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Volumn 22, Issue 6, 2008, Pages 443-452

Ginsenoside Rb1 preconditioning protects against myocardial infarction after regional ischemia and reperfusion by activation of phosphatidylinositol-3- kinase signal transduction

Author keywords

Akt; Ginseng; Ginsenoside Rb1; Infarct size; Myocardial reperfusion injury; Phosphatidylinositol 3 kinase; Wortmannin

Indexed keywords

CREATINE KINASE; CREATINE KINASE MB; GINSENOSIDE RB 1; LACTATE DEHYDROGENASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; TRIPHENYLTETRAZOLIUM; TROPONIN T; WORTMANNIN;

EID: 55949136010     PISSN: 09203206     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10557-008-6129-4     Document Type: Article
Times cited : (83)

References (61)
  • 1
    • 0036016028 scopus 로고    scopus 로고
    • Cardioprotective effects of 9-hydroxyellipticine on ischemia and reperfusion in isolated rat heart
    • K Saeki I Obi N Ogiku M Shigekawa T Imagawa T Matsumoto 2002 Cardioprotective effects of 9-hydroxyellipticine on ischemia and reperfusion in isolated rat heart Jpn J Pharmacol 89 21 28
    • (2002) Jpn J Pharmacol , vol.89 , pp. 21-28
    • Saeki, K.1    Obi, I.2    Ogiku, N.3    Shigekawa, M.4    Imagawa, T.5    Matsumoto, T.6
  • 2
    • 0036269528 scopus 로고    scopus 로고
    • Pharmacological possibilities for protection against myocardial reperfusion injury
    • QD Wang J Pernow PO Sjöquist L Rydén 2002 Pharmacological possibilities for protection against myocardial reperfusion injury Cardiovasc Res 55 25 37
    • (2002) Cardiovasc Res , vol.55 , pp. 25-37
    • Wang, Q.D.1    Pernow, J.2    Sjöquist, P.O.3    Rydén, L.4
  • 3
    • 0022402059 scopus 로고
    • Myocardial reperfusion: A double-edged sword?
    • E Braunwald RA Kloner 1985 Myocardial reperfusion: a double-edged sword? J Clin Invest 76 1713 1719
    • (1985) J Clin Invest , vol.76 , pp. 1713-1719
    • Braunwald, E.1    Kloner, R.A.2
  • 4
    • 0031055348 scopus 로고    scopus 로고
    • Reperfusion injury: A review of the pathophysiology, clinical manifestations and therapeutic options
    • SR Maxwell GY Lip 1997 Reperfusion injury: a review of the pathophysiology, clinical manifestations and therapeutic options Int J Cardiol 58 95 117
    • (1997) Int J Cardiol , vol.58 , pp. 95-117
    • Maxwell, S.R.1    Lip, G.Y.2
  • 5
    • 0032730499 scopus 로고    scopus 로고
    • Mechanisms of myocardial reperfusion injury
    • JL Park BR Lucchesi 1999 Mechanisms of myocardial reperfusion injury Ann Thorac Surg 68 1905 1912
    • (1999) Ann Thorac Surg , vol.68 , pp. 1905-1912
    • Park, J.L.1    Lucchesi, B.R.2
  • 7
    • 0344549853 scopus 로고    scopus 로고
    • Ginseng pharmacology: Multiple constituents and multiple actions
    • AS Attele JA Wu CS Yuan 1999 Ginseng pharmacology: multiple constituents and multiple actions Biochem Pharmacol 58 1685 1693
    • (1999) Biochem Pharmacol , vol.58 , pp. 1685-1693
    • Attele, A.S.1    Wu, J.A.2    Yuan, C.S.3
  • 8
    • 0030757369 scopus 로고    scopus 로고
    • Panax ginseng pharmacology: A nitric oxide link?
