Lovastatin attenuates ionizing radiation-induced normal tissue damage in vivo

Radiotherapy and Oncology

Volumn 92, Issue 3, 2009, Pages 492-499

  Ostrau, Christian ^a   Hülsenbeck, Johannes ^a   Herzog, Melanie ^a   Schad, Arno ^a   Torzewski, Michael ^b   Lackner, Karl J ^b   Fritz, Gerhard ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

^b University Medical Center   (Germany)

Author keywords

Cell death; Ionizing radiation; Normal tissue damage; Statins; Stress responses

Indexed keywords

BETA ACTIN; COLLAGEN TYPE 1; COLLAGEN TYPE 3; CONNECTIVE TISSUE GROWTH FACTOR; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; HISTONE H2A; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 6; MESSENGER RNA; MEVINOLIN; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DNA DAMAGE; DRUG EFFECT; ENZYME PHOSPHORYLATION; FEMALE; GENOTOXICITY; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RADIATION DOSE; RADIATION INJURY; RADIATION RESPONSE; THROMBOCYTOPENIA; TISSUE INJURY; WHOLE BODY RADIATION;

ANIMALS; CELL SURVIVAL; DISEASE MODELS, ANIMAL; DNA DAMAGE; DOSE-RESPONSE RELATIONSHIP, RADIATION; FEMALE; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; INFLAMMATION MEDIATORS; INTESTINES; LIVER; LOVASTATIN; LUNG; MICE; MICE, INBRED BALB C; NF-KAPPA B; PROBABILITY; RADIATION DOSAGE; RADIATION INJURIES; RADIATION INJURIES, EXPERIMENTAL; RADIATION, IONIZING; RANDOM ALLOCATION; REFERENCE VALUES; RNA, MESSENGER; TUMOR NECROSIS FACTOR-ALPHA;

EID: 69949134568     PISSN: 01678140     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.radonc.2009.06.020     Document Type: Article

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