Mechanisms of endothelial dysfunction after ionized radiation: Selective impairment of the nitric oxide component of endothelium-dependent vasodilation

British Journal of Pharmacology

Volumn 138, Issue 5, 2003, Pages 837-844

  Soloviev, Anatoly I ^a   Tishkin, Sergey M ^a   Parshikov, Alexander V ^a   Ivanova, Irina V ^a   Goncharov, Eugene V ^a   Gurney, Alison M ^b  

^a STATE INSTITUTION NATIONAL RESEARCH CENTER FOR RADIATION MEDICINE OF THE NATIONAL ACADEMY OF MEDICAL SCIENCES OF UKRAINE   (Ukraine)

^b UNIVERSITY OF STRATHCLYDE   (United Kingdom)

Author keywords

EDHF; Endothelium; NO; Oxidative stress; Rabbit aorta; Radiation

Indexed keywords

ACETYLCHOLINE; ALPHA TOCOPHEROL; ANTIOXIDANT; APAMIN; CALCIMYCIN; CHARYBDOTOXIN; COBALT; ENDOTHELIUM DERIVED HYPERPOLARIZING FACTOR; GLYCERYL TRINITRATE; INDOMETACIN; LINSIDOMINE; N(G) NITROARGININE; NITRIC OXIDE; NITROPRUSSIDE SODIUM;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AORTA; ARTICLE; BLOOD VESSEL FUNCTION; CONTROLLED STUDY; DOSE RESPONSE; GAMMA RADIATION; HYPERPOLARIZATION; IONIZING RADIATION; MALE; MEMBRANE POTENTIAL; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN FUNCTION; RABBIT; RADIATION DOSE; VASCULAR ENDOTHELIUM; VASCULAR SMOOTH MUSCLE; VASODILATATION; WHOLE BODY RADIATION;

ANIMALS; AORTA, THORACIC; DOSE-RESPONSE RELATIONSHIP, DRUG; DOSE-RESPONSE RELATIONSHIP, RADIATION; ENDOTHELIUM, VASCULAR; MALE; NITRIC OXIDE; RABBITS; RADIATION, IONIZING; VASODILATION;

EID: 0037350668     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0705079     Document Type: Article

References (26)