    • CN Gillis 1997 Panax ginseng pharmacology: a nitric oxide link? Biochem Pharmacol 54 1 8
    • (1997) Biochem Pharmacol , vol.54 , pp. 1-8
    • Gillis, C.N.1
  • 9
    • 0037036187 scopus 로고    scopus 로고
    • Protective effect of ginsenosides, active ingredients of Panax ginseng, on kainic acid-induced neurotoxicity in rat hippocampus
    • JH Lee SR Kim CS Bae D Kim H Hong S Nah 2002 Protective effect of ginsenosides, active ingredients of Panax ginseng, on kainic acid-induced neurotoxicity in rat hippocampus Neurosci Lett 325 129 133
    • (2002) Neurosci Lett , vol.325 , pp. 129-133
    • Lee, J.H.1    Kim, S.R.2    Bae, C.S.3    Kim, D.4    Hong, H.5    Nah, S.6
  • 10
    • 0031009473 scopus 로고    scopus 로고
    • Protection of ischemic hippocampal neurons by ginsenoside Rb1, a main ingredient of ginseng root
    • JH Lim TC Wen S Matsuda J Tanaka N Maeda H Peng 1997 Protection of ischemic hippocampal neurons by ginsenoside Rb1, a main ingredient of ginseng root Neurosci Res 28 191 200
    • (1997) Neurosci Res , vol.28 , pp. 191-200
    • Lim, J.H.1    Wen, T.C.2    Matsuda, S.3    Tanaka, J.4    Maeda, N.5    Peng, H.6
  • 11
    • 0029085452 scopus 로고
    • Effects of ginsenoside Rb1 and Rg1 on synaptosomal free calcium level, ATPase and calmodulin in rat hippocampus
    • M Liu J Zhang 1995 Effects of ginsenoside Rb1 and Rg1 on synaptosomal free calcium level, ATPase and calmodulin in rat hippocampus Chin Med J (Engl) 108 544 547
    • (1995) Chin Med J (Engl) , vol.108 , pp. 544-547
    • Liu, M.1    Zhang, J.2
  • 12
  • 13
    • 0029147487 scopus 로고
    • Effects of Panax notoginseng saponins on posthypoxic cell damage of neurons in vitro
    • KY Jiang ZN Qian 1995 Effects of Panax notoginseng saponins on posthypoxic cell damage of neurons in vitro Zhongguo Yao Li Xue Bao 16 399 402
    • (1995) Zhongguo Yao Li Xue Bao , vol.16 , pp. 399-402
    • Jiang, K.Y.1    Qian, Z.N.2
  • 14
    • 0029704284 scopus 로고    scopus 로고
    • Influences of ginsenosides Rb1 and Rg1 on reversible focal brain ischemia in rats
    • YG Zhang TP Liu 1996 Influences of ginsenosides Rb1 and Rg1 on reversible focal brain ischemia in rats Zhongguo Yao Li Xue Bao 17 44 48
    • (1996) Zhongguo Yao Li Xue Bao , vol.17 , pp. 44-48
    • Zhang, Y.G.1    Liu, T.P.2
  • 15
    • 0642317065 scopus 로고    scopus 로고
    • Effect of ginsenoside-Rb1 on cardiomyocyte apoptosis after ischemia and reperfusion in rats
    • L Guan W Li Z Liu 2002 Effect of ginsenoside-Rb1 on cardiomyocyte apoptosis after ischemia and reperfusion in rats J Huazhong Univ Sci Technolog Med Sci 22 212 215
    • (2002) J Huazhong Univ Sci Technolog Med Sci , vol.22 , pp. 212-215
    • Guan, L.1    Li, W.2    Liu, Z.3
  • 16
    • 0346059584 scopus 로고    scopus 로고
    • Primary and secondary signaling pathways in early preconditioning that converge on the mitochondria to produce cardioprotection
    • E Murphy 2004 Primary and secondary signaling pathways in early preconditioning that converge on the mitochondria to produce cardioprotection Circ Res 94 7 16
    • (2004) Circ Res , vol.94 , pp. 7-16
    • Murphy, E.1
  • 17
    • 33845982523 scopus 로고    scopus 로고
    • Signaling pathway of nitric oxide production induced by ginsenoside Rb1 in human aortic endothelial cells: A possible involvement of androgen receptor
