COBALT 60; MALONALDEHYDE; SUPEROXIDE DISMUTASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN DAMAGE; COBALT TELETHERAPY; CONTROLLED STUDY; DISEASE SEVERITY; ENZYME ACTIVITY; MALE; NONHUMAN; PRIORITY JOURNAL; RADIATION DOSE; RADIATION PROTECTION; RAT; RETINA INJURY; VITAMIN SUPPLEMENTATION;

ANIMALS; ANTIOXIDANTS; BRAIN; BRAIN CHEMISTRY; BRAIN INJURIES; CARNITINE; CATALASE; DRUG THERAPY, COMBINATION; MALE; MALONDIALDEHYDE; RADIATION INJURIES, EXPERIMENTAL; RATS; RATS, SPRAGUE-DAWLEY; RETINA; SUPEROXIDE DISMUTASE; VITAMIN E;

EID: 41049096163     PISSN: 03445607     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10143-007-0118-0     Document Type: Article

References (56)

1. Aebi H (1984) Catalase in vitro. Methods Enzymol 105:121-126
2. Altas E, Ertekin MV, Gundogdu C, Demirci E (2006) l-Carnitine reduces cochlear damage induced by gamma irradiation in Guinea pigs. Ann Clin Lab Sci 36:312-318
3. Arafa HM, Abd-Allah AR, El-Mahdy MA, Ramadan LA, Hamada FM (2003) Immunomodulatory effects of l-carnitine and q10 in mouse spleen exposed to low-frequency high-intensity magnetic field. Toxicology 187:171-181
4. Arockia Rani PJ, Panneerselvam C (2001) Carnitine as a free radical scavenger in ageing. Exp Gerentol 36:1713-1726
5. Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254
6. Canturk NZ, Canturk Z, Utkan NZ, Yenisey C, Ozbilim G, Yildirir C, Yalman Y (1998) Cytoprotective effects of alpha tocopherol against liver injury induced by extrahepatic biliary obstruction. East Afr Med J 75:77-80
7. Caruso A, Cutuli VM, De Bernardis E, Leonardi G, Amico-Roxas M (1995) Protective effect of propionyl-l-carnitine against PAF-induced rat paw oedema. Pharmacol Res 31:67-72
8. Chan AS, Cheung MC, Law SC, Chan JH (2004) Phase II study of alpha-tocopherol in improving the cognitive function of patients with temporal lobe radionecrosis. Cancer 100:398-404
9. Chang B, Nishikawa M, Sato E, Utsumi K, Inoue M (2002) l-Carnitine inhibits cisplatin-induced injury of the kidney and small intestine. Arch Biochem Biophys 405:55-64
10. Cifone MG, Alesse E, Di Marzio L, Ruggeri B, Zazzeroni F, Moretti S, Famularo G, Steinberg SM, Vullo E, De Simone C (1997) Effect of l-carnitine treatment in vivo on apoptosis and ceramide generation in peripheral blood lymphocytes from AIDS patients. Proc Assoc Am Physicians 109:146-153
11. Dhitavat S, Ortiz D, Rogers E, Rivera E, Shea TB (2005) Folate, vitamin E, and acetyl-l-carnitine provide synergistic protection against oxidative stress resulting from exposure of human neuroblastoma cells to amyloid-beta. Brain Res 1061:114-117
12. Drago JR, Nesbitt JA, Badalament RA, Smith J (1988) Chemotherapy and vitamin E in treatment of Nb rat prostate tumors. In Vivo 2:399-401
13. Erdem AF, Cesur M, Alici HA, Erdogan F, Dogan N, Kursad H, Yuksek MS (2005) Effects of sevoflurane and desflurane in CA1 after incomplete cerebral ischemia in rats. Saudi Med J 26:1424-1428
14. Ergun O, Ulman C, Kilicalp AS, Ulman I (2001) Carnitine as a preventive agent in experimental renal ischemia-reperfusion injury. Urol Res 29:186-189
15. Erol FS, Topsakal C, Ozveren MF, Kaplan M, Ilhan N, Ozercan IH, Yildiz OG (2004) Protective effects of melatonin and vitamin E in brain damage due to gamma radiation: an experimental study. Neurosurg Rev 27:65-69
16. Ferreira PR, Fleck JF, Diehl A, Barletta D, Braga-Filho A, Barletta A, Ilha L (2004) Protective effect of alpha-tocopherol in head and neck cancer radiation-induced mucositis: a double-blind randomized trial. Head Neck 26:313-321
17. Grammas P, Hamdheydari L, Benaksas EJ, Mou S, Pye QN, Wechter WJ, Floyd RA, Stewart C, Hensley K (2004) Anti-inflammatory effects of tocopherol metabolites. Biochem Biophys Res Commun 319:1047-1052