1. ALLEN, J.B., SAGERMAN, R.H. & STUART, M,J. (1981). Irradiation decreases vascular prostacyclin formation with no concomitant effect on platelet thromboxane production. Lancet, 2, 1193-1196.
2. BARABOY, V.A. (1997). Biological effects in animals. Changes in biochemical indices of the organism vitally important systems. In Chernobyl catastrophe. Baryakhtar, V. (ed) pp. 285-288. Ukraine, Kiev: Editorial House of Annual Issue 'Export of Ukraine'.
3. BECKMAN, J.A., THAKORE, A., KALINOWSKI, B.H., HARRIS, J.R. & CREAGER, M.A. (2001). Radiation therapy impairs endothelium-dependent vasodilation in humans. J. Am. Coll. Cardiol., 37, 761-765.
4. GRATWOHL, A., JOHN, L., BALDOMERO, H., ROTH, J., TICHELLI, A., NISSEN, C., LYMAN, S.D. & WODNAR-FILIPOWICZ, A. (1998). FLT-3 ligand provides hematopoietic protection from total body irradiation in rabbits. Blood, 92, 765-769.
5. KEANEY, J.F., GAZIANO, J.M., XU, A., FREI, B., CURRAN-CELANTANO, J., SHWAERY, G.T., LOSCALZO, J. & VITA, J.A. (1993). Dietary antioxidants preserve endothelium-dependent vessel relaxation in cholesterol-fed rabbits. Proc. Natl. Acad. Sci. USA, 90, 11880-11884.
6. KHOMAZJUK, I.N. (1998). The problem of essential hypertension in survivors after Chernobyl catastrophe. Proceedings of the 2nd International Conference. Long-term health consequences of the Chernobyl disaster. World Health Organization - Chernobyl interinfom, Kiev, p. 398-399.
7. KLIMOV, D.V. & ADZIARKHA, K.N. (2001). Risk factors for the development of hypertension in the liquidators of 1986-1987. (Abstract of the 3rd International Confererence. Health effects of the Chernobyl accident: results of the 15-year follow-up studies. June 4-8, 2001, Kiev, Ukraine). Intern. J. of Radiation Med. 3, 59.
8. LELIUK, V.G. & GUSKOVA, A.K. (1998). Evaluation of the relationship between the cerebrovascular diseases and ionizing radiation exposure at the late period after irradiation. Proceedings of the 2nd International Conference: Long-term health consequences of the Chernobyl disaster. World Health Organization - Chernobylinterinfom, Kiev, p. 274-275.
9. MAYNARD, K.I., STEWART-LEE, A.L., MILNER, P. & BURNSTOCK, G. (1992). X-irradiation attenuates relaxant responses in the rabbit ear artery. Br. J. Pharmacol., 105, 126-128.
10. MAJOR, O., KEMENY, A.A., FORSTER, D.M., JAKUBOWSKI, J. & MORICE, A.H. (1996). In vitro contractility studies of the rat middle cerebral artery after stereotactic Gamma Knife radio-surgery. Stereotact. Funct. Neurosurg., 66 (Suppl 1), 17-28.
11. MENENDEZ, J.C., CASANOVA, D., AMADO, J.A., SALAS, E., GARSIA-UNZUETA, M.T., FERNANDEZ, F., PEREZ DE LA LASTRA, M. & BERRAZUETA, J.R. (1998). Effects of radiation on endothelial function. I. J. Radiation Oncology Biol. Phys., 41, 905-913.
12. MOMBOULI, J.V. & VANHOUTTE, P.M. (1997). Endothelium-derived hyperpolarizing factor(s): updating the unknown. Trends Pharmacol. Sci., 18, 252-256.
13. ON, Y.K., KIM, H.S., KIM, S.Y., CHAE, I.H., OH, B.H., LEE, M.M., PARK, Y.B., CHOI, Y.S. & CHUNG, M.H. (2001). Vitamin C prevents radiation-induced endothelium-dependent vasomotor dysfunction and de-endothelialization by inhibiting oxidative damage in the rat. Clin. Exp. Pharmacol. Physiol., 28, 816-821.
14. 60. Br. J. Pharmacol., 123, 653-660.
15. RADI, R., BECKMAN, J., BUSH, K. & FREEMAN, B. (1991). Peroxynitrite-induced membrane lipid peroxydation: the cytotoxic potential of superoxide and nitric oxide. Arch. of Biophys. and Biochem., 288, 481-487.
16. RUBANYI, G.M. & VANHOUTTE, P.M. (1986). Superoxide anions and hyperoxia inactivate EDRR. Am. J. Physiol., 250, H822-H827.
17. RUIZ, E. & TEJERINA, T. (1999). Is L-citrulline an EDHF in the rabbit aorta? In Endothelim-dependent hyperpolarizations. ed.- Vanhoutte, P. pp. 399-403. The Netherlands: Harwood Academic Publishers.
18. SERKIZ, Y.I. (1997). Peculiarities of the low efficiency radiation biological effects. In Chernobyl catastrophe, Baryakhtar, V. (ed.) pp. 279-281. Ukraine, Kiev, Editorial House of Annual Issue 'Export of Ukraine'.
19. SHENG-TANNER, X., BUMP, E.A. & HEDLEY, D.W. (1998). An oxidative stress-mediated death pathway in irradiated human leukemia cells mapped using multilaser flow cytometry. Radiat. Res., 150, 636-647.
20. SUGIHARA, T., HATTORI, Y., YAMAMOTO, Y., QI, F.Z., ICHIKAWA, R., SAIO, A., LIU, M.Y., ABE, K. & CANNO, M. (1999). Preferential impairment of nitric oxide-dependent relaxation in human cervical arteries after irradiation. Circulation, 100, 635-641.
21. SYDORYK, Y.P., DRUZHINA, M.O., BURLAKA, A.P. & PUKNOVA, G.G. (1997). Biological effects in animals. Changes of biophysical characteristics in the organs and in the blood. In Chernobyl catastrophe, Baryakhtar, V. (ed.) pp. 282-284. Ukraine, Kiev, Editorial House of Annual Issue 'Export of Ukraine'.
22. TARANENKO, V.M., TISHKIN, S.M. & RUDNEV, M.I. (1992). The ionised radiation-induced changes of vascular wall reactivity. Proc. Acad. Sci. U.S.S.R. (Moscow), 322, 600-603.
23. TISHKIN, S.M. (1998). The influence of ionising radiation on some antianginal drugs action. Drugs (Ukraine), 2, 62-65.
24. VOROBYOV, V.I. & STEPANOV, R.P. (1985). Ionizing radiation and blood vessels. Moscow, Energoatomizdat, 296 p.
25. WARFIELD, M.E., SCHNEIDKRAUT, M.J., CUNARD, C.M., RAMWELL, P.W. & KOT, P.A. (1989). Reactivity of rat abdominal aorta to U46619 following whole-body gamma irradiation. Radiat. Res., 117, 459-468.
26. WONG, F.L., YAMADA, M., SASAKI, H., KODAMA, K., AKIBA, S., SHIMAOKA, K. & HOSODA, Y. (1993). Noncancer disease incidence in the atomic bomb survivors: 1958-1986. Radiat. Res., 135, 418-430.