    • J Yu M Eto M Akishita A Kaneko Y Ouchi T Okabe 2007 Signaling pathway of nitric oxide production induced by ginsenoside Rb1 in human aortic endothelial cells: a possible involvement of androgen receptor Biochem Biophys Res Commun 353 764 769
    • (2007) Biochem Biophys Res Commun , vol.353 , pp. 764-769
    • Yu, J.1    Eto, M.2    Akishita, M.3    Kaneko, A.4    Ouchi, Y.5    Okabe, T.6
  • 19
    • 0029704284 scopus 로고    scopus 로고
    • Influences of ginsenosides Rb1 and Rg1 on reversible focal brain ischemia in rats
    • YG Zhang TP Liu 1996 Influences of ginsenosides Rb1 and Rg1 on reversible focal brain ischemia in rats Zhongguo Yao Li Xue Bao 17 44 48
    • (1996) Zhongguo Yao Li Xue Bao , vol.17 , pp. 44-48
    • Zhang, Y.G.1    Liu, T.P.2
  • 20
    • 0029655506 scopus 로고    scopus 로고
    • Ginseng root prevents learning disability and neuronal loss in gerbils with 5-minute forebrain ischemia
    • TC Wen H Yoshimura S Matsuda JH Lim M Sakanaka 1996 Ginseng root prevents learning disability and neuronal loss in gerbils with 5-minute forebrain ischemia Acta Neuropathol 91 15 22
    • (1996) Acta Neuropathol , vol.91 , pp. 15-22
    • Wen, T.C.1    Yoshimura, H.2    Matsuda, S.3    Lim, J.H.4    Sakanaka, M.5
  • 21
    • 4344586929 scopus 로고    scopus 로고
    • Simvastatin acutely reduces myocardial reperfusion injury in vivo by activating the phosphatidylinositide 3-kinase/Akt pathway
    • S Wolfrum A Dendorfer M Schutt B Weidtmann A Heep K Tempel 2004 Simvastatin acutely reduces myocardial reperfusion injury in vivo by activating the phosphatidylinositide 3-kinase/Akt pathway J Cardiovasc Pharmacol 44 348 355
    • (2004) J Cardiovasc Pharmacol , vol.44 , pp. 348-355
    • Wolfrum, S.1    Dendorfer, A.2    Schutt, M.3    Weidtmann, B.4    Heep, A.5    Tempel, K.6
  • 22
    • 0037177142 scopus 로고    scopus 로고
    • Nitric oxide mediates the antiapoptotic effect of insulin in myocardial ischemia-reperfusion: The roles of PI3K, Akt, and endothelial nitric oxide synthase phosphorylation
    • F Gao E Gao TL Yue EH Ohlstein BL Lopez TA Christopher 2002 Nitric oxide mediates the antiapoptotic effect of insulin in myocardial ischemia-reperfusion: the roles of PI3K, Akt, and endothelial nitric oxide synthase phosphorylation Circulation 105 1497 1502
    • (2002) Circulation , vol.105 , pp. 1497-1502
    • Gao, F.1    Gao, E.2    Yue, T.L.3    Ohlstein, E.H.4    Lopez, B.L.5    Christopher, T.A.6
  • 23
    • 29744459498 scopus 로고    scopus 로고
    • Chronic erythropoietin treatment limits infarct-size in the myocardium in vitro
    • AJ Bullard DM Yellon 2005 Chronic erythropoietin treatment limits infarct-size in the myocardium in vitro Cardiovasc Drugs Ther 19 333 336
    • (2005) Cardiovasc Drugs Ther , vol.19 , pp. 333-336
    • Bullard, A.J.1    Yellon, D.M.2
  • 24
    • 33646341764 scopus 로고    scopus 로고
    • Prevention of ischemic neuronal death by intravenous infusion of a ginseng saponin, ginsenoside Rb(1), that upregulates Bcl-x(L) expression
    • B Zhang R Hata P Zhu K Sato TC Wen L Yang 2006 Prevention of ischemic neuronal death by intravenous infusion of a ginseng saponin, ginsenoside Rb(1), that upregulates Bcl-x(L) expression J Cereb Blood Flow Metab 26 708 721