18. Gulcin I (2006) Antioxidant and antiradical activities of l-carnitine. Life Sci 78:803-811
19. Jain SK, McVie R, Duett J, Herbst JJ (1989) Erythrocyte membrane lipid peroxidation and glycocylated hemoglobin in diabetes. Diabetes 38:1539-1543
20. Kagerud A, Holm G, Larsson H, Peterson HI (1978) Tocopherol and local X-ray irradiation of two transplantable rat tumours. Cancer Lett 5:123-129
21. Kagerud A, Peterson HI (1981) Tocopherol in irradiation of experimental neoplasms. Influence of dose and administration. Acta Radiol Oncol 20:97-100
22. Karslioglu I, Ertekin MV, Kocer I, Taysi S, Sezen O, Gepdiremen A, Balci E (2004) Protective role of intramuscularly administered vitamin E on the levels of lipid peroxidation and the activities of antioxidant enzymes in the lens of rats made cataractous with gamma-irradiation. Eur J Ophthalmol 14:478-485
23. Kawasaki N, Lee JD, Shimizu H, Ueda T (1996) Long-term l-carnitine treatment prolongs the survival in rats with adriamycin-induced heart failure. J Card Fail 2:293-299
24. Kelly GS (1998) l-carnitine: therapeutic applications of a conditionally-essential amino acid. Altern Med Rev 3:345-360
25. Kocer I, Kulacoglu D, Altuntas I, Gundogdu C, Gullulu G (2003) Protection of the retina from ischemia-reperfusion injury by l-carnitine in guinea pigs. Eur J Ophthalmol 13:80-85
26. Kocer I, Taysi S, Ertekin MV, Karslioglu I, Gepdiremen A, Sezen O, Serifoglu K (2007) The effect of l-carnitine in the prevention of ionizing radiation-induced cataracts: a rat model. Graefes Arch Clin Exp Ophthalmol 245:588-597 (Aug 17)
27. Kumar B, Jha MN, Cole WC, Bedford JS, Prasad KN (2002) d-Alpha-tocopheryl succinate (vitamin E) enhances radiation-induced chromosomal damage levels in human cancer cells, but reduces it in normal cells. J Am Coll Nutr 21:339-343
28. Kurita H, Kawahara N, Asai A, Ueki K, Shin M, Kirino T (2001) Radiation-induced apoptosis of oligodendrocytes in the adult rat brain. Neurol Res. 23:869-874
29. Lamproglou I, Boisserie G, Mazeron JJ, Bok B, Baillet F, Drieu K (2000) Effect of Ginkgo biloba extract (EGb 761) on rats in an experimental model of acute encephalopathy after total body irradiation. Cancer Radiother 4:202-206
30. Lonergan PE, Martin DS, Horrobin DF, Lynch MA (2002) Neuroprotective effect of eicosapentaenoic acid in hippocampus of rats exposed to gamma-irradiation. J Biol Chem 277:20804-20811
31. Loster H, Bohm U (2001) l-carnitine reduces malondialdehyde concentrations in isolated rat hearts in dependence on perfusion conditions. Mol Cell Biochem 217:83-90
32. Mansour HH (2006) Protective role of carnitine ester against radiation-induced oxidative stress in rats. Pharmacol Res 54:165-171
33. Moretti S, Famularo G, Marcellini S, Boschini A, Santini G, Trinchieri V, Lucci L, Alesse E, De Simone C (2002) l-carnitine reduces lymphocyte apoptosis and oxidant stress in HIV-1-infected subjects treated with zidovudine and didanosine. Antioxid Redox Signal 4:391-403
34. Mut M, Oge K, Zorlu F, Undeger U, Erdem S, Ozcan OE (2004) Effects of ionizing radiation on brain tissue surrounding arteriovenous malformations: an experimental study in a rat caroticojugular fistula model. Neurosurg Rev 27:121-127
35. Mutlu-Turkoglu U, Erbil Y, Oztezcan S, Olgac V, Toker G, Uysal M (2000) The effect of selenium and/or vitamin E treatments on radiation-induced intestinal injury in rats. Life Sci 66:1905-1913
36. Neuzil J, Tomasetti M, Mellick AS, Alleva R, Salvatore BA, Birringer M, Fariss MW (2004) Vitamin E analogues: a new class of inducers of apoptosis with selective anti-cancer effects. Curr Cancer Drug Targets 4:355-372
37. Nieder C, Andratschke NH, Wiedenmann N, Molls M (2004) Prevention of radiation-induced central nervous system toxicity: a role for amifostine? Anticancer Res 24:3803-3809
