Dietary inhibition of xanthine oxidase attenuates radiation-induced endothelial dysfunction in rat aorta

Journal of Applied Physiology

Volumn 108, Issue 5, 2010, Pages 1250-1258

  Soucy, Kevin G ^a   Lim, Hyun Kyo ^b   Attarzadeh, David O ^a   Santhanam, Lakshmi ^a   Kim, Jae Hyung ^a   Bhunia, Anil K ^a   Sevinc, Baris ^a   Ryoo, Sungwoo ^c   Vazquez, Marcelo E ^d   Nyhan, Daniel ^a   Shoukas, Artin A ^a   Berkowitz, Dan E ^a  

^a DEPARTMENT OF PATHOLOGY   (United States)

^b Yonsei University Wonju   (South Korea)

^c Kangwon National University   (South Korea)

^d BROOKHAVEN NATIONAL LABORATORY   (United States)

Author keywords

Gamma radiation; Nitric oxide; Nitrosoredox imbalance; Oxidative stress; Oxypurinol

Indexed keywords

ENZYME INHIBITOR; NITRIC OXIDE; OXIPURINOL; SUPEROXIDE; VASODILATOR AGENT; XANTHINE OXIDASE;

ANIMAL; AORTA; ARTICLE; BLOOD FLOW; DIET; DISEASE MODEL; DOPPLER FLOWMETRY; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; ELASTICITY; ENZYMOLOGY; GAMMA RADIATION; MALE; METABOLISM; PATHOPHYSIOLOGY; PULSATILE FLOW; RADIATION EXPOSURE; RADIATION INJURY; RAT; SPRAGUE DAWLEY RAT; TIME; VASCULAR DISEASE; VASCULAR ENDOTHELIUM; VASODILATATION; WHOLE BODY RADIATION;

ANIMALS; AORTA; DIET; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ELASTICITY; ENDOTHELIUM, VASCULAR; ENZYME INHIBITORS; GAMMA RAYS; MALE; NITRIC OXIDE; OXYPURINOL; PULSATILE FLOW; RADIATION INJURIES, EXPERIMENTAL; RATS; RATS, SPRAGUE-DAWLEY; REGIONAL BLOOD FLOW; SUPEROXIDES; TIME FACTORS; ULTRASONOGRAPHY, DOPPLER; VASCULAR DISEASES; VASODILATION; VASODILATOR AGENTS; WHOLE-BODY IRRADIATION; XANTHINE OXIDASE;

EID: 77951971147     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.00946.2009     Document Type: Article

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