    • (2006) J Cereb Blood Flow Metab , vol.26 , pp. 708-721
    • Zhang, B.1    Hata, R.2    Zhu, P.3    Sato, K.4    Wen, T.C.5    Yang, L.6
  • 25
    • 33847697715 scopus 로고    scopus 로고
    • Ginsenoside Rb1 protects against damage to the spiral ganglion cells after cochlear ischemia
    • K Fujita N Hakuba R Hata I Morizane T Yoshida M Shudou 2007 Ginsenoside Rb1 protects against damage to the spiral ganglion cells after cochlear ischemia Neurosci Lett 415 113 117
    • (2007) Neurosci Lett , vol.415 , pp. 113-117
    • Fujita, K.1    Hakuba, N.2    Hata, R.3    Morizane, I.4    Yoshida, T.5    Shudou, M.6
  • 26
    • 0029059913 scopus 로고
    • Calcium channel blockade and anti-free-radical actions of panaxadiol saponins Rb1, Rb2, Rb3, Rc, and Rd
    • GG Zhong CW Sun YY Li H Qi CY Zhao Y Jiang 1995 Calcium channel blockade and anti-free-radical actions of panaxadiol saponins Rb1, Rb2, Rb3, Rc, and Rd Zhongguo Yao Li Xue Bao 16 255 260
    • (1995) Zhongguo Yao Li Xue Bao , vol.16 , pp. 255-260
    • Zhong, G.G.1    Sun, C.W.2    Li, Y.Y.3    Qi, H.4    Zhao, C.Y.5    Jiang, Y.6
  • 27
    • 18844457413 scopus 로고    scopus 로고
    • Ginsenoside Rb1 blocks homocysteine-induced endothelial dysfunction in porcine coronary arteries
    • W Zhou H Chai PH Lin AB Lumsden Q Yao C Chen 2005 Ginsenoside Rb1 blocks homocysteine-induced endothelial dysfunction in porcine coronary arteries J Vasc Surg 41 861 868
    • (2005) J Vasc Surg , vol.41 , pp. 861-868
    • Zhou, W.1    Chai, H.2    Lin, P.H.3    Lumsden, A.B.4    Yao, Q.5    Chen, C.6
  • 28
    • 0142248962 scopus 로고    scopus 로고
    • Red wine prevents homocysteine-induced endothelial dysfunction in porcine coronary arteries
    • W Fu BS Conklin PH Lin AB Lumsden Q Yao C Chen 2003 Red wine prevents homocysteine-induced endothelial dysfunction in porcine coronary arteries J Surg Res 115 82 91
    • (2003) J Surg Res , vol.115 , pp. 82-91
    • Fu, W.1    Conklin, B.S.2    Lin, P.H.3    Lumsden, A.B.4    Yao, Q.5    Chen, C.6
  • 29
    • 11144355507 scopus 로고    scopus 로고
    • Estrogen blocks homocysteine-induced endothelial dysfunction in porcine coronary arteries(1,2)
    • TA Spencer H Chai W Fu G Ramaswami MW Cox BS Conklin 2004 Estrogen blocks homocysteine-induced endothelial dysfunction in porcine coronary arteries(1,2) J Surg Res 118 83 90
    • (2004) J Surg Res , vol.118 , pp. 83-90
    • Spencer, T.A.1    Chai, H.2    Fu, W.3    Ramaswami, G.4    Cox, M.W.5    Conklin, B.S.6
  • 30
    • 2442686484 scopus 로고    scopus 로고
    • Vascular effects of Siberian ginseng (Eleutherococcus senticosus): Endothelium-dependent NO- and EDHF-mediated relaxation depending on vessel size
    • CY Kwan WB Zhang SM Sim T Deyama S Nishibe 2004 Vascular effects of Siberian ginseng (Eleutherococcus senticosus): endothelium-dependent NO- and EDHF-mediated relaxation depending on vessel size Naunyn Schmiedebergs Arch Pharmacol 369 473 480
    • (2004) Naunyn Schmiedebergs Arch Pharmacol , vol.369 , pp. 473-480
    • Kwan, C.Y.1    Zhang, W.B.2    Sim, S.M.3    Deyama, T.4    Nishibe, S.5
  • 31
    • 0029853361 scopus 로고    scopus 로고
    • Cardiovascular protection by ginsenosides and their nitric oxide releasing action