38. Onem G, Aral E, Enli Y, Oguz EO, Coskun E, Aybek H, Ozcan AV, Sacar M, Bir LS, Baltalarli A et al (2006) Neuroprotective effects of l-carnitine and vitamin E alone or in combination against ischemia-reperfusion injury in rats. J Surg Res 131:124-130
39. Osakada F, Hashino A, Kume T, Katsuki H, Kaneko S, Akaike A (2003) Neuroprotective effects of alpha-tocopherol on oxidative stress in rat striatal cultures. Eur J Pharmacol 465:15-22
40. Peker S, Abacioglu U, Sun I, Yuksel M, Pamir MN (2004) Irradiation after surgically induced brain injury in the rat: timing in relation to severity of radiation damage. J Neurooncol 70:17-21
41. Pisano C, Pratesi G, Laccabue D, Zunino F, Lo Giudice P, Bellucci A, Pacifici L, Camerini B, Vesci L, Castorina M et al (2003) Paclitaxel and cisplatin-induced neurotoxicity: a protective role of acetyl-l-carnitine. Clin Cancer Res 9:5756-5767
42. Porock D (2002) Factors influencing the severity of radiation skin and oral mucosal reactions: development of a conceptual framework. Eur J Cancer Care 11:33-43
43. Rani PJ, Panneerselvam C (2002) Effect of l-carnitine on brain lipid peroxidation and antioxidant enzymes in old rats. J Gerontol A Biol Sci Med Sci 57:134-137
44. Reznick AZ, Kagan VE, Ramsey R, Tsuchiya M, Khwaja S, Serbinova EA, Packer L (1992) Antiradical effects in l-propionyl carnitine protection of the heart against ischemia-reperfusion injury: the possible role of iron chelation. Arch Biochem Biophys 296:394-401
45. Savitha S, Tamilselvan J, Anusuyadevi M, Panneerselvam C (2005) Oxidative stress on mitochondrial antioxidant defense system in the aging process: role of DL-alpha-lipoic acid and l-carnitine. Clin Chim Acta 355:173-180
46. Shaheen AA, Hassan SM (1991) Radioprotection of whole-body gamma-irradiation-induced alteration in some haematological parameters by cysteine, vitamin E and their combination in rats. Strahlenther Onkol 167:498-501
47. Shimizu T, Iwanaga M, Yasunaga A, Urata Y, Goto S, Shibata S, Rondo T (1998) Protective role of glutathione synthesis on radiation-induced DNA damage in rabbit brain. Cell Mol Neurobiol 18:299-310
48. Sun Y, Oberley LW, Li Y (1988) A simple method for clinical assay of superoxide dismutase. Clin Chem 34:497-500
49. Tetik O, Yagdi T, Islamoglu F, Calkavur T, Posacioglu H, Atay Y, Ayik F, Canpolat L Yuksel M (2002) The effects of l-carnitine on spinal cord ischemia/reperfusion injury in rabbits. Thorac Cardiovasc Surg 50:11-15
50. Traber MG, Packer L (1995) Vitamin E: beyond antioxidant function. Am J Clin Nutr 62;1501-1509
51. Ucuncu H, Ertekin MV, Yoruk O, Sezen O, Ozkan A, Erdogan F, Kiziltunc A, Gundogdu C (2006) Vitamin E and l-carnitine, separately or in combination, in the prevention of radiation-induced oral mucositis and myelosuppression: a controlled study in a rat model. J Radiat Res 47:91-102
52. Undeger U, Giray B, Zorlu AF, Oge K, Bacaran N (2004) Protective effects of melatonin on the ionizing radiation induced DNA damage in the rat brain. Exp Toxicol Pathol 55:379-384
53. Vanella A, Russo A, Acquaviva R, Campisi A, Di Giacomo C, Sorrenti V, Barcellona ML (2000) l-Propiony l-carnitine as superoxide scavenger, antioxidant, and DNA cleavage protector. Cell Biol Toxicol 16:99-104
54. Wolf R, Wolf D, Ruocco V (1998) Vitamin E: the radical protector. J Eur Acad Dermatol Venereol 10:103-117
55. Yoshimura M, Kashiba M, Oka J, Sugisawa A, Umegaki K (2002) Vitamin E prevents increase in oxidative damage to lipids and DNA in liver of ODS rats given total body X-ray irradiation. Free Radic Res 36:107-112
56. Zou W, Noh SK, Owen KQ, Koo SI (2005) Dietary l-carnitine enhances the lymphatic absorption of fat and alpha-tocopherol in ovariectomized rats. J Nutr 135:753-756