    • X Chen 1996 Cardiovascular protection by ginsenosides and their nitric oxide releasing action Clin Exp Pharmacol Physiol 23 728 732
    • (1996) Clin Exp Pharmacol Physiol , vol.23 , pp. 728-732
    • Chen, X.1
  • 32
    • 0016168385 scopus 로고
    • The reduction of infarct size-an idea whose time (for testing) has come
    • E Braunwald PR Maroko 1974 The reduction of infarct size-an idea whose time (for testing) has come Circulation 50 206 209
    • (1974) Circulation , vol.50 , pp. 206-209
    • Braunwald, E.1    Maroko, P.R.2
  • 33
    • 34347212063 scopus 로고    scopus 로고
    • Darbepoetin alfa protects the rat heart against infarction: Dose-response, phase of action, and mechanisms
    • JE Baker D Kozik AK Hsu X Fu JS Tweddell GJ Gross 2007 Darbepoetin alfa protects the rat heart against infarction: dose-response, phase of action, and mechanisms J Cardiovasc Pharmacol 49 337 345
    • (2007) J Cardiovasc Pharmacol , vol.49 , pp. 337-345
    • Baker, J.E.1    Kozik, D.2    Hsu, A.K.3    Fu, X.4    Tweddell, J.S.5    Gross, G.J.6
  • 34
    • 11444267248 scopus 로고    scopus 로고
    • Isoflurane protects against myocardial infarction during early reperfusion by activation of phosphatidylinositol-3-kinase signal transduction: Evidence for anesthetic-induced postconditioning in rabbits
    • PC Chiari MW Bienengraeber PS Pagel JG Krolikowski JR Kersten DC Warltier 2005 Isoflurane protects against myocardial infarction during early reperfusion by activation of phosphatidylinositol-3-kinase signal transduction: evidence for anesthetic-induced postconditioning in rabbits Anesthesiology 102 102 109
    • (2005) Anesthesiology , vol.102 , pp. 102-109
    • Chiari, P.C.1    Bienengraeber, M.W.2    Pagel, P.S.3    Krolikowski, J.G.4    Kersten, J.R.5    Warltier, D.C.6
  • 35
    • 0037325914 scopus 로고    scopus 로고
    • Bradykinin limits infarction when administered as an adjunct to reperfusion in mouse heart: The role of PI3K, Akt and eNOS
    • RM Bell DM Yellon 2003 Bradykinin limits infarction when administered as an adjunct to reperfusion in mouse heart: the role of PI3K, Akt and eNOS J Mol Cell Cardiol 35 185 193
    • (2003) J Mol Cell Cardiol , vol.35 , pp. 185-193
    • Bell, R.M.1    Yellon, D.M.2
  • 36
    • 0032787638 scopus 로고    scopus 로고
    • Myocardial protection by insulin is dependent on phospatidylinositol 3-kinase but not protein kinase C or KATP channels in the isolated rabbit heart
    • CP Baines L Wang MV Cohen JM Downey 1999 Myocardial protection by insulin is dependent on phospatidylinositol 3-kinase but not protein kinase C or KATP channels in the isolated rabbit heart Basic Res Cardiol 94 188 198
    • (1999) Basic Res Cardiol , vol.94 , pp. 188-198
    • Baines, C.P.1    Wang, L.2    Cohen, M.V.3    Downey, J.M.4
  • 37
    • 0036623989 scopus 로고    scopus 로고
    • PI3 kinase and not p42/p44 appears to be implicated in the protection conferred by ischemic preconditioning
    • MM Mocanu RM Bell DM Yellon 2002 PI3 kinase and not p42/p44 appears to be implicated in the protection conferred by ischemic preconditioning J Mol Cell Cardiol 34 661 668
    • (2002) J Mol Cell Cardiol , vol.34 , pp. 661-668
    • Mocanu, M.M.1    Bell, R.M.2    Yellon, D.M.3
  • 39
    • 0033534088 scopus 로고    scopus 로고
    • Adenoviral gene transfer of activated phosphatidylinositol 3′-kinase and Akt inhibits apoptosis of hypoxic cardiomyocytes in vitro
    • T Matsui L Li F del Monte Y Fukui TF Franke RJ Hajjar 1999 Adenoviral gene transfer of activated phosphatidylinositol 3′-kinase and Akt inhibits apoptosis of hypoxic cardiomyocytes in vitro Circulation 100 2373 2379
    • (1999) Circulation , vol.100 , pp. 2373-2379
    • Matsui, T.1    Li, L.2    Del Monte, F.3    Fukui, Y.4    Franke, T.F.5    Hajjar, R.J.6
  • 40
    • 0034651983 scopus 로고    scopus 로고
    • Akt promotes survival of cardiomyocytes in vitro and protects against ischemia-reperfusion injury in mouse heart
    • Y Fujio T Nguyen D Wencker RN Kitsis K Walsh 2000 Akt promotes survival of cardiomyocytes in vitro and protects against ischemia-reperfusion injury in mouse heart Circulation 101 660 667
    • (2000) Circulation , vol.101 , pp. 660-667
    • Fujio, Y.1    Nguyen, T.2    Wencker, D.3    Kitsis, R.N.4    Walsh, K.5
  • 41
    • 33746257059 scopus 로고    scopus 로고
    • Granulocyte colony-stimulating factor mediates cardioprotection against ischemia/reperfusion injury via phosphatidylinositol-3-kinase/Akt pathway in canine hearts
    • H Takahama T Minamino A Hirata A Ogai H Asanuma M Fujita 2006 Granulocyte colony-stimulating factor mediates cardioprotection against ischemia/reperfusion injury via phosphatidylinositol-3-kinase/Akt pathway in canine hearts Cardiovasc Drugs Ther 20 159 165
    • (2006) Cardiovasc Drugs Ther , vol.20 , pp. 159-165
    • Takahama, H.1    Minamino, T.2    Hirata, A.3    Ogai, A.4    Asanuma, H.5    Fujita, M.6
  • 42
    • 35348975175 scopus 로고    scopus 로고
    • The cardioprotective effect of a statin and cilostazol combination: Relationship to Akt and endothelial nitric oxide synthase activation
    • S Manickavasagam Y Ye Y Lin RJ Perez-Polo MH Huang CY Lui 2007 The cardioprotective effect of a statin and cilostazol combination: relationship to Akt and endothelial nitric oxide synthase activation Cardiovasc Drugs Ther 21 321 330
    • (2007) Cardiovasc Drugs Ther , vol.21 , pp. 321-330
    • Manickavasagam, S.1    Ye, Y.2    Lin, Y.3    Perez-Polo, R.J.4    Huang, M.H.5    Lui, C.Y.6
  • 43
    • 3042511840 scopus 로고    scopus 로고
    • Role of Akt signaling in mitochondrial survival pathway triggered by hypoxic preconditioning
    • T Uchiyama RM Engelman N Maulik DK Das 2004 Role of Akt signaling in mitochondrial survival pathway triggered by hypoxic preconditioning Circulation 109 3042 3049
    • (2004) Circulation , vol.109 , pp. 3042-3049
    • Uchiyama, T.1    Engelman, R.M.2    Maulik, N.3    Das, D.K.4
  • 44
    • 0034683064 scopus 로고    scopus 로고
    • Ischemic preconditioning activates phosphatidylinositol-3-kinase upstream of protein kinase C
    • H Tong W Chen C Steenbergen E Murphy 2000 Ischemic preconditioning activates phosphatidylinositol-3-kinase upstream of protein kinase C Circ Res 87 309 315
    • (2000) Circ Res , vol.87 , pp. 309-315
    • Tong, H.1    Chen, W.2    Steenbergen, C.3    Murphy, E.4
  • 45
    • 4043060632 scopus 로고    scopus 로고
    • Postconditioning: A form of "modified reperfusion" protects the myocardium by activating the phosphatidylinositol 3-kinase-Akt pathway
    • A Tsang DJ Hausenloy MM Mocanu DM Yellon 2004 Postconditioning: a form of "modified reperfusion" protects the myocardium by activating the phosphatidylinositol 3-kinase-Akt pathway Circ Res 95 230 232
    • (2004) Circ Res , vol.95 , pp. 230-232
    • Tsang, A.1    Hausenloy, D.J.2    Mocanu, M.M.3    Yellon, D.M.4
  • 46
    • 29144474535 scopus 로고    scopus 로고
    • PI 3-kinase regulates the mitochondrial transition pore in controlled reperfusion and postconditioning
    • JC Bopassa R Ferrera O Gateau-Roesch E Couture-Lepetit M Ovize 2005 PI 3-kinase regulates the mitochondrial transition pore in controlled reperfusion and postconditioning Cardiovasc Res 69 178 185
    • (2005) Cardiovasc Res , vol.69 , pp. 178-185
    • Bopassa, J.C.1    Ferrera, R.2    Gateau-Roesch, O.3    Couture-Lepetit, E.4    Ovize, M.5
  • 47
    • 11244270630 scopus 로고    scopus 로고
    • Postconditioning's protection is not dependent on circulatin blood factors or cells but involves adenosine receptors and requires PI3-kinase and guanylyl cyclase activation
    • XM Yang S Philipp JM Downey MV Cohen 2005 Postconditioning's protection is not dependent on circulatin blood factors or cells but involves adenosine receptors and requires PI3-kinase and guanylyl cyclase activation Basic Res Cardiol 100 57 63
    • (2005) Basic Res Cardiol , vol.100 , pp. 57-63
    • Yang, X.M.1    Philipp, S.2    Downey, J.M.3    Cohen, M.V.4
  • 48
    • 11444267248 scopus 로고    scopus 로고
    • Isoflurane protects against myocardial infarction during early reperfusion by activation of phosphatidylinositol-3-kinase signal transduction: Evidence for anesthetic-induced postconditioning in rabbits
    • PC Chiari MW Bienengraeber PS Pagel JG Krolikowski JR Kersten DC Warltier 2005 Isoflurane protects against myocardial infarction during early reperfusion by activation of phosphatidylinositol-3-kinase signal transduction: evidence for anesthetic-induced postconditioning in rabbits Anesthesiology 102 102 109
    • (2005) Anesthesiology , vol.102 , pp. 102-109
    • Chiari, P.C.1    Bienengraeber, M.W.2    Pagel, P.S.3    Krolikowski, J.G.4    Kersten, J.R.5    Warltier, D.C.6
  • 49
    • 1142309743 scopus 로고    scopus 로고
    • New directions for protecting the heart against ischemia-reperfusion injury: Targeting the reperfusion injury salvage kinase (RISK)-pathway
    • DJ Hausenloy DM Yellon 2004 New directions for protecting the heart against ischemia-reperfusion injury: targeting the reperfusion injury salvage kinase (RISK)-pathway Cardiovasc Res 61 448 460
    • (2004) Cardiovasc Res , vol.61 , pp. 448-460
    • Hausenloy, D.J.1    Yellon, D.M.2
  • 50
    • 20044367874 scopus 로고    scopus 로고
    • Glucagon like peptide-1 is protective against myocardial ischemia/reperfusion injury when given either as a preconditioning mimetic or at reperfusion in an isolated rat heart model
    • AK Bose MM Mocanu RD Carr DM Yellon 2005 Glucagon like peptide-1 is protective against myocardial ischemia/reperfusion injury when given either as a preconditioning mimetic or at reperfusion in an isolated rat heart model Cardiovasc Drugs Ther 19 9 11
    • (2005) Cardiovasc Drugs Ther , vol.19 , pp. 9-11
    • Bose, A.K.1    Mocanu, M.M.2    Carr, R.D.3    Yellon, D.M.4
  • 51
    • 0032566691 scopus 로고    scopus 로고
    • Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1
    • JA Le Good WH Ziegler DB Parekh DR Alessi P Cohen PJ Parker 1998 Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1 Science 281 2042 2045
    • (1998) Science , vol.281 , pp. 2042-2045
    • Le Good, J.A.1    Ziegler, W.H.2    Parekh, D.B.3    Alessi, D.R.4    Cohen, P.5    Parker, P.J.6
  • 52
    • 0036081804 scopus 로고    scopus 로고
    • Preconditioning blocks cardiocyte apoptosis: Role of K(ATP) channels and PKC-epsilon
    • H Liu HY Zhang X Zhu Z Shao Z Yao 2002 Preconditioning blocks cardiocyte apoptosis: role of K(ATP) channels and PKC-epsilon Am J Physiol Heart Circ Physiol 282 H1380 H1386
    • (2002) Am J Physiol Heart Circ Physiol , vol.282
    • Liu, H.1    Zhang, H.Y.2    Zhu, X.3    Shao, Z.4    Yao, Z.5
  • 53
    • 0033542476 scopus 로고    scopus 로고
    • Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation
    • S Dimmeler I Fleming B Fisslthaler C Hermann R Busse AM Zeiher 1999 Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation Nature 399 601 605
    • (1999) Nature , vol.399 , pp. 601-605
    • Dimmeler, S.1    Fleming, I.2    Fisslthaler, B.3    Hermann, C.4    Busse, R.5    Zeiher, A.M.6
  • 54
    • 0030941354 scopus 로고    scopus 로고
    • Modulation of the mitochondrial permeability transition by nitric oxide
    • MY Balakirev VV Khramtsov G Zimmer 1997 Modulation of the mitochondrial permeability transition by nitric oxide Eur J Biochem 246 710 718
    • (1997) Eur J Biochem , vol.246 , pp. 710-718
    • Balakirev, M.Y.1    Khramtsov, V.V.2    Zimmer, G.3
  • 55
    • 34548130846 scopus 로고    scopus 로고
    • Neuroprotective effects of ginsenoside Rb1 on transient cerebral ischemia in rats
    • QL Yuan CX Yang P Xu 2007 Neuroprotective effects of ginsenoside Rb1 on transient cerebral ischemia in rats Brain Res 1167 1 12
    • (2007) Brain Res , vol.1167 , pp. 1-12
    • Yuan, Q.L.1    Yang, C.X.2    Xu, P.3
  • 56
    • 13444293396 scopus 로고    scopus 로고
    • Anti-amnestic and anti-aging effects of ginsenoside Rg1 and Rb1 and its mechanism of action
    • Y Cheng LH Shen JT Zhang 2005 Anti-amnestic and anti-aging effects of ginsenoside Rg1 and Rb1 and its mechanism of action Acta Pharmacol Sin 26 143 149
    • (2005) Acta Pharmacol Sin , vol.26 , pp. 143-149
    • Cheng, Y.1    Shen, L.H.2    Zhang, J.T.3
  • 57
    • 4444341635 scopus 로고    scopus 로고
    • Modulating angiogenesis: The yin and the yang in ginseng
    • S Sengupta SA Toh LA Sellers 2004 Modulating angiogenesis: the yin and the yang in ginseng Circulation 110 1219 1225
    • (2004) Circulation , vol.110 , pp. 1219-1225
    • Sengupta, S.1    Toh, S.A.2    Sellers, L.A.3
  • 60
    • 0030991792 scopus 로고    scopus 로고
    • PAF-induced MAPK activation is inhibited by wortmannin in neutrophils and macrophages
    • I Ferby I Waga K Kume C Sakanaka T Shimizu 1996 PAF-induced MAPK activation is inhibited by wortmannin in neutrophils and macrophages Adv Exp Med Biol 416 321 326
    • (1996) Adv Exp Med Biol , vol.416 , pp. 321-326
    • Ferby, I.1    Waga, I.2    Kume, K.3    Sakanaka, C.4    Shimizu, T